Hypertension Research最新文献_第10页

Impact of inter-twin growth discordance on preeclampsia: based on ultrasonic estimated fetal weight. 双胞胎间生长不一致对子痫前期的影响：基于超声估计胎儿体重。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-04 DOI: 10.1038/s41440-024-02027-5

Lan Chen, Zhijuan Cao, Ping Qiao, Xiaohua Liu, Hao Ying

{"title":"Impact of inter-twin growth discordance on preeclampsia: based on ultrasonic estimated fetal weight.","authors":"Lan Chen, Zhijuan Cao, Ping Qiao, Xiaohua Liu, Hao Ying","doi":"10.1038/s41440-024-02027-5","DOIUrl":"10.1038/s41440-024-02027-5","url":null,"abstract":"A retrospective cohort study with 4396 twins who registered before 13 gestational weeks and delivered between January 2013 and December 2020 at Shanghai First Maternity and Infant Hospital, China, was conducted to clarify causal associations between inter-twin estimated fetal weight discordance and preeclampsia. Ultrasound measurements of fetal biometry were collected until the confirmation of preeclampsia diagnosis or the termination of pregnancy (when preeclampsia did not occur). Inter-twin discordance was divided into binary variables using cut-offs of 10%, 15%, and 20%. The associations between inter-twin discordance and preeclampsia were analyzed using generalized estimating equations and group-based trajectory modeling methods. The incidence of preeclampsia was 13.9%, among which 21.8% of cases were diagnosed at early onset and 55.3% at a severe stage. Inter-twin discordance based on estimated fetal weight during pregnancy was positively associated with preeclampsia. The associations were robust and constant by treating the discordance as continuous and binary. Two groups, the stable trajectory group, including 92% of participants, and the changing trajectory group, including 8% of participants, were divided according to the group-based trajectory models. Compared with the stable trajectory group, the risk of developing preeclampsia in the changing trajectory group increased by 50.3% (OR = 1.502, 95%CI: 1.073, 2.105). Subgroup analysis showed positive association primarily in early-onset preeclampsia (OR: 3.859, CI: 2.293, 6.494) and severe preeclampsia (OR: 1.896, CI: 1.264, 2.844) subgroups. These findings can provide a direction to reduce the incidence of preeclampsia in twin pregnancies, considering growth discordance as a high-risk factor in clinical practice.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New possibilities for protective arms by changing the structure of angiotensin (1-9). 通过改变血管紧张素的结构为保护臂提供新的可能性（1-9）。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-03 DOI: 10.1038/s41440-024-02035-5

Masaki Mogi

引用次数: 0

Current updates and future perspectives in uric acid research, 2024. 尿酸研究的最新进展和未来展望，2024。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-03 DOI: 10.1038/s41440-024-02031-9

Masanari Kuwabara, Ryusuke Ae, Koki Kosami, Mehmet Kanbay, Ana Andres-Hernando, Ichiro Hisatome, Miguel A Lanaspa

{"title":"Current updates and future perspectives in uric acid research, 2024.","authors":"Masanari Kuwabara, Ryusuke Ae, Koki Kosami, Mehmet Kanbay, Ana Andres-Hernando, Ichiro Hisatome, Miguel A Lanaspa","doi":"10.1038/s41440-024-02031-9","DOIUrl":"10.1038/s41440-024-02031-9","url":null,"abstract":"Uric acid, the final product of purine metabolism, plays a significant role in hypertension Research on uric acid has advanced significantly, particularly regarding its links to hypertension and cardiovascular disease (CVD). Our 2023 review covered the relationship between uric acid, hypertension; and CVD, however, numerous new studies have emerged since then. This paper provides an update, summarizing recent findings over the past two years on hyperuricemia and its association with hypertension, preeclampsia, arteriosclerosis, kidney disease, sleep-disordered breathing, CVD, and so on. Hyperuricemia, often driven by reduced uric acid excretion or increased production, is influenced by genetic factors and lifestyle habits, including high-purine foods, alcohol, and fructose intake. While hyperuricemia has been proposed to contribute to hypertension and CVD through mechanisms like inflammasome activation and oxidative stress, its causal role remains debated. Further clinical and basic science studies on hyperuricemia and purine metabolism are necessary to clarify its impact on CVD and guide therapeutic approaches.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining body mass index and muscle function in investigating mortality among older hypertensive patients. 结合体重指数和肌肉功能调查老年高血压患者的死亡率。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-03 DOI: 10.1038/s41440-024-02032-8

Ayumi Toba

引用次数: 0

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-02 DOI: 10.1038/s41440-024-01999-8

Nobuyuki Miyai, Yan Zhang, Nao Nagatomo, Azuna Kinoshita, Yukiko Sougawa, Miyoko Utsumi, Mikio Arita

{"title":"Age- and sex-related reference values for central blood pressure parameters in middle-aged and older Japanese adults: the Wakayama study.","authors":"Nobuyuki Miyai, Yan Zhang, Nao Nagatomo, Azuna Kinoshita, Yukiko Sougawa, Miyoko Utsumi, Mikio Arita","doi":"10.1038/s41440-024-01999-8","DOIUrl":"https://doi.org/10.1038/s41440-024-01999-8","url":null,"abstract":"Central blood pressure (BP) is more strongly associated with cardiovascular events than brachial BP. Few studies have described age-related changes in central BP in the general Japanese population. This study aimed to provide reference values for central BP parameters according to the age and sex, using data from 2964 participants aged 40-89 years (mean age: 60 years) who had no history of overt cardiovascular or chronic kidney disease and had not received antihypertensive, lipid-lowering, or hypoglycemic treatments. The central aortic pressure waveform was measured noninvasively by pulse wave analysis using the SphygmoCor XCEL operating system. Central systolic BP (cSBP), pulse pressure (cPP), and augmentation pressure (AP) exhibited a curvilinear relationship with age, with men having significantly higher cSBP but lower cPP and AP than women (cSBP: 132 mmHg vs. 123 mmHg, P < 0.001; cPP, 50 mmHg vs. 55 mmHg, P = 0.001; and AP: 24 mmHg vs. 32 mmHg, P = 0.002). Reference percentiles for cSBP, cPP, and AP were determined for each 5-year age group using the LMS method. Multiple regression analyses showed that age-standardized z-scores for cSBP, cPP, and AP were significantly associated with hypertension, dyslipidemia, diabetes mellitus, abdominal obesity, and heavy smoking, after adjusting for potential confounders. In conclusion, this study provides age- and sex-specific percentiles of central BP parameters in middle-aged and older Japanese adults. These reference values allow a more accurate interpretation of results and may be useful for diagnosis and management of hypertension in clinical practice and for risk stratification in population studies.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond blood pressure target goals: treatment responsiveness as a key prognostic factor in hypertensive patients with coronary artery disease. 超越血压目标：治疗反应性是高血压合并冠心病患者的关键预后因素

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-02 DOI: 10.1038/s41440-024-02034-6

Akiyoshi Ogimoto

引用次数: 0

Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism. 矿化皮质激素受体拮抗剂、醛固酮合成酶抑制剂的进化，以及原发性醛固酮增多症的替代治疗方法。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-11-29 DOI: 10.1038/s41440-024-01970-7

Yuichi Yoshida, Hirotaka Shibata

{"title":"Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism.","authors":"Yuichi Yoshida, Hirotaka Shibata","doi":"10.1038/s41440-024-01970-7","DOIUrl":"https://doi.org/10.1038/s41440-024-01970-7","url":null,"abstract":"Primary aldosteronism (PA) is a prevalent and curable secondary hypertensive disorder that accounts for 5-13% of all hypertension cases. The prevalence of resistant hypertension, cerebral and cardiovascular diseases, and renal complications is higher in PA patients than in those with essential hypertension. Appropriate diagnosis and treatment at an early stage may suppress cerebral and cardiovascular events. Lifestyle modifications recommended for essential hypertensive patients, including dietary salt restriction and appropriate calorie intake to avoid fat accumulation, play a crucial role in suppressing overactivation of the mineralocorticoid receptor (MR), which helps to control blood pressure and prevent end-organ damage. Esaxerenone is a safe mineralocorticoid receptor antagonist (MRA) with strong antihypertensive and anti-albuminuric effects. Aldosterone synthase inhibitors (ASIs) have been developed, which are antihypertensive agents with a new mechanism of action. The pharmacological mechanisms of MRAs and ASIs differ; MRAs block MR activity by preventing aldosterone and/or cortisol from binding to the MR, while ASIs block aldosterone secretion from the adrenal gland. Other new treatments, such as robot-assisted laparoscopic adrenalectomy, percutaneous computed tomography radiofrequency ablation, transvenous radiofrequency catheter ablation, and super-selective adrenal arterial embolization have been developed. Further research will lead to better treatments for PA patients and reduce the frequency of cerebral and cardiovascular events.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive disorders of pregnancy: impact on future blood pressure and cardiovascular disease. 妊娠期高血压疾病：对未来血压和心血管疾病的影响

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-11-29 DOI: 10.1038/s41440-024-02010-0

Yasuaki Dohi

引用次数: 0

Advanced maternal age elevates the prevalence of hypertensive disorders in women of Japanese, independent of blood pressure: a study from the Japan Environment and Children's study. 来自日本环境与儿童研究的一项研究表明，高龄产妇增加了日本女性高血压疾病的患病率，与血压无关。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-11-29 DOI: 10.1038/s41440-024-02019-5

Hiroyuki Uchinuma, Kyoichiro Tsuchiya, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Zentaro Yamagata

{"title":"Advanced maternal age elevates the prevalence of hypertensive disorders in women of Japanese, independent of blood pressure: a study from the Japan Environment and Children's study.","authors":"Hiroyuki Uchinuma, Kyoichiro Tsuchiya, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Zentaro Yamagata","doi":"10.1038/s41440-024-02019-5","DOIUrl":"https://doi.org/10.1038/s41440-024-02019-5","url":null,"abstract":"Hypertensive disorders of pregnancy (HDP) are leading causes of maternal and infant mortality, and maternal age is a known factor influencing maternal and pediatric outcomes during childbirth. This study aimed to clarify the impact of maternal age-specific blood pressure (BP) and its patterns on the risk of HDP using data from a large nationwide study in Japan. This cohort study (N = 100,949) used data from the Japan Environment and Children's Study. The outcome variables in this study were HDP at each trimester of pregnancy. We stratified the participants into groups according to their age. The risk of HDP tended to be higher in women aged ≥35 years than in those aged <35 years, even at the same BP level. The BP patterns in the first and second trimesters of pregnancy showed a significantly increased risk of developing HDP at a higher BP in the first trimester, even when the BP in the second trimester was the same. The risk of HDP was equivalent in women aged <35 years and those aged≥ 35 years with an approximately 10 mmHg lower BP. In contrast, in women aged ≥35 years, a low diastolic BP in early pregnancy and pulse pressure (PP) > 60 mmHg significantly increased the risk of HDP. This large national cohort study indicates that the risk of HDP is associated with maternal age and PP in Japan. Early diagnosis of HDP can be achieved by focusing on the BP in the first trimester of pregnancy and PP.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of echocardiographic findings in patients with aldosterone-producing adenomas: adrenalectomy versus mineralocorticoid receptor antagonists. 醛固酮产生性腺瘤患者超声心动图表现的比较：肾上腺切除术与矿皮质激素受体拮抗剂。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-11-28 DOI: 10.1038/s41440-024-02008-8

Tatsuya Haze

引用次数: 0