Hypertension Research最新文献

{"title":"Correction: Angiotensin II blockers improves cardiac coronary flow under hemodynamic pressure overload.","authors":"Wei-Ting Chang, Sudeshna Fisch, Seema Dangwal, Michael Chen, Susan Cheng, Zhih-Cherng Chen, Ronglih Liao","doi":"10.1038/s41440-025-02389-4","DOIUrl":"https://doi.org/10.1038/s41440-025-02389-4","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effect of the renin-angiotensin-aldosterone system inhibitors on time to nucleic acid negative conversion in hypertensive patients with SARS-CoV-2 omicron infection: a propensity score matching study.","authors":"Ru Wen, Jingwen Li, Fengxi Chen, Jian Liu, Peng Xu, Mengfei Li, Jingwei Li, Liang Tan, Chen Liu","doi":"10.1038/s41440-025-02386-7","DOIUrl":"https://doi.org/10.1038/s41440-025-02386-7","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between lifestyle habits and blood pressure in Japanese high school students: a student-driven exploratory survey.","authors":"Aya Shiraki, Atsushi Tanaka, Mari Ishida, Kimika Arakawa, Ako Fukami, Takuya Kishi, Koichi Node","doi":"10.1038/s41440-025-02381-y","DOIUrl":"https://doi.org/10.1038/s41440-025-02381-y","url":null,"abstract":"<p><p>This cross-sectional observational study investigates the relationship between lifestyle habits and blood pressure in 244 Japanese high school students from Kogakukan High School. The mean blood pressure was 119.5 ± 11.3/71.3 ± 9.5 mmHg, with 9% of participants meeting the criteria for hypertension (≥ 140/85 mmHg). Hypertensive students had a shorter sleep duration than non-hypertensive students (P = 0.050). Multivariate analysis revealed that systolic blood pressure was significantly associated with male sex (β = -0.274, P < 0.001) and higher body mass index (β = 0.261, P < 0.001). Diastolic blood pressure was significantly influenced by female sex (β = 0.166, P < 0.001) and sugar intake (β = 0.152, P = 0.028). No significant associations were found with salt score, caffeine consumption, or aerobic exercise. These findings highlight the influence of sex, body mass index, dietary sugar, and sleep duration on adolescent blood pressure regulation, emphasizing the need for early lifestyle interventions to mitigate hypertension risk. Relationship between Lifestyle and Blood Pressure Levels in Japanese High School Students. Hypertensive students had shorter sleep durations; systolic blood pressure levels were associated with BMI and male sex, and diastolic blood pressure levels were linked to sugar intake and female sex. BMI, body mass index; HT, hypertension.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive dementia and blood pressure management from JSH2025.","authors":"Masaki Mogi","doi":"10.1038/s41440-025-02399-2","DOIUrl":"https://doi.org/10.1038/s41440-025-02399-2","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing artificial light at night exposure in the urban environment could decrease light pollution-related hypertension in children.","authors":"Le-Bing Wang, Hong-Xing Zou, Xiao-Yi Liu, Xiao-Fan Lu, Jing-Yao Wang, Cheng Li, Shuo Zhang, Si-Han Wu, Han-Yu Yang, Yang Zhou, Li-Zi Lin, Ru-Qing Liu, Zhong Lin, Guang-Hui Dong, Li-Wen Hu","doi":"10.1038/s41440-025-02380-z","DOIUrl":"https://doi.org/10.1038/s41440-025-02380-z","url":null,"abstract":"<p><p>Elevated blood pressure in children is related to the hypertension in adults. Reducing environmental factors linked to hypertension in children is necessary to prevent hypertension in adults. To investigate the associations between outdoor artificial light at night (ALAN) and blood pressure among children. We recruited 9354 children aged 5-17 in the Seven Northeastern Cities Study between 2012 and 2013. Trained nurses measured their blood pressure with a mercury sphygmomanometer. We defined hypertension as systolic blood pressure (SBP) or diastolic blood pressure (DBP) ≥95th age-sex-height-specific percentile. We geocoded the address of each child and linked it to estimated outdoor ALAN within 500 m (ALAN_-500 m) sourced from the VIIRS/DNB. We utilized generalized linear mixed-effect models to assess the associations of outdoor ALAN and blood pressure and the odds of hypertension. Effect modification by age, sex, weight status, and other potential factors was also explored. The SBP, DBP, and mean arterial pressure at quartile 4 (Q4) of outdoor ALAN_-500 m against Q1 increased in 1.45 (95% CI: 0.31-2.59) mmHg, 2.09 (95% CI: 1.18-2.99) mmHg, and 1.87 (95% CI: 0.99-2.76) mmHg, respectively. The odds of hypertension increased by 30% in Q3 of outdoor ALAN_-500 m compared to Q1 (OR = 1.30, 95% CI: 1.05-1.61). Furthermore, stronger effect estimates were observed among children aged ≤11 years (Q4, β = 5.07[3.28-6.85] vs β = 1.54[0.37-2.71] for DBP) and who were overweight (Q4, OR = 1.95[1.17-3.22] vs OR = 0.89[0.60-1.32] for hypertension). Living in areas with high outdoor ALAN exposure increased the odds of hypertension in children, especially in children aged ≤11 years and overweight. Reducing outdoor ALAN is important for preventing hypertension and controlling blood pressure in children. The study found a positive association between outdoor ALAN and blood pressure and hypertension.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of risk factors for osteoporosis with a focus on hypertension and estimation of the causal effect of hypertension on osteoporosis using causal forest.","authors":"Takuya Uematsu, Shuko Nojiri, Wataru Urasaki, Yuji Nishizaki","doi":"10.1038/s41440-025-02372-z","DOIUrl":"https://doi.org/10.1038/s41440-025-02372-z","url":null,"abstract":"<p><p>The current study aimed to comprehensively investigate the factors that most significantly increase the likelihood of developing osteoporosis, which is of great importance for aging populations. To this end, we focus on hypertension (HT) and examine its interaction and causal effect on osteoporosis. Using an administrative claims database, a nested case-control study and time-to-event analysis were conducted focusing on Japanese individuals aged ≥65 years. The results of the nested case-control study showed that rheumatoid arthritis (RA) had the highest odds ratio (OR = 1.961, 95% CI = 1.85-2.078), followed by HT (OR = 1.722, 95% CI = 1.659-1.787). In the time-to-event analysis, RA had the highest hazard ratio (HR = 2.133, 95% CI = 1.972-2.308), followed by chronic kidney disease (CKD) (HR = 1.473, 95% CI = 1.354-1.602), chronic obstructive pulmonary disease (HR = 1.46, 95% CI = 1.323-1.611), and HT (HR = 1.269, 95% CI = 1.21-1.331). Additionally, significant interactions were observed when HT co-existed with CKD, disorders of lipoprotein metabolism and other lipidemias (DLM), and RA. Moreover, the summary causal tree results of the conditional average treatment effect (CATE) using a causal inference approach revealed that the subgroup with DLM = 0, diabetes mellitus (DM) = 0, and RA = 0 exhibited the highest estimated CATE of 0.372, suggesting a strong independent causal effect of HT on osteoporosis in this group.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy.","authors":"Kaori Mikami, Takashi Nagase, Hisaki Kishino, Nobuhiro Nakamura, Yoshiro Suzuki, Hiroshi Fukuhara, Taiji Matsusaka, Keiko Nonomura, Miki Nagase","doi":"10.1038/s41440-025-02383-w","DOIUrl":"https://doi.org/10.1038/s41440-025-02383-w","url":null,"abstract":"<p><p>Piezo1 is a mechanosensitive ion channel that mediates a broad range of biological and pathological phenomena in living organisms, including hypertension and hypertensive nephropathy. We previously reported the upregulation of Piezo1 in the glomerular podocytes of hypertensive nephropathy mice in vivo and a mechanical stretch-induced podocyte injury cascade via Piezo1 and Rac1 in vitro, suggesting the pathogenic involvement of Piezo1. However, recent reports on podocyte-specific Piezo1 knockout mice with various podocyte injury models other than hypertension have yielded inconsistent results, indicating pathogenic and anti-pathogenic roles of Piezo1. In this study, we generated podocyte-specific Piezo1 knockout mice and examined their podocyte phenotypes under normotensive and hypertensive conditions induced by angiotensin II and a high-salt diet. Podocyte-specific Piezo1 knockout mice did not spontaneously develop podocyte injury. Angiotensin II infusion and a high-salt diet for 14 days caused hypertension, but not significant podocyte injury and proteinuria in the littermate control mice, which were strengthened by podocyte-specific Piezo1 deletion. Through comprehensive transcriptome analysis of the glomeruli of wild-type and podocyte-specific Piezo1 knockout mice, we found altered expression of several genes, including Rhpn1 encoding Rho GTPase binding protein Rhophilin1. Podocyte injury in hypertensive podocyte-specific Piezo1 knockout mice was inhibited by the angiotensin II receptor blocker losartan, the anti-hypertensive drug hydralazine, and partially ameliorated by the Rho kinase inhibitor fasudil, suggesting that podocyte injury in the knockout mice may be mediated by Rhophilin1 and/or Rho signaling downstream of Piezo1. Findings related to the hypertensive podocyte injury model support the possible anti-pathogenic protective roles of Piezo1. We created podocyte-specific Piezo1 KO mice, and hypertension was induced by angiotensin II and a high-salt diet. Hypertension-evoked proteinuria and podocyte injury were exaggerated in the KO mice. They were ameliorated by anti-hypertensive drugs and Rho kinase inhibitor, suggesting protective roles of Piezo1 and involvement of RhoA signaling.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure\".","authors":"Yuru Fu, Yuanyuan Wang","doi":"10.1038/s41440-025-02394-7","DOIUrl":"https://doi.org/10.1038/s41440-025-02394-7","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitor requires co-administration with diuretics to effectively reduce interstitial fluid retention: the DAPA-BODY trial.","authors":"Takahiro Masuda, Maki Asakura-Kinoshita, Kentaro Oka, Ken Ohara, Masato Sakai, Marina Miura, Kyohei Misawa, Keiji Hirai, Masato Morinari, Tetsu Akimoto, Kazuyuki Shimada, Daisuke Nagata, Yoshiyuki Morishita","doi":"10.1038/s41440-025-02388-5","DOIUrl":"https://doi.org/10.1038/s41440-025-02388-5","url":null,"abstract":"<p><p>We previously demonstrated that combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor with diuretics significantly reduces interstitial fluid volume without excessive depletion of circulating plasma volume or activation of the renin-angiotensin-aldosterone system (RAAS). However, the differential effects of SGLT2 inhibitor monotherapy versus combination therapy with diuretics on fluid dynamics in patients with pre-existing fluid retention remain unclear. This study included patients with fluid retention, defined by an extracellular water to total body water (ECW/TBW) ratio > 0.400, as measured by bioimpedance analysis. We evaluated 6-month changes in body fluid status and serum copeptin levels, a surrogate marker for vasopressin, between two groups: patients receiving SGLT2 inhibitor dapagliflozin monotherapy (SGLT2i group, n = 13; estimated glomerular filtration rate [eGFR] 25.0 ± 8.5 mL/min/1.73 m²) and those receiving dapagliflozin in combination with loop or thiazide diuretics (SGLT2i + diuretic group, n = 18; eGFR 29.8 ± 15.2 mL/min/1.73 m²). Changes in systolic blood pressure and estimated plasma volume did not significantly differ between groups. However, reductions in ECW/TBW, TBW, and interstitial fluid were significantly greater in the combination group than in the monotherapy group. Moreover, the increase in serum copeptin was significantly suppressed in the SGLT2i + diuretic group. No significant intergroup differences were observed in renin and aldosterone changes. These findings suggest that co-administration of SGLT2 inhibitor with diuretics can more effectively reduce interstitial fluid retention without inducing excessive plasma volume reduction or RAAS activation.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive sleep apnea and arterial stiffness: is heart rate a mediator?","authors":"Takatoshi Kasai","doi":"10.1038/s41440-025-02384-9","DOIUrl":"https://doi.org/10.1038/s41440-025-02384-9","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}