Hypertension Research最新文献

Combining muscle strengthening activity and aerobic exercise: a prescription for better health in patients with hypertension 肌肉强化活动与有氧运动相结合：改善高血压患者健康的良方

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01868-4

Tatsuya Maruhashi, Yukihito Higashi

引用次数: 0

QKD interval as a noninvasive method for evaluation of atherosclerosis 将 QKD 间隔作为评估动脉粥样硬化的无创方法

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01879-1

Takuro Kubozono

引用次数: 0

Bilateral superselective adrenal artery embolization for bilateral primary aldosteronism: a novel approach in an efficacy and safety proof-of-principle trial 双侧超选择性肾上腺动脉栓塞治疗双侧原发性醛固酮增多症：疗效和安全性原理验证试验中的一种新方法

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01881-7

Xin Li, Rui Feng, Rui Xiang, Li Tao, Yong-peng Zhao, Ping Tang, Zhong Zuo, Dian-Sa Gao, Qin Lou, Peng Pu, Yue-Ming Chen, Jie Chen, Feng-Jie Lv, Ling Wang, Hong Zhao, Qiu-Yue Shi, Yu-Tian He, Nouman Ali Khan, Jing Chang, Min Mao

{"title":"Bilateral superselective adrenal artery embolization for bilateral primary aldosteronism: a novel approach in an efficacy and safety proof-of-principle trial","authors":"Xin Li, Rui Feng, Rui Xiang, Li Tao, Yong-peng Zhao, Ping Tang, Zhong Zuo, Dian-Sa Gao, Qin Lou, Peng Pu, Yue-Ming Chen, Jie Chen, Feng-Jie Lv, Ling Wang, Hong Zhao, Qiu-Yue Shi, Yu-Tian He, Nouman Ali Khan, Jing Chang, Min Mao","doi":"10.1038/s41440-024-01881-7","DOIUrl":"https://doi.org/10.1038/s41440-024-01881-7","url":null,"abstract":"Superselective adrenal artery embolization (SAAE) offers a novel approach for treating primary aldosteronism (PA). In this study, we aimed to assess the efficacy and safety of SAAE for the treatment of PA based on the lateralization results obtained from adrenal vein sampling (AVS).In this prospective study, we enrolled 40 patients with PA who underwent SAAE. The patients were categorized into two groups, unilateral PA and bilateral PA, based on AVS results. Clinical parameters and biochemical markers were assessed at 3 and 12 months postoperatively. The primary outcomes were changes in blood pressure and defined daily dose (DDD) of antihypertensive medications compared to baseline. Thirty-eight patients achieved technical success, with favorable clinical and biochemical efficacy rates. At three months postoperatively, the clinical efficacy rates were 79.2% and 78.6% for the UPA and BPA groups, respectively. At 12 months, the rates were 83.3% and 71.4%, respectively. Both groups exhibited a significant decrease in average blood pressure at 3 and 12 months compared with baseline (P < 0.001), and there was also a notable reduction in DDD (P < 0.05). At three months, the biochemical efficacy rates were 61.9% and 58.3% in the UPA and BPA groups, respectively. Due to loss to follow-up, biochemical indicators were not assessed at 12 months postoperatively. No severe adverse reactions occurred during or after SAAE. Patients with both UPA and BPA can benefit from SAAE. The superiority of bilateral adrenal artery embolization in the treatment of BPA over unilateral adrenal artery embolization requires further investigation.<figure></figure>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary antioxidant indices and hypertension among Chinese adults 中国成年人膳食抗氧化指数与高血压之间的关系

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01839-9

Xiaoxia Li, Qingan Wang, Xinrong Liu, Qiuqiu Lan, Yixuan Xue, Jiaxing Zhang, Yuhong Zhang, Yi Zhao

{"title":"Association between dietary antioxidant indices and hypertension among Chinese adults","authors":"Xiaoxia Li, Qingan Wang, Xinrong Liu, Qiuqiu Lan, Yixuan Xue, Jiaxing Zhang, Yuhong Zhang, Yi Zhao","doi":"10.1038/s41440-024-01839-9","DOIUrl":"https://doi.org/10.1038/s41440-024-01839-9","url":null,"abstract":"The effect of dietary antioxidants on blood pressure (BP) regulation and hypertension risk remains largely unknown. This study aimed to comprehensively assess the impacts of dietary antioxidants on systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), and hypertension risk among Chinese adults. The cross-sectional study assessed data from 12,046 Chinese adults, evaluating dietary antioxidant quality scores (DAQS) and total antioxidant capacity (DTAC) via a validated food frequency questionnaire. MAP was derived using the formula DBP + (0.412 ×PP), with PP calculated as SBP - DBP. The relationship between DAQS, DTAC, and hypertension prevalence was analyzed using multivariable logistic regression. Among participants not taking antihypertensive medications, those in the highest groups of DTAC and DAQS had significantly lower SBP, DBP, MAP, and PP compared to those in the lowest groups (all p-trends <0.001). Relative to the lowest quintile (Q1) of DTAC (adjusted odds ratios (OR) for hypertension decreased in Q2 (OR 0.90, 95%CI 0.79–1.03), Q3 (OR 0.65, 95% CI 0.56–0.76), Q4 (OR 0.51, 95% CI 0.43–0.60), and Q5 (OR 0.38, 95% CI 0.31–0.46) (p trend <0.001). For DQAS, hypertension OR of category 5 was 0.38 (95% CI 0.32–0.46) compared to that of category 1. Increased vitamin A, Zinc, and selenium intake correlated with reduced hypertension risk. A significant non-linear DTAC and linear DAQS relationships were observed and hypertension risk. Antioxidant-rich diets markedly lowered SBP, DBP, MAP, PP, and hypertension risk.<figure></figure>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse pressure amplification as a hemodynamic predictor of cardiovascular disease 脉压放大作为心血管疾病的血液动力学预测指标

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01880-8

Junichiro Hashimoto

引用次数: 0

Autonomic neuromodulation for cardiomyopathy associated with metabolic syndrome - Prevention of precursors for heart failure with preserved ejection fraction- 自律神经调节治疗代谢综合征相关心肌病--预防射血分数保留型心力衰竭的前兆--

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01886-2

Michiaki Nagai, Karl-Philipp Rommel, Sunny S. Po, Tarun W. Dasari

引用次数: 0

Effects of bilateral renal denervation on open-loop baroreflex function and urine excretion in spontaneously hypertensive rats 双侧肾神经支配对自发性高血压大鼠开环气压反射功能和尿液排泄的影响

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01883-5

Toru Kawada, Masafumi Fukumitsu, Hiroki Matsushita, Yuki Yoshida, Kei Sato, Hidetaka Morita, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Keita Saku

{"title":"Effects of bilateral renal denervation on open-loop baroreflex function and urine excretion in spontaneously hypertensive rats","authors":"Toru Kawada, Masafumi Fukumitsu, Hiroki Matsushita, Yuki Yoshida, Kei Sato, Hidetaka Morita, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Keita Saku","doi":"10.1038/s41440-024-01883-5","DOIUrl":"https://doi.org/10.1038/s41440-024-01883-5","url":null,"abstract":"Bilateral renal denervation (RDN) decreases arterial pressure (AP) or delays the development of hypertension in spontaneously hypertensive rats (SHR), but whether bilateral RDN significantly modifies urine output function during baroreflex-mediated acute AP changes remains unknown. We quantified the relationship between AP and normalized urine flow (nUF) in SHR that underwent bilateral RDN (n = 9) and compared the results with those in sham-operated SHR (n = 9). Moreover, we examined the acute effect of an angiotensin II type 1 receptor blocker telmisartan (2.5 mg/kg) on the AP–nUF relationship. Bilateral RDN significantly decreased AP by narrowing the response range of the total arc of the carotid sinus baroreflex. The slopes of nUF versus the mean AP (in μL·min−1·kg−1·mmHg−1) in the sham and RDN groups under baseline conditions were 0.076 ± 0.045 and 0.188 ± 0.039, respectively; and those after telmisartan administration were 0.285 ± 0.034 and 0.416 ± 0.078, respectively. The effect of RDN on the nUF slope was marginally significant (P = 0.059), which may have improved the controllability of urine output in the RDN group. The effect of telmisartan on the nUF slope was significant (P < 0.001) in the sham and RDN groups, signifying the contribution of circulating or locally produced angiotensin II to determining urine output function regardless of ongoing renal sympathetic nerve activity.<figure></figure>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure polygenic risk scores tackle hard endpoints 血压多基因风险评分解决硬终点问题

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01876-4

Felix Vaura

引用次数: 0

IL-1β and vascular inflammation in hypertension and metabolic diseases? IL-1β 与高血压和代谢性疾病中的血管炎症？

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01884-4

Azhagu Madhavan Sivalingam, Arjun Pandian

引用次数: 0

Usefulness and caveats of real-world data for research on hypertension and its association with cardiovascular or renal disease in Japan 真实世界数据对日本高血压及其与心血管疾病或肾脏疾病关系研究的实用性和注意事项

IF 5.4 2区医学

Hypertension Research Pub Date : 2024-09-11 DOI: 10.1038/s41440-024-01875-5

Michihiro Satoh, Shingo Nakayama, Maya Toyama, Hideaki Hashimoto, Takahisa Murakami, Hirohito Metoki

{"title":"Usefulness and caveats of real-world data for research on hypertension and its association with cardiovascular or renal disease in Japan","authors":"Michihiro Satoh, Shingo Nakayama, Maya Toyama, Hideaki Hashimoto, Takahisa Murakami, Hirohito Metoki","doi":"10.1038/s41440-024-01875-5","DOIUrl":"https://doi.org/10.1038/s41440-024-01875-5","url":null,"abstract":"The role of real-world data, collected from clinical practice rather than clinical trials, has become increasingly important for investigating real-life situations, such as treatment effects. In Japan, evidence on hypertension, cardiovascular diseases, and kidney diseases using real-world data is increasing. These studies are mainly based on “the insurer-based real-world data” collected as electronic records, including data from health check-ups and medical claims such as JMDC database, DeSC database, the Japan Health Insurance Association (JHIA) database, or National Databases of Health Insurance Claims and Specific Health Checkups (NDB). Based on the insurer-based real-world data, traditional but finely stratified associations between hypertension and cardiovascular or kidney diseases can be explored. The insurer-based real-world data are also useful for pharmacoepidemiological studies that capture the distribution and trends of drug prescriptions; combined with annual health check-up data, the effectiveness of drugs can also be examined. Despite the usefulness of insurer-based real-world data collected as electronic records from a wide range of populations, we must be cautious about several points, including issues regarding population uncertainty, the validity of cardiovascular outcomes, the accuracy of blood pressure, traceability, and biases, such as indication and immortal biases. While a large sample size is considered a strength of real-world data, we must keep in mind that it does not overcome the problem of systematic error. This review discusses the usefulness and pitfalls of insurer-based real-world data in Japan through recent examples of Japanese research on hypertension and its association with cardiovascular or kidney disease.<figure></figure>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0