Hypertension Research最新文献_第8页

Rethinking salt reduction in older adults with hypertension

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-12 DOI: 10.1038/s41440-025-02138-7

Kimika Arakawa

引用次数: 0

Dipping status assessed by home vs. ambulatory blood pressure monitoring

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-12 DOI: 10.1038/s41440-025-02139-6

Yi-Bang Cheng, Yan Li

引用次数: 0

The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-12 DOI: 10.1038/s41440-025-02099-x

Jooeun Jeon, Keum Ji Jung, Heejin Kimm, Ji-young Lee, Chung-Mo Nam, Sun Ha Jee

{"title":"The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence","authors":"Jooeun Jeon, Keum Ji Jung, Heejin Kimm, Ji-young Lee, Chung-Mo Nam, Sun Ha Jee","doi":"10.1038/s41440-025-02099-x","DOIUrl":"10.1038/s41440-025-02099-x","url":null,"abstract":"This study aims to evaluate the causal association of blood pressure (BP) with type 2 diabetes (T2D) and assess the cumulative effect of genetic predisposition of high BP or glycemic for future clinical in Korea. To assess the bidirectional causal association between fasting blood sugar (FBS) and systolic blood pressure (SBP) in the large biobank, five MR methods (a 2-stage least squares (2SLS) regression, inverse-variance weighted (IVW), 2 median-based (simple and weighted) and MR-Egger) were applied using the weighted genetic risk score (wGRS). A bidirectional causality was found in all five methods, and there was no horizontal pleiotropy. Using the 2SLS regression method, genetically determined 10 mm/Hg elevation of SBP caused an increased 0.63 mmol/L FBS (p < 0.0001). Men had a particularly strong bidirectional causal relationship. Distinct predicted trajectories based on genetically determined SBP and FBS levels were identified using group-based trajectory modeling (GBTM). To assess the risk of subsequent hypertension or T2D in each trajectory, the Cox proportional hazard model, and adjusted covariates (including wGRS) were conducted. An uncontrol predicted SBP pattern (fluctuated plot) had a higher risk of subsequence T2D than a control-predicted pattern (HR: 1.25, 95% CI: 1.00–1.58). In the Korean middle-aged, it was significantly demonstrated that there is a bidirectional causality between high BP and T2D, which is different from previous studies in Europe. Specially, cumulative high blood pressure predisposition by the genetic variants may affect to risk of T2D incidence. Prevention of high BP must be followed in lifespan.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1274-1284"},"PeriodicalIF":4.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02099-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary supplements and prevention of preeclampsia

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-10 DOI: 10.1038/s41440-025-02144-9

Takafumi Ushida, Sho Tano, Seiko Matsuo, Kazuya Fuma, Kenji Imai, Hiroaki Kajiyama, Tomomi Kotani

{"title":"Dietary supplements and prevention of preeclampsia","authors":"Takafumi Ushida, Sho Tano, Seiko Matsuo, Kazuya Fuma, Kenji Imai, Hiroaki Kajiyama, Tomomi Kotani","doi":"10.1038/s41440-025-02144-9","DOIUrl":"10.1038/s41440-025-02144-9","url":null,"abstract":"Preeclampsia (PE) is a common pregnancy complication characterized by hypertension, proteinuria, and end-organ dysfunction. However, to date, no effective treatment has been established other than iatrogenic delivery, and the importance of prevention as an alternative approach to addressing PE has been emphasized. There is growing evidence on the effectiveness of pharmacological and non-pharmacological prophylaxis in preventing PE. In this review, we focused on dietary supplements as non-pharmacological prophylaxis for PE. Calcium is a well-documented supplement for the prevention of PE. Daily 500 mg calcium supplementation can roughly halve the risk of PE in settings where calcium intake is low, including in Japan. According to recent systematic reviews and network meta-analyses, current evidence on the efficacy of vitamin D supplementation is inconsistent. Although vitamin D is a candidate for the prevention of PE, future large-scale randomized control trials are necessary to draw definitive conclusions. We also reviewed other dietary supplements, including vitamins (vitamins A, B6, C, and E, folic acid, and multivitamins), minerals (magnesium, zinc, and iron), amino acids (l-arginine and l-carnitine), anti-oxidants (lycopene, resveratrol, and astaxanthin), and other agents (omega-3 fatty acids, coenzyme Q10, melatonin, and s-equol). In this study, we provide a comprehensive approach to help develop better preventive strategies and ultimately reduce the burden of PE.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1444-1457"},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02144-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aorticorenal ganglion ablation for blood pressure lowering in canine models

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-10 DOI: 10.1038/s41440-025-02129-8

Teng Xu, Yake Lou, Qiaoqiao Li, Jing Huang

{"title":"Aorticorenal ganglion ablation for blood pressure lowering in canine models","authors":"Teng Xu, Yake Lou, Qiaoqiao Li, Jing Huang","doi":"10.1038/s41440-025-02129-8","DOIUrl":"10.1038/s41440-025-02129-8","url":null,"abstract":"Studies have shown that renal denervation (RDN) can lower blood pressure (BP) in patients with refractory hypertension, but issues such as renal sympathetic nerve reinnervation and suboptimal BP reduction remain unresolved. In this study, we identified the aorticorenal ganglion (ARG) in canines by observing ambulatory BP responses following electrical stimulation of the ARG. We injected cholera toxin subunit B combined with Alexa Fluor™ 555, a nerve tracer, into the identified ARG and confirmed its innervation of the renal artery and kidney by observing fluorescence in adjacent tissues. Twelve experimental canines were divided equally into an intervention group, which received ARG ablation using 95% ethanol, and a sham control group, which received normal saline. Our results demonstrated that ARG ablation significantly reduced systolic, diastolic, and mean arterial pressures, with minimal impact on heart rate. Additionally, ARG ablation lowered plasma and renal cortex norepinephrine levels, and reduced tyrosine hydroxylase expression in the renal cortex. No adverse events were observed during the 3-month follow-up period. These findings suggest that the ARG may serve as a novel target for RDN and could offer a therapeutic alternative for patients who do not respond to or experience elevated BP after RDN.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1503-1513"},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JSH2024 smoke-free declaration “Stop All Tobacco Products”

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-024-02073-z

Kimika Arakawa, Yuichi Akasaki, Ako Fukami, Satoko Sakata, Ken Sugimoto, Hirochika Ryuno, Mai Kabayama, Mitsuru Ohishi, JSH Smoke-Free Promotion Committee members, Koichi Node

引用次数: 0

Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02098-y

Haruhiko Shimizu, Takeshi Murakoshi, Shohei Wakisaka, Yuri Hamada, Yumi Shimizu, Kentaro Iga, Hiroko Konno, Kiguna Sei

{"title":"Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study","authors":"Haruhiko Shimizu, Takeshi Murakoshi, Shohei Wakisaka, Yuri Hamada, Yumi Shimizu, Kentaro Iga, Hiroko Konno, Kiguna Sei","doi":"10.1038/s41440-025-02098-y","DOIUrl":"10.1038/s41440-025-02098-y","url":null,"abstract":"A history of preeclampsia is the most important risk factor for its development in subsequent pregnancies. However, few studies have focused on the details of previous cases of preeclampsia. This single-institution, retrospective study evaluated the risk of developing preeclampsia in subsequent pregnancies in patients with a history of preeclampsia. Among singleton pregnant women who delivered at our hospital between 2017 and 2021, those who developed hypertensive disorders of pregnancy (HDP) for the first time were recruited. We retrospectively followed patients who had a subsequent pregnancy and delivery at our hospital before 2023 for a recurrence of preeclampsia. Maternal characteristics, time of HDP onset, and mean arterial pressure (MAP) during the first and early second trimester of the subsequent pregnancy were recorded. Of the 7485 deliveries, 413 were first-episode HDP cases, and the outcomes of subsequent pregnancies were noted in 48 patients with initial preeclampsia. Ten patients (21%) had a recurrence of preeclampsia, and those with early onset preeclampsia on the first pregnancy were more likely to have a recurrence (non-recurrent, 4 (11%) vs. recurrent, 5 (50%); p = 0.012). Analysis of the MAP in 40 patients showed higher recurrence rates in patients with elevations in MAP during the early second trimester (ΔMAP (early second − first trimester) median: −6 mmHg vs −3.3 mmHg, p = 0.03). Approximately 20% of patients with initial preeclampsia experience recurrence. The timing of onset in the primary pregnancy is an important predictive factor for preeclampsia in subsequent pregnancies. Changes in MAP may be useful indicators for predicting preeclampsia.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1315-1320"},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure and in-hospital outcomes in patients hospitalized with atrial fibrillation: findings from the CCC-AF project

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02125-y

Zhaoqing Sun, Yongchen Hao, Jun Liu, Na Yang, Haimei Wang, Yue Qi, Dong Zhao, Jing Liu, On behalf of the CCC-AF Investigators

{"title":"Blood pressure and in-hospital outcomes in patients hospitalized with atrial fibrillation: findings from the CCC-AF project","authors":"Zhaoqing Sun, Yongchen Hao, Jun Liu, Na Yang, Haimei Wang, Yue Qi, Dong Zhao, Jing Liu, On behalf of the CCC-AF Investigators","doi":"10.1038/s41440-025-02125-y","DOIUrl":"10.1038/s41440-025-02125-y","url":null,"abstract":"The relationship between blood pressure (BP) levels and adverse outcomes in patients with atrial fibrillation (AF) is incompletely understood. Our study aims to elucidate the relationship between BP levels upon admission and in-hospital outcomes in patients hospitalized with AF. Based on the Improving Care for Cardiovascular Disease in China-AF (CCC-AF) project, patients hospitalized with AF collected from 236 hospitals in China from 2015 to 2019 were included in current analysis. A total of 60 390 patients hospitalized with AF were included. Using systolic BP (SBP)/diastolic BP (DBP) of 130–139/80–89 mmHg upon admission as the reference, SBP/DBP ≥160/100 mmHg was associated with an increased risk of stroke/transient ischemic attack (TIA) (adjusted OR, 1.65; 95% CI, 1.27–2.15; P < 0.001) and heart failure (HF) (adjusted OR, 1.29; 95% CI, 1.18–1.41; P < 0.001). SBP/DBP < 120/ < 80 mmHg was associated with an increased risk of HF (adjusted OR, 1.24; 95% CI, 1.14–1.34; P < 0.001), and all-cause death (adjusted OR, 1.90; 95% CI, 1.90–3.86; P < 0.001). A similar pattern was observed in the analysis of the relationship between SBP and DBP levels and in-hospital outcomes, respectively. Among patients hospitalized with AF, higher BP levels upon admission are associated with an increased risk of stroke/TIA and HF, and lower BP levels are associated with an increased risk of HF and all-cause death. Hence, physicians should pay attention to higher and lower BP levels. Randomized trials to identify the optimal treatment target for AF patients are warranted.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1331-1341"},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocturia and sleep blood pressure - A key link in a vicious cycle?

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02136-9

Michiaki Nagai, Tarun W. Dasari

引用次数: 0

Challenges in monitoring nighttime blood pressure

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-03 DOI: 10.1038/s41440-025-02132-z

Naoko Tomitani

引用次数: 0