Hypertension最新文献

{"title":"Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome.","authors":"Daniel Ezzat, Maria A Pabon, Linke Li, Annie Chang, Nore De Moor, Zhi Yu, So Mi Jemma Cho, Pradeep Natarajan, Cassandra N Spracklen, Erin S LeBlanc, Charles B Eaton, Michael J LaMonte, Marcia L Stefanick, JoAnn E Manson, Nisha Parikh, Alexander P Reiner, Jason D Roh, Diana C Soria-Contreras, Rosangela Akemi Hoshi, Samia Mora, Olga V Demler, Camille E Powe, Michael C Honigberg","doi":"10.1161/HYPERTENSIONAHA.126.27750","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27750","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders of pregnancy (HDP) affect over 10% of pregnancies worldwide, but their association with cardiovascular-kidney-metabolic (CKM) syndrome remains unexplored.</p><p><strong>Methods: </strong>The present study included parous UK Biobank participants. The primary exposure was HDP history. CKM syndrome was categorized from stage 0 (no risk factors) to 4 (cardiovascular disease). Logistic regression tested the association of HDP history with CKM stage, adjusted for age, age², race, Townsend Deprivation Index, and smoking status. Cox models evaluated progression to stage 4, in addition, adjusting for baseline CKM stage. Replication analyses were performed in the Women Health Initiative, with CKM stage assessed at 2 study visits.</p><p><strong>Results: </strong>Among 219 639 UK Biobank (mean age, 56.9 years) and 3591 Women Health Initiative participants (61.7 years at baseline, 78.1 years at the follow-up visit), 2836 (1.3%) and 304 (8.4%), respectively, had a history of HDP. In the UK Biobank, HDP history was significantly associated with higher CKM stage (adjusted odds ratio, 3.40 [95% CI, 3.12-3.71]; <i>P</i><0.001) in ordinal logistic regression. Compared with CKM stage 0, HDP history was associated with higher odds of stages 2 to 4 (adjusted odds ratios, 6.34, 11.20, and 7.43, respectively; all <i>P</i><0.001). Over a median follow-up of 13.6 years, prior HDP was associated with progression to stage 4 (adjusted hazard ratio, 1.24 [95% CI, 1.10-1.40]; <i>P</i><0.001). Replication in the Women Health Initiative produced consistent results.</p><p><strong>Conclusions: </strong>HDP history was associated with greater CKM stage and progression to advanced CKM syndrome, supporting its use as an early life predictor of adverse CKM trajectories.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Hypertension and the Brain's Waste Drainage System.","authors":"Marah Alian, Christopher Le, Anna Williams, Joanna Wardlaw, Helene Benveniste","doi":"10.1161/HYPERTENSIONAHA.126.26767","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.126.26767","url":null,"abstract":"<p><p>An important system for brain waste clearance comprises a series of interconnected fluid and tissue compartments: the cerebrospinal fluid compartment, the glymphatic system, and the dura with the meningeal lymphatic vasculature, which drains to the cervical lymphatics. Although exchanges between these compartments are increasingly well documented, the mechanisms underlying their crosstalk and especially the regulation of brain waste clearance efficiency-including the role of immune surveillance along this pathway-remain incompletely understood. This interconnected pathway, designated the glymphatic-meningeal-cervical-lymphatic axis, is critically dependent on the cerebral vasculature, both structurally and functionally. Yet given this intimate vascular dependence, the effects of chronic hypertension-one of the most prevalent chronic diseases worldwide-on the structural and functional integrity of this axis remain remarkably understudied. This review examines each component of this pathway in physiological sequence, evaluating the evidence for hypertension-related dysfunction at each node and identifying where critical gaps remain.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging in Hypertension: A Multifaceted Approach to Investigate the Brain.","authors":"Sebastiano La Ferla, Lorenzo Carnevale","doi":"10.1161/HYPERTENSIONAHA.126.26773","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.126.26773","url":null,"abstract":"<p><p>The brain is the most metabolically demanding organ, whose integrity and homeostasis are highly sensitive to changes in blood perfusion. Cerebrovascular alterations are therefore major drivers in the development of neurodegenerative diseases and cognitive impairment. Among cardiovascular conditions, hypertension is associated with a wide spectrum of structural and functional brain changes, being a major risk factor for dementia. The multitude of cerebrovascular alterations and consequent injuries linked to hypertension covers distinct, yet interdependent, brain aspects, from modifications in vascular morphology and hemodynamics to features of white matter or cortical damage, eventually leading to disruption of brain activity and cognitive decline. Neuroimaging approaches probe structural properties of brain tissue and vasculature, as well as cerebral perfusion and function, enabling the investigation of hypertension-induced alterations in a minimally invasive manner. In this review, we navigate through neuroimaging techniques that have been employed to study the impact of hypertension on the brain. Particularly, we highlight how these modalities can provide a multifaceted characterization of cerebral injury in hypertension, thus clarifying its relationship with structural, functional, and homeostatic brain properties.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Blood-Brain Barrier Imaging in Aging Community Cohorts.","authors":"Mervin Tee, Ashwati Vipin, Jiannan Huang, Wei Ying Tan, Xiangyuan Huang, James Xiao Yuan Chen, Smriti Ghildiyal, Pricilia Tanoto, Klaus Eickel, Matthias Günther, Beatriz E Padrela, Jan Petr, Henk J M M Mutsaerts, Nagaendran Kandiah, Saima Hilal","doi":"10.1161/HYPERTENSIONAHA.126.27718","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.126.27718","url":null,"abstract":"<p><strong>Background: </strong>Cerebral perfusion is a critical determinant of brain health and cognitive function, and vascular dysfunction contributes to small-vessel disease and neurodegeneration. Multiecho time-encoded arterial spin labeling is an emerging magnetic resonance imaging technique that enables noninvasive quantification of cerebral blood flow (CBF), arterial transit time (ATT), and blood-brain barrier water exchange time (Tex) without exogenous contrast. This study examined how demographic and vascular risk factors influence cerebral hemodynamics and their relation to structural imaging and cognitive scores.</p><p><strong>Methods: </strong>Participants were drawn from 2 community-based cohorts, comprising 527 adults aged 30 to 95 years. All underwent harmonized 3T multiecho arterial spin labeling and structural magnetic resonance imaging, alongside detailed cognitive testing. Linear and logistic regression models evaluated associations between cerebral hemodynamics, age, sex, vascular risk factors, brain structure, and cognition, adjusting for demographic, vascular, and intracranial volume.</p><p><strong>Results: </strong>Older age was independently associated with lower CBF and Tex and longer ATT, with a nonlinear age-ATT relationship suggesting accelerated change in later life. Males showed lower CBF and Tex and higher ATT than females, independent of age and vascular risk factors. Hypertension and higher blood pressure were associated with lower Tex, reduced CBF, and longer ATT; diabetes was associated with reduced CBF. Longer ATT correlated with smaller gray and hippocampal volumes and greater white matter hyperintensity. Lower Tex was related to higher white matter hyperintensity volume as well as poorer semantic fluency.</p><p><strong>Conclusions: </strong>Multiecho arterial spin labeling captures blood-brain barrier-related and hemodynamic changes associated with age, sex, and vascular risk factors, supporting its use as a noninvasive imaging biomarker for early cerebrovascular injury relevant to cardiovascular health.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study.","authors":"Amy Y Habib, Ross A Okazaki, Brenton R Prescott, Vanessa Xanthakis, Leroy L Cooper, Connie W Tsao, Emelia J Benjamin, Ramachandran S Vasan, Naomi M Hamburg, Gary F Mitchell","doi":"10.1161/HYPERTENSIONAHA.126.27015","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27015","url":null,"abstract":"<p><strong>Background: </strong>Women have lower pulse pressure (PP) than men as young adults, but higher PP after a midlife PP nadir. This PP reversal is often attributed to lower estrogen levels at menopause. However, a detailed analysis of hemodynamic changes around the time of menopause has not been performed.</p><p><strong>Methods: </strong>Relations between the timing of menopause and sex differences in PP were assessed in the Framingham Heart Study cohorts (N=6760 unique participants) across 3 visits spanning 14 years. Women were categorized into 4 groups by age at menopause: persistently premenopausal or postmenopausal with early (<25th percentile, age <48 years), average (25th to 74th percentile, age 48-53), or late (≥75th percentile, age >53 years) menopause age.</p><p><strong>Results: </strong>PP decreased with increasing age in women and men under 40 years of age, being lower in women than in men. PP increased with age in women and men after midlife and was higher in women than in men after age 60. Nadirs in midlife PP, adjusted for vascular risk factors, occurred at 47 years of age in men and at 39, 38, 37, and 37 years of age in the 4 menopause groups, respectively, with nadirs in the postmenopausal groups occurring an average of 6, 14, and 19 years before menopause.</p><p><strong>Conclusions: </strong>PP transitions from a falling to a rising profile approximately a decade earlier in women than in men, and up to 2 decades before the onset of menopause in women, suggesting that factors other than age of menopause are involved.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurovascular Signaling in the Perivascular Space: Biophysical Principles and Disruption in Hypertension.","authors":"Thomas A Longden, Abigail Vigderman, Suyeon Ju, Dominic P Isaacs","doi":"10.1161/HYPERTENSIONAHA.126.26766","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26766","url":null,"abstract":"<p><p>The brain's vasculature-from pial arteries through penetrating arterioles and the capillary bed to venous drainage-is enveloped by a narrow, compositionally elaborate perivascular space that provides the primary signaling interface between neural tissue and blood vessels. Here, we advance the principle that the geometry and composition of this space are not constant but change systematically along the vascular tree, and that perivascular space composition at these locations imposes biophysical constraints that dictate the fidelity and gain of neurovascular signaling. We argue that its narrow micro-to-nanodomain geometry, basement membrane sieving effects, and the anionic environment created by heparan sulfate proteoglycans favor small aqueous mediators-potassium, nitric oxide (NO), and adenosine-for rapid, spatially targeted blood flow control, while constraining lipophilic mediators, such as prostaglandins and epoxyeicosatrienoic acids, toward predominantly autocrine action. Reassessing glymphatic fluid flux as a proposed source of vascular mechanical input, we find that the relevant shear forces fall several orders of magnitude below the threshold required to engage canonical smooth muscle mechanotransduction, arguing against a direct mechanical role for perivascular flow. We then synthesize how hypertension degrades each layer of this system: perivascular space expansion dilutes mediator concentrations, barrier breakdown admits plasma proteins capable of sequestering signaling molecules, and inflammation dysregulates the vascular ion channels that serve as signaling effectors. Framing the perivascular space as a biophysically constrained signaling compartment helps reconcile disparate observations of mediator selectivity and fluid mechanics, identifies how its progressive disruption may contribute to cerebrovascular dysfunction associated with chronic hypertension, and may help identify novel targets for preventing or reversing cognitive decline and neurodegeneration.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistant Hypertension: A Genetic Window on Aldosterone, Potassium, and Missed Clinical Opportunities.","authors":"Marianna Danielli, Patricia B Munroe","doi":"10.1161/HYPERTENSIONAHA.126.27554","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.126.27554","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"83 9","pages":"e27554"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Synergy of Finerenone and Empagliflozin in Lowering Blood Pressure.","authors":"Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B McGill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann","doi":"10.1161/HYPERTENSIONAHA.126.27036","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27036","url":null,"abstract":"<p><strong>Background: </strong>This secondary analysis of the CONFIDENCE (combination effect of fInerenone and empagliflozin in participants with chronic kidney disease and type 2 diabetes using a UACR endpoint) trial (REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05254002) assessed systolic blood pressure (SBP) changes with empagliflozin/finerenone combination therapy versus monotherapy in people with chronic kidney disease and type 2 diabetes across baseline SBP categories. We assessed SBP response predictors and whether early (day 30) SBP changes mediate urinary albumin-to-creatinine ratio reductions.</p><p><strong>Methods: </strong>Participants (n=800) were stratified by baseline SBP (<130 mm Hg; ≥130 mm Hg). Outcomes included SBP response (≥10 mm Hg reduction from baseline at day 180) and longitudinal SBP changes, analyzed by linear mixed-effects models and logistic regression. Causal mediation analysis, a secondary exploratory analysis, evaluated the effect of day 30 SBP change on day 180 urinary albumin-to-creatinine ratio reduction.</p><p><strong>Results: </strong>At baseline, 532 (66%) participants had SBP ≥130 mm Hg; 268 (34%) had SBP <130 mm Hg. Combination therapy increased SBP response odds versus finerenone (odds ratio, 1.83 [95% CI, 1.21-2.76]; <i>P</i>=0.004) or empagliflozin (odds ratio, 1.45 [95% CI, 0.97-2.17]; <i>P</i>=0.07). The strongest predictor of response was baseline SBP (odds ratio, 2.04 per 10 mm Hg higher SBP; <i>P</i><0.0001). Combination therapy significantly reduced SBP versus monotherapies in the ≥130 mm Hg (<i>P</i><0.0001) but not in the <130 mm Hg group. SBP reduction mediated <10% of the total urinary albumin-to-creatinine ratio reduction. Acute kidney injury and hyperkalemia incidences were similar across SBP subgroups.</p><p><strong>Conclusions: </strong>Combination therapy reduced SBP more than monotherapies in participants with SBP ≥130 mm Hg. Urinary albumin-to-creatinine ratio reduction appeared largely independent of SBP changes at day 30; though this secondary analysis was limited by reliance on clinic blood pressure measurement. Prospective studies with ambulatory blood pressure monitoring are required.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27036"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Denervation Modulates Hypothalamic Neuroinflammation via P2X7R/PI3K/Akt.","authors":"Wei Liang, Qian Liu, Qiongying Wang, Wenting Wang, Xiaowei Zhang, Heng Yu, Xiaofang Zhang, Xu Zhao, Runmin Sun, Jing Yu","doi":"10.1161/HYPERTENSIONAHA.126.26793","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26793","url":null,"abstract":"<p><strong>Background: </strong>Hypertension remains the leading global contributor to cardiovascular mortality. Although renal denervation (RDN) has demonstrated efficacy, the central neurobiological mechanisms sustaining its sympathoinhibitory effects remain unclear. We investigated whether RDN modulates the ATP and P2X7R (P2X7 receptor)/PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B) signaling axis in the hypothalamic paraventricular nucleus to attenuate neuroinflammation and blood pressure.</p><p><strong>Methods: </strong>Eight-week-old male spontaneously hypertensive rats were randomly assigned to either sham surgery or RDN (combined physical/chemical ablation; n=8 per group). Systolic blood pressure was longitudinally monitored using tail-cuff plethysmography. Cardiac target-organ injury was assessed using hematoxylin-eosin and Masson's trichrome staining. ATP levels, P2X7R expression, and PI3K/Akt phosphorylation in the paraventricular nucleus were quantified by ELISA, Western blotting, and immunofluorescence. A selective P2X7R antagonist (HY-50697/A-740003) was used for pharmacological validation.</p><p><strong>Results: </strong>RDN significantly reduced systolic blood pressure in spontaneously hypertensive rats (from 210.3 to 143.2 mm Hg, <i>P</i><0.0001) and markedly ameliorated left ventricular hypertrophy and myocardial fibrosis. Mechanistically, RDN substantially decreased ATP concentrations in the paraventricular nucleus (from 406.81 to 292.98 nmol/L, <i>P</i><0.0001), downregulated P2X7R protein expression, and suppressed pathological activation of the PI3K/Akt signaling pathway, accompanied by reduced proinflammatory cytokine production. Pharmacological inhibition of P2X7R functionally phenocopied the antihypertensive and central anti-inflammatory effects induced by RDN.</p><p><strong>Conclusions: </strong>RDN was associated with reduced blood pressure and attenuation of central ATP-related neuroinflammatory signaling, beyond peripheral sympathetic disruption. The ATP/P2X7R/PI3K/Akt axis may represent a candidate pathway linking renal signaling to central sympathetic regulation, warranting further investigation as a potential mechanistic target in resistant hypertension.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26793"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Donald Seldin Lecture: Leveraging Diverse Population Genomics and Multiomics Integration for Gene Discovery of Cardiovascular and Kidney Diseases.","authors":"Andrea R V R Horimoto, Nora Franceschini","doi":"10.1161/HYPERTENSIONAHA.126.26092","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26092","url":null,"abstract":"<p><p>This review discusses the implications of frameworks leveraging genetic admixture and multiomics data for advancing gene discovery in cardiovascular and kidney disease research. By broadening gene discovery efforts to additional populations that have a disproportionately high risk of disease and leveraging genetic diversity in admixed populations, studies can identify population-enriched risk variants that traditionally have been missed in genome-wide association studies. The use of multiomics approaches, including the transcriptome, proteome, and metabolome, advances a mechanistic understanding of disease beyond associations. As single-cell omics technologies continue to improve, their integration into gene discovery may help uncover cell-type-specific regulatory pathways and more precise biological contexts. The full potential of these approaches depends on sustained investment in diverse, well-characterized omics data sets, methodological innovation in multiancestry statistical approaches, and interdisciplinary collaboration bridging genomics, epidemiology, and clinical medicine. These efforts will need to be translated into clinically actionable insights, including ancestry-informed risk stratification and targeted therapeutics, to improve outcomes for cardiovascular and kidney diseases.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26092"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}