Hypertension Research最新文献

{"title":"Comment on \"Diet-induced obesity impairs salt-dependent downregulation of NCC activity\".","authors":"Deming Liu","doi":"10.1038/s41440-026-02864-6","DOIUrl":"https://doi.org/10.1038/s41440-026-02864-6","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Changes in segmental arterial stiffness and volume dynamics across the arterial tree during noradrenaline administration in rabbits.","authors":"Shuji Sato, Mao Takahashi, Yoshinobu Nagasawa, Megumi Aimoto, Satoshi Kawakami, Kazuhiro Shimizu, Kohji Shirai, Akira Takahara","doi":"10.1038/s41440-026-02868-2","DOIUrl":"10.1038/s41440-026-02868-2","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-pregnancy BMI and hypertensive disorders of pregnancy in Japan: population burden and simulated BMI reduction scenarios for preconception and interpregnancy care.","authors":"Sho Tano, Sumire Fujito, Tatsuo Inamura, Kazuya Fuma, Seiko Matsuo, Satoru Katsuki, Masato Yoshihara, Mamoru Yamashita, Tomomi Kotani, Hiroaki Kajiyama, Takafumi Ushida","doi":"10.1038/s41440-026-02847-7","DOIUrl":"https://doi.org/10.1038/s41440-026-02847-7","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy (HDP) is a major cause of maternal morbidity worldwide. Although a higher pre-pregnancy body mass index (BMI) increases HDP risk, how HDP cases are distributed across BMI levels in relatively lean populations remains poorly characterized. We evaluated the association between pre-pregnancy BMI and HDP, the distribution of HDP cases across BMI levels, and model-predicted HDP incidence under hypothetical BMI distributions.This large-scale multicenter, retrospective study used longitudinal records of singleton pregnancies from 12 obstetric facilities in Japan between 2009 and 2024. The BMI-HDP association was modeled using parity-stratified spline logistic regression. Model-predicted HDP incidence under hypothetical BMI distributions was estimated using spline-based standardization with woman-level bootstrap resampling.Among 52,042 pregnancies, 2,592 (5.0%) developed HDP. Although nulliparous women had higher baseline risk than multiparous women, the BMI-associated risk gradient was similar across parity groups. Most pregnancies were within normal BMI ranges, and most HDP cases arose in women without overweight or obesity. A population-wide 0.5 kg/m² downward BMI shift yielded a 5.5% relative reduction in model-predicted HDP incidence, compared with 6.7% under a BMI cap of 25.0 kg/m². A population-wide 1.0 kg/m² downward shift yielded a 10.2% relative reduction, compared with 12.1% under a BMI cap of 23.0 kg/m².Pre-pregnancy BMI was associated with HDP risk across the BMI continuum, while many HDP cases occurred within moderate BMI ranges. Modest downward BMI shifts yielded model-predicted HDP incidence similar to selected BMI-capping scenarios. These findings provide quantitative benchmarks for population-wide and high-risk approaches to preconception weight management.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension detection, treatment and control in young adults in Australia.","authors":"Ritu Trivedi, Niamh Chapman, Michael O Falster, Andrew E Moran, Aletta E Schutte, Bin Zhou, Dean S Picone","doi":"10.1038/s41440-026-02812-4","DOIUrl":"https://doi.org/10.1038/s41440-026-02812-4","url":null,"abstract":"<p><p>Young adult hypertension increases risk of future cardiovascular disease but is often overlooked. We aimed to identify opportunities to reduce blood pressure among younger adults by determining the drivers of hypertension detection, treatment and control in young adults in Australia. A cross-sectional analysis of adults aged 18 to 39 years using nationally representative 2017-18 National Health Survey data was conducted. Hypertension was defined as measured blood pressure ≥140/90 mmHg and/or antihypertensive medication use. Outcomes included the proportion of people with hypertension who self-reported (detection), who were taking ≥1 antihypertensive class (treatment), and whose blood pressure was controlled (control). Control was defined as taking ≥1 class of antihypertensive and having systolic <140 mmHg and diastolic blood pressure <90 mmHg. Analyses were by stratified by sex, health services interaction, geographical location and socioeconomic status, with subgroup analyses among those with cardiometabolic risk factors. The survey sample (n = 5217) was representative of N = 7,533,625 adults aged 18 to 39 years (49.9% women). Hypertension prevalence was 10.7% (95% CI: 9.6% to 11.7%). Among those with hypertension, detection was 9.4%, treatment was 6.8% and control was 4.5%. Young adults who had a recent blood pressure check and resided in major cities had higher detection, treatment and control rates than their counterparts, potentially due to greater access to healthcare. In conclusion, these findings suggest that there is a need to better detect and manage hypertension in young adults, potentially by developing tailored approaches that are specific to different contexts and ultimately supporting prevention of cardiovascular disease in later life.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the triglyceride-glucose index and arterial stiffness in adolescents: the Wakayama study.","authors":"Nobuyuki Miyai, Yan Zhang, Yukiko Sougawa, Hiroko Hayakawa, Kumiko Tsuji, Kazufumi Terada, Miyoko Utsumi, Mikio Arita","doi":"10.1038/s41440-026-02837-9","DOIUrl":"https://doi.org/10.1038/s41440-026-02837-9","url":null,"abstract":"<p><p>Insulin resistance plays an important role in early vascular dysfunction during adolescence. The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. This study aimed to examine the association between the TyG index and arterial stiffness in adolescents. This cross-sectional study included 617 adolescents aged 15-18 years in a school-based setting. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) using an automated oscillometric device with appropriately sized cuffs. Blood samples were collected after an overnight fast to calculate the TyG index and the homeostasis model assessment of insulin resistance (HOMA-IR). When participants were categorized into tertiles of the TyG index, baPWV increased significantly across tertiles. This association was observed in both obese and non-obese participants. In multivariable linear regression models adjusting for age, sex, systolic blood pressure, BMI z-score, heart rate, HDL cholesterol, HbA1c, and serum uric acid, the TyG index remained independently associated with baPWV; however, this association was attenuated after further adjustment for HOMA-IR. Receiver operating characteristic curve analysis showed that the area under the curve for the TyG index was comparable to that for HOMA-IR in identifying elevated baPWV. These results suggest that the TyG index was significantly associated with arterial stiffness in adolescents, regardless of obesity status. Although its predictive performance was similar to that of HOMA-IR, the TyG index may serve as a practical marker of early vascular alterations in this population.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting skin sympathetic nerve activity spectral characteristics are associated with orthostatic sympathetic responses and exaggerated orthostatic pressor response in hypertension.","authors":"Mayumi Morita, Takashi Kusayama, Keisuke Narita, Kenichi Katsurada, Yuta Nagamori, Kazutaka Takeuchi, Yoichiro Nakagawa, Shuhei Iwaisako, Soichiro Usui, Kenji Sakata, Kazuomi Kario, Masayuki Takamura","doi":"10.1038/s41440-026-02836-w","DOIUrl":"https://doi.org/10.1038/s41440-026-02836-w","url":null,"abstract":"<p><p>Substantial interindividual variability exists in orthostatic sympathetic and blood pressure (BP) responses among patients with hypertension. We investigated whether resting skin sympathetic nerve activity (SKNA) spectral characteristics are associated with this variability and with exaggerated orthostatic pressor responses (EPR). In 108 patients with hypertension, BP and SKNA were recorded in the supine and active standing positions. SKNA amplitude (average SKNA [aSKNA]) and frequency-domain parameters (low-frequency [LF] and high-frequency [HF] components, LF/HF ratio) were analyzed. Patients were stratified into low-LF/HF and high-LF/HF groups based on the median supine SKNA-derived LF/HF ratio. EPR was defined as a systolic BP increase of ≥ 20 mmHg at 3 min of active standing. Active standing significantly increased aSKNA (P < 0.001), whereas the overall SKNA-derived LF/HF ratio showed no significant change (P = 0.081). Upon standing, the low-LF/HF group exhibited a significant increase in LF/HF (P = 0.004), whereas the high-LF/HF group exhibited a decrease (P < 0.001), with an attenuation of the between-group difference during standing (P = 0.162). EPR occurred exclusively in the low-LF/HF group (13.0% vs. 0%, P = 0.013). In a receiver operating characteristic analysis, the supine LF/HF ratio discriminated EPR with an area under the curve of 0.863 (95% confidence interval, 0.775-0.950). Resting SKNA spectral characteristics may characterize interindividual variability in orthostatic sympathetic responses and be associated with EPR, offering a non-invasive approach for sympathetic phenotyping in hypertension In patients with hypertension, the supine SKNA-derived LF/HF ratio was inversely associated with its orthostatic change. LF/HF ratio increased during standing in the low-LF/HF group but decreased in the high-LF/HF group, with smaller group difference during standing. The supine LF/HF ratio showed potential for discriminating exaggerated orthostatic pressor responses.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between caregiving duration and hypertension among family caregivers: the TMM CommCohort study.","authors":"Rieko Hatanaka, Naoki Nakaya, Michihiro Satoh, Kumi Nakaya, Mana Kogure, Ippei Chiba, Sayuri Tokioka, Masato Takase, Taku Obara, Satoshi Nagaie, Takahisa Murakami, Hirohito Metoki, Yohei Hamanaka, Masatsugu Orui, Eiichi N Kodama, Nobuo Fuse, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa","doi":"10.1038/s41440-026-02848-6","DOIUrl":"https://doi.org/10.1038/s41440-026-02848-6","url":null,"abstract":"<p><p>With the global increase in elderly individuals requiring long-term care, family caregivers face significant physical and psychosocial burdens. This study examined the association between caregiving duration and hypertension using three indices: morning and evening home blood pressure (HBP) and research blood pressure (BP). This cross-sectional study included 13,518 participants from the Tohoku Medical Megabank Community-Based Cohort Study. Caregiving time was categorized via questionnaire. Hypertension was defined according to the Japanese Society of Hypertension Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025 (HBP ≥ 135/85 mmHg, research BP ≥ 140/90 mmHg, or medication use). Multivariable robust Poisson regression estimated prevalence ratios (PRs), adjusted for demographics, lifestyle and social psychological factors. Participants providing care \"almost all day\" had significantly higher PRs for morning (PR: 1.26; 95% CI: 1.07-1.48) and evening hypertension (PR: 1.27; 95% CI: 1.03-1.56) than non-caregivers. Notably, no significant association was observed with research BP-defined hypertension. Stratified analyses revealed that these associations were particularly prominent among caregivers aged <65 years (P-interaction for morning hypertension = 0.003). The interaction between sex and caregiving time was not significant. Prolonged caregiving burden is associated with a higher prevalence of hypertension in the morning and evening, particularly among working-age caregivers. Because these risks were not captured by research BP, HBP monitoring is essential for cardiovascular risk management in caregivers. Social policies and clinical interventions should target younger caregivers to mitigate the physiological strain of 24-h caregiving responsibilities.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Japanese Society of Hypertension practical consensus guidelines for seasonal blood pressure management: foreword from Japanese Association of Hypertension.","authors":"Hiromi Rakugi","doi":"10.1038/s41440-026-02823-1","DOIUrl":"https://doi.org/10.1038/s41440-026-02823-1","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of esaxerenone versus angiotensin II receptor blockers in older patients with hypertension, with and without type 2 diabetes mellitus: a predefined subgroup analysis of the ESCORT-HT study.","authors":"Mitsuru Ohishi, Kazuomi Kario, Hiroyuki Ohbayashi, Hajime Ishii, Mitsutoshi Kato, Minoru Nozaki, Norio Abiru, Toshiki Fukui, Kazushi Nomura, Yasushi Fukushima, Naoki Itabashi, Kazuaki Uchiyama, Masafumi Nishizawa, Yoshiki Hata, Noriko Nakamura, Satoshi Kodono, Kunio Hirano, Tomohiro Katsuya, Tatsuo Shimosawa, Kazuhito Shiosakai, Taketoshi Furugori, Takashi Taguchi","doi":"10.1038/s41440-026-02779-2","DOIUrl":"https://doi.org/10.1038/s41440-026-02779-2","url":null,"abstract":"<p><p>This predefined subgroup analysis of the ESCORT-HT study evaluated the antihypertensive efficacy, organ-protective effects, and safety profile of esaxerenone compared with an angiotensin II receptor blocker (ARB) in patients aged ≥65 years with hypertension on amlodipine, stratified by the presence or absence of type 2 diabetes mellitus (T2DM). In the T2DM subgroup, 65 patients received esaxerenone and 55 received an ARB. In the non-T2DM subgroup, 135 and 145 patients received these treatments, respectively. The least squares mean change from baseline at the end of treatment in morning home systolic blood pressure in the T2DM subgroup was -10.9 (95% confidence interval -13.5, -8.4) mmHg in esaxerenone-treated patients and -8.8 (-11.5, -6.0) mmHg in ARB-treated patients; in the non-T2DM subgroup, these were -10.5 (-12.3, -8.7) mmHg and -9.1 (-10.8, -7.3) mmHg, respectively. Although this subgroup analysis was not powered to formally demonstrate non-inferiority, the between-treatment differences in morning home SBP were consistent with the non-inferiority of esaxerenone to ARBs based on the margin used in the primary analysis in both the T2DM and non-T2DM subgroups. Urinary albumin-to-creatinine ratio (UACR) significantly decreased in esaxerenone-treated patients with T2DM (-33.4%), but not in those without T2DM. In contrast, UACR significantly decreased in ARB-treated patients without T2DM (-21.2%), but not in those with T2DM. One esaxerenone-treated patient in the non-T2DM subgroup had a serum potassium level ≥6.0 mEq/L, and a low proportion of esaxerenone-treated patients in the non-T2DM subgroup had hypokalemia (2.2%). Overall, this subgroup analysis showed favorable antihypertensive and kidney-protective effects (based on UACR) of esaxerenone, combined with an acceptable safety profile, in patients with hypertension. Moreover, antihypertensive effects were observed regardless of T2DM status, supporting the use of esaxerenone in older patients with hypertension and comorbid T2DM.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declaration for Advancing Implementation Hypertension 2026 - implementing hypertension measures across society for good blood pressure for all.","authors":"Kazuomi Kario, Satoshi Hoshide, Akira Nishiyama, Shigeru Shibata, Yusuke Ohya, Hiromi Rakugi","doi":"10.1038/s41440-026-02825-z","DOIUrl":"https://doi.org/10.1038/s41440-026-02825-z","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}