Hypertension Research最新文献

{"title":"Correction: Clinical studies in Myxomatous Mitral Valve Disease dogs: most prescribed ACEI inhibits ACE2 enzyme activity and ARB increases AngII pool in plasma","authors":"Smruti K. Nair, Elliot V. Hersh, Kenneth B. Margulies, Henry Daniell","doi":"10.1038/s41440-025-02157-4","DOIUrl":"10.1038/s41440-025-02157-4","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1678-1678"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02157-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of six surrogate insulin resistance indexes for predicting hypertension risk in rural Chinese adults","authors":"Ge Liu, Lu Cao, Hongwei Wen, Mengna Liu, Xinxin He, Mengdi Wang, Yijia Su, Fan Xu, Jingli Kong, Canjie Piao, Aijun Xu, Ming Zhang, Fulan Hu, Dongsheng Hu, Yang Zhao","doi":"10.1038/s41440-025-02147-6","DOIUrl":"10.1038/s41440-025-02147-6","url":null,"abstract":"Insulin resistance (IR) is a complex abnormality and associated with hypertension. We aimed to assess the associations of six alternate IR measures and risk of hypertension, and to compare the predictive values for hypertension. We assessed 11,223 non-hypertensive Chinese adults enrolled in The Rural Chinese Cohort Study during 2007–2008. Six surrogate IR indexes were new visceral adiposity index (NVAI), Chinese visceral adiposity index (CVAI), weight-adjusted waist index (WWI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and visceral adiposity index (VAI). The relative risks (RR) and 95% confidence intervals (95% CI) of the six IR indicators and hypertension were estimated by using modified Poisson regression models with three adjusted models. During a median follow-up of 11.1 years, 3373 (30.05%) study participants developed hypertension. The cumulative incidence of hypertension showed an increasing trend with higher levels of all six IR surrogates. Significant associations of all the IR measures with incident hypertension were found in fully adjusted model, and the highest quartile group RRs (95% CIs) for hypertension were, 2.19 (1.88–2.55), 1.60 (1.42–1.81), 1.38 (1.25–1.53), 1.47 (1.31–1.65), 1.18 (1.04–1.34) and 1.25 (1.08–1.44) for NVAI, CVAI, WWI, LAP, TyG index and VAI, respectively, compared with lowest quartile group. Further, NVAI had the maximum predictive power for hypertension among six IR measures with the largest AUC of 0.706 (0.697–0.714). NVAI, CVAI, WWI, LAP, and TyG index were all independently associated with greater risk of incident hypertension, among which NVAI is the most powerful predictor for hypertension in rural Chinese adults.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1285-1294"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office and home blood pressure and their difference according to frailty status among community-dwelling older adults: the NOSE study","authors":"Yuka Ohata, Mai Kabayama, Kayo Godai, Michiko Kido, Yaya Li, Yuya Akagi, Naoko Murakami, Hiroko Yoshida, Mariko Hosokawa, Yuka Tachibana, Yuka Fukata, Chihiro Anzai, Kaoru Hatta, Yurie Maeyama, Arisa Wada, Sumiyo Hashimoto, Hiromi Hatanaka, Makiko Higashi, Takeshi Kikuchi, Keiji Terauchi, Fumie Matsuno, Sho Nagayoshi, Kei Asayama, Takayoshi Ohkubo, Hiromi Rakugi, Yasuharu Tabara, Kei Kamide","doi":"10.1038/s41440-025-02145-8","DOIUrl":"10.1038/s41440-025-02145-8","url":null,"abstract":"The relationship between frailty and blood pressure (BP) is inconsistent, and limited research has compared BP by frailty status using long-term home BP measurements. We aimed to identify office and home BP and determine differences according to frailty status, stratified by taking antihypertensives in community-dwelling older adults. This cross-sectional study was part of the ongoing non-randomized intervention NOSE study. Participants were aged ≥ 64 years. Frailty was categorized robust, pre-frailty, or frailty using the revised Japanese version of the Cardiovascular Health Study criteria. Office BP was measured in survey settings, and each participant was instructed to take home BP. We used the average home BP for 4 weeks post-survey. An analysis of covariance analyzed the relationship between frailty and office and home BP, and their differences stratified by antihypertensive use. We included 418 older participants (mean age: 72.8 years); 39.5% were male, 40.4% were taking antihypertensives, and 6.7% had frailty. Individuals with frailty taking antihypertensives had higher home morning systolic BP (SBP) than those with robust (134.2 vs. 145.7 mmHg, P = 0.018) and pre-frailty (135.6 vs. 145.7 mmHg, P = 0.024). The difference between office and morning home SBP in treated participants was 7.1 mmHg (robust), 4.7 mmHg (pre-frailty), and −5.1 mmHg (frailty), showing significant differences (robust vs. frailty: P = 0.005, pre-frailty vs. frailty: P = 0.016). Home morning SBP was higher in individuals with frailty taking antihypertensives compared to those without frailty, and it may be higher than office BP. Individuals with frailty should measure home BP for good BP control.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1389-1398"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02145-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Cautious interpretation of the findings of no increasing risk of breast cancer in users of calcium channel blockers from the population-based cohort study in Taiwan","authors":"Shin-Yi Lin, Hsin-Yi Huang, Chi-Chuan Wang","doi":"10.1038/s41440-025-02141-y","DOIUrl":"10.1038/s41440-025-02141-y","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1673-1674"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term pulse pressure variability: a novel prognostic marker and therapeutic target in patients with vascular Ehlers-Danlos syndrome? Preliminary results from a pilot study","authors":"Giacomo Buso, Roberto Gatta, Federica Corvini, Nicola Laera, Claudia Agabiti-Rosei, Anna Paini, Giuseppe Bulgari, Beatrice Petroboni, Fabio Bertacchini, Carlo Aggiusti, Deborah Stassaldi, Sara Capellini, Massimo Salvetti, Carolina De Ciuceis, Marco Ritelli, Marina Venturini, Marina Colombi, Maria Lorenza Muiesan","doi":"10.1038/s41440-025-02135-w","DOIUrl":"10.1038/s41440-025-02135-w","url":null,"abstract":"Vascular Ehlers-Danlos syndrome (vEDS) is an inherited connective tissue disorder characterized by arterial fragility. Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity capable of reducing rates of vascular events in this setting, though the underlying mechanisms have yet to be elucidated. In particular, no conclusive evidence exists on its impact on blood pressure (BP) parameters in patients with vEDS. Accordingly, the aim of our study was to perform a comprehensive assessment of BP profile in a cohort of patients with vEDS receiving celiprolol titrated to the maximum tolerated dose. Consecutive outpatients with molecularly confirmed vEDS undergoing office BP measurement and 24-h ambulatory BP monitoring (ABPM) were retrospectively evaluated. Using 24-h systolic BP, diastolic BP, mean BP, and pulse pressure (PP) (mmHg) values, indices of short-term BP variability were calculated. A generalized linear regression model was applied to analyze the correlation between initial values of BP parameters and their variation with celiprolol therapy. Overall, 20 subjects were included (12 females). Eight patients (40%) had 24-h ABPM values consistent with hypertension. Five subjects (25%) defined hypertensives at 24-h ABPM had optimal BP control at office BP measurement, suggesting a “masked” hypertension. A significant correlation was found between initial values of indices of short-term PP variability and their change with celiprolol therapy, with a particularly high Pearson’s index for PP coefficient of variation (r = −0.926; p < 0.001). In patients with vEDS, 24-h ABPM is confirmed a reliable tool in identifying hypertension phenotypes. Treatment with celiprolol may reduce PP variability proportionally to its initial magnitude. Dedicated studies on larger cohorts should evaluate whether short-term PP variability is a reliable prognostic marker and therapeutic target in this clinical setting. In our study, treatment with celiprolol seemed to reduce short-term PP variability proportionally to its initial magnitude in patients with vEDS. Furthermore, two out of four patients experiencing vascular events during the study period displayed the highest short-term PP variability values recorded in the entire cohort. Further research should evaluate whether such parameters are reliable prognostic markers and therapeutic targets in this clinical setting. ABPM ambulatory blood pressure monitoring, ARV average real variability, BP blood pressure, CV coefficient of variation, DBP diastolic blood pressure, PP pulse pressure, SBP systolic blood pressure, SD standard deviation, TRI time-rate index, vEDS vascular Ehlers-Danlos syndrome.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1529-1541"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02135-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of self-monitoring devices measuring the urinary sodium-to-potassium ratio, urinary salt (sodium) excretion, or salt concentration in foods for blood pressure management: a systematic review and meta-analysis.","authors":"Takashi Hisamatsu, Kohei Ueda, Kimika Arakawa, Shintaro Minegishi, Yukiko Okami, Minako Kinuta, Keiko Kondo, Hiroshige Jinnouchi, Maho Ishihara, Makiko Abe, Atsushi Sakima, Katsuyuki Miura, Hisatomi Arima","doi":"10.1038/s41440-025-02124-z","DOIUrl":"10.1038/s41440-025-02124-z","url":null,"abstract":"<p><p>Self-monitoring devices that measure the urinary sodium-to-potassium (Na/K) ratio, urinary salt or sodium excretion, or salt concentration in foods have emerged as tools that can guide dietary adjustments for blood pressure (BP) control. This systematic review and meta-analysis investigated whether these self-monitoring devices can help to control BP in adults. The PubMed, Cochrane Library, and Ichushi-Web databases were searched to identify randomized controlled trials that compared the effect of these devices (with or without additional dietary education) plus usual care on BP with that of usual care alone. The pooled effect of weighted mean difference between the intervention and control groups at the end of follow-up was estimated by random-effects meta-analysis. The primary outcome was the change in BP. Secondary outcomes included changes in the urinary Na/K ratio, and sodium and potassium excretions. Of 1525 studies screened, eight (with 1442 participants) were eligible for inclusion. Meta-analysis showed greater reductions in systolic BP by 2.45 (95% confidence interval, 0.04, 4.86) mmHg and diastolic BP by 1.38 (-0.15, 2.90) mmHg in the intervention vs. control groups. However, heterogeneity was high (I² = 69.4% for systolic BP and 65.1% for diastolic BP). The BP-lowering effect was not statistically different across different follow-up durations (4 weeks or 2-6 months) and intervention approaches (self-monitoring alone or combined with dietary education) (all p values for heterogeneity >0.1). Reductions in the urinary Na/K ratio and sodium excretion were greater in the intervention group. Self-monitoring devices may assist with BP reduction by promoting decreased sodium intake and increased potassium intake.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home blood pressure-based treatment with hypertension specialists: a better strategy for overcoming uncontrolled blood pressure","authors":"Atsushi Sakima","doi":"10.1038/s41440-025-02140-z","DOIUrl":"10.1038/s41440-025-02140-z","url":null,"abstract":"Schematic illustration of home BP-based treatment supported by hypertension specialists to overcome clinical inertia. The combination of support and feedback from hypertension specialists to patients and primary care physicians may improve the antihypertensive efficacy of HBPM. BP blood pressure, HBPM home blood pressure monitoring.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1656-1659"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02140-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best reviewers of Hypertension Research 2024","authors":"Kazuomi Kario","doi":"10.1038/s41440-025-02128-9","DOIUrl":"10.1038/s41440-025-02128-9","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1261-1264"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41440-025-02128-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intensive versus standard blood pressure control on cardiovascular outcomes in adult patients with hypertension: a systematic review and meta-analysis.","authors":"Tatsuya Haze, Kenichi Katsurada, Satoko Sakata, Masanari Kuwabara, Norifumi Nishida, Tatsuhiko Azegami, Atsushi Sakima, Hisashi Kai","doi":"10.1038/s41440-025-02131-0","DOIUrl":"https://doi.org/10.1038/s41440-025-02131-0","url":null,"abstract":"<p><p>We conducted a systematic review and meta-analysis to evaluate the effects of intensive versus standard antihypertensive therapy on cardiovascular outcomes in adult patients with hypertension. The primary endpoints were composite cardiovascular events, all-cause death, cardiovascular death, and serious adverse events. The secondary endpoints included cognitive impairment, hypotension, syncope, acute kidney injury, and composite renal outcomes. Eight trials classifying a systolic blood pressure (SBP) target of <130 mmHg as intensive control was adopted in the primary analysis. The intensive blood pressure (BP) control significantly reduced the relative risk (RR) for cardiovascular events and cardiovascular death compared to standard BP control (RR 0.83 [95% confidence interval, 0.76-0.90] and 0.74 [0.56-0.97], respectively). The intensive BP control tended to reduce the RR for all-cause death, but not significant (0.89 [0.78-1.02]). On the other hand, the intensive BP control significantly increased the RR for serious adverse events, hypotension, and syncope (1.59 [1.19-2.12], 1.96 [1.04-3.70], and 2.36 [1.95-2.85], respectively). The intensive BP control significantly increased the RR for acute kidney injury (2.65 [1.78-3.95]), but did not affect for composite renal outcomes (1.38 [0.83-2.31]). For cognitive impairment, no significant increase or decrease in risk was observed (0.93 [0.68-1.26]). Based on these findings, we recommend the intensive BP control targeting SBP below 130 mmHg to achieve significant reductions in cardiovascular events and cardiovascular death, accompanied by careful monitoring for potential adverse events including acute kidney injury, hypotension, syncope related with the intensive BP control.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism","authors":"Yuhong Yang,&nbsp;Yuqing Liu,&nbsp;Tracy Ann Williams,&nbsp;Maoting Gao,&nbsp;Yutong Yan,&nbsp;Meiling Bao,&nbsp;Jun Tao,&nbsp;Guodong Ma,&nbsp;Min Wang,&nbsp;Zhiqing Xia,&nbsp;Zhiheng Zhang,&nbsp;Tao Yang,&nbsp;Min Sun","doi":"10.1038/s41440-025-02143-w","DOIUrl":"10.1038/s41440-025-02143-w","url":null,"abstract":"Primary aldosteronism (PA) caused by aldosterone hypersecretion is treated by adrenalectomy or medications. Histopathologic examination of resected adrenals reveals diverse histopathologic features. This study aimed to investigate the potential association of peripheral and adrenal tissue metabolic profiles with the histopathologic features of PA. The retrospective study included 105 surgically treated and 43 medically treated patients with PA. Adrenal specimens were categorized according to the HISTALDO (HISTopathology of primary ALDOsteronism) consensus. Peripheral and adrenal tissue metabolic profiles were assessed, including adiposity, adipokines and fatty acid abundances. The distinct fatty acid, arachidonic acid, was further functionally characterized. Surgically treated patients with classical histopathologic findings (n = 71) displayed lower body mass indexes, a lower prevalence of obesity, smaller waist circumference and visceral adipose tissue areas, and lower leptin concentrations compared with operated patients with the nonclassical histopathology (n = 34). No such differences were identified between the nonclassical histopathology group and medically treated group. Distinct concentrations of 18 out of 35 peripheral venous fatty acids, including arachidonic acid, were identified among the 3 groups. Further, accumulation of arachidonic acid was demonstrated in 4 aldosterone-producing adenomas compared with paired adjacent cortex possibly linked with suppressed peroxisomal beta-oxidation. Stimulation of human adrenocortical cells with arachidonic acid or peroxisomal beta-oxidation inhibitor caused 3.8-fold (P = 0.0050) and 1.7-fold (P = 0.0328) amplification of CYP11B2 expression, respectively, which were ablated by BAPTA-AM or KN93, and induced oxidative stress and apoptosis. Our findings show metabolic heterogeneity related to histopathology and support a role for arachidonic acid in PA pathophysiology.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 4","pages":"1363-1378"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}