Hypertension Research最新文献_第2页

Downregulation of carotid body activity using low-intensity focused ultrasound: a potential treatment option for refractory hypertension. 利用低强度聚焦超声波下调颈动脉体活动：难治性高血压的一种潜在治疗方案。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01977-0

Yasuyoshi Takei

引用次数: 0

Impact of wrist-measured nocturnal hypertension on cardiovascular prognosis: study design and baseline characteristics of the WISDOM-Night study. 腕部测量的夜间高血压对心血管预后的影响：WISDOM-Night 研究的研究设计和基线特征。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01978-z

Naoki Nakagawa

引用次数: 0

Home blood pressure control and prescribing patterns of anti-hypertensive medications in a home blood pressure-based hypertension-specialized clinic in Japan: a sub-analysis of the Ohasama study. 日本以家庭血压为基础的高血压专科门诊的家庭血压控制和抗高血压药物处方模式：Ohasama 研究的子分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01954-7

Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

{"title":"Home blood pressure control and prescribing patterns of anti-hypertensive medications in a home blood pressure-based hypertension-specialized clinic in Japan: a sub-analysis of the Ohasama study.","authors":"Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai","doi":"10.1038/s41440-024-01954-7","DOIUrl":"10.1038/s41440-024-01954-7","url":null,"abstract":"Although the benefits of anti-hypertensive treatment are well known, the proportion of hypertensive patients with controlled blood pressure (BP) remains suboptimal. The present study aimed to compare BP control conditions in a hypertension-specialized clinic and non-hypertension-specialized clinics. This cross-sectional study used data from 379 treated patients who measured home BP in the Ohasama study between 2016 and 2019 (men: 43.0%, age: 71.6 years). Of those, 172 patients were managed at the hypertension-specialized clinic where physicians distributed home BP devices to each patient, evaluated the home BP data, and adjusted medications to maintain home BP values according to the recent Japanese guidelines. When we set morning home systolic/diastolic BP of <135/ < 85 mmHg as controlled BP, 93.6% of patients fulfilled the controlled home BP range, compared to 43.0% in non-specialized clinics (n = 207). The proportion of the patients with home morning BP < 125/ < 75 mmHg was 73.3% in the hypertension-specialized clinic and 20.8% in the non-hypertension-specialized clinics. Hypertension-specialized clinics prescribed three or more anti-hypertensive drug classes to 41.9% of patients, compared to 15.2% in non-specialized clinics. In the hypertension-specialized clinic, angiotensin II receptor blockers were most commonly prescribed (86.6%), followed by dihydropyridine calcium channel blockers (77.9%), thiazide (including thiazide-like) diuretics (30.2%), mineralocorticoid receptor blockers (23.8%), and beta- and alpha-beta blockers (10.5%). In conclusion, the proportion of patients with controlled home BP was excellent in the hypertension-specialized clinic. Home BP-based hypertension practices, as recommended in the current Japanese guidelines, may be the key to achieving sufficient BP control.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CureAPP HT is expected to be one piece of the puzzle that physicians and patients can work together to solve the problem of uncontrolled hypertension. CureAPP HT有望成为医生和患者共同解决高血压失控问题的一块拼图。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01962-7

Tetsuro Yoshida

引用次数: 0

Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma. 评估肾上腺切除术和矿质皮质激素受体拮抗剂对醛固酮腺瘤患者心脏重塑和舒张功能的影响。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01946-7

Yu-Ching Chang, Xue-Ming Wu, Tsung-Yan Chen, Uei-Lin Chen, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Fang-Yu Yang, Zheng-Wei Chen, Yi-Yao Chang, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Chi-Sheng Hung, Yen-Hung Lin

{"title":"Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma.","authors":"Yu-Ching Chang, Xue-Ming Wu, Tsung-Yan Chen, Uei-Lin Chen, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Fang-Yu Yang, Zheng-Wei Chen, Yi-Yao Chang, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Chi-Sheng Hung, Yen-Hung Lin","doi":"10.1038/s41440-024-01946-7","DOIUrl":"https://doi.org/10.1038/s41440-024-01946-7","url":null,"abstract":"Cardiac remodeling and diastolic dysfunction in patients with aldosterone-producing adenomas (APA) can be improved after adrenalectomy. However, the effect of mineralocorticoid receptor antagonist (MRA) treatment remains unclear. The aim of this study is to evaluate the effect of MRA on cardiac remodeling and diastolic dysfunction in patients with PA. We prospectively enrolled patients with APA from 1993 to 2023, who either received medical treatment with MRAs or underwent adrenalectomy. Biochemical characteristics and echocardiographic findings were collected at baseline and one year after treatment. Propensity score matching was conducted based on baseline biochemical characteristics, left ventricular mass index (LVMI), and diastolic function. A total of 467 APA patients were enrolled in the study. After propensity score matching, 159 patients who underwent adrenalectomy were matched with 159 patients who received MRAs. After therapy, patients who received MRAs showed significant improvement in diastolic function after one year of treatment but not LVMI. Compared to the MRA group, the adrenalectomy group had greater improvement in systolic blood pressure, plasma aldosterone concentration, plasma renin activity, aldosterone-to-renin ratio, and LVMI. In multivariable regression analysis, pretreatment echocardiographic values were significantly associated with changes in both LVMI and E/e', while the treatment strategy showed a significant association with changes in LVMI. Thus, one year after therapy, both adrenalectomy and MRA are effective in improving diastolic function in patients with APA. However, adrenalectomy is more effective than MRA treatment in reversing cardiac remodeling in patients with APA.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis. 脉搏波速度与脑微小出血之间的关系：系统回顾和荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01963-6

Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Iris Otero-Luis

{"title":"Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis.","authors":"Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Iris Otero-Luis","doi":"10.1038/s41440-024-01963-6","DOIUrl":"https://doi.org/10.1038/s41440-024-01963-6","url":null,"abstract":"Cerebral microbleeds are associated with events that are among the highest mortality and disability events combined worldwide, as well as with hypertensive vasculopathy. The aim of the present study was to investigate the relationship between a marker of hypertensive vasculopathy, arterial stiffness assessed by pulse wave velocity, and cerebral microbleeds. A systematic review and meta-analysis was performed using PubMed, Scopus, and Web of Science, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Cochrane Collaboration Handbook statements. Data extraction, quality assessment and statistical analyses were performed following pre-established criteria. Twenty-one studies involving 18,436 participants were included. Higher levels of pulse wave velocity were associated with a higher presence of cerebral microbleeds p-OR = 1.26 (95% CI; 1.09-1.45), with considerable heterogeneity; even adjusting for potential confounding variables p-OR = 1.12 (95% CI, 1.05-1.20), with substantial heterogeneity. Only the percentage of women was related to p-OR in the adjusted model. Sensitivity analyses confirmed the robustness of our results. Adjusted models showed publication bias. Higher levels of arterial stiffness are associated with greater presence of cerebral microbleeds. This phenomenon may be caused by damage to the brain under higher blood flow loads, in turn due to age-induced reversal of the stiffness gradient between large and small vessels. As the world's population is undergoing demographic ageing, our results underline the importance of establishing pulse wave velocity as a cardiovascular marker for early screening and delaying the onset of the characteristic signs of both diseases.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of low-intensity isometric handgrip training on home blood pressure in hypertensive patients: a randomized controlled trial. 低强度等距手握训练对高血压患者家庭血压的影响：随机对照试验。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-23 DOI: 10.1038/s41440-024-01961-8

Yuki Nemoto, Yuko Yamaki, Takako Takahashi, Tomonori Satoh, Satoshi Konno, Masanori Munakata

{"title":"Effects of low-intensity isometric handgrip training on home blood pressure in hypertensive patients: a randomized controlled trial.","authors":"Yuki Nemoto, Yuko Yamaki, Takako Takahashi, Tomonori Satoh, Satoshi Konno, Masanori Munakata","doi":"10.1038/s41440-024-01961-8","DOIUrl":"https://doi.org/10.1038/s41440-024-01961-8","url":null,"abstract":"We examined if lower intensity isometric handgrip (IHG) training than usual load could significantly reduce home blood pressure (HBP) in treated Japanese hypertensive patients. Sixty patients (mean age, 66.9 years; 44.6% men) with high blood pressure to grade 1 hypertension level were randomly assigned to an IHG or control group. The IHG group performed IHG training for 12 weeks, followed by a 12 weeks of detraining. The control group did not any IHG training. The IHG training comprised four sets of 2-min isometric contractions at 15% of maximum voluntary contraction (MVC) or half than usual, including 1 min of rest between sets, for ≥3 days a week. At the end of the former phase, both morning and evening systolic HBP (HSBP) and evening diastolic HBP (HDBP) were significantly higher than those at baseline in the control group while neither morning nor evening HSBP remained unchanged in the IHG group. Morning HBPs increased at the end of the latter phase than those at the end of the former phase in the IHG group and remained unchanged in the control group. The change (Δ) in morning HSBP from baseline to the end of the former phase was smaller in the IHG group than that in the control group (Δ4.1 mmHg vs. Δ0.0 mmHg, p = 0.05). A similar tendency was observed after adjusting baseline HSBP and seasonal variation (p = 0.06). In conclusion, a 12-week IHG training at 15% of MVC significantly lowered morning HSBP by approximately 4.0 mmHg in treated Japanese hypertensive patients. This study showed that a 12-week IHG training at 15% of MVC lowered morning HSBP by about 4.0 mmHg in treated Japanese hypertensive patients. Continuous low-intensity IHG training may provide a stable hypotensive effect in high blood pressure to grade 1 hypertensive population.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peak nighttime home blood pressure as a novel predictor of stroke risk: insights from the J-HOP study. 作为中风风险新预测指标的夜间家庭血压峰值：J-HOP 研究的启示。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-23 DOI: 10.1038/s41440-024-01967-2

Naoki Nakagawa

引用次数: 0

Development of real-world evidence studies for hypertension in Japan. 在日本开展高血压实证研究。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-23 DOI: 10.1038/s41440-024-01965-4

Tadashi Sofue

引用次数: 0

The effect of digital therapeutics intervention on improving hypertension management in adults: a meta-analysis of randomized controlled trial. 数字治疗干预对改善成人高血压管理的影响：随机对照试验荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-23 DOI: 10.1038/s41440-024-01892-4

Lu Liu, Jiayue Guo, Xitong Jiao, Lili You

{"title":"The effect of digital therapeutics intervention on improving hypertension management in adults: a meta-analysis of randomized controlled trial.","authors":"Lu Liu, Jiayue Guo, Xitong Jiao, Lili You","doi":"10.1038/s41440-024-01892-4","DOIUrl":"10.1038/s41440-024-01892-4","url":null,"abstract":"Digital therapeutics (DTx) intervention is an emerging therapy for the treatment and long-term management of hypertension. We aim to systematically evaluate the overall effect of DTx intervention on improving hypertension management. The systematic review and meta-analysis of RCTs was conducted and the PubMed, EMBASE, Web of Science, and Cochrane Library were searched to identify eligible RCTs published between Jan 1, 1982 and Sep 10, 2023. Random-effect models were utilized to pool estimates of net changes in systolic blood pressure (BP), diastolic BP, BP control rate, body mass index, weight, waist circumference, and physical activity between the DTx group and control group. 15 RCTs were included with a total of 3789 participants. Compared with the control group, DTx intervention was associated with significant changes in systolic BP, diastolic BP, and BP control rate of -3.75 mmHg(95% CI -5.74 to 1.77), -1.79 mmHg (95% CI -2.81 to -0.77) and 1.47% (95% CI 1.10 to 1.95), respectively. In addition, DTx intervention was statistically significant for improving other risk factors such as lower BMI (-0.5 kg/m2, 95% CI -0.86 to -0.15), increased physical activity (66.73 min/week, 95%CI 49.64 to 83.81), and reduced waist circumference (-2.91 cm, 95% CI -5.15 to -0.66). No difference between groups was demonstrated in weight (P = 0.30). Subgroup analyses revealed consistent effects of the change in SBP and DBP across study duration, age, sample size, patient baseline status, and intervention scenario settings(P > 0.05). DTx intervention may be useful for lowering BP and long-term management of hypertension. More large-size trials providing evidence on the same product are needed.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0