Hypertension Research最新文献_第10页

Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis. 患者护理团队对高血压患者血压控制的影响：系统回顾和荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1038/s41440-025-02152-9

Yuichi Akasaki, Yasunori Suematsu, Kengo Azushima, Yuhei Shiga, Atsushi Sakima, Michihiro Satoh, Hisatomi Arima, Nobuhito Hirawa

{"title":"Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.","authors":"Yuichi Akasaki, Yasunori Suematsu, Kengo Azushima, Yuhei Shiga, Atsushi Sakima, Michihiro Satoh, Hisatomi Arima, Nobuhito Hirawa","doi":"10.1038/s41440-025-02152-9","DOIUrl":"10.1038/s41440-025-02152-9","url":null,"abstract":"Hypertension is a significant risk factor for cardiovascular diseases, with its global prevalence doubling over the past three decades. Despite advancements in antihypertensive therapies, approximately 50% of patients with hypertension fail to achieve their target blood pressure (BP) levels, underscoring the need for innovative care strategies. Patient care teams comprising multidisciplinary healthcare providers have shown promise in improving BP management. This systematic review and meta-analysis were aimed at evaluating the effectiveness of patient care teams involving physicians in hypertension management. To this end, PubMed, Cochrane CENTRAL, and IchuShi-Web were comprehensively searched and 61 randomized controlled trials including 64,857 participants were identified. Compared with usual care, interventions by patient care teams significantly reduced office systolic BP (mean difference: -6.31 mmHg; 95% confidence interval: -7.71 to -4.90) and decreased the risk of uncontrolled BP by 27% (risk ratio: 0.73; 95% confidence interval: 0.68-0.79). Subgroup analyses demonstrated consistent BP reductions across various team leadership roles, such as physicians, nurses, and pharmacists, and across different intervention durations. These findings highlight the effectiveness of team-based BP management in achieving improved BP control, regardless of team composition or the follow-up period. Multidisciplinary care offers a viable approach to addressing the unmet needs of patients with hypertension, potentially improving cardiovascular outcomes. This evidence supports integrating patient care teams into hypertension management, particularly in settings requiring physician oversight. Future research should focus on refining team structures and tailoring interventions to diverse healthcare environments to enhance their impact.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":"1827-1838"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early onset of hypertension and increased relative risks of chronic kidney disease and mortality: two population-based cohort studies in United Kingdom and Hong Kong. 早发性高血压和慢性肾脏疾病和死亡率的相对风险增加：英国和香港的两项基于人群的队列研究

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1038/s41440-025-02188-x

Kiki Sn Liu, Boyuan Wang, Ivy L Mak, Edmond Ph Choi, Cindy Lk Lam, Eric Yf Wan

{"title":"Early onset of hypertension and increased relative risks of chronic kidney disease and mortality: two population-based cohort studies in United Kingdom and Hong Kong.","authors":"Kiki Sn Liu, Boyuan Wang, Ivy L Mak, Edmond Ph Choi, Cindy Lk Lam, Eric Yf Wan","doi":"10.1038/s41440-025-02188-x","DOIUrl":"10.1038/s41440-025-02188-x","url":null,"abstract":"This study aimed to evaluate the association between hypertension (HT) onset age and later risks of chronic kidney diseases (CKD) and mortality. Adult patients without CKD from 2008 to 2013 were identified using electronic medical records from United Kingdom (UK) and Hong Kong (HK). Patients newly diagnosed with HT and those without were included in the HT and control groups, respectively. All subjects were stratified into six age groups (18-39, 40-49, 50-59, 60-69, 70-79, ≥80). Multivariable Cox proportional hazard regression, adjusted with baseline characteristics and fine stratification weights, was conducted to investigate the association between HT onset and risks of CKD, renal decline, end-stage renal disease (ESRD), and all-cause mortality. Subjects were followed up from baseline until an outcome event, death, or administrative end of the cohort, whichever occurred first. A total of 4,413,551 and 3,132,951 subjects were included in the UK and HK cohorts, respectively. HT was significantly associated with increased risks of outcome, but the hazard ratios (HRs) decreased with increasing onset age. In the UK cohort, the HRs (95% confidence intervals) for subjects aged 18-39 and ≥80 were 3.69 (3.53, 3.86) and 2.01 (1.96, 2.06) for CKD, 3.83 (3.60, 4.07) and 3.17 (2.97, 3.38) for renal decline, 17.26 (14.34, 20.77) and 2.55 (2.12, 3.07) for ESRD, 2.88 (2.66, 3.11) and 1.09 (1.07, 1.12) for mortality. The HK cohort exhibited a similar pattern. Our study concluded that early onset of HT significantly affects renal health later in life, while the contribution decreases with the onset age of HT.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":"1963-1971"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats. 基于大鼠转录组学分析的高血压潜在生物标志物鉴定。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1038/s41440-025-02200-4

Wei Gu, Jielin Liu, Ya Liu, Zuoguang Wang

{"title":"Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats.","authors":"Wei Gu, Jielin Liu, Ya Liu, Zuoguang Wang","doi":"10.1038/s41440-025-02200-4","DOIUrl":"10.1038/s41440-025-02200-4","url":null,"abstract":"Hypertension is a complex disorder influenced by genetic predisposition, neural and endocrine dysregulation, cardiovascular and renal dysfunction, and unhealthy lifestyles. It is a major risk factor for many diseases. However, the pathophysiological mechanisms underlying hypertension have not been systematically characterized to date. In this study, we compared physiological and molecular changes between spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY, control strain) models using RNA sequencing. Blood pressure increased significantly in SHR models over 3-15 weeks compared with WKY control rats. Furthermore, indicators of cardiac remodeling and fibrosis were elevated in SHR on echocardiography and immunohistochemical analyses. RNA sequencing findings revealed differentially expressed genes between SHRs and WKYs in each week, which were related to dysregulation of Epstein-Barr virus infection, fluid shear stress and atherosclerosis, RNA degradation, and endocrine resistance. Transcriptome analysis showed that differentially expressed genes related to hypertension were involved in the hypoxia inducible factor-1 (HIF-1) and interleukin-17 (IL-17) signaling pathways. Furthermore, Gene Ontology (GO) functional analysis showed that differentially expressed genes were mainly associated with catalytic activity and protein binding. The Venn diagram analysis identified KCNE1, Lad1, SLC9A3, and Frzb as potential targets of hypertension. In addition, the expression of these four genes exhibited excellent sensitivity and specificity, suggesting their potential diagnostic utility in hypertension. These findings support a theoretical basis for understanding hypertension and related heart remodeling.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":"1939-1950"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-year nighttime blood pressure changes after radiofrequency renal denervation: pooled results from the SPYRAL HTN trials. 射频肾去神经后2年夜间血压变化：来自SPYRAL HTN试验的汇总结果。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1038/s41440-025-02186-z

Kazuomi Kario, David E Kandzari, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Minglei Liu, Michael Böhm, Raymond R Townsend

{"title":"Two-year nighttime blood pressure changes after radiofrequency renal denervation: pooled results from the SPYRAL HTN trials.","authors":"Kazuomi Kario, David E Kandzari, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Minglei Liu, Michael Böhm, Raymond R Townsend","doi":"10.1038/s41440-025-02186-z","DOIUrl":"10.1038/s41440-025-02186-z","url":null,"abstract":"Elevated nighttime blood pressure (BP) and abnormal circadian dipping patterns are associated with advanced age and coexisting illnesses and are attributed to autonomic dysfunction. Radiofrequency renal denervation (RF RDN) effectively lowers BP throughout 24 h and thus may provide an effective antihypertensive therapeutic option. This analysis assesses the effects of RDN on nocturnal hypertension with different dipper patterns defined by nighttime/daytime BP ratio (i.e. dippers, non-dippers, risers) through 2 years in patients randomized to RDN from the SPYRAL HTN-OFF MED and -ON MED trials. Office and 24-h ambulatory BP, were also evaluated in patients stratified by age, obstructive sleep apnea (OSA), type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Among 388 patients, the baseline nighttime systolic BP (SBP) was 139.3 ± 11.3 mmHg. Patients with a riser pattern had the highest baseline nighttime SBP (152.7 ± 8.0 mmHg). At 2 years, patients experienced a significant reduction from baseline (p < 0.0001) in nighttime (-12.0 ± 17.1 mmHg), morning (-14.8 ± 20.0 mmHg), daytime (-13.8 ± 14.7 mmHg), and 24-h SBP (-13.4 ± 14.2 mmHg). The greatest reduction in SBP was in risers at nighttime (-23.7 ± 14.3 mmHg). RDN was equally effective in lowering nighttime BP in patients ≥65 years old or with OSA, CKD, or T2DM. In this pooled dataset of RF RDN patients, clinically meaningful reductions in BP over a 24-h period were observed through 2 years irrespective of dipping status. RF RDN may reduce the risk of cardiovascular outcomes in patients with uncontrolled hypertension, especially in those with elevated nighttime BP who may be the most challenging to treat.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":"1951-1962"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural damage and lower myelin content in the Brainstem associated with hypertension. 脑干微结构损伤和髓磷脂含量降低与高血压有关。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1038/s41440-025-02184-1

Joji Ishikawa

引用次数: 0

Blood pressure at hospital admission: a window into the prognoses of patients with atrial fibrillation. 入院时的血压：心房颤动患者预后的窗口。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1038/s41440-025-02196-x

Takahiro Okumura, Satoshi Yanagisawa, Toyoaki Murohara

引用次数: 0

Post-dialysis blood pressure: inaccuracy or lack of standardization? 透析后血压：不准确还是缺乏标准化？

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1038/s41440-025-02206-y

Rodrigo Bezerra, Fernanda S Gorayeb-Polacchini, Flavio Teles, Luís Cláudio S Pinto, Wilson Nadruz

引用次数: 0

Combination of medical therapy and percutaneous transluminal renal angioplasty versus medical therapy alone for patients with atherosclerotic renal artery stenosis: systematic review and meta-analysis. 药物治疗联合经皮腔内肾血管成形术对动脉粥样硬化性肾动脉狭窄患者的治疗效果：系统评价和荟萃分析

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-04 DOI: 10.1038/s41440-025-02166-3

Takeshi Fujiwara, Yoshio Iwashima, Keisuke Narita, Michihiro Satoh, Atsushi Sakima

{"title":"Combination of medical therapy and percutaneous transluminal renal angioplasty versus medical therapy alone for patients with atherosclerotic renal artery stenosis: systematic review and meta-analysis.","authors":"Takeshi Fujiwara, Yoshio Iwashima, Keisuke Narita, Michihiro Satoh, Atsushi Sakima","doi":"10.1038/s41440-025-02166-3","DOIUrl":"10.1038/s41440-025-02166-3","url":null,"abstract":"We investigated whether the combination of medical therapy plus percutaneous transluminal renal angioplasty (PTRA) provides superior clinical outcomes compared to those afforded by medical therapy alone in patients with hypertension due to atherosclerotic renal artery stenosis (ARAS) by conducting a systematic review and meta-analysis of the relevant randomized controlled trials (RCTs). The evaluated outcomes included: (1) cardiovascular disease (CVD)-related mortality, (2) the incidence of CVD events, (3) changes in blood pressure (BP), (4) suppression of renal function decline, (5) changes in the number of antihypertensive drugs used, and (6) serious adverse events. Nine RCTs involving 2275 patients were analyzed, revealing that the combination therapy significantly reduced the number of antihypertensive drugs compared to medical therapy alone (mean difference: -0.42, 95% confidence interval: -0.71 to -0.12). However, there were no significant differences between the combination therapy and medical therapy alone in CVD mortality, the incidence of CVD events, BP changes, suppression of renal function decline, or serious adverse events. The included studies demonstrated a low-to-moderate risk of bias, with performance and detection bias being the most prominent concerns. Together our findings demonstrate that compared to medical therapy alone, the combination of medical therapy + PTRA reduced the number of antihypertensive drugs used but did not improve adverse CVD or renal outcomes. The quality of the included RCTs represents a potential limitation of this analysis.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":"1870-1879"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The voices of elementary school students can change the rate of hypertension control in the community! ~One Healthy Wall Newspaper Moved Us~. 小学生的声音可以改变社区高血压控制率！~一份健康墙报感动了我们~

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.1038/s41440-025-02190-3

Tetsuro Yoshida

引用次数: 0

Is lenvatinib-induced blood pressure elevation a favorable prognostic factor in patients with hepatocellular carcinoma? lenvatinib诱导的血压升高是肝细胞癌患者预后的有利因素吗？

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1038/s41440-025-02197-w

Satoshi Kidoguchi

引用次数: 0