Hypertension Research最新文献

{"title":"Blood pressure management for stroke patients beyond the JSH 2025 guidelines.","authors":"Kazunori Toyoda","doi":"10.1038/s41440-026-02765-8","DOIUrl":"https://doi.org/10.1038/s41440-026-02765-8","url":null,"abstract":"<p><p>As scientific evidence on blood pressure reduction in patients with chronic stroke accumulates year by year, target blood pressure levels recommended in guidelines, both in Japan and internationally, have tended to become lower. In addition, with respect to antihypertensive strategies, the Japanese Society of Hypertension Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025 (JSH2025) assign a higher level of recommendation to the angiotensin receptor-neprilysin inhibitor and mineralocorticoid receptor antagonist, in addition to the conventional first-line major drugs. In patients with resistant hypertension, renal denervation can be clinically used in Japan from 2026. However, the effect of stroke prevention in these newer drugs or renal denervation remains unclear and should be further elucidated. Recommendations for blood pressure management in acute-phase stroke, particularly ischemic stroke without receiving reperfusion therapy, remain unsettled, despite the fact that the validity of relatively strict blood pressure targets has been examined in multiple clinical trials to date. Target blood pressure for stroke patients and stepwise approach to blood pressure-lowering treatment.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieved home systolic blood pressure and cardiovascular risk in older hypertensive patients.","authors":"Yufei Ji, Xinyi Peng, Jingjing Bai, Qirui Song, Jun Cai","doi":"10.1038/s41440-026-02787-2","DOIUrl":"https://doi.org/10.1038/s41440-026-02787-2","url":null,"abstract":"<p><p>Intensive blood pressure treatment reduces cardiovascular events, but the optimal achieved home systolic blood pressure (SBP) level for older patients with hypertension remains uncertain. This secondary analysis was based on data from the Strategy of Blood Pressure Intervention in Older Hypertensive Patients trial. Morning and evening home blood pressure measurements obtained between 3 and 12 months after enrollment were used to calculate the achieved home SBP. Participants were then categorized into four achieved home SBP groups: <125 mmHg, 125-130 mmHg, 130-135 mmHg, and ≥135 mmHg. The primary outcome was a composite of cardiovascular events. Among 7681 participants included in this analysis, 261 primary events occurred during the median follow-up of 3.43 years. Compared with home SBP ≥ 135 mmHg, the absolute risk reduction for the primary composite outcome was 1.70% in the <125 mmHg group, 1.36% in the 125-130 mmHg group. In multivariable analyses, home SBP < 125 mmHg and 125-130 mmHg were associated with lower risks of the primary composite outcome, with adjusted HRs of 0.62 (95% CI, 0.42-0.90) and 0.66 (95% CI, 0.47-0.94), respectively. Similar protective associations were observed for stroke (adjusted HR, 0.36; 95% CI, 0.19-0.66). Lower home SBP categories were not associated with a statistically significant increase in the primary safety outcome. These findings suggest that achieving home SBP below 130 mmHg, and further approaching 125 mmHg in selected patients with a high risk of stroke and good treatment tolerance, may provide additional cardiovascular benefit beyond the conventional threshold.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between high-altitude erythrocytosis and arterial stiffness in long-term high-altitude residents.","authors":"Yanan Li, Jun Ma, Xin Zhang, Dengdeng Lawang, Qianjin Wang, Xiaoping Chen","doi":"10.1038/s41440-026-02785-4","DOIUrl":"https://doi.org/10.1038/s41440-026-02785-4","url":null,"abstract":"<p><p>High-altitude erythrocytosis (HAE) may have vascular implications, but its association with arterial stiffness in long-term high-altitude residents remains unclear. We conducted a cross-sectional study of adults from Chengdu and high-altitude areas of Sichuan Province between January 2024 and February 2026. After excluding participants with ankle-brachial index <0.90 or atrial fibrillation, 3346 participants were included (2271 low-altitude and 1075 high-altitude residents). Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV); the primary outcome was mean baPWV, and the clinical outcome was mean baPWV ≥1800 cm/s. High-altitude residents had higher mean baPWV than low-altitude residents (1576.1 ± 403.1 vs 1474.4 ± 309.4 cm/s), with a higher prevalence of mean baPWV ≥1800 cm/s (23.8% vs 14.8%). Among high-altitude residents, 114 had HAE and 961 did not. Participants with HAE had higher mean baPWV (1969.4 ± 563.0 vs 1529.5 ± 352.0 cm/s). After adjustment for age, sex, body mass index, systolic blood pressure, heart rate, smoking, alcohol drinking, diabetes, lipid parameters and estimated glomerular filtration rate, HAE remained associated with higher mean baPWV (β, 297.5 cm/s; 95% CI, 219.6-375.5; P < 0.001) and higher odds of mean baPWV ≥1800 cm/s (OR, 3.30; 95% CI, 1.98-5.48; P < 0.001). Hemoglobin-category, continuous hemoglobin, and restricted cubic spline analyses supported a positive, nonlinear hemoglobin-baPWV association. HAE was associated with greater baPWV burden among long-term high-altitude residents, but causality cannot be inferred.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148827687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional blood-pressure-lowering effect of exercise in adults on stable antihypertensive medication: a systematic review and meta-analysis of randomised controlled trials.","authors":"Paula Etayo-Urtasun, Mikel L Sáez de Asteasu, Mikel Izquierdo","doi":"10.1038/s41440-026-02784-5","DOIUrl":"https://doi.org/10.1038/s41440-026-02784-5","url":null,"abstract":"<p><p>Physical exercise and antihypertensive medications are routinely co-prescribed for treating hypertension. Contemporary international guidelines separately establish the expected effects of pharmacological and exercise interventions. However, meta-analytical evidence assessing the additional effect of exercise on antihypertensive medication is lacking. We conducted a systematic review and meta-analysis of randomised controlled trials evaluating the effects of exercise interventions in adults receiving stable antihypertensive medication. The outcomes included blood pressure parameters, body composition, lipid profiles, glycaemic markers, and cardiorespiratory fitness. Mean differences (MDs) with 95% CIs were pooled using random-effects models, and the risk of bias of the studies was assessed using the RoB2 tool. This systematic review with meta-analysis was registered in PROSPERO (CRD420261277175). Forty-eight studies (2085 participants across 57 publications) fulfilled the inclusion criteria. Compared with usual care on a background of stable medication, exercise reduced office SBP (MD -7.9 mmHg; 95% CI -10.3 to -5.6; I² = 78%) and office DBP (-4.4; -5.8 to -3.1; I² = 64%). The magnitude of these reductions is comparable to that expected from adding a further antihypertensive agent, although the certainty of evidence was low and the prediction intervals were wide. Beyond these effects, significant improvements were observed across multiple outcomes, including office mean blood pressure (MAP), 24 h ambulatory DBP, daytime DBP, nighttime ambulatory blood pressure, body weight, BMI, HDL-c, triglycerides, fasting glucose, and cardiorespiratory fitness. In contrast, no significant between-group differences were observed for changes in 24 h ambulatory SBP, daytime SBP, 24 h MAP, daytime MAP, body fat percentage, waist circumference, total cholesterol, LDL-c, and HbA1c levels. Evidence quality ranged from low to very low for ambulatory SBP, whereas it was moderate for diastolic and nocturnal measurements. No exercise modality (aerobic, resistance, combined, high-intensity interval, or isometric training) was significantly superior to another for any outcome. Adding structured exercise to stable antihypertensive therapy was associated with further reductions in office blood pressure and several ambulatory blood-pressure indices, and with improvements in cardiovascular risk factors; however, given the heterogeneity and risk of bias, the certainty was low to moderate for most estimates, and trials testing exercise-guided medication adjustment are warranted.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness and safety of oral antihypertensive agents for severe asymptomatic hypertension: A systematic review and network meta-analysis of randomized controlled trials.","authors":"Wachira Wongtanasarasin, Thanat Tangpaisarn, Karan Srisurapanont, Praew Kotruchin","doi":"10.1038/s41440-026-02783-6","DOIUrl":"https://doi.org/10.1038/s41440-026-02783-6","url":null,"abstract":"<p><p>Severe asymptomatic hypertension is a common presentation in acute care, yet the optimal choice of oral antihypertensive therapy remains uncertain due to limited comparative evidence. We performed a systematic review and network meta-analysis of randomized controlled trials evaluating oral antihypertensive agents in adults with severe asymptomatic hypertension. Electronic databases (PubMed, Embase, CENTRAL, and CINAHL) were searched from inception to December 2025. The primary outcome was short-term treatment success, defined as a clinically meaningful reduction in blood pressure within 4 h. Random-effects models were used to estimate risk ratios (RRs) with 95% confidence intervals (CIs), and treatments were ranked using P-scores. Certainty of evidence was assessed using the GRADE approach. Five trials were included. All pharmacologic treatments reduced blood pressure in the short term. Compared with the remaining interventions, beta blockers (RR 1.07, 95% CI 0.59-1.92), calcium channel blockers (RR 1.02, 95% CI 0.59-1.78), and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (RR 1.01, 95% CI 0.64-1.58) were associated with a higher likelihood of treatment success at 120-240 min, although these were not statistically significant. Both direct and indirect comparisons showed no significant differences among treatments. Ranking analyses suggested beta-blockers had the highest probability of effectiveness (P-score 0.63), but with substantial uncertainty. Adverse events were infrequently reported and generally mild. Overall certainty of evidence was very low. Oral antihypertensive agents lower blood pressure in the short term, but no single class demonstrates clear superiority, underscoring the need for individualized management and larger, high-quality comparative trials.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to the letter to the editor entitled \"Reflections on \"Predictive value of high-density lipoprotein cholesterol and the cardio-ankle vascular index on cardiovascular outcomes in subjects with cardiovascular risks: the COUPLING study\"\".","authors":"Tomoyuki Kabutoya, Kazuomi Kario","doi":"10.1038/s41440-026-02780-9","DOIUrl":"https://doi.org/10.1038/s41440-026-02780-9","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ankle-brachial index and brachial-ankle pulse wave velocity as markers of severe aortic regurgitation: a hospital-based cohort study.","authors":"Ran Sumida, Yuko Kato, Shinya Suzuki, Naomi Hirota, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Junji Yajima, Takeshi Yamashita, Yasuo Okumura, Tokuhisa Uejima, Yuji Oikawa","doi":"10.1038/s41440-026-02743-0","DOIUrl":"https://doi.org/10.1038/s41440-026-02743-0","url":null,"abstract":"<p><p>Severe aortic regurgitation (AR) causes characteristic peripheral hemodynamic changes. This study aimed to evaluate the association between vascular parameters and AR severity and determine whether ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) reflect these changes and can serve as markers for identifying severe AR. We retrospectively analyzed 6769 patients undergoing echocardiography and vascular function testing, excluding patients with peripheral artery disease, dialysis, atrial fibrillation, or moderate or severe non-AR valvular disease. Participants were stratified by AR grade (0-4). Associations were examined using multivariable logistic regression. Receiver operating characteristic (ROC) curve analysis was performed for ABI and baPWV, and an optimal cutoff-based four-group classification was constructed. ABI remained stable across AR grades 0-3 and sharply increased in AR 4 (median 1.35), whereas baPWV was lowest in AR 4 (1307 cm/s). ABI (per 0.01 increase; odds ratio [OR] 1.16, 95% confidence interval [CI] 1.13-1.18) and baPWV (per 100 cm/s increase; OR 0.80, 95% CI 0.74-0.86) were independently associated with AR 4. Area under the curve was 0.88 and 0.75 for ABI and baPWV, increasing to 0.90 in the combined model. In a combined model using ROC-derived cutoffs (ABI ≥ 1.26 and baPWV <1330 cm/s), the high-ABI/low-baPWV group showed independently increased odds of AR 4 after adjustment for age, sex, and brachial pulse pressure (OR 49.71, 95% CI 22.15-88.54). Elevated ABI and reduced baPWV served as complementary markers of severe AR, and their combined assessment may facilitate early identification and prompt referral for echocardiographic evaluation.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of hypertension and understanding of home blood pressure monitoring among hypertensive patients in India: results from the GRAND Study.","authors":"Anuj Maheshwari, Noriko Matsushita, Rituparna Barooah, Smitha Bhat, Natarajan Bhavatharini, Arun Goel, Aloke Kumar Gupta, Amit Gupta, Arvind Gupta, Vitull Kumar Gupta, Aravinda Jagadeesha, Rachna Parashar, Bijay Patni, Banshi Saboo, Divya Saxena, Nagendra Kumar Singh, Ramji Singh, Ruchi Singh, Saurabh Srivastava, Sachiko Ohde, Yutaka Imai, Narsingh Verma, Takayoshi Ohkubo","doi":"10.1038/s41440-026-02763-w","DOIUrl":"https://doi.org/10.1038/s41440-026-02763-w","url":null,"abstract":"<p><p>Home blood pressure monitoring (HBPM) is recommended for the management of hypertension; however, patients' understanding of hypertension and HBPM remains insufficient. This multicenter cross-sectional study assessed knowledge of hypertension and HBPM among 1920 patients receiving pharmacological treatment across 12 states in India and identified factors associated with relatively higher knowledge. Knowledge was evaluated across four domains: understanding of clinic and home blood pressure (BP) thresholds, awareness of causes of hypertension, recognition of risks associated with uncontrolled BP, and awareness of the benefits of HBPM. The median knowledge score was 1 (range 0-7), indicating generally low knowledge. Knowledge varied across domains, with particularly poor understanding of BP thresholds and limited awareness of HBPM benefits, while awareness of causes and complications was relatively higher but still insufficient. Relatively higher knowledge (≥75th percentile) was observed in 38.0% of participants and was more common among participants with prior HBPM experience than among those without prior HBPM experience (46.9% vs. 29.9%, p < 0.001). Higher education, type of healthcare facility, and prior HBPM experience were associated with relatively higher knowledge. These findings suggest that knowledge of hypertension among patients in India is limited and domain-specific, with critical gaps in areas essential for interpreting and utilizing BP measurements. Improving hypertension management may require not only promoting HBPM but also strengthening patient education. Clinical trial registration status: Registered at Clinical Trials Registry-India (CTRI) under CTRI/2023/02/049486 on 06 February 2023.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Alysis-001 cuffless blood pressure estimation algorithm against the European Society of Hypertension awake/asleep test criteria in hypertensive patients.","authors":"Kazuhiro Hongyo, Atsushi Hirayama, Kosuke Shimizu, Taisuke Ueno, Taku Fujimoto, Akitoshi Hara, Hiroshi Koriyama, Yoichi Takami, Yoshio Iwashima, Ryo Kawasaki, Koichi Yamamoto","doi":"10.1038/s41440-026-02728-z","DOIUrl":"https://doi.org/10.1038/s41440-026-02728-z","url":null,"abstract":"<p><p>Accurate ambulatory blood pressure monitoring (ABPM) is essential for cardiovascular risk assessment and hypertension management, but conventional cuff-based ABPM causes discomfort and sleep disturbance, potentially affecting measurement reliability. The European Society of Hypertension (ESH) established evaluation criteria for cuffless blood pressure devices, with the awake/asleep test as the primary evaluation test for automated wearable devices. This study evaluated whether Alysis-001, a software-based cuffless blood pressure estimation algorithm using sensor data from a wrist-worn device, meets ESH awake/asleep test criteria in hypertensive patients under two data extraction strategies: (1) arm-stabilized periods only ( ≥ 10 s static); (2) including low-intensity activity (high-intensity excluded). We prospectively enrolled 92 hypertensive outpatients receiving antihypertensive treatment who simultaneously wore Alysis Wear and underwent conventional 24-h ABPM; 78 completed the study. Under both strategies, Alysis-001 demonstrated excellent agreement with reference ABPM across all measurement periods, with intraclass correlation coefficients exceeding 0.70 for systolic and diastolic blood pressure. Alysis-001 successfully met all ESH awake/asleep test criteria under both strategies: mean difference between awake-asleep blood pressure changes ≤5 mmHg, standard deviation ≤8 mmHg, and correlation coefficients ≥0.70 for both systolic and diastolic blood pressure. Alysis-001 also demonstrated high sensitivity, specificity, and accuracy in identifying non-dippers under both strategies. To our knowledge, this represents the first evaluation of a Device Type 3 cuffless blood pressure algorithm (automated, wearable, demographic-calibrated, not at heart level) meeting ESH awake/asleep test criteria, suggesting Alysis-001's potential as a clinically viable alternative for ambulatory blood pressure monitoring in hypertensive patients.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family history of hypertension may have a stronger association with the incidence of hypertension than previously estimated: the SBS study","authors":"Yasuharu Tabara,&nbsp;Yoko Sato,&nbsp;Sayaka Nagao-Sato,&nbsp;Shin Koga","doi":"10.1038/s41440-026-02782-7","DOIUrl":"10.1038/s41440-026-02782-7","url":null,"abstract":"A family history (FH) of hypertension is associated with an increased risk of new-onset hypertension. However, the risk of FH estimated in normotensives using conventional methods may have been somewhat underestimated by excluding early-onset cases, who are highly likely to have FH of hypertension. This large-scale longitudinal study on a middle-aged population (mean age: 46.8 years) revealed that the hazard ratio of FH of hypertension for the development of hypertension was higher when calculated for the entire study population (N = 34,792), including hypertensives at baseline by treating them as left-censored cases, using an interval-censored Cox proportional hazards model (1.73, 95% confidence interval: 1.67–1.79, P &lt; 0.001) than that calculated in normotensives (n = 28,271) using a conventional Cox model (1.35, 95% confidence interval: 1.28–1.44, P &lt; 0.001). The effect of changes in the possible confounders during the follow-up period was negligible. Thus, the risk of FH of hypertension for the development of hypertension may be higher than previously reported.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"49 10","pages":"2736-2740"},"PeriodicalIF":5.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}