Hypertension Research最新文献_第7页

Comment on: Renal denervation alleviates vascular remodeling in spontaneously hypertensive rats by regulating perivascular adipose tissue. 评论肾脏去神经通过调节血管周围脂肪组织缓解自发性高血压大鼠的血管重塑

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-17 DOI: 10.1038/s41440-024-01889-z

Raúl Daniel Aguilar Castañeda

引用次数: 0

Stage 1 hypertension in early pregnancy: a key indicator of adverse perinatal outcomes. 妊娠早期1期高血压：不良围产期结局的关键指标

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-17 DOI: 10.1038/s41440-024-02043-5

Yoshitsugu Chigusa

引用次数: 0

Interplay between lncRNAs and microrNAs in hypertension. lncrna和microrna在高血压中的相互作用。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-17 DOI: 10.1038/s41440-024-01888-0

Gokul Sudhakaran

引用次数: 0

The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients. 组织金属蛋白酶抑制剂-1与醛固酮性腺瘤患者KCNJ5突变的关系

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-17 DOI: 10.1038/s41440-024-02030-w

No-Ting Lin, Tsung-Yan Chen, Xue-Ming Wu, Yi-Yao Chang, Cheng-Hsuan Tsai, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Ching-Chu Lu, Jeff Shih-Chieh Chueh, Vin-Cent Wu, Chi-Sheng Hung, Zheng-Wei Chen, Yen-Hung Lin

{"title":"The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients.","authors":"No-Ting Lin, Tsung-Yan Chen, Xue-Ming Wu, Yi-Yao Chang, Cheng-Hsuan Tsai, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Ching-Chu Lu, Jeff Shih-Chieh Chueh, Vin-Cent Wu, Chi-Sheng Hung, Zheng-Wei Chen, Yen-Hung Lin","doi":"10.1038/s41440-024-02030-w","DOIUrl":"https://doi.org/10.1038/s41440-024-02030-w","url":null,"abstract":"KCNJ5 somatic mutations in aldosterone-producing adenoma (APA) are linked to higher left ventricular mass index (LVMI) and worse diastolic function. We previously identified an association between plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and an aldosterone-induced increase in LVMI and diastolic dysfunction. This study aimed to investigate the association between the presence of KCNJ5 somatic mutation and plasma TIMP-1 in APA patients. We enrolled 60 APA patients undergoing adrenalectomy, including 30 with KCNJ5 mutations (KCNJ5(+)) and 30 without (KCNJ5(-)). Clinical characteristics, echocardiographic data (including LVMI, inappropriately excessive LVMI (ieLVMI), and diastolic function) and plasma TIMP-1 levels were measured before surgery and 1 year postoperatively. The results showed that the KCNJ5(+) group had higher plasma TIMP-1 levels (P = 0.004) compared to the KCNJ5(-) group. The correlation between the KCNJ5 mutations and TIMP-1 levels remained significant after multiple regression analysis. To detect KCNJ5 mutations, receiver operating characteristic curve analysis showed TIMP-1 had the best area under the curve (AUC) value among various clinical parameters (AUC = 0.682, 95% confidence interval = 0.549-0.796, P = 0.008). Post-adrenalectomy, only the KCNJ5(+) group showed significant decrease in LVMI (P = 0.001) and log-transformed TIMP-1 levels (P = 0.035). Changes in ieLVMI before and after surgery were consistently correlated with changes in TIMP-1 levels in multivariable regression analysis. In conclusion, KCNJ5 somatic mutations in APA are associated with higher plasma TIMP-1 levels. In addition, TIMP-1 is an effective biomarker for detecting the presence of KCNJ5 mutations in APA patients.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of stage 1 hypertension before 20 gestational weeks on pregnancy outcomes in twin pregnancies: a retrospective cohort study. 20 孕周前 1 期高血压对双胎妊娠结局的影响：一项回顾性队列研究。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-16 DOI: 10.1038/s41440-024-02001-1

Yuanqing Xia, Yunfan Yang, Xiaohan Su, Yiting Chen, Renyi Hua, Li Gao, Shuping Lyu, Yuru Tan, Dongjian Yang, Lu Liu, Yanlin Wang

{"title":"Impact of stage 1 hypertension before 20 gestational weeks on pregnancy outcomes in twin pregnancies: a retrospective cohort study.","authors":"Yuanqing Xia, Yunfan Yang, Xiaohan Su, Yiting Chen, Renyi Hua, Li Gao, Shuping Lyu, Yuru Tan, Dongjian Yang, Lu Liu, Yanlin Wang","doi":"10.1038/s41440-024-02001-1","DOIUrl":"10.1038/s41440-024-02001-1","url":null,"abstract":"To explore the association between stage 1 hypertension before 20 weeks of gestation and twin pregnancy outcomes and to examine whether the association varies by prepregnancy BMI, conception mode, or chorionicity, we conducted a single-center, retrospective, hospital-based cohort study. All women who delivered twins between July 2014 and December 2020 were recruited. Logistic regression and linear regression models were used to identify associations. Among the 2069 included twin pregnancies, 1326 had normotension (< 130/80 mm Hg), and 743 had stage 1 hypertension (130-139/80-89 mm Hg). Compared with normotension, stage 1 hypertension was associated with higher risks of hypertension disorders of pregnancy (adjusted OR: 2.07, 95% CI: 1.62 ~ 2.64), gestational hypertension (adjusted OR: 3.99, 95% CI: 2.42 ~ 6.58), preeclampsia (adjusted OR: 1.71, 95% CI: 1.30 ~ 2.25), early preterm birth (adjusted OR: 1.58, 95%CI: 1.16 ~ 2.15), and small for gestational age (adjusted OR:1.45, 95%CI: 1.20 ~ 1.75). In particular, there were interaction effects between chorionicity and stage 1 hypertension on the risk of early preterm birth (Pinteraction = 0.014). In conclusion, stage 1 hypertension before 20 weeks of gestation is associated with a higher risk of adverse outcomes in twin pregnancies, and the associations vary by prepregnancy BMI and chorionicity. Obstetricians should take this into careful consideration during prenatal care to mitigate the potential risks of twins.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of nocturnal blood pressure dipping status detected by home vs. ambulatory blood pressure monitoring: analysis of J-HOP Nocturnal BP Study data. 家庭血压监测与门诊血压监测检测到的夜间血压下降状况比较：J-HOP 夜间血压研究数据分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-16 DOI: 10.1038/s41440-024-02059-x

Naoko Tomitani, Satoshi Hoshide, Kazuomi Kario

引用次数: 0

Correction: Deep learning assists early-detection of hypertension-mediated heart change on ECG signals. 纠正：深度学习有助于早期发现高血压介导的心电信号心脏变化。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-16 DOI: 10.1038/s41440-024-01980-5

Chengwei Liang, Fan Yang, Xiaobing Huang, Lijuan Zhang, Ying Wang

引用次数: 0

Commentary on 'Physician knowledge, awareness and instructions of home blood pressure monitoring: Asia HBPM survey in Taiwan' a large gap between the guidelines and reality. 关于 "医生对家庭血压监测的了解、认识和指导：台湾亚洲 HBPM 调查 "的评论，指南与现实之间存在巨大差距。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-13 DOI: 10.1038/s41440-024-02058-y

Jiwon Seo, Sungha Park

引用次数: 0

Second home blood pressure measurements per occasion predict incident cardiovascular events in type 2 diabetes: KAMOGAWA-HBP study. 第二次家庭血压测量可预测 2 型糖尿病患者的心血管事件：KAMOGAWA-HBP 研究。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-13 DOI: 10.1038/s41440-024-02049-z

Madoka Sumi, Emi Ushigome, Nobuko Kitagawa, Noriyuki Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Naoko Nakanishi, Hiroshi Okada, Masahide Hamaguchi, Michiaki Fukui

{"title":"Second home blood pressure measurements per occasion predict incident cardiovascular events in type 2 diabetes: KAMOGAWA-HBP study.","authors":"Madoka Sumi, Emi Ushigome, Nobuko Kitagawa, Noriyuki Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Naoko Nakanishi, Hiroshi Okada, Masahide Hamaguchi, Michiaki Fukui","doi":"10.1038/s41440-024-02049-z","DOIUrl":"10.1038/s41440-024-02049-z","url":null,"abstract":"Home blood pressure (HBP) monitoring is a better prognostic predictor than clinical BP monitoring. However, the suggested number of HBP measurements in each occasion varies across guidelines. The study aimed to identify which HBP measurements in each occasion are more closely associated with new cardiovascular events in patients with type 2 diabetes. This retrospective cohort study included 1082 patients with type 2 diabetes without a history of macrovascular complications. HBP was measured three times each morning and evening for 14 days, and the average value over the 14 days was calculated. During a median follow-up of 7.0 years, 117 patients (11.1%) had cardiovascular events. The Cox proportional hazards model was used to examine the association between the average morning home systolic BP (MHSBP) for the 1st, 2nd, and 3rd measurements and cardiovascular events. The adjusted hazard ratios (HR) (95% confidence interval) for the onset of cardiovascular events in the 2nd and 3rd mean MHSBP were 1.129 (1.008-1.265) and 1.135 (1.010-1.275), respectively. The area under the receiver-operating characteristic curve (AUC) for the 2nd, 1st/2nd, 2nd/3rd, and 1st/2nd/3rd mean MHSBP was significantly greater than that of the 1st mean MHSBP (p = 0.040, p = 0.014, p = 0.020, and p = 0.021, respectively). No significant difference was observed between the AUC of the 2nd/3rd and 1st/2nd/3rd mean MHSBP and that of the 1st/2nd mean MHSBP. We recommend that HBP measurements be taken just twice per occasion to predict cardiovascular events in patients with type 2 diabetes.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder. 考虑到伴有肥胖和糖耐量障碍的候选肾脏供者的年龄相关性肾功能下降，超滤过的定义。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-12-12 DOI: 10.1038/s41440-024-02020-y

Akihiro Tsuda, Katsuhito Mori, Hideki Uedono, Shinya Nakatani, Yuki Nagata, Masafumi Kurajoh, Shinsuke Yamada, Tomoaki Morioka, Eiji Ishimura, Junji Uchida, Masanori Emoto

{"title":"Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder.","authors":"Akihiro Tsuda, Katsuhito Mori, Hideki Uedono, Shinya Nakatani, Yuki Nagata, Masafumi Kurajoh, Shinsuke Yamada, Tomoaki Morioka, Eiji Ishimura, Junji Uchida, Masanori Emoto","doi":"10.1038/s41440-024-02020-y","DOIUrl":"10.1038/s41440-024-02020-y","url":null,"abstract":"The definition of hyperfiltration, the main pathogenesis in renal impairment in obesity and diabetes mellitus, is uncertain. Glomerular filtration rate (GFR) declines physiologically with aging, and there is inaccuracy in GFR in obesity due to body surface area (BSA) correction. Here, we defined hyperfiltration using GFR without BSA correction, but with inclusion of aging, and investigated hyperfiltration using this definition and absolute GFR > 125 mL/min. The subjects were 180 kidney donor candidates (56.4 ± 11.3 years old, 79 males). GFR was evaluated using inulin clearance. A two-hour 75-g oral glucose tolerance test was also performed. The subjects were divided into four groups with and without a combination of glucose tolerance disorder and BMI. Normal glucose tolerance (NGT) and BMI < 25 kg/m2 were defined as normal, and hyperfiltration was defined as the upper 95% confidence interval of the relationship of aging and GFR in normal cases, and compared with GFR > 125 mL/min. RESULTS: GFR without BSA correction and UAE in non-NGT subjects with obesity were higher than in other groups, but GFR with BSA correction did not show this relationship. In multiple regression analysis, BMI was independently associated with GFR without BSA correction, but not with BSA correction. Aging was consistently associated with GFR. The prevalence of hyperfiltration by our definition (GFR = -0.883 × Age + 167.398) was significantly higher than that using GFR > 125 mL/min (P < 0.0001). Hyperfiltration in obesity and/or glucose tolerance disorder should be evaluated using GFR without BSA correction and including the decline of GFR due to aging.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0