Hypertension最新文献

{"title":"Hickam's Dictum in Hypertension.","authors":"Gregory L Hundemer, Brian D M Blew, Ashish Gupta, Julie L V Shaw, Jason Wasserman, Jan N Basile, Swapnil Hiremath","doi":"10.1161/HYPERTENSIONAHA.125.23975","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.23975","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"82 9","pages":"1413-1420"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin.","authors":"Gaetano Santulli, Valeria Visco, Fahimeh Varzideh, Germano Guerra, Urna Kansakar, Maurizio Gasperi, Anna Marro, Scott Wilson, Mario Nicola Vittorio Ferrante, Antonella Pansini, Armando Pirone, Francesco Di Lorenzo, Domenico Tartaglia, Guido Iaccarino, Gaetano Macina, Esther Densu Agyapong, Imma Forzano, Stanislovas S Jankauskas, Klara Komici, Michele Ciccarelli, Pasquale Mone","doi":"10.1161/HYP.0000000000000250","DOIUrl":"https://doi.org/10.1161/HYP.0000000000000250","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"82 9","pages":"e189"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Altered AT1 Receptor Regulation of ETB Receptors in Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats.","authors":"Chunyu Zeng, Ulrich Hopfer, Laureano D Asico, Gilbert M Eisner, Robin A Felder, Pedro A Jose","doi":"10.1161/HYP.0000000000000252","DOIUrl":"https://doi.org/10.1161/HYP.0000000000000252","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"82 9","pages":"e191"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Postpartum Renal Structure After Hypertensive Pregnancy Disorders.","authors":"Hannah R Cutler, Jamie Kitt, Prenali D Sattwika, Lucy E M Finnigan, Ana Estevez-Fernandez, Yvonne Kenworthy, Katie Suriano, Annabelle Frost, Samuel Krasner, Casey Johnson, Annabelle McCourt, Rebecca Mills, Katherine Tucker, Alexandra Cairns, Cristian Roman, Christina Aye, Lucy Mackillop, Basky Thilaganathan, Lucy C Chappell, Betty Raman, Adam J Lewandowski, Winok Lapidaire, Paul Leeson","doi":"10.1161/HYPERTENSIONAHA.125.25130","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.25130","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive pregnancies are associated with increased risks of renal failure in pregnancy and later life. However, traditional markers of renal function normalize postpartum, making identification of those at future disease risk difficult. We studied whether the type and severity of hypertensive pregnancy associated with postpartum renal structure.</p><p><strong>Methods: </strong>One hundred twenty-five women from interventional trials (61 preeclamptic, 33 gestational hypertension, and 31 normotensive pregnancy), aged ≥18 years, were imaged using magnetic resonance imaging 6 to 12 months postpartum. Anthropometric, demographic, blood pressure, and blood sample data were collected during pregnancy and postpartum. Kidney volume indexed to body surface area and corticomedullary differentiation were compared between groups using a 1-way ANCOVA, whereas associations with other outcomes were assessed using correlation tests.</p><p><strong>Results: </strong>Postpartum total kidney volume indexed to body surface area was smaller in women who had preeclampsia compared with those who had gestational hypertension or a normotensive pregnancy (<i>P</i>=0.049). Total kidney volume postpartum correlated with estimated glomerular filtration rate at delivery (<i>P</i><0.001). However, smaller volumes were not explained by reduced corticomedullary differentiation, which only differed in women with gestational hypertension compared with preeclamptic (<i>P</i>=0.02) and normotensive women (<i>P</i>=0.007). There were no associations between renal measures and blood pressure during or after pregnancy.</p><p><strong>Conclusions: </strong>At 6 to 12 months postpartum, preeclamptic women have smaller kidney volumes than women with gestational hypertension or normotensive pregnancies. These smaller volumes relate to lower renal function at delivery but not corticomedullary differentiation, which only differed in women with gestational hypertension.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifiers: NCT04273854 and NCT05434195.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Risk-Based Approaches in Blood Pressure Management: Reflections on the 2025 AHA/ACC Statement.","authors":"Kazem Rahimi, Milad Nazarzadeh, Anthony Rodgers","doi":"10.1161/HYPERTENSIONAHA.125.25564","DOIUrl":"10.1161/HYPERTENSIONAHA.125.25564","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Effects of Sucrose in Experimental Animals and Humans.","authors":"Yuki Nakayama, Katherine J Elliott, Satoru Eguchi","doi":"10.1161/HYPERTENSIONAHA.125.25720","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.25720","url":null,"abstract":"<p><p>Sucrose, a disaccharide composed of glucose and fructose, is one of the most widely consumed dietary sugars. The recent global rise in sugar intake is a growing concern regarding its potential contribution to the development of metabolic and cardiovascular disorders. While the metabolic effects of glucose and fructose have been extensively studied individually, the impact of sucrose on cardiovascular health remains an evolving area of research. In rats with a high-sucrose diet, hallmarks of metabolic syndrome were observed including weight gain, insulin resistance, ≈15-mm Hg elevation in blood pressure, and systemic inflammation. It also caused disruptions in gut microbiota. Recently, we reported that high-sucrose ingestion via drinking water induces hypertension and cardiovascular complications associated with hyperinsulinemia in mice. In humans, excessive sucrose intake is associated with elevated plasma glucose, insulin, and lipid levels, particularly in individuals with obesity. Although long-term epidemiological data are limited, a recent study demonstrated that sucrose intake increased the risk for hypertension in women. These findings highlight the need to reassess the relationship between sucrose consumption and cardiovascular disease in humans. This review discusses current evidence from both animal and human studies covering molecular mechanisms and pathophysiological outcomes to explore how sucrose influences cardiovascular and metabolic health. As sucrose remains a major component of global diets, particularly in industrialized nations, further longitudinal and mechanistic studies are needed to clarify its long-term health consequences. Reducing excess sucrose intake may represent a prudent public health strategy, especially for individuals at increased risk for cardiovascular diseases including hypertension.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"c-Fos Mediates Preeclampsia Through p-AMPK/Detyrosinated Tubulin Pathway.","authors":"Yihong Huang, Shanshan Zhao, Chumei Zeng, Shaole Shi, Zhuyu Li, Lixia Shen, Huizhen Geng, Zilian Wang, Dongyu Wang","doi":"10.1161/HYPERTENSIONAHA.124.24416","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.24416","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is a systemic disorder unique to pregnancy that is associated with trophoblast dysfunction. Although the c-Fos (FBJ osteosarcoma oncogene) is essential for placental development, its mechanistic role in preeclampsia remains unclear.</p><p><strong>Methods: </strong>We identified c-Fos as a hub gene through an analysis of cell-free RNA from maternal plasma and single-cell RNA sequencing of preeclamptic placentas. We assessed c-Fos expression in the placenta and plasma and examined its correlation with lipids. Functional changes upon the viral modulation of c-Fos in trophoblast cells were evaluated. Untargeted lipidomics and RNA sequencing were conducted to uncover the downstream mechanisms, and the findings were validated in trophoblast cells and a preeclampsia-like murine model.</p><p><strong>Results: </strong>c-Fos expression was decreased in maternal peripheral plasma from early to mid-pregnancy and in the placenta of preeclampsia patients. Furthermore, c-Fos expression levels were negatively correlated with neutral lipid accumulation. c-Fos deficiency impaired trophoblast invasion, proliferation, and syncytialization while promoting apoptosis. Reduced c-Fos expression also led to lipid droplet aggregation and mitochondrial dysfunction. Mechanistically, c-Fos silencing inhibited the p-AMPK (phosphorylated AMP-activated protein kinase)/detyrosinated tubulin pathway, disrupting lipid droplet trafficking and metabolism and promoting lipid droplet accumulation and an altered lipid profile. c-Fos deficiency induced a preeclampsia-like phenotype in mice, whereas c-Fos overexpression partially alleviated preeclampsia symptoms.</p><p><strong>Conclusions: </strong>c-Fos downregulation inhibits the p-AMPK/detyrosinated tubulin pathway, driving lipid droplet accumulation and consequent trophoblast dysfunction, revealing c-Fos as a potential therapeutic target for preeclampsia.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway.","authors":"Ying Li, Hong-Li Jiang, Lei Chen, Jia-Yue Yu, Sachin Aryal, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Zhi-Ming Dai, Li-Li Huang, Qi Liu, Hua Liu, Li-Min Wei, Xue Zhao, Xiao-Min Liu, Juan Bai, Xiao-Lian Shi, Qing Su, Meng-Lu Xu, Ishan Manandhar, Pritam Bardhan, Ya-Nan Wang, Ting Yao, Bina Joe, Tao Yang, Hong-Bao Li","doi":"10.1161/HYPERTENSIONAHA.125.25052","DOIUrl":"10.1161/HYPERTENSIONAHA.125.25052","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a leading risk factor for all-cause mortality worldwide, affecting ≈1.3 billion people. Imbalanced gut microbiota contributes to blood pressure elevation. We recently reported sex differences in the responses of gut microbiota to environmental stimuli, such as salt, with male gut microbiota being more vulnerable to induce high blood pressure than female microbiota. In this study, we investigated the mechanisms by which gut microbiota regulate blood pressure in a sex-dependent manner.</p><p><strong>Methods: </strong>Antibiotic treatment, gonadectomy, sex hormone replenishment, and treatment with trimethylamine N-oxide or its blocker were performed in male and female spontaneously hypertensive rats.</p><p><strong>Results: </strong>We observed sex differences in gut microbiota composition and sex-specific blood pressure responses to antibiotic treatment in pubertal spontaneously hypertensive rats. In gonadectomized rats treated with sex hormones, we found that the male sex hormone dihydrotestosterone elevated blood pressure, reshaped gut microbiota, and increased levels of microbiota-derived metabolites, trimethylamine and treatment with trimethylamine N-oxide. The accumulation of treatment with trimethylamine N-oxide in plasma and the paraventricular nucleus of the hypothalamus was associated with inflammation and sympathetic activation.</p><p><strong>Conclusions: </strong>These findings underscore the mechanistic role of dihydrotestosterone in gut microbiota-mediated sex-specific blood pressure regulation and suggest that targeting the gut microbiota-treatment with trimethylamine N-oxide pathway may provide new therapeutic strategies for male hypertension.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Search for Primary Aldosteronism in Clinical Settings.","authors":"John M Flack,Michael G Buhnerkempe,Garry L R Jennings","doi":"10.1161/hypertensionaha.125.25461","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.25461","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"13 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing the 2025 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Leveraging Evidence to Push the Boundaries of Clinical Care.","authors":"Cian P McCarthy,John W McEvoy,Jennifer L Cluett","doi":"10.1161/hypertensionaha.125.25418","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.25418","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"19 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}