Hypertension Research最新文献_第8页

Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management. 妊娠期高血压疾病的可视化风险修改：个性化解释性体重管理预测模型的开发和验证。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-11 DOI: 10.1038/s41440-024-02024-8

Sho Tano, Tomomi Kotani, Takafumi Ushida, Seiko Matsuo, Masato Yoshihara, Kenji Imai, Fumie Kinoshita, Yoshinori Moriyama, Masataka Nomoto, Shigeru Yoshida, Mamoru Yamashita, Yasuyuki Kishigami, Hidenori Oguchi, Hiroaki Kajiyama

{"title":"Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management.","authors":"Sho Tano, Tomomi Kotani, Takafumi Ushida, Seiko Matsuo, Masato Yoshihara, Kenji Imai, Fumie Kinoshita, Yoshinori Moriyama, Masataka Nomoto, Shigeru Yoshida, Mamoru Yamashita, Yasuyuki Kishigami, Hidenori Oguchi, Hiroaki Kajiyama","doi":"10.1038/s41440-024-02024-8","DOIUrl":"https://doi.org/10.1038/s41440-024-02024-8","url":null,"abstract":"The growing recognition of the importance of interpregnancy weight management in reducing hypertensive disorders of pregnancy (HDP) underscores the importance of effective preventive strategies. However, developing effective systems remains a challenge. We aimed to bridge this gap by constructing a prediction model. This study retrospectively analyzed the data of 1746 women who underwent two childbirths across 14 medical facilities, including both tertiary and primary facilities. Data from 2009 to 2019 were used to create a derivation cohort (n = 1746). A separate temporal-validation cohort was constructed by adding data between 2020 and 2024 (n = 365). Furthermore, the external-validation cohort was constructed using the data from another tertiary center between 2017 and 2023 (n = 340). We constructed a prediction model for HDP development in the second pregnancy by applying logistic regression analysis using 5 primary clinical information: maternal age, pre-pregnancy body mass index, and HDP history; and pregnancy interval and weight change velocity between pregnancies. Model performance was assessed across all three cohorts. HDP in the second pregnancy occurred 7.3% in the derivation, 10.1% in the temporal-validation, and 7.9% in the external-validation cohorts. This model demonstrated strong discrimination, with c-statistics of 0.86, 0.88, and 0.86 for the respective cohorts. Precision-recall area under the curve values were 0.90, 0.85, and 0.91, respectively. Calibration showed favorable intercepts (-0.02 to -0.00) and slopes (0.96-1.02) for all cohorts. In conclusion, this externally validated model offers a robust basis for personalized interpregnancy weight management goals for women planning future pregnancies.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further development in the trees of the immune system is expected to elucidate the mechanisms of blood pressure elevation. 免疫系统树的进一步发展有望阐明血压升高的机制。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-09 DOI: 10.1038/s41440-024-02053-3

Masaki Mogi

引用次数: 0

Association between pulse pressure and risk of acute kidney injury after intracerebral hemorrhage. 脉压与脑出血后急性肾损伤风险的关系。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-09 DOI: 10.1038/s41440-024-02046-2

Yuichiro Ohya, Fumi Irie, Kuniyuki Nakamura, Takuya Kiyohara, Yoshinobu Wakisaka, Tetsuro Ago, Ryu Matsuo, Masahiro Kamouchi, Takanari Kitazono

{"title":"Association between pulse pressure and risk of acute kidney injury after intracerebral hemorrhage.","authors":"Yuichiro Ohya, Fumi Irie, Kuniyuki Nakamura, Takuya Kiyohara, Yoshinobu Wakisaka, Tetsuro Ago, Ryu Matsuo, Masahiro Kamouchi, Takanari Kitazono","doi":"10.1038/s41440-024-02046-2","DOIUrl":"https://doi.org/10.1038/s41440-024-02046-2","url":null,"abstract":"The aim of this study was to determine whether pulse pressure (PP), an indicator of arterial stiffness, was independently associated with the risk of acute kidney injury (AKI) following intracerebral hemorrhage (ICH). We enrolled patients with acute ICH from a multicenter stroke registry in Fukuoka, Japan, from June 2007 to September 2019. The mean PP, measured three times on the third day after admission, was categorized into three groups based on tertiles: G1 < 54 mmHg, G2 54-64 mmHg, and G3 ≥ 65 mmHg. AKI was defined as an increase of ≥0.3 mg/dL or ≥150% in serum creatinine levels above baseline during hospitalization. The associations between PP and AKI were evaluated using logistic regression analyses. Overall, 1512 patients with acute ICH (mean age: 69.8 ± 13.5 years; 56.4% men) were included in the analysis. The incidence rates of AKI were 5.6%, 11.0%, and 13.2% in groups G1, G2, and G3, respectively. The odds ratio (95% confidence interval) of AKI was significantly elevated in G2 (1.77 [1.07-2.91]) and G3 (1.82 [1.10-3.03]) compared to G1, even after adjusting for initial systolic blood pressure (SBP) values on admission and subsequent SBP reductions. This significant association was observed in patients with an initial SBP < 200 mmHg (P for heterogeneity, 0.045) and those receiving intravenous antihypertensive therapy in the acute stage (P for heterogeneity, 0.03). High PP should be recognized as a novel potential risk factor for AKI following ICH. High pulse pressure was significantly associated with an increased risk of acute kidneyinjury following intracranial hemorrhage. Pulse pressure should be recognized as anovel potential risk factor and one of the predictors of acute kidney injury afterintracranial hemorrhage.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardio-ankle index, ankle-brachial index and supine hypertension for the improved prediction of cardiovascular outcomes in hypertension. 心踝指数、踝肱指数和仰卧位高血压对高血压患者心血管预后的预测作用。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02042-6

Wei Zhang, Ji-Guang Wang

引用次数: 0

Digital hypertension, implementation hypertension, and internationalization - 3 pillars of Japanese Society of Hypertension 2024–2026 advancing hypertension science from Japan to the world in the information network era 数字高血压、实施高血压、国际化——日本高血压学会2024-2026的三大支柱，在信息网络时代推动高血压科学从日本走向世界。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02045-3

Kazuomi Kario, Akira Nishiyama, Shigeru Shibata, Hisatomi Arima, Masato Furuhashi, Atsuhiro Ichihara, Mari Ishida, Tomohiro Katsuya, Takuya Kishi, Katsuyuki Miura, Shin-ichiro Miura, Masaki Mogi, Mitsuru Ohishi, Hirotaka Shibata, Tatsuo Shimosawa, Akira Sugawara, Kouichi Tamura, Kazunori Toyoda, Koichi Yamamoto, Koichi Node

引用次数: 0

THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring. THRA1/PGC-1α/SIRT3通路调节氧化应激，并参与甲状腺功能低下母鼠后代高血压的发生。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02023-9

Jun Guo, Yajun Shi, Xi Yu, Yan Zhao, Bin Wei, Ming Huo, Likui Lu, Lingjun Li, Qinqin Gao, Miao Sun

{"title":"THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring.","authors":"Jun Guo, Yajun Shi, Xi Yu, Yan Zhao, Bin Wei, Ming Huo, Likui Lu, Lingjun Li, Qinqin Gao, Miao Sun","doi":"10.1038/s41440-024-02023-9","DOIUrl":"10.1038/s41440-024-02023-9","url":null,"abstract":"Many epidemiologic and animal studies have shown that maternal hypothyroidism is associated with an increased risk of hypertension in offspring in later life. In this study, we established a maternal hypothyroidism rat model to explore the underlying mechanism that contributes to elevated blood pressure in adult male offspring of hypothyroid mothers. The levels of thyroid hormones (THs) in the offspring were measured using ELISA kits. Blood pressure (BP) and depressor response were recorded in conscious, freely moving rats. Vascular reactivity was conducted in isolated mesenteric arteries (MAs) using a myograph. We used real-time quantitative PCR (RT-qPCR) and Western blots to examine the mRNA and protein expression of relevant molecules in MAs. The A7r5 cells were transfected with small interfering RNA (siRNA) to further investigate the gene functions. The following findings were observed: Basal systolic BP and diastolic BP was significantly increased, accompanied by attenuated depressor response and decreased vascular sensitivity to sodium nitroprusside (SNP). Reactive Oxygen Species (ROS) levels in the MAs were enhanced, along with decreased expression of the THRA1/PGC-1α/SIRT3 pathway. In A7r5 cells, triiodothyronine (T3) pretreatment improved the PGC-1α/SIRT3 pathway and reduced ROS levels after H2O2-induced oxidative stress. In contrast, the knockdown of THRA1 or SIRT3 diminished the above effects of T3. Down-regulation of THRA1 contributed to a decline in the PGC-1α/SIRT3 pathway, which causes an increased production of ROS. This indicates that the T3-THRA1/PGC-1α/SIRT3 pathway plays a protective role in the regulation of BP and may be a potential therapeutic strategy against hypertension.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence for exercise therapies including isometric handgrip training for hypertensive patients. 包括等长握力训练在内的运动疗法对高血压患者的疗效。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02033-7

S Miura

引用次数: 0

Quantity and variety of food groups consumption and the risk of hypertension in adults: a prospective cohort study. 一项前瞻性队列研究：食物种类与成人高血压风险的关系

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02036-4

Yuanxiu Wei, Xinyue Su, Gangling Wang, Cheng Zu, Qiguo Meng, Yanjun Zhang, Sisi Yang, Ziliang Ye, Yuanyuan Zhang, Xianhui Qin

{"title":"Quantity and variety of food groups consumption and the risk of hypertension in adults: a prospective cohort study.","authors":"Yuanxiu Wei, Xinyue Su, Gangling Wang, Cheng Zu, Qiguo Meng, Yanjun Zhang, Sisi Yang, Ziliang Ye, Yuanyuan Zhang, Xianhui Qin","doi":"10.1038/s41440-024-02036-4","DOIUrl":"10.1038/s41440-024-02036-4","url":null,"abstract":"The prospective association of dietary diversity and different food groups with the risk of hypertension in the general Chinese adults has not been evaluated. We aimed to evaluate the relationship of variety and quantity of 12 major food groups with new-onset hypertension in the Chinese adults. A total of 11,118 adults from the China Health and Nutrition Survey (CHNS) were included. The study outcome was new-onset hypertension, defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg or diagnosed hypertension by physician or under antihypertensive treatment during the follow-up. During a median follow-up period of 6.0 years, 3867 participants occurred new-onset hypertension. There was a L-shaped relationship of dietary variety score with new-onset hypertension (P for nonlinearity < 0.001). Compared with those in the quartile 1 of dietary variety score, participants in the quartile 2-4 were associated with a significantly lower risk of hypertension (HR, 0.64; 95% CI: 0.59, 0.69). In addition, there were U-shaped associations of dairy products, vegetables, aquatic products, nuts, red meat, whole grains, refined grains, processed meat, and poultry intake with new-onset hypertension, and L-shaped associations of fruits, legumes, and eggs intake with new-onset hypertension (all P for nonlinearity < 0.001). In conclusion, there was an inverse association of dietary variety score with new-onset hypertension in the Chinese adults. Furthermore, there was a negative association between different food group intake and new-onset hypertension when food group intake was relatively low; however, the risk of hypertension increased or plateaued when the intake exceeded a certain threshold.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Home blood pressure and hypertension control. 家庭血压和高血压控制。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02016-8

Mohammed Siddiqui, James Brian Byrd

引用次数: 0

Blood pressure measurement and nocturnal dipping patterns are heavily affected by body posture through changes in hydrostatic pressure between the arm and the heart. 通过手臂和心脏之间静水压力的变化，身体姿势严重影响血压测量和夜间下沉模式。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-06 DOI: 10.1038/s41440-024-02056-0

Niklas Pilz, Krzysztof Narkiewicz, Jacek Wolf, Kazuomi Kario, Tinta Visser, Oliver S Opatz, Alma Reuter, Laura J Dippel, Leon Fesseler, Viktor Heinz, Andreas Patzak, Tomas L Bothe

{"title":"Blood pressure measurement and nocturnal dipping patterns are heavily affected by body posture through changes in hydrostatic pressure between the arm and the heart.","authors":"Niklas Pilz, Krzysztof Narkiewicz, Jacek Wolf, Kazuomi Kario, Tinta Visser, Oliver S Opatz, Alma Reuter, Laura J Dippel, Leon Fesseler, Viktor Heinz, Andreas Patzak, Tomas L Bothe","doi":"10.1038/s41440-024-02056-0","DOIUrl":"https://doi.org/10.1038/s41440-024-02056-0","url":null,"abstract":"Nocturnal blood pressure (BP) shows the highest predictive power for cardiovascular events. However, there is a poor reproducibility of personalized dipping patterns in single individuals. We hypothesize that changes in body position during sleep cause variations in hydrostatic pressure,leading to incorrect BP values and dipping classifications. 26 subjects aged 18-30 years, as well as 25 participants aged 50 years and older underwent ambulatory BP measurements on the left arm, as well as determination of the hydrostatic pressure difference between the cuff and heart level during BP measurement. We observed that the BP measurement cuff was above the heart level (negative hydrostatic pressure) mostly through the night. Laying on the right side revealed the largest hydrostatic pressure difference and maximum incorrect BP measurement, with a mean of -9.61 mmHg during sleep. Correcting for hydrostatic pressure led to reclassification of nocturnal hypertension in 14 subjects (27.5%). Dipping patterns changed in 19 participants (37.3%). In total, 25 subjects (49.0%) changed either their nocturnal hypertension and/or their dipping classification. Our findings underscore the importance of accounting for hydrostatic pressure in ambulatory BP monitoring. Changes in body posture during sleep provide a plausible reason for the variability seen in nocturnal dipping patterns. Further research should focus on incorporating hydrostatic pressure compensation mechanisms in 24-h BP measurement. Limiting the noticeable effect of hydrostatic pressure differences could greatly improve hypertension diagnosis, classification, and treatment monitoring.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0