Hypertension Research最新文献_第6页

Dietary supplements and prevention of preeclampsia.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-10 DOI: 10.1038/s41440-025-02144-9

Takafumi Ushida, Sho Tano, Seiko Matsuo, Kazuya Fuma, Kenji Imai, Hiroaki Kajiyama, Tomomi Kotani

{"title":"Dietary supplements and prevention of preeclampsia.","authors":"Takafumi Ushida, Sho Tano, Seiko Matsuo, Kazuya Fuma, Kenji Imai, Hiroaki Kajiyama, Tomomi Kotani","doi":"10.1038/s41440-025-02144-9","DOIUrl":"https://doi.org/10.1038/s41440-025-02144-9","url":null,"abstract":"Preeclampsia (PE) is a common pregnancy complication characterized by hypertension, proteinuria, and end-organ dysfunction. However, to date, no effective treatment has been established other than iatrogenic delivery, and the importance of prevention as an alternative approach to addressing PE has been emphasized. There is growing evidence on the effectiveness of pharmacological and non-pharmacological prophylaxis in preventing PE. In this review, we focused on dietary supplements as non-pharmacological prophylaxis for PE. Calcium is a well-documented supplement for the prevention of PE. Daily 500 mg calcium supplementation can roughly halve the risk of PE in settings where calcium intake is low, including in Japan. According to recent systematic reviews and network meta-analyses, current evidence on the efficacy of vitamin D supplementation is inconsistent. Although vitamin D is a candidate for the prevention of PE, future large-scale randomized control trials are necessary to draw definitive conclusions. We also reviewed other dietary supplements, including vitamins (vitamins A, B6, C, and E, folic acid, and multivitamins), minerals (magnesium, zinc, and iron), amino acids (l-arginine and l-carnitine), anti-oxidants (lycopene, resveratrol, and astaxanthin), and other agents (omega-3 fatty acids, coenzyme Q10, melatonin, and s-equol). In this study, we provide a comprehensive approach to help develop better preventive strategies and ultimately reduce the burden of PE.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aorticorenal ganglion ablation for blood pressure lowering in canine models.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-10 DOI: 10.1038/s41440-025-02129-8

Teng Xu, Yake Lou, Qiaoqiao Li, Jing Huang

{"title":"Aorticorenal ganglion ablation for blood pressure lowering in canine models.","authors":"Teng Xu, Yake Lou, Qiaoqiao Li, Jing Huang","doi":"10.1038/s41440-025-02129-8","DOIUrl":"https://doi.org/10.1038/s41440-025-02129-8","url":null,"abstract":"Studies have shown that renal denervation (RDN) can lower blood pressure (BP) in patients with refractory hypertension, but issues such as renal sympathetic nerve reinnervation and suboptimal BP reduction remain unresolved. In this study, we identified the aorticorenal ganglion (ARG) in canines by observing ambulatory BP responses following electrical stimulation of the ARG. We injected cholera toxin subunit B combined with Alexa Fluor™ 555, a nerve tracer, into the identified ARG and confirmed its innervation of the renal artery and kidney by observing fluorescence in adjacent tissues. Twelve experimental canines were divided equally into an intervention group, which received ARG ablation using 95% ethanol, and a sham control group, which received normal saline. Our results demonstrated that ARG ablation significantly reduced systolic, diastolic, and mean arterial pressures, with minimal impact on heart rate. Additionally, ARG ablation lowered plasma and renal cortex norepinephrine levels, and reduced tyrosine hydroxylase expression in the renal cortex. No adverse events were observed during the 3-month follow-up period. These findings suggest that the ARG may serve as a novel target for RDN and could offer a therapeutic alternative for patients who do not respond to or experience elevated BP after RDN.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JSH2024 smoke-free declaration “Stop All Tobacco Products”

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-024-02073-z

Kimika Arakawa, Yuichi Akasaki, Ako Fukami, Satoko Sakata, Ken Sugimoto, Hirochika Ryuno, Mai Kabayama, Mitsuru Ohishi, JSH Smoke-Free Promotion Committee members, Koichi Node

引用次数: 0

Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02098-y

Haruhiko Shimizu, Takeshi Murakoshi, Shohei Wakisaka, Yuri Hamada, Yumi Shimizu, Kentaro Iga, Hiroko Konno, Kiguna Sei

{"title":"Evaluating the risk factors for preeclampsia in subsequent pregnancies in patients with a history of preeclampsia: a single-institution retrospective study.","authors":"Haruhiko Shimizu, Takeshi Murakoshi, Shohei Wakisaka, Yuri Hamada, Yumi Shimizu, Kentaro Iga, Hiroko Konno, Kiguna Sei","doi":"10.1038/s41440-025-02098-y","DOIUrl":"https://doi.org/10.1038/s41440-025-02098-y","url":null,"abstract":"A history of preeclampsia is the most important risk factor for its development in subsequent pregnancies. However, few studies have focused on the details of previous cases of preeclampsia. This single-institution, retrospective study evaluated the risk of developing preeclampsia in subsequent pregnancies in patients with a history of preeclampsia. Among singleton pregnant women who delivered at our hospital between 2017 and 2021, those who developed hypertensive disorders of pregnancy (HDP) for the first time were recruited. We retrospectively followed patients who had a subsequent pregnancy and delivery at our hospital before 2023 for a recurrence of preeclampsia. Maternal characteristics, time of HDP onset, and mean arterial pressure (MAP) during the first and early second trimester of the subsequent pregnancy were recorded. Of the 7485 deliveries, 413 were first-episode HDP cases, and the outcomes of subsequent pregnancies were noted in 48 patients with initial preeclampsia. Ten patients (21%) had a recurrence of preeclampsia, and those with early onset preeclampsia on the first pregnancy were more likely to have a recurrence (non-recurrent, 4 (11%) vs. recurrent, 5 (50%); p = 0.012). Analysis of the MAP in 40 patients showed higher recurrence rates in patients with elevations in MAP during the early second trimester (ΔMAP (early second - first trimester) median: -6 mmHg vs -3.3 mmHg, p = 0.03). Approximately 20% of patients with initial preeclampsia experience recurrence. The timing of onset in the primary pregnancy is an important predictive factor for preeclampsia in subsequent pregnancies. Changes in MAP may be useful indicators for predicting preeclampsia.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure and in-hospital outcomes in patients hospitalized with atrial fibrillation: findings from the CCC-AF project.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02125-y

Zhaoqing Sun, Yongchen Hao, Jun Liu, Na Yang, Haimei Wang, Yue Qi, Dong Zhao, Jing Liu

{"title":"Blood pressure and in-hospital outcomes in patients hospitalized with atrial fibrillation: findings from the CCC-AF project.","authors":"Zhaoqing Sun, Yongchen Hao, Jun Liu, Na Yang, Haimei Wang, Yue Qi, Dong Zhao, Jing Liu","doi":"10.1038/s41440-025-02125-y","DOIUrl":"https://doi.org/10.1038/s41440-025-02125-y","url":null,"abstract":"The relationship between blood pressure (BP) levels and adverse outcomes in patients with atrial fibrillation (AF) is incompletely understood. Our study aims to elucidate the relationship between BP levels upon admission and in-hospital outcomes in patients hospitalized with AF. Based on the Improving Care for Cardiovascular Disease in China-AF (CCC-AF) project, patients hospitalized with AF collected from 236 hospitals in China from 2015 to 2019 were included in current analysis. A total of 60 390 patients hospitalized with AF were included. Using systolic BP (SBP)/diastolic BP (DBP) of 130-139/80-89 mmHg upon admission as the reference, SBP/DBP ≥160/100 mmHg was associated with an increased risk of stroke/transient ischemic attack (TIA) (adjusted OR, 1.65; 95% CI, 1.27-2.15; P < 0.001) and heart failure (HF) (adjusted OR, 1.29; 95% CI, 1.18-1.41; P < 0.001). SBP/DBP < 120/ < 80 mmHg was associated with an increased risk of HF (adjusted OR, 1.24; 95% CI, 1.14-1.34; P < 0.001), and all-cause death (adjusted OR, 1.90; 95% CI, 1.90-3.86; P < 0.001). A similar pattern was observed in the analysis of the relationship between SBP and DBP levels and in-hospital outcomes, respectively. Among patients hospitalized with AF, higher BP levels upon admission are associated with an increased risk of stroke/TIA and HF, and lower BP levels are associated with an increased risk of HF and all-cause death. Hence, physicians should pay attention to higher and lower BP levels. Randomized trials to identify the optimal treatment target for AF patients are warranted.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocturia and sleep blood pressure - A key link in a vicious cycle?

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-05 DOI: 10.1038/s41440-025-02136-9

Michiaki Nagai, Tarun W Dasari

引用次数: 0

Challenges in monitoring nighttime blood pressure.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-02-03 DOI: 10.1038/s41440-025-02132-z

Naoko Tomitani

引用次数: 0

Correction: Daytime exercises predict nighttime events: association between an exaggerated blood pressure response to exercise and obstructive sleep apnea.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-01-30 DOI: 10.1038/s41440-025-02127-w

Hiromitsu Sekizuka

引用次数: 0

Impact of SARS-CoV-2 variants on viral infectivity and the role of the renin-angiotensin-aldosterone system.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-01-28 DOI: 10.1038/s41440-025-02115-0

Yasushi Matsuzawa, Kenichi Tsujita

引用次数: 0

Effects of obstructive sleep apnea on nocturnal changes in blood pressure - a retrospective study.

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-01-27 DOI: 10.1038/s41440-024-02079-7

Fang-Chi Lin, Hao-Min Cheng, Ming-Ling Yih, Shiang-Fen Huang, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hwa-Yen Chiu

{"title":"Effects of obstructive sleep apnea on nocturnal changes in blood pressure - a retrospective study.","authors":"Fang-Chi Lin, Hao-Min Cheng, Ming-Ling Yih, Shiang-Fen Huang, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hwa-Yen Chiu","doi":"10.1038/s41440-024-02079-7","DOIUrl":"10.1038/s41440-024-02079-7","url":null,"abstract":"To explore the effects of obstructive sleep apnea (OSA) on nocturnal changes in blood pressure (BP), we enrolled 2037 participants who underwent polysomnography (PSG) between 2019 and 2020 and examined BP changes before and after sleep. BP was measured in the evening and the following morning using an electronic wrist sphygmomanometer in the supine position. The severity of OSA was determined by PSG and graded based on the apnea/hypopnea index (AHI). Participants with OSA (AHI ≥ 5 events/h) had significantly higher morning systolic BP (SBP) and diastolic BP (DBP) compared to their evening measurements. BP values, whether measured in the evening or the morning, as well as the nocturnal changes (differences between morning and evening values), showed significant correlations with the AHI for both SBP and DBP, even after adjusting for confounders such as age, sex, body mass index, and the presence of comorbidities, including hypertension, heart failure, coronary artery disease, diabetes, renal disorder, and cerebrovascular attack. After standardization, the extent of nocturnal changes in DBP was greater than SBP, especially among participants with severe OSA. In a logistic regression model with serial multivariate adjustments, OSA was found to be independently associated with morning hypertension, particularly in individuals with moderate to severe OSA.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0