Hypertension Research最新文献

Author's reply to the letter regarding "Serum adiponectin as a potential biomarker of therapeutic effect on cardiac metabolism in hypertensive patients with reduced ejection fraction". 作者回复关于“血清脂联素作为射血分数降低的高血压患者心脏代谢治疗效果的潜在生物标志物”的信函。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-20 DOI: 10.1038/s41440-026-02854-8

Haruhito Harada, Hisashi Kai

引用次数: 0

Longitudinal association between body weight change and brachial-ankle pulse wave velocity in patients with treated hypertension or diabetes mellitus: A post hoc analysis of the FMD-J study B. 高血压或糖尿病患者体重变化与臂踝脉波速度的纵向关联：FMD-J研究的事后分析

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-19 DOI: 10.1038/s41440-026-02849-5

Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Aya Mizobuchi, Farina Mohamad Yusoff, Yukiko Nakano, Yukihito Higashi

{"title":"Longitudinal association between body weight change and brachial-ankle pulse wave velocity in patients with treated hypertension or diabetes mellitus: A post hoc analysis of the FMD-J study B.","authors":"Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Aya Mizobuchi, Farina Mohamad Yusoff, Yukiko Nakano, Yukihito Higashi","doi":"10.1038/s41440-026-02849-5","DOIUrl":"https://doi.org/10.1038/s41440-026-02849-5","url":null,"abstract":"We investigated cross-sectional associations between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) and longitudinal associations between body weight change and baPWV over 3 years in 874 patients with treated hypertension or diabetes mellitus without coronary artery disease (475 men; mean age, 61.9 ± 9.5 years). baPWV was measured at baseline, 1.5 years, and 3 years. At baseline, BMI was inversely correlated with baPWV (r = -0.14, P < 0.001), and multivariate analysis confirmed this association (β = -12.5, P < 0.001). In generalized linear mixed-effects models adjusted for concurrent systolic blood pressure, heart rate, and other covariates, neither continuous percentage change in body weight (β = -1.2, P = 0.08) nor categorical body weight change (≥5% increase: β = -10.6, P = 0.45; ≥5% decrease: β = 18.0, P = 0.15) was associated with longitudinal changes in baPWV, with no interaction across baseline BMI categories. The modest body weight changes observed in this cohort were not significantly associated with longitudinal changes in baPWV.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projected prevalence of hypertension and untreated/uncontrolled hypertension in Japan through 2040. 预计到2040年日本高血压和未治疗/未控制高血压的患病率。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-19 DOI: 10.1038/s41440-026-02814-2

Yusuke Yoshikawa, Soshiro Ogata, Rajib Mondal, Yuichiro Yano, Hisatomi Arima, Chris Kypridemos, Eri Kiyoshige, Kunihiro Nishimura

{"title":"Projected prevalence of hypertension and untreated/uncontrolled hypertension in Japan through 2040.","authors":"Yusuke Yoshikawa, Soshiro Ogata, Rajib Mondal, Yuichiro Yano, Hisatomi Arima, Chris Kypridemos, Eri Kiyoshige, Kunihiro Nishimura","doi":"10.1038/s41440-026-02814-2","DOIUrl":"https://doi.org/10.1038/s41440-026-02814-2","url":null,"abstract":"Accurate projections of future hypertension prevalence are essential for planning effective public health strategies to prevent cardiovascular mortality. This study aimed to project the future prevalence of hypertension in Japan through 2040. Prevalence estimates of hypertension and untreated/uncontrolled hypertension stratified by sex and age groups were obtained from the National Health and Nutrition Survey from 1986 to 2019. Hypertension was defined as systolic blood pressure (BP) ≥ 140 mmHg, diastolic BP ≥ 90 mmHg, or use of antihypertensive medication, and untreated/uncontrolled hypertension as systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Three approaches were compared: a Bayesian Lee-Carter model, a model assuming monotonic prevalence change, and a constant-prevalence model. The projected prevalence estimates were applied to the population projections from the Vital Statistics of Japan. The Bayesian Lee-Carter model demonstrated the best predictive accuracy among the three models. The model projected that hypertension prevalence remained stable among men from 47.1% (95% credible interval [CI], 45.6-48.6%) in 2020 to 48.2% (44.6-52.4%) in 2040, and among women from 36.7% (35.5-37.8%) to 35.6% (32.8-38.3%). In contrast, untreated/uncontrolled hypertension prevalence would decline among men from 31.9% (28.6-34.6%) to 26.7% (18.0-38.4%), and among women from 23.1% (21.3-24.8%) to 17.2% (13.1-22.6%). The prevalence of hypertension in Japan is projected to remain largely unchanged through 2040, while the prevalence of untreated/uncontrolled hypertension is projected to decline. The findings suggest that public health policies and clinical efforts for BP control should be maintained and further strengthened to sustain and accelerate the trend.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential uric acid-lowering effect of sacubitril/valsartan. 苏比里尔/缬沙坦潜在的降尿酸作用。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-19 DOI: 10.1038/s41440-026-02853-9

Shunichiro Tsukamoto

引用次数: 0

Low systolic blood pressure in treated non-proteinuric CKD: cardiovascular harm or a marker of cardiac vulnerability? 非蛋白尿CKD治疗的低收缩压：心血管危害还是心脏易损性的标志？

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-16 DOI: 10.1038/s41440-026-02860-w

Yi Lu, Zhujun Wang

引用次数: 0

Insulin-mediated impairment of NCC responsiveness in diet-induced obesity: a new link to salt-sensitive hypertension. 饮食性肥胖中胰岛素介导的NCC反应性损伤：与盐敏感性高血压的新联系

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-16 DOI: 10.1038/s41440-026-02842-y

Yuichi Akasaki

引用次数: 0

Cuffless blood pressure monitoring: one step closer to validation. 无袖带血压监测：离验证又近了一步。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-16 DOI: 10.1038/s41440-026-02852-w

Dean S Picone, Rémi Goupil

引用次数: 0

Carotid energy pulsatility index provides complementary hemodynamic information to renal function in a community-based cohort. 在社区队列中，颈动脉能量脉动指数为肾功能提供了补充的血流动力学信息。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-16 DOI: 10.1038/s41440-026-02845-9

Chih-Chen Liao, Jiun-Jr Wang, Chih-Cheng Wu, Chi-Jung Huang, Chen-Huan Chen, Shao-Yuan Chuang, Hao-Min Cheng

{"title":"Carotid energy pulsatility index provides complementary hemodynamic information to renal function in a community-based cohort.","authors":"Chih-Chen Liao, Jiun-Jr Wang, Chih-Cheng Wu, Chi-Jung Huang, Chen-Huan Chen, Shao-Yuan Chuang, Hao-Min Cheng","doi":"10.1038/s41440-026-02845-9","DOIUrl":"https://doi.org/10.1038/s41440-026-02845-9","url":null,"abstract":"Conventional hemodynamic, including Carotid-femoral pulse wave velocity (cfPWV), characteristic impedance (Zc), and brachial pulse pressure, do not directly quantify pulsatile energy transmission through the arterial system. Carotid energy pulsatility index (PI), derived from synchronized carotid pressure-flow waveforms, may capture this complementary aspect of arterial hemodynamics. We examined whether carotid energy PI was independently associated with renal function after accounting for conventional vascular hemodynamic measures. Participants from the community-based Cardiovascular Disease Risk Factors Two-Township Study (CVDFACTS) underwent synchronized carotid pressure-flow waveform assessment. Associations of carotid energy PI with eGFR were evaluated using multivariable, restricted cubic spline, and segmented regression analyses. Among 1424 participants (46.8% men; mean age 59.7 ± 11.9 years), higher carotid energy PI was independently associated with lower eGFR after adjustment for covariates (standardized β = -0.088, 95% CI -0.136 to -0.039; P < 0.001). Restricted cubic spline and segmented regression analyses identified turning points at 11.395 m/s for cfPWV and 0.043 for carotid energy PI. Compared with participants with low cfPWV and low carotid energy PI, those with concurrent elevations in both parameters had lower eGFR (β = -3.58, 95% CI -6.03 to -1.12; P = 0.004). Carotid energy PI was independently associated with renal function, with the greatest renal burden observed when pulsatile energy and arterial stiffness were jointly elevated. These findings suggest that carotid energy PI provides information complementary to conventional vascular measures.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LipReg4 deletion blocks hypertension induced by gut S. aureofaciens Tü117. LipReg4缺失阻断肠道金黄色葡萄球菌诱导的高血压117。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-16 DOI: 10.1038/s41440-026-02851-x

Xiaowang Lv, Teng Yang, Zhiwei Wang, Hao Shen, Aiqin Mao, Tingting Zhou

{"title":"LipReg4 deletion blocks hypertension induced by gut S. aureofaciens Tü117.","authors":"Xiaowang Lv, Teng Yang, Zhiwei Wang, Hao Shen, Aiqin Mao, Tingting Zhou","doi":"10.1038/s41440-026-02851-x","DOIUrl":"https://doi.org/10.1038/s41440-026-02851-x","url":null,"abstract":"Streptomyces aureofaciens (S. aureofaciens) Tü117 and its metabolite α-lipomycin have been implicated in high-salt-induced hypertension. Previous studies showed that high-salt intake increases gut Tü117 abundance and circulating α-lipomycin levels. Mechanistically, α-lipomycin acts as a TRPV4 antagonist, impairing nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)- mediated endothelium-dependent vasodilation and thereby promoting vascular dysfunction and blood pressure (BP) elevation. However, whether hypertension is driven by Tü117 itself or specifically by α-lipomycin production remains unclear. Here, we generated a LipReg4 deletion mutant strain (ΔTü117) using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 genome editing to selectively abolish α-lipomycin biosynthesis. Deletion of LipReg4 did not markedly affect bacterial growth but completely abolished α-lipomycin production. Compared with Tü117, ΔTü117 failed to increase circulating α-lipomycin levels or induce a sustained elevation in BP. These findings identify α-lipomycin as the key metabolite mediating Tü117-induced hypertension. They further support a direct role of gut microbial metabolites in host BP regulation.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incremental value of DXA-derived visceral versus total adiposity beyond routine anthropometric assessment for hypertension discrimination: a population-based study. 一项基于人群的研究：dxa衍生的内脏脂肪与总脂肪的增量价值超过常规人体测量评估对高血压的区分。

IF 5 2区医学

Hypertension Research Pub Date : 2026-10-15 DOI: 10.1038/s41440-026-02857-5

Tadesse Asmamaw Dejenie, Haider Mannan, Evan Atlantis

{"title":"Incremental value of DXA-derived visceral versus total adiposity beyond routine anthropometric assessment for hypertension discrimination: a population-based study.","authors":"Tadesse Asmamaw Dejenie, Haider Mannan, Evan Atlantis","doi":"10.1038/s41440-026-02857-5","DOIUrl":"https://doi.org/10.1038/s41440-026-02857-5","url":null,"abstract":"Hypertension is strongly linked to obesity, yet it remains uncertain whether DXA-derived measures of adiposity improve hypertension discrimination beyond routine anthropometric assessment and whether any incremental value reflects visceral rather than total adiposity. This study examined whether DXA-derived visceral and total adiposity provide incremental discriminatory value beyond routine anthropometric assessment for hypertension discrimination. We analyzed 7817 adults aged 20-59 years from the 2013 to 2018 National Health and Nutrition Examination Survey with valid DXA measurements. Discriminatory performance and the incremental value of DXA-derived adiposity measures beyond anthropometric assessment were evaluated using receiver operating characteristic curve analysis, model fit, and reclassification metrics. Among routinely available anthropometric measures, waist circumference demonstrated the highest discriminatory performance for hypertension (AUC 0.791, 95% CI: 0.780-0.802). Addition of DXA-derived visceral adiposity significantly improved discrimination (AUC 0.865, ΔAUC = 0.074) and significantly improved model fit beyond waist circumference (P < 0.001), whereas total adiposity measured by fat mass index provided negligible incremental value (ΔAUC = 0.0020) and did not improve model fit. Reclassification metrics yielded consistent findings, and results generally remained robust across sensitivity analyses; however, when hypertension was defined using measured blood pressure alone, the incremental improvement was attenuated (ΔAUC = 0.012 vs. 0.074). Among DXA-derived adiposity measures, only visceral adiposity provided meaningful incremental discriminatory value beyond the best-performing routine anthropometric measure, whereas total adiposity did not. These findings suggest that when DXA-based body composition assessment is performed, the clinically relevant information may be derived from visceral rather than total adiposity.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0