Hypertension Research最新文献_第8页

Targeting a systolic blood pressure of <130 mmHg is beneficial in adults with hypertension aged ≥75 years: a systematic review and meta-analysis 收缩压<130 mmHg对≥75岁高血压患者有益：一项系统回顾和荟萃分析

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-12 DOI: 10.1038/s41440-025-02302-z

Yoichi Nozato, Yume Nohara-Shitama, Takuro Kubozono, Hiroshi Akasaka, Yoichi Takami, Hisatomi Arima, Atsushi Sakima, Koichi Yamamoto

{"title":"Targeting a systolic blood pressure of <130 mmHg is beneficial in adults with hypertension aged ≥75 years: a systematic review and meta-analysis","authors":"Yoichi Nozato, Yume Nohara-Shitama, Takuro Kubozono, Hiroshi Akasaka, Yoichi Takami, Hisatomi Arima, Atsushi Sakima, Koichi Yamamoto","doi":"10.1038/s41440-025-02302-z","DOIUrl":"10.1038/s41440-025-02302-z","url":null,"abstract":"Recent clinical trials have raised important questions regarding optimal blood pressure (BP) targets in older adults with hypertension. In the 2019 Japanese Society of Hypertension guidelines, a systolic BP (SBP) target of <140 mmHg is recommended for individuals aged ≥75 years. However, subsequent randomized controlled trials (RCTs) have shown potential cardiovascular and mortality benefits associated with strict BP targets. We conducted an updated systematic review and meta-analysis to evaluate the efficacy and safety of intensive SBP control (<130 mmHg) compared with less intensive control (≥130 mmHg) in patients with hypertension aged ≥75 years. We searched MEDLINE, Cochrane Library, and Ichushi Web for publications up to May 30, 2024, supplemented by manual searches. Seven RCTs that met predefined eligibility criteria were included in the final meta-analysis. Among patients aged ≥75 years, intensive SBP lowering was associated with significantly reduced risks of composite cardiovascular events (risk ratio [RR]: 0.61, 95% confidence interval [CI]: 0.40–0.94, p = 0.03), all-cause mortality (RR: 0.72, 95% CI: 0.56–0.93, p = 0.01), and cardiovascular mortality (RR: 0.55, 95% CI: 0.35–0.88, p = 0.01), with no increase in serious adverse events (RR: 1.00, 95% CI: 0.93–1.08, p = 0.97). Stroke incidence did not differ significantly between groups. Similar results were observed when the analysis was expanded to include studies that enrolled participants aged ≥70 years. These findings support the safety and clinical benefits of targeting an SBP of <130 mmHg in older adults with hypertension.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2527-2536"},"PeriodicalIF":4.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02302-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant advancement in the understanding of baroreceptor biology by molecular identification of putative baroreceptors in aortic arch tissue 主动脉弓组织中压力感受器的分子鉴定在对压力感受器生物学的理解上取得了重大进展。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-07 DOI: 10.1038/s41440-025-02323-8

Takuya Kishi

引用次数: 0

Copy number loss Of APP cause thoracic aortic dissection APP拷贝数丢失导致胸主动脉夹层。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-07 DOI: 10.1038/s41440-025-02315-8

Qiannan Gao, Minghui Bao, Jiangshan Tan, Haizeng Zhang, Luyun Fan, Yiran Zhou, Liyan Mao, Chengjun Huang, Weili Zhang, Bin Geng, Xiaohan Fan, Jun Cai, Zhenzhen Chen

{"title":"Copy number loss Of APP cause thoracic aortic dissection","authors":"Qiannan Gao, Minghui Bao, Jiangshan Tan, Haizeng Zhang, Luyun Fan, Yiran Zhou, Liyan Mao, Chengjun Huang, Weili Zhang, Bin Geng, Xiaohan Fan, Jun Cai, Zhenzhen Chen","doi":"10.1038/s41440-025-02315-8","DOIUrl":"10.1038/s41440-025-02315-8","url":null,"abstract":"Thoracic aortic dissection (TAD) is a leading cause of sudden cardiovascular death. Although a limited number of copy number variations (CNVs) have been reported in small cohorts of patients with hereditary TAD or sporadic aortic dissection, a comprehensive investigation and functional validation of CNVs in sporadic TAD using large-scale whole genome sequencing (WGS) data remain lacking. To address this gap, we conducted whole genome sequencing in two independent case–control studies, involving 257 patients with sporadic TAD and 132 controls. We generated gene knockout mice to explore the role of the target gene in TAD progression in vivo. Additionally, RNA-seq analysis and molecular biology experiments were performed in vitro to elucidate the underlying mechanisms. In the discovery and validation cohorts, we identified four CNVs genes (DSCAM, APP, LINC00907, PROCR) potentially pivotal in the pathogenesis of TAD. Among these, only APP displayed reduced expression in the aortas of TAD patients compared to controls. Deletion of APP exacerbated elastic fiber fragmentation and promoted TAD formation in both β-aminopropionitrile (BAPN)-induced and PCSK9/AngII-induced TAD models. In vitro, the loss of APP facilitated vascular smooth muscle cells (VSMCs) apoptosis and the switch to a secretory phenotype. Our study is the first to report novel CNVs of APP in TAD, demonstrating that APP deficiency accelerates the initiation and progression of TAD. These findings suggest that APP represents a promising therapeutic target and a potential genetic risk factor for TAD.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2641-2653"},"PeriodicalIF":4.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02315-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension 肺动脉高压与原发性高血压模型中的肾素-血管紧张素系统。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-07 DOI: 10.1038/s41440-025-02299-5

Yuki Nakayama, Satoru Eguchi

引用次数: 0

Delayed treatment initiation as one of the crucial factors in clinical inertia: lessons from a real-world database research 延迟开始治疗是临床惰性的关键因素之一：来自真实世界数据库研究的经验教训。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-05 DOI: 10.1038/s41440-025-02320-x

Michihiro Satoh, Hiroki Nobayashi, Yutaro Iwabe

引用次数: 0

Can Japan contribute to developing research on the relation between blood pressure variability and suicide risk? 日本能否为开展血压变异性与自杀风险之间关系的研究做出贡献？

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-05 DOI: 10.1038/s41440-025-02319-4

Koshi Nakamura

引用次数: 0

Making time at a worksite increased medical visits by employees with hypertension at small-to-medium worksites in Okinawa, Japan 在日本冲绳的中小型工厂，在工作场所安排时间增加了患有高血压的员工的就医次数。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-05 DOI: 10.1038/s41440-025-02316-7

Koshi Nakamura, Shota Kudaka, Atsushi Sakima

{"title":"Making time at a worksite increased medical visits by employees with hypertension at small-to-medium worksites in Okinawa, Japan","authors":"Koshi Nakamura, Shota Kudaka, Atsushi Sakima","doi":"10.1038/s41440-025-02316-7","DOIUrl":"10.1038/s41440-025-02316-7","url":null,"abstract":"This longitudinal study investigated whether a worksite healthcare policy of making time for medical visits (exposure factor) facilitated attendance (outcome) at these visits for treatment of newly identified hypertension after a health checkup. The study included employees at small-to-medium companies in Okinawa, Japan, who had a systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, no history of hypertension in the last year, and were not taking antihypertensive medication. Pre-existing data on worksite characteristics, employees’ health checkups, and health insurance claims were collected. A multilevel logistic regression model was used to calculate the odds ratio for the worksite group providing time to attend the medical visit, with the worksite group not providing this time acting as the reference. In the 2906 participants with newly identified hypertension employed at 1366 worksites, the cumulative incidence of interest increased gradually with longer follow-up in both groups, although the incidence was higher in the group providing time for the visit. After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for visits by the end of the 4th, 5th, and 6th months after the health checkup in the group with time for a medical visit were 1.80 (1.13–2.86), 1.72 (1.10–2.70), and 1.55 (0.99–2.45), respectively. Similar patterns were observed for every stratum of company size, business category, and healthcare administrator status. These results indicate that a worksite making time for a visit to a medical facility was associated with increased visits by employees with newly identified hypertension at a health checkup.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2584-2594"},"PeriodicalIF":4.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive accuracy of sFlt-1/PlGF ratio for preeclampsia and adverse outcomes: prospective, multicenter including primary, secondary, and tertiary care institutions, observational study in Japan sFlt-1/PlGF比率对子痫前期和不良结局的预测准确性：日本一、二、三级医疗机构的前瞻性、多中心观察性研究

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-04 DOI: 10.1038/s41440-025-02282-0

Tomomi Yamazaki, Ana Sofia Cerdeira, Yuko Teraoka, Yuriko Oomori, Yurika Mukai, Jun Sugimoto, Iemasa Koh, Kouji Banno, Manu Vatish, Yoshiki Kudo

{"title":"Predictive accuracy of sFlt-1/PlGF ratio for preeclampsia and adverse outcomes: prospective, multicenter including primary, secondary, and tertiary care institutions, observational study in Japan","authors":"Tomomi Yamazaki, Ana Sofia Cerdeira, Yuko Teraoka, Yuriko Oomori, Yurika Mukai, Jun Sugimoto, Iemasa Koh, Kouji Banno, Manu Vatish, Yoshiki Kudo","doi":"10.1038/s41440-025-02282-0","DOIUrl":"10.1038/s41440-025-02282-0","url":null,"abstract":"Obstetric care in Japan is organized in 3 levels and half of all deliveries are conducted at primary facilities without neonatal intensive care unit. We evaluated the predictive accuracy of the sFlt-1/PlGF ratio for the onset of preeclampsia and adverse outcomes in pregnant women with suspected preeclampsia at multiple facilities in Japan, including primary facilities. 356 pregnant women from 18 + 0 to 36 + 6 weeks of pregnancy were enrolled. 303 women were included in the final analysis. The negative predictive value for ruling out preeclampsia within 1 week using the cut-off value 38 was 98.4% (95% CI, 96.2–99.3) with a negative likelihood ratio of 0.22 (95% CI, 0.09–0.53). The positive predictive value for ruling in preeclampsia within 4 weeks using the cut-off value 38 was 48.2% (95% CI, 38.0–58.5). The positive predictive value using a cut-off value of 85 was 65.0% (95% CI, 44.1–81.4) with a positive likelihood ratio of 12.21 (95% CI, 5.20–28.80). The positive predictive value for prediction of adverse outcomes within 4 weeks using the cut-off value 38 was 64.8% (95% CI, 53.1–75.0). To clarify the accuracy of the test currently covered by insurance in Japan, we additionally conducted an analysis focusing on pregnant women between 18 + 0 and 35 + 6 weeks, yielding even higher accuracy. Pregnant women with sFlt-1/PlGF ratio >38 should be referred to a higher-level medical institution. The appropriate use of sFlt-1/PlGF supported by a robust collaboration between primary and tertiary care institutions may help to improve perinatal outcomes in Japan.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2548-2557"},"PeriodicalIF":4.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02282-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive heart disease: is it really a pathology? 高血压性心脏病：真的是一种病理吗？

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-04 DOI: 10.1038/s41440-025-02312-x

Maria Giulia Bellicini

引用次数: 0

Be careful of hidden friends 小心隐藏的朋友。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-01 DOI: 10.1038/s41440-025-02326-5

Masaki Mogi

引用次数: 0