Hypertension Research最新文献_第6页

Time in target range for systolic blood pressure and glucose with cardiovascular disease and all-cause mortality risks. 收缩压和血糖处于目标范围的时间与心血管疾病和全因死亡风险的关系。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-30 DOI: 10.1038/s41440-024-01969-0

Yijun Zhang, Xue Tian, Qin Xu, Xue Xia, Shuohua Chen, Yi Wang, Shouling Wu, Anxin Wang

{"title":"Time in target range for systolic blood pressure and glucose with cardiovascular disease and all-cause mortality risks.","authors":"Yijun Zhang, Xue Tian, Qin Xu, Xue Xia, Shuohua Chen, Yi Wang, Shouling Wu, Anxin Wang","doi":"10.1038/s41440-024-01969-0","DOIUrl":"https://doi.org/10.1038/s41440-024-01969-0","url":null,"abstract":"Evidence on the combined effect of time in the target range (TTR) for systolic blood pressure (SBP) and fasting blood glucose (FBG) in real-world settings was scarce. We aimed to evaluate the separate and combined effects of SBP TTR and FBG TTR on cardiovascular disease (CVD) and all-cause mortality risks among participants with comorbidity of hypertension and diabetes. The data was derived from the Kailuan study. The target ranges for SBP and FBG were set as 110-140 mmHg and 3.9-7.0 mmol/L, and linear interpolation to calculate TTR. Cox proportional hazard regression models were used to estimate the separate and combined effects of SBP TTR and FBG TTR on CVD and all-cause mortality risks. We included 11,899 participants with hypertension and diabetes comorbidity whose mean age was 54.52 ± 10.36 years, and 9,873 (83.00%) were male. After a follow-up of 6.67 years, 1,381 cases of CVD and 2,148 cases of all-cause mortality were documented. In the fully adjusted model, compared with the participants with both SBP TTR and FBG TTR lower than 25%, participants with both greater SBP TTR and FBG TTR had the lowest risks of CVD (HR: 0.53; 95%CI: 0.57-0.78) and mortality (HR: 0.59; 95%CI: 0.47-0.74). Per 1 SD increase in SBP TTR was associated with a 14% reduction in CVD risk (HR, 0.86; 95% CI, 0.80-0.92) and a 10% reduction in mortality risk (HR, 0.90; 95% CI, 0.85-0.95), all significant results were maintained in the FBG TTR analyses. Both higher SBP TTR and FBG TTR were associated with lower risks of CVD and all-cause mortality in participants with comorbidity of hypertension and diabetes. Simultaneous control of SBP and FBG within the target ranges is a beneficial strategy for CVD prevention.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of atherosclerotic cerebro-cardiovascular disease: a key objective in blood pressure management for coronary artery disease in East Asia. 预防动脉粥样硬化性脑心血管疾病：东亚冠心病血压管理的关键目标。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-30 DOI: 10.1038/s41440-024-01966-3

Hisashi Kai

引用次数: 0

Relationship between white-coat hypertension and office isolated systolic or diastolic hypertension: an ambulatory blood pressure monitoring study. 白大衣高血压与办公室孤立收缩性或舒张性高血压之间的关系：流动血压监测研究。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-29 DOI: 10.1038/s41440-024-01973-4

Christian S Dal Pont, Fábio Argenta, Rodrigo Bezerra, Gustavo M Viana, Siegmar Starke, Guilherme S A Azevedo, Marco A Mota-Gomes, Weimar S Barroso, Roberto D Miranda, Eduardo C D Barbosa, Andréa A Brandão, Camila L D M Feitosa, Thales A T Gonçalves, Fernando Nobre, Decio Mion, Andrei C Sposito, Audes D M Feitosa, Wilson Nadruz

{"title":"Relationship between white-coat hypertension and office isolated systolic or diastolic hypertension: an ambulatory blood pressure monitoring study.","authors":"Christian S Dal Pont, Fábio Argenta, Rodrigo Bezerra, Gustavo M Viana, Siegmar Starke, Guilherme S A Azevedo, Marco A Mota-Gomes, Weimar S Barroso, Roberto D Miranda, Eduardo C D Barbosa, Andréa A Brandão, Camila L D M Feitosa, Thales A T Gonçalves, Fernando Nobre, Decio Mion, Andrei C Sposito, Audes D M Feitosa, Wilson Nadruz","doi":"10.1038/s41440-024-01973-4","DOIUrl":"https://doi.org/10.1038/s41440-024-01973-4","url":null,"abstract":"This study investigated the prevalence of white-coat hypertension (WCH) among individuals with office isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH). We evaluated 9122 individuals [57.0 ± 14.5 years, 51% men] with office blood pressure ≥140/90 mmHg who underwent ambulatory blood pressure monitoring (ABPM) and were categorized into younger (<40-years), middle-aged (≥40 and <60-years) and older (≥60-years) groups. The prevalence of WCH in SDH, ISH, and IDH was 18, 61, and 37% in younger, 16, 55, and 29% in middle-aged, and 23, 51, and 40% in older individuals. Multivariable logistic regression analysis showed a higher likelihood of WCH in ISH (4.1, 3.6, and 2.1-fold all p < 0.001) and IDH (1.9, 1.5, and 1.5-fold; all p < 0.001) compared to SDH among younger, middle-aged and older individuals, respectively. These data indicate that ISH and, to a minor extent, IDH are linked to a higher prevalence of WCH derived from ABPM exams.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of dietary potassium and salt substitution in the prevention and management of hypertension. 膳食钾和食盐替代品在预防和控制高血压中的作用。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-29 DOI: 10.1038/s41440-024-01862-w

Yook-Chin Chia, Feng J He, Maong-Hui Cheng, Jinho Shin, Hao-Min Cheng, Apichard Sukonthasarn, Tzung-Dau Wang, Minh Van Huynh, Peera Buranakitjaroen, Jorge Sison, Saulat Siddique, Yuda Turana, Narsingh Verma, Jam Chin Tay, Markus P Schlaich, Ji-Guang Wang, Kazoumi Kario

{"title":"Role of dietary potassium and salt substitution in the prevention and management of hypertension.","authors":"Yook-Chin Chia, Feng J He, Maong-Hui Cheng, Jinho Shin, Hao-Min Cheng, Apichard Sukonthasarn, Tzung-Dau Wang, Minh Van Huynh, Peera Buranakitjaroen, Jorge Sison, Saulat Siddique, Yuda Turana, Narsingh Verma, Jam Chin Tay, Markus P Schlaich, Ji-Guang Wang, Kazoumi Kario","doi":"10.1038/s41440-024-01862-w","DOIUrl":"https://doi.org/10.1038/s41440-024-01862-w","url":null,"abstract":"Cardiovascular diseases (CVD) continue to be the leading cause of deaths and disability worldwide and the major contributor is hypertension. Despite all the improvements in detecting hypertension together with technological advances and affordable, efficacious and relatively free of adverse effects anti-hypertensive agents, we continue to struggle to prevent the onset of hypertension and to control blood pressure (BP) to acceptable targets. The poor control of hypertension is commonly due to non-adherence to medications. Another reason is the failure to adopt diet and lifestyle changes. Reduction of dietary salt intake is important for lowering BP but the role of potassium intake is also important. Globally the intake of sodium is double that of the recommended 2 gm per day (equivalent to 5 gm of sodium chloride/salt) and half that of the daily recommended intake of potassium of 3500 mg/day, giving a sodium-to-potassium ratio of >1, when ideally it should be <1. Many studies have shown that a higher potassium intake is associated with lower BPs, particularly when coupled concurrently with a lower sodium intake giving a lower sodium to potassium ratio. Most hypertension guidelines, while recommending reduction of salt intake to a set target, do not specifically recommend a target for potassium intake nor potassium supplementation. Here we review the role of potassium and salt substitution with potassium in the management of hypertension. Hence, the focus of dietary changes to lower BP and improve BP control should not be on reduction of salt intake alone but more importantly should include an increase in potassium intake.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of carotid body activity using low-intensity focused ultrasound: a potential treatment option for refractory hypertension. 利用低强度聚焦超声波下调颈动脉体活动：难治性高血压的一种潜在治疗方案。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01977-0

Yasuyoshi Takei

引用次数: 0

Impact of wrist-measured nocturnal hypertension on cardiovascular prognosis: study design and baseline characteristics of the WISDOM-Night study. 腕部测量的夜间高血压对心血管预后的影响：WISDOM-Night 研究的研究设计和基线特征。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01978-z

Naoki Nakagawa

引用次数: 0

Home blood pressure control and prescribing patterns of anti-hypertensive medications in a home blood pressure-based hypertension-specialized clinic in Japan: a sub-analysis of the Ohasama study. 日本以家庭血压为基础的高血压专科门诊的家庭血压控制和抗高血压药物处方模式：Ohasama 研究的子分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-28 DOI: 10.1038/s41440-024-01954-7

Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

{"title":"Home blood pressure control and prescribing patterns of anti-hypertensive medications in a home blood pressure-based hypertension-specialized clinic in Japan: a sub-analysis of the Ohasama study.","authors":"Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai","doi":"10.1038/s41440-024-01954-7","DOIUrl":"10.1038/s41440-024-01954-7","url":null,"abstract":"Although the benefits of anti-hypertensive treatment are well known, the proportion of hypertensive patients with controlled blood pressure (BP) remains suboptimal. The present study aimed to compare BP control conditions in a hypertension-specialized clinic and non-hypertension-specialized clinics. This cross-sectional study used data from 379 treated patients who measured home BP in the Ohasama study between 2016 and 2019 (men: 43.0%, age: 71.6 years). Of those, 172 patients were managed at the hypertension-specialized clinic where physicians distributed home BP devices to each patient, evaluated the home BP data, and adjusted medications to maintain home BP values according to the recent Japanese guidelines. When we set morning home systolic/diastolic BP of <135/ < 85 mmHg as controlled BP, 93.6% of patients fulfilled the controlled home BP range, compared to 43.0% in non-specialized clinics (n = 207). The proportion of the patients with home morning BP < 125/ < 75 mmHg was 73.3% in the hypertension-specialized clinic and 20.8% in the non-hypertension-specialized clinics. Hypertension-specialized clinics prescribed three or more anti-hypertensive drug classes to 41.9% of patients, compared to 15.2% in non-specialized clinics. In the hypertension-specialized clinic, angiotensin II receptor blockers were most commonly prescribed (86.6%), followed by dihydropyridine calcium channel blockers (77.9%), thiazide (including thiazide-like) diuretics (30.2%), mineralocorticoid receptor blockers (23.8%), and beta- and alpha-beta blockers (10.5%). In conclusion, the proportion of patients with controlled home BP was excellent in the hypertension-specialized clinic. Home BP-based hypertension practices, as recommended in the current Japanese guidelines, may be the key to achieving sufficient BP control.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CureAPP HT is expected to be one piece of the puzzle that physicians and patients can work together to solve the problem of uncontrolled hypertension. CureAPP HT有望成为医生和患者共同解决高血压失控问题的一块拼图。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01962-7

Tetsuro Yoshida

引用次数: 0

Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma. 评估肾上腺切除术和矿质皮质激素受体拮抗剂对醛固酮腺瘤患者心脏重塑和舒张功能的影响。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01946-7

Yu-Ching Chang, Xue-Ming Wu, Tsung-Yan Chen, Uei-Lin Chen, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Fang-Yu Yang, Zheng-Wei Chen, Yi-Yao Chang, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Chi-Sheng Hung, Yen-Hung Lin

{"title":"Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma.","authors":"Yu-Ching Chang, Xue-Ming Wu, Tsung-Yan Chen, Uei-Lin Chen, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Fang-Yu Yang, Zheng-Wei Chen, Yi-Yao Chang, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Chi-Sheng Hung, Yen-Hung Lin","doi":"10.1038/s41440-024-01946-7","DOIUrl":"10.1038/s41440-024-01946-7","url":null,"abstract":"Cardiac remodeling and diastolic dysfunction in patients with aldosterone-producing adenomas (APA) can be improved after adrenalectomy. However, the effect of mineralocorticoid receptor antagonist (MRA) treatment remains unclear. The aim of this study is to evaluate the effect of MRA on cardiac remodeling and diastolic dysfunction in patients with PA. We prospectively enrolled patients with APA from 1993 to 2023, who either received medical treatment with MRAs or underwent adrenalectomy. Biochemical characteristics and echocardiographic findings were collected at baseline and one year after treatment. Propensity score matching was conducted based on baseline biochemical characteristics, left ventricular mass index (LVMI), and diastolic function. A total of 467 APA patients were enrolled in the study. After propensity score matching, 159 patients who underwent adrenalectomy were matched with 159 patients who received MRAs. After therapy, patients who received MRAs showed significant improvement in diastolic function after one year of treatment but not LVMI. Compared to the MRA group, the adrenalectomy group had greater improvement in systolic blood pressure, plasma aldosterone concentration, plasma renin activity, aldosterone-to-renin ratio, and LVMI. In multivariable regression analysis, pretreatment echocardiographic values were significantly associated with changes in both LVMI and E/e', while the treatment strategy showed a significant association with changes in LVMI. Thus, one year after therapy, both adrenalectomy and MRA are effective in improving diastolic function in patients with APA. However, adrenalectomy is more effective than MRA treatment in reversing cardiac remodeling in patients with APA.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis. 脉搏波速度与脑微小出血之间的关系：系统回顾和荟萃分析。

IF 4.3 2区医学

Hypertension Research Pub Date : 2024-10-25 DOI: 10.1038/s41440-024-01963-6

Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Iris Otero-Luis

{"title":"Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis.","authors":"Carla Geovanna Lever-Megina, Iván Cavero-Redondo, Alicia Saz-Lara, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Iris Otero-Luis","doi":"10.1038/s41440-024-01963-6","DOIUrl":"https://doi.org/10.1038/s41440-024-01963-6","url":null,"abstract":"Cerebral microbleeds are associated with events that are among the highest mortality and disability events combined worldwide, as well as with hypertensive vasculopathy. The aim of the present study was to investigate the relationship between a marker of hypertensive vasculopathy, arterial stiffness assessed by pulse wave velocity, and cerebral microbleeds. A systematic review and meta-analysis was performed using PubMed, Scopus, and Web of Science, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Cochrane Collaboration Handbook statements. Data extraction, quality assessment and statistical analyses were performed following pre-established criteria. Twenty-one studies involving 18,436 participants were included. Higher levels of pulse wave velocity were associated with a higher presence of cerebral microbleeds p-OR = 1.26 (95% CI; 1.09-1.45), with considerable heterogeneity; even adjusting for potential confounding variables p-OR = 1.12 (95% CI, 1.05-1.20), with substantial heterogeneity. Only the percentage of women was related to p-OR in the adjusted model. Sensitivity analyses confirmed the robustness of our results. Adjusted models showed publication bias. Higher levels of arterial stiffness are associated with greater presence of cerebral microbleeds. This phenomenon may be caused by damage to the brain under higher blood flow loads, in turn due to age-induced reversal of the stiffness gradient between large and small vessels. As the world's population is undergoing demographic ageing, our results underline the importance of establishing pulse wave velocity as a cardiovascular marker for early screening and delaying the onset of the characteristic signs of both diseases.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0