Hypertension Research最新文献_第2页

JSH2025 guidelines new viewpoints. JSH2025指导新观点。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-25 DOI: 10.1038/s41440-025-02296-8

Yusuke Ohya, Atsushi Sakima

引用次数: 0

Partner's dual use of new tobacco products and combustible cigarettes in early pregnancy was associated with hypertensive disorders of pregnancy: a cross-sectional study. 伴侣在妊娠早期双重使用新型烟草制品和可燃香烟与妊娠高血压疾病相关：一项横断面研究

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-23 DOI: 10.1038/s41440-025-02275-z

Miki Akiyama, Takehiro Michikawa, Yuki Takeda, Keiko Asakura, Haruhiko Imamura, Minami Sugimoto, Yuji Nishiwaki

{"title":"Partner's dual use of new tobacco products and combustible cigarettes in early pregnancy was associated with hypertensive disorders of pregnancy: a cross-sectional study.","authors":"Miki Akiyama, Takehiro Michikawa, Yuki Takeda, Keiko Asakura, Haruhiko Imamura, Minami Sugimoto, Yuji Nishiwaki","doi":"10.1038/s41440-025-02275-z","DOIUrl":"https://doi.org/10.1038/s41440-025-02275-z","url":null,"abstract":"It is an urgent issue to clarify whether new tobacco products have adverse pregnancy effects. As far as we know, however, there is no study of the association between passive smoking by new tobacco products and pregnancy complications, including hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM). We explored the association between partner's smoking at home during early pregnancy as an indicator of passive smoking and pregnancy complications. Participants were recruited from 16 obstetric clinics and hospitals within seven Japanese regions from December 2019 to March 2023 and answered a self-administered questionnaire. Among them, we conducted a cross-sectional analysis of 1354 postpartum women who did not smoke during early pregnancy. We categorized the participants into four groups based on their partner's smoking status: dual users (combustible cigarettes and new tobacco products), new tobacco product-only users, combustible cigarette-only users, and non-smokers at home (reference). We performed Firth's penalized logistic regression analysis and estimated the odds ratio (OR) of HDP and GDM diagnosis. The majority of partners were non-smokers (85.4%), followed by new tobacco product-only users (7.2%), dual users (4.4%), and combustible cigarette-only users (2.9%). The prevalence of HDP and GDM was 3.2% and 6.3%, respectively. For women whose partners were dual users, the multivariable-adjusted OR of HDP was 4.54 (95% confidence interval, 1.60-12.82). There was no association between partner's smoking status and GDM. We found an association between the partner's dual use of new tobacco products and combustible cigarettes in early pregnancy and HDP.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry. 钠-葡萄糖共转运蛋白2抑制剂诱导的腺苷增加通过激活肾-脂肪自主神经回路促进脂肪分解和体重减轻。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-23 DOI: 10.1038/s41440-025-02287-9

Aika Hagiwara, Shintaro Yamaguchi, Kazutoshi Miyashita, Kenichiro Kinouchi, Kaori Hayashi, Hiroshi Itoh

{"title":"Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry.","authors":"Aika Hagiwara, Shintaro Yamaguchi, Kazutoshi Miyashita, Kenichiro Kinouchi, Kaori Hayashi, Hiroshi Itoh","doi":"10.1038/s41440-025-02287-9","DOIUrl":"https://doi.org/10.1038/s41440-025-02287-9","url":null,"abstract":"Sodium-glucose co-transporter 2 (SGLT2) inhibitors promote weight loss in patients with type 2 diabetes mellitus; however, the underlying mechanisms remain unknown. This study investigated the role of renal autonomic nerves in SGLT2 inhibitor-induced lipolysis and body weight reduction by utilizing the renal denervation technique. The results indicated that renal autonomic nerves mediated lipolysis in mice fed a high-fat diet following treatment with tofogliflozin, an SGLT2 inhibitor. The effect was attenuated by renal denervation or β3-adrenergic blockade. Metabolomic analysis revealed that treatment with tofogliflozin elevated renal adenosine, which in turn activated adipose sympathetic nerves, as evidenced by increased norepinephrine concentrations in adipose tissue, thereby promoting lipolysis. These findings uncover a novel reno-adipose neurocircuitry linking renal energy depletion to systemic fatty acid oxidation, providing insights into the sustained weight-reducing effects of SGLT2 inhibitors. A scheme illustrating SGLT2 inhibitor-induced activation of reno-adipose autonomic neurocircuitry, which promotes lipolysis and weight reduction.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis. Author's response to comments from Cui, Ruixin (2025). 脉搏波速度与脑微出血的关系：一项系统综述和荟萃分析。作者对崔瑞新（2025）评论的回应。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-18 DOI: 10.1038/s41440-025-02294-w

Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara

引用次数: 0

Evidence for the relation between obesity and nocturnal blood pressure patterns. 肥胖和夜间血压模式之间关系的证据。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-18 DOI: 10.1038/s41440-025-02290-0

Ionas Papassotiriou, Sotiria Spiliopoulou, Gerasimos Barlas, Damianos Dragonas, Konstantinos Rizogiannis, Nefeli Tsoutsoura, Efstathios Manios

{"title":"Evidence for the relation between obesity and nocturnal blood pressure patterns.","authors":"Ionas Papassotiriou, Sotiria Spiliopoulou, Gerasimos Barlas, Damianos Dragonas, Konstantinos Rizogiannis, Nefeli Tsoutsoura, Efstathios Manios","doi":"10.1038/s41440-025-02290-0","DOIUrl":"https://doi.org/10.1038/s41440-025-02290-0","url":null,"abstract":"Obesity often leads to elevated blood pressure (BP) and hypertension, but its effect on nocturnal BP patterns has not been adequately examined. Therefore, the aim of this study was to examine the association between body mass index (BMI)/obesity and nocturnal hypertension and BP dipping. 6767 adult patients (53.6% females) were included in this study, measured for their weight and height to estimate BMI, and they categorized as normal weight, overweight or obese. A 24-hour ambulatory BP monitoring was also performed by all patients. Nocturnal hypertension was defined as >120/70 mmHg nocturnal systolic/diastolic BP. Patients were considered as dippers if BP dipping was >10% or non-dippers otherwise. Obesity was not significantly associated with nocturnal hypertension in multivariate analysis (OR:1.03, 95%CI: 0.78-1.36), but subgroup analysis revealed that obese treatment-naïve hypertensive patients had a 2.8 (OR:2.76, 95%CI:1.36-5.59) higher risk of nocturnal hypertension than normal-weight. Obese patients had also 42% (OR:1.42, 95%CI: 1.13-1.79) more risk of being non-dippers than dippers compared to those with normal weight, while subgroup analysis showed that this association was still present in treatment naïve (OR:1.43, 95%CI: 1.09-1.88) and under treatment hypertensive adults (OR:1.37, 95%CI: 1.11-1.68), but not in normotensives (OR:0.96, 95%CI: 0.75-1.22). Restricted cubic spline models did not show any significant non-linear association between BMI and nocturnal SBP, DBP, or dipping (p for non-linearity > 0.05). These results indicate that high BMI is associated with disturbed nocturnal BP patterns, a relationship that is more profound among hypertensive adults.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis. 点评：脉搏波速度与脑微出血之间的关系：一项系统综述和荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-18 DOI: 10.1038/s41440-025-02291-z

Ruixin Cui

引用次数: 0

Comparison between vascular age based on brachial-ankle pulse wave velocity or carotid-femoral pulse wave velocity. 基于肱-踝脉波速度与颈-股脉波速度的血管年龄比较。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-18 DOI: 10.1038/s41440-025-02281-1

Tianhui Dong, Fangfang Fan, Hongyu Chen, Zhichen Dong, Leyuan Yang, Yiming Luo, Zifeng Qiu, Ran Fang, Qiwen Zheng, Xiangning Zhang, Jianping Li, Yong Huo, Yan Zhang

{"title":"Comparison between vascular age based on brachial-ankle pulse wave velocity or carotid-femoral pulse wave velocity.","authors":"Tianhui Dong, Fangfang Fan, Hongyu Chen, Zhichen Dong, Leyuan Yang, Yiming Luo, Zifeng Qiu, Ran Fang, Qiwen Zheng, Xiangning Zhang, Jianping Li, Yong Huo, Yan Zhang","doi":"10.1038/s41440-025-02281-1","DOIUrl":"https://doi.org/10.1038/s41440-025-02281-1","url":null,"abstract":"Vascular age (VA) as a surrogate of chronological age can improve cardiovascular risk prediction. This study examines which vascular age calculated by brachial-ankle pulse wave velocity (baPWV) or carotid-femoral pulse wave velocity (cfPWV) has a stronger association with the risk of cardiovascular events. This prospective study included 5723 participants from a community-based atherosclerosis cohort in Beijing, China. VA was defined as the predicted age in a multivariable regression model, including classical cardiovascular risk factors, treatment, and pulse wave velocity (baPWV or cfPWV). Residuals by regressing vascular age on chronological age were defined as ∆-age, and the 10th and 90th percentiles of ∆-age were used as cutoffs to define supernormal vascular aging, normal vascular aging, and early vascular aging, respectively. During the median 3.1-year follow-up period, 173 (3.0%) composite endpoints were observed. After adjusting for age and sex, ∆-age calculated by baPWV was significantly associated with cardiovascular risk (hazard ratio [HR]: 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.025). After adjusting for traditional cardiovascular risk factors, early vascular aging group calculated by baPWV had an increased cardiovascular risk (HR: 1.84, 95% CI: 1.25-2.73, p = 0.002), compared with the normal vascular aging group. In contrast, no significant results were observed in the analyses of VA calculated by cfPWV. Since baPWV is a simple and convenient method, VA calculated by baPWV is more valuable for cardiovascular disease risk prediction of large sample population. The association between VA based on baPWV or cfPWV and MACE. EVA early vascular aging, normal VA normal vascular aging, SUPERNOVA supernormal vascular aging.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent risk of ascending artery dilatation in non-functional adrenal incidentaloma. 非功能性肾上腺偶发瘤上升动脉扩张的隐性风险。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-15 DOI: 10.1038/s41440-025-02274-0

Osamu Yamazaki, Atsuro Chonan, Yumika Yakuwa, Shigeru Shibata

引用次数: 0

Re: Comment on: Optimal blood pressure target for patients with prior stroke: a systematic review and meta-analysis. 评论：既往卒中患者的最佳血压目标：系统回顾和荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-15 DOI: 10.1038/s41440-025-02286-w

Toshiki Maeda, Hisatomi Arima

引用次数: 0

Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model. 肾神经刺激引导下血压升高/降低部位肾去神经支配对高血压犬模型心房神经和结构重构的影响。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-07-10 DOI: 10.1038/s41440-025-02258-0

Dan Li, Yuxiang Long, Hao Zhou, Weijie Chen, Yinchuan Lai, Yiwen Ren, Xiaomin Ma, Hongyu Kuang, Xinyu Hu, Guangliang Liu, Zhiyu Ling, Peilin Xiao, Yuehui Yin

{"title":"Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model.","authors":"Dan Li, Yuxiang Long, Hao Zhou, Weijie Chen, Yinchuan Lai, Yiwen Ren, Xiaomin Ma, Hongyu Kuang, Xinyu Hu, Guangliang Liu, Zhiyu Ling, Peilin Xiao, Yuehui Yin","doi":"10.1038/s41440-025-02258-0","DOIUrl":"https://doi.org/10.1038/s41440-025-02258-0","url":null,"abstract":"Hypertension is a common condition in cardiovascular medicine, and can lead to atrial enlargement, atrial fibrosis, and even the development of atrial fibrillation. Renal denervation (RDN) causes reduction in blood pressure (BP), but its effects on hypertension-related atrial remodeling remain unclear. This study aimed to explore the effects of RDN at BP-elevation/reduction sites guided by renal nerve stimulation (RNS) on atrial neural and structural remodeling in a hypertensive canine model. The twenty-four Chinese Kunming dogs were divided into three groups: (1) the reduced BP response ablation group (RRA group, n = 8), (2) the renal stimulation control group (RSC group, n = 8), and (3) the elevated BP response ablation group (ERA group, n = 8), which were followed for 4 weeks. Our results showed that in terms of atrial neural remodeling, compared with the RSC group, the ERA group exhibited reduced tyrosine hydroxylase (TH) protein expression and a lower TH/ choline acetyltransferase (ChAT) ratio. In contrast, the RRA group showed lower ChAT and muscarinic acetylcholine receptor 2 (CM2) protein expression, and an elevated TH/ChAT ratio. Compared with the RSC group, the ERA group presented a smaller myocyte area, reduced collagen I protein expression, and lower myocardial interstitial collagen fiber content. In contrast, the RRA group presented a larger myocyte area, increased collagen I protein expression, and greater collagen fiber content. Overall, RDN at elevated BP response sites improved atrial neural and structural remodeling under hypertensive conditions, whereas RDN at reduced BP response sites exacerbated the imbalance between atrial sympathetic and parasympathetic nerve activity and worsened structural remodeling.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0