高血压和动脉僵硬对社区筛查参与者靶器官损伤的综合影响。

IF 4.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2025-02-19 DOI:10.1038/s41440-025-02163-6

Yoshitsugu Sunagawa, Akio Ishida, Masanobu Yamazato, Yusuke Ohya, Kenya Kusunose

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引用次数: 0

摘要

我们研究了高血压和高脉搏波速度（PWV）对靶器官损伤、蛋白尿和左心室肥厚（LVH）的影响，每一种都用一次测量来评估。这项观察性横断面研究包括13186名患者，他们在健康检查期间接受了肱-踝PWV （baPWV）测量、尿液分析和心电图。测定baPWV同时测定血压（BP）。蛋白尿和LVH分别用尿试纸试验和心电图进行评估。参与者根据他们的高血压（是/否，定义为血压≥140/90 mmHg）和baPWV（高/低，临界值为14.0 m/s）状态分为四组。参与者的平均年龄为53±11岁，蛋白尿和LVH患病率分别为594（4.5%）和1716（13.0%）。与低baPWV的非高血压组相比，高baPWV的非高血压组（比值比[OR] 1.41[95%可信区间（CI）， 1.07-1.86]）、低baPWV的高血压组（比值比[OR] 2.66 [95% CI, 1.78-3.97]）和高baPWV的高血压组（比值比[OR] 2.80 [95% CI, 2.18-3.61]）显示出更高的多变量调整蛋白尿风险。低baPWV高血压组发生蛋白尿的风险明显高于非高血压高baPWV组。LVH也得到了类似的结果。高血压和高baPWV与蛋白尿和LVH患病率独立相关。单次血压测量评估的高血压可能是蛋白尿和LVH比高baPWV更重要的危险因素。高血压和高臂踝脉波速度与蛋白尿和左心室肥厚的发生率独立相关。单次血压测量评估的高血压可能是蛋白尿和左心室肥厚的重要危险因素，而不是高臂踝脉波速度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Combined effects of hypertension and arterial stiffness on target organ damage among community-based screening participants

查看原文本刊更多论文

Combined effects of hypertension and arterial stiffness on target organ damage among community-based screening participants

We investigated the impact of hypertension and high pulse wave velocity (PWV), each assessed in a single measurement, on target organ damage, proteinuria, and left ventricular hypertrophy (LVH). This observational cross-sectional study included 13,186 patients who underwent brachial-ankle PWV (baPWV) measurement, urinalysis, and electrocardiography during a health check-up. Blood pressure (BP) was measured at the time of baPWV measurement. Proteinuria and LVH were evaluated using a urine dipstick test and electrocardiography, respectively. Participants were categorized into four groups based on their hypertension (yes/no, defined as BP ≥ 140/90 mmHg) and baPWV (high/low, cutoff value of 14.0 m/s) statuses. The mean age of the participants was 53 ± 11 years, and the prevalence of proteinuria and LVH was 594 (4.5%) and 1716 (13.0%), respectively. Compared with the non-hypertension with low baPWV group, the non-hypertension with high baPWV (odds ratio [OR] 1.41 [95% confidence interval (CI), 1.07–1.86]), hypertension with low baPWV (OR 2.66 [95% CI, 1.78–3.97]), and hypertension with high baPWV groups (OR 2.80 [95% CI, 2.18–3.61]) exhibited a higher multivariate-adjusted risk for proteinuria. The hypertension with low baPWV group had a significantly higher risk of proteinuria than the non-hypertension with high baPWV group. Similar results were obtained for LVH. Hypertension and a high baPWV were independently associated with the prevalence of proteinuria and LVH. Hypertension assessed in a single BP measurement is likely to be a more important risk factor for proteinuria and LVH than high baPWV. Hypertension and high brachial-ankle pulse wave velocity were independently associated with the prevalence of proteinuria and left ventricular hypertrophy. Hypertension assessed in a single blood pressure measurement is likely to be a more important risk factor for proteinuria and left ventricular hypertrophy than high brachial-ankle pulse wave velocity.

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来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.