Hypertension Research最新文献

{"title":"Digital hypertension - what we need for the high-quality management of hypertension in the new era.","authors":"Kazuomi Kario, Kei Asayama, Hisatomi Arima, Chisa Matsumoto, Naoki Nakagawa, Akihiro Nomura, Michihiro Satoh, Keisuke Shinohara, Naoko Tomitani, Koichi Yamamoto, Satoshi Hoshide","doi":"10.1038/s41440-025-02307-8","DOIUrl":"https://doi.org/10.1038/s41440-025-02307-8","url":null,"abstract":"<p><p>Digital technologies are playing an increasing role in hypertension management. Digital hypertension is a new field that integrates advancing technologies into hypertension management. This research area encompasses various aspects of digital transformation technologies, including the development of novel blood pressure (BP) measurement devices-whether cuffless or cuff-based sensors-the transmission of large-scale time-series BP data, cloud-based computing and analysis of BP indices, presentation of the results, and feedback systems for both patients and physicians. A key component of this approach is novel blood pressure (BP) monitoring devices. This article summarizes the latest information and discussions about \"held at the 2024 Japan Society of Hypertension scientific meeting. Novel BP monitoring includes cuffless devices that estimate BP, but cuffless devices require achieving accuracy without the need for calibration using conventional cuff-based devices. New BP monitoring devices can provide information on novel biomarkers beyond BP and may improve risk assessment and outcomes. Integration of BP data with omics and clinical information should enable personalized hypertension management. Key data gaps relating to novel BP monitoring devices are accuracy/validation in different settings/populations, association between BP metrics and hard clinical outcomes, and measurement/interpretation of BP variability data. Human- and health system-related factors also need to be addressed or overcome before these devices can be successfully integrated into routine clinical practice. If these things can be achieved, new BP monitoring technologies could transform hypertension management and play a pivotal role in the future of remote healthcare. This article summarizes the latest information and discussions about digital hypertension from the Digital Hypertension symposium that took place during the 2024 Japan Society of Hypertension scientific meeting.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to a letter to the editor regarding \"Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage\".","authors":"Kentaro Kohagura","doi":"10.1038/s41440-025-02385-8","DOIUrl":"https://doi.org/10.1038/s41440-025-02385-8","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric perspective supporting the concept of heterogeneous afferent arteriolopathy in hypertensive nephrosclerosis.","authors":"Nobuo Tsuboi, Takaya Sasaki, Kotaro Haruhara","doi":"10.1038/s41440-025-02376-9","DOIUrl":"10.1038/s41440-025-02376-9","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral small vessel disease tells us the existence of primary aldosteronism.","authors":"Masaki Mogi","doi":"10.1038/s41440-025-02379-6","DOIUrl":"https://doi.org/10.1038/s41440-025-02379-6","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive blood pressure control <130/80 mmHg is recommended for prevention of MCI and dementia from the New JSH2025 and AHA/ACC2025 guidelines.","authors":"Masaki Mogi, Satoshi Hoshide, Kazuomi Kario","doi":"10.1038/s41440-025-02378-7","DOIUrl":"https://doi.org/10.1038/s41440-025-02378-7","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of TMAO levels with vascular function in patients with hypertension.","authors":"Takayuki Yamaji, Yuji Takaeko, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Yukiko Nakano, Takanori Harada, Takahiro Harada, Aya Mizobuchi, Yusuke Saito, Shunsuke Tanigawa, Tatsuya Maruhashi, Ayumu Nakashima, Yukihito Higashi","doi":"10.1038/s41440-025-02346-1","DOIUrl":"https://doi.org/10.1038/s41440-025-02346-1","url":null,"abstract":"<p><p>Increased trimethylamine-N-oxide (TMAO) level is a known risk factor for hypertension. Hypertension is associated with vascular dysfunction. Recently, it has been shown that endothelial function is impaired in relation to an increase in TMAO level. However, there is no information on the relationship between TMAO levels and vascular function in patients with hypertension. The purpose of this study was to evaluate the independent variables for circulating TMAO levels and to evaluate the relationships of circulating TMAO levels with vascular function assessed by flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) in patients with hypertension. This study was a cross-sectional study. A total of 333 subjects with hypertension were enrolled in this study. Log TMAO levels were significantly correlated with age (r = 0.24, p < 0.01), low-density lipoprotein cholesterol (r = -0.15, p < 0.01), creatinine (r = 0.28, p < 0.01), estimated glomerular filtration rate (eGFR) (r = -0.28, p < 0.01), and uric acid (r = 0.13, p = 0.02). Multiple linear regression analysis revealed that age (β = 0.17, p = 0.03), eGFR (β = -0.22, p < 0.01) and receiving three or more kinds of antihypertensive drugs (β = 0.15, p = 0.02) were independent predictors of log TMAO levels. FMD (r = -0.11, p = 0.04) and NID (r = -0.11, p = 0.04) were significantly correlated with log TMAO levels. After adjustment for confounding factors for vascular function, log TMAO level was not an independent predictor of FMD and NID. These findings suggest that circulating TMAO levels are associated with age, eGFR, and receiving three or more kinds of antihypertensive drugs but not with vascular function in patients with hypertension. Clinical Trial Registry Information: http://www.umin.ac.jp (UMIN000003409).</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher systolic blood pressure difference in left not right upper limb is associated with all-cause mortality risk in a community-based population.","authors":"Min Li, Fangfang Fan, Jia Jia, Jianping Li, Wei Ma, Yan Zhang","doi":"10.1038/s41440-025-02361-2","DOIUrl":"https://doi.org/10.1038/s41440-025-02361-2","url":null,"abstract":"<p><p>This study investigated inter-arm systolic blood pressure difference (IASBPD) and mortality risks in 8628 Chinese community residents from an atherosclerosis cohort. IASBPD was calculated by subtracting the systolic blood pressure of the left arm from that of the right arm. Participants were categorized as |IASBPD| <10 mmHg or ≥10 mmHg. These groups were further subdivided into four categories according to specific IASBPD values. The endpoints included all-cause mortality and cardiovascular mortality. Over a median follow-up of 9.87 years, a total of 442 all-cause and 138 cardiovascular deaths were recorded. Compared to |IASBPD| <10 mmHg group, the |IASBPD| ≥10 mmHg group had a 53% increase in all-cause mortality risk (adjusted HR = 1.53, P = 0.002) and a 71% increase in cardiovascular mortality risk (adjusted HR = 1.71, P = 0.021). When comparing specific IASBPD, no significant increase in all-cause mortality risk was observed in the group with a right arm higher ≥10 mmHg (adjusted HR = 1.17, P = 0.507) or in the group with a left arm higher ≤10 mmHg (adjusted HR = 0.90, P = 0.329). Conversely, the left arm higher >10 mmHg group demonstrated a significant 59% increase in the risk of all-cause mortality (adjusted HR = 1.59, P = 0.013). While the association with cardiovascular mortality was not statistically significant in this subgroup, the trend paralleled that observed for all-cause mortality. In conclusion, an elevated IASBPD is significantly associated with all-cause and cardiovascular mortality risks, with higher IASBPD in the left arm showing a stronger link to all-cause mortality risk.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of 24-hour urinary aldosterone for primary aldosteronism in patients with or without discontinuation of antihypertensive medications.","authors":"Mei You, Xin Li, Huandong Zhao, Zhongping Bai, Yushuang Liu, Qing Zhou, Qiang Li, Ruomei Yang, Hexuan Zhang, Hongbo He, Zhiming Zhu, Zhencheng Yan","doi":"10.1038/s41440-025-02375-w","DOIUrl":"https://doi.org/10.1038/s41440-025-02375-w","url":null,"abstract":"<p><p>Primary aldosteronism (PA) is the most common form of secondary hypertension. However, its diagnosis is complicated by the need to withdraw interfering antihypertensive medications. Traditionally, 24-h urinary aldosterone (Uald) level measurement is employed as part of the oral sodium loading test to diagnose PA. However, the diagnostic efficacy of 24-h Uald for PA under a usual diet and without drug washout remains unclear. This retrospective study enrolled 583 patients with essential hypertension (EH) and 259 patients with PA, as well as an external validation cohort comprising 157 hypertensive patients. Patients with unilateral PA presented higher 24-h Uald levels than those with bilateral PA. Combination antihypertensive therapy reduced 24-h Uald levels in both EH and PA groups. Receiver operating characteristic curve analysis revealed similar areas under the curve for 24-h Uald diagnosing PA between the off-medication group (0.879, 95% CI = 0.834-0.925) and the on-medication group (0.851, 95% CI = 0.817-0.886). The optimal 24-h Uald cut-offs for PA diagnosis were 9.57 μg (sensitivity 79.4%, specificity 88.6%) in the off-medication group and 8.41 μg (sensitivity 75.8%, specificity 79.4%) in the on-medication group, with closely matched thresholds observed between patients receiving renin-increasing medications (8.52 μg) and those on combined renin-increasing and renin-suppressing therapy (8.39 μg). The diagnostic accuracy of 24-h Uald reached 89.2% in the external validation cohort. Our research indicates that the 24-h Uald test is clinically feasible for diagnosing PA without additional sodium supplementation or drug washout. However, the diagnostic threshold for 24-h Uald should be adjusted downward in patients on medications.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Predictive accuracy of sFlt-1/PlGF ratio for preeclampsia and adverse outcomes: prospective, multicenter including primary, secondary, and tertiary care institutions, observational study in Japan\".","authors":"Yuru Fu, Yuanyuan Wang","doi":"10.1038/s41440-025-02377-8","DOIUrl":"https://doi.org/10.1038/s41440-025-02377-8","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of low carbohydrate diet score with blood pressure levels and hypertension among middle-aged Japanese: the Toon Health Study.","authors":"Shoaib Aziz, Koutatsu Maruyama, Saori Miyazaki, Kiyohide Tomooka, Takeshi Tanigawa, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa, Isao Saito","doi":"10.1038/s41440-025-02373-y","DOIUrl":"https://doi.org/10.1038/s41440-025-02373-y","url":null,"abstract":"<p><p>Hypertension is one of the major risk factors for cardiovascular diseases. However, limited evidence exists to explain the association between low-carbohydrate diet (LCD) scores and hypertension. This cross-sectional study examined the association between LCD scores and hypertension among the Japanese population, which was conducted among 2032 men and women aged 30-79 years. We measured systolic and diastolic blood pressure levels, inquired about taking antihypertensive medication, and defined hypertension and isolated systolic hypertension (ISH). Dietary intake was measured through a food frequency questionnaire, and LCD scores (total, animal-based, and plant-based) were calculated. Higher total LCD scores tended to be associated with lower multivariable means of SBP (p for trend = 0.06), and higher animal-based LCD scores also tended to be associated with lower multivariable means of SBP (p for trend = 0.06). Higher animal-based LCD scores tended to be negatively associated with hypertension; the multivariable OR (95% confidence intervals: CIs) for hypertension in the highest quintile of animal-based LCD score was 0.77 (0.48-1.21, p for trend = 0.19), and higher total LCD scores tended to be negatively associated with ISH; multivariable-adjusted OR and 95% CIs of the highest score was 0.55 (0.31-0.99, p for trend = 0.11). However, we did not find any significant associations between total and plant-based LCD scores and hypertension. Although the association did not reach the level of significance, in conclusion, the high LCD scores, especially total and animal-based LCD scores, tended to be negatively associated with hypertension and ISH in the Japanese population.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}