Hypertension Research最新文献

{"title":"Human plasma metabolomics reveals metabolic targets for intervention in salt-sensitive hypertension","authors":"Pengfei Yang, Xiangbo Chen, Mingxiao Liu, Xian Li, Yang Wang, Jianjun Mu, Yanan Ouyang, Tailin Wu, Zhe Yang, Di Gao, Zhongmin Tian","doi":"10.1038/s41440-025-02280-2","DOIUrl":"10.1038/s41440-025-02280-2","url":null,"abstract":"Salt-sensitive hypertension (SSH) is a major risk factor for cardiovascular disease, but its metabolic mechanisms remain unclear. This study investigates the plasma metabolic profile of SSH patients to identify potential therapeutic targets. Additionally, SSH patients were identified through an oral salt-loading test. Plasma metabolomics was performed by utilizing GC-MS and LC-MS, followed by network correlation analysis, pathway enrichment, receiver operating characteristic analysis, and linear regression analysis. The findings were validated in Dahl salt-sensitive (SS) rats, with glycine supplementation evaluated as a potential therapeutic intervention. Firstly, plasma metabolomics illustrated distinct metabolic alterations in SSH patients, with substantially increased levels of fumaric acid, pyruvat,e and lactic acid, as well as significantly decreased levels of glycine, leucine and β-alanine (p < 0.05). Additionally, Glycine and β-alanine levels decreased by 61% and 68% compared to the control group. Secondly, pathway enrichment analysis identified disruptions in amino acid metabolism, particularly Arginine biosynthesis pathway, TCA pathway, glycine, serine, and threonine metabolism pathways were significantly enriched (p < 0.05). Correlation network analysis identified fumarate as a hub metabolite in the pathophysiology of SSH. Glycine showed the highest predictive value for SSH (AUC = 94.6181%) and was negatively correlated with blood pressure. Finally, glycine supplementation in SS rats substantially reduced salt-induced hypertension (p < 0.001) by improving renal amino acid metabolism and enhancing nitric oxide production. This study identifies glycine as a crucial metabolic target for SSH intervention. Glycine supplementation effectively alleviates SSH in animal models, indicating its potential for clinical applications. Future research should focus on exploring glycine-based therapies in clinical trials. These authors contributed equally:","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2567-2583"},"PeriodicalIF":4.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"South Korea vs. Japan: participation in the 10th Annual Meeting of the Korean Society of Clinical Hypertension","authors":"Einosuke Mizuta, Yuusaku Sugihara, Tsuguru Hatta","doi":"10.1038/s41440-025-02300-1","DOIUrl":"10.1038/s41440-025-02300-1","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2753-2754"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronizing science and society: JSH2025 Guidelines × “Asakatsu BP” action – Morning Blood Pressure 130 Campaign","authors":"Kazuomi Kario, Yusuke Ohya","doi":"10.1038/s41440-025-02295-9","DOIUrl":"10.1038/s41440-025-02295-9","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2512-2514"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02295-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary sodium-to-potassium ratio as a marker for apparent treatment-resistant hypertension in patients with chronic kidney disease","authors":"Yutaka Kakizoe","doi":"10.1038/s41440-025-02303-y","DOIUrl":"10.1038/s41440-025-02303-y","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2725-2726"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02303-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From binary to gradient: EUS-RFA redefines primary aldosteronism therapy","authors":"Zhixin Xu, Jing Chang","doi":"10.1038/s41440-025-02288-8","DOIUrl":"10.1038/s41440-025-02288-8","url":null,"abstract":"EUS-RFA redefines PA treatment, shifting from a binary (surgery or drugs) to a gradient paradigm (ablation, drugs, surgery). Outcomes: EUS-RFA (FABULAS, Argentesi et al., The Lancet 2025): 75% biochemical remission, 43% clinical remission; medical treatment (PAMO criteria[9]): 52.9% biochemical response, 18.3% clinical response; surgery (PASO criteria[8]): 94% biochemical remission, 84% clinical remission.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2763-2765"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure","authors":"Kaori Kitaoka, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Atsushi Mizuno, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Tatsuhiko Azegami, Kaori Hayashi, Koichi Node, Yuji Furui, Katsuyuki Miura, Hideo Yasunaga, Norihiko Takeda","doi":"10.1038/s41440-025-02284-y","DOIUrl":"10.1038/s41440-025-02284-y","url":null,"abstract":"Hypertension is a major risk factor for cardiovascular diseases. This study aimed to clarify blood pressure (BP) management after the health check-up among individuals with grade II or severer hypertension, defined as systolic BP (SBP) ≥ 160 mmHg or diastolic BP (DBP) ≥ 100 mmHg in Japan. This retrospective study used the JMDC Claims Database (2005–2022) in Japan, including 63,785 individuals (median age 50 years; men 75.3%) with BP above grade II hypertension thresholds during the health check-up. We evaluated the BP control and treatment status at 1 year after the first check-up. Poisson regression with robust error variance analyses were performed to assess the association with grade II or severer hypertension at 1 year after the first check-up. Notably, 45.4% continued to have grade II or severer hypertension at 1 year after the first check-up. Among the individuals, 54.5% visited a medical institution within 3 months after undergoing a health check-up, only 23.6% were prescribed antihypertensive medications at 1 year after the first check-up. Factors associated with sustained grade II or severer hypertension included per 5 years lower in age (relative risk [RR]: 1.01, 95% confidence interval [CI]: 1.01–1.02), obesity (RR: 1.04, 95% CI: 1.02–1.06), and skipping breakfast ≥3 times per week (RR: 1.06, 95% CI: 1.04–1.08). Despite strong recommendations for medical consultation, BP control remains inadequate among individuals with grade II or severer hypertension, nearly half of individuals had SBP ≥ 160 mmHg or DBP ≥ 100 mmHg at 1 year after the first check-up in our study. The findings highlight the need for prompt follow-up, particularly among younger adults and those with unhealthy lifestyles.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2537-2547"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02284-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JSH2025 guidelines new viewpoints","authors":"Yusuke Ohya, Atsushi Sakima","doi":"10.1038/s41440-025-02296-8","DOIUrl":"10.1038/s41440-025-02296-8","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2497-2499"},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02296-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partner’s dual use of new tobacco products and combustible cigarettes in early pregnancy was associated with hypertensive disorders of pregnancy: a cross-sectional study","authors":"Miki Akiyama, Takehiro Michikawa, Yuki Takeda, Keiko Asakura, Haruhiko Imamura, Minami Sugimoto, Yuji Nishiwaki","doi":"10.1038/s41440-025-02275-z","DOIUrl":"10.1038/s41440-025-02275-z","url":null,"abstract":"It is an urgent issue to clarify whether new tobacco products have adverse pregnancy effects. As far as we know, however, there is no study of the association between passive smoking by new tobacco products and pregnancy complications, including hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM). We explored the association between partner’s smoking at home during early pregnancy as an indicator of passive smoking and pregnancy complications. Participants were recruited from 16 obstetric clinics and hospitals within seven Japanese regions from December 2019 to March 2023 and answered a self-administered questionnaire. Among them, we conducted a cross-sectional analysis of 1354 postpartum women who did not smoke during early pregnancy. We categorized the participants into four groups based on their partner’s smoking status: dual users (combustible cigarettes and new tobacco products), new tobacco product-only users, combustible cigarette-only users, and non-smokers at home (reference). We performed Firth’s penalized logistic regression analysis and estimated the odds ratio (OR) of HDP and GDM diagnosis. The majority of partners were non-smokers (85.4%), followed by new tobacco product-only users (7.2%), dual users (4.4%), and combustible cigarette-only users (2.9%). The prevalence of HDP and GDM was 3.2% and 6.3%, respectively. For women whose partners were dual users, the multivariable-adjusted OR of HDP was 4.54 (95% confidence interval, 1.60–12.82). There was no association between partner’s smoking status and GDM. We found an association between the partner’s dual use of new tobacco products and combustible cigarettes in early pregnancy and HDP.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2558-2566"},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02275-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry","authors":"Aika Hagiwara, Shintaro Yamaguchi, Kazutoshi Miyashita, Kenichiro Kinouchi, Kaori Hayashi, Hiroshi Itoh","doi":"10.1038/s41440-025-02287-9","DOIUrl":"10.1038/s41440-025-02287-9","url":null,"abstract":"Sodium-glucose co-transporter 2 (SGLT2) inhibitors promote weight loss in patients with type 2 diabetes mellitus; however, the underlying mechanisms remain unknown. This study investigated the role of renal autonomic nerves in SGLT2 inhibitor-induced lipolysis and body weight reduction by utilizing the renal denervation technique. The results indicated that renal autonomic nerves mediated lipolysis in mice fed a high-fat diet following treatment with tofogliflozin, an SGLT2 inhibitor. The effect was attenuated by renal denervation or β3-adrenergic blockade. Metabolomic analysis revealed that treatment with tofogliflozin elevated renal adenosine, which in turn activated adipose sympathetic nerves, as evidenced by increased norepinephrine concentrations in adipose tissue, thereby promoting lipolysis. These findings uncover a novel reno-adipose neurocircuitry linking renal energy depletion to systemic fatty acid oxidation, providing insights into the sustained weight-reducing effects of SGLT2 inhibitors. A scheme illustrating SGLT2 inhibitor-induced activation of reno-adipose autonomic neurocircuitry, which promotes lipolysis and weight reduction.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2664-2676"},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis. Author’s response to comments from Cui, Ruixin (2025)","authors":"Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara","doi":"10.1038/s41440-025-02294-w","DOIUrl":"10.1038/s41440-025-02294-w","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 9","pages":"2473-2474"},"PeriodicalIF":4.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02294-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}