Hypertension Research最新文献

{"title":"Mashike: a town of zero-hypertension.","authors":"Naoki Nakagawa","doi":"10.1038/s41440-025-02366-x","DOIUrl":"https://doi.org/10.1038/s41440-025-02366-x","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to manage water and salt intake during the hot summer of 2025.","authors":"Takuya Kishi, Katsuyuki Miura, Atsushi Sakima, Yukari Takemi, Tatsuo Shimosawa, Chisa Matsumoto, Kazuomi Kario","doi":"10.1038/s41440-025-02367-w","DOIUrl":"https://doi.org/10.1038/s41440-025-02367-w","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of a wearable watch-type oscillometric blood pressure monitor in rest and ambulatory blood pressure measurements.","authors":"Yi Zhou, Wei Zhang, Xin-Yu Wang, Yi Zhou, Yan Li, Ji-Guang Wang","doi":"10.1038/s41440-025-02345-2","DOIUrl":"https://doi.org/10.1038/s41440-025-02345-2","url":null,"abstract":"<p><p>The aim of this study was to evaluate the accuracy of a watch-type oscillometric BP monitor HUAWEI WATCH D2 for rest and ambulatory BP measurements and compare with a conventional ambulatory BP monitor (A&D TM-2430, Tokyo, Japan). Subjects were recruited to fulfill the age, gender, BP and cuff distributions of the AAMI/ESH/ISO Universal Standard in the general population. Two cuffs of the test device were used for wrist circumference 13-16 (medium) and 16-21 cm (large), respectively. During the ambulatory validation study, subjects were asked to pedal at a low workload to elevate heart rate. For the 24-h ambulatory measurement, two BP monitoring devices were simultaneously worn on the same arm with the A&D cuff on the patient's left arm and the HUAWEI WATCH D2 on the left wrist. In the study on rest BP measurement, 95 subjects were recruited and 85 were analyzed. For validation criterion 1, the mean ± standard deviation (SD) of the differences between the test device and reference BP readings was -1.6 ± 6.4/-1.9 ± 5.0 mmHg. For criterion 2, the SD of the mean BP differences between the test device and reference BP readings per subject was 5.8/4.7 mmHg. In the ambulatory validation study, the mean difference between the device and observers was -0.9 ± 7.3 mmHg and -0.7 ± 4.9 mmHg for systolic and diastolic BP, respectively. We also compared the 24-h BP data with the HUAWEI WATCH D2 and cuff-based A&D in 35 adults. The mean difference (±SD) in systolic/diastolic BP between the device and A&D were -1.1 ± 6.3/1.0 ± 4.2 mmHg, -2.0 ± 6.5/-0.2 ± 4.7 mmHg and 1.2 ± 6.7/ 4.2 ± 4.4 mmHg for 24-h, daytime and nighttime, respectively. The watch-type oscillometric BP monitor HUAWEI WATCH D2 has met the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2: 2018/AMD 1: 2020) in both rest and ambulatory measurements. Moreover, the HUAWEI WATCH D2 achieved acceptable agreement with 24-h ambulatory BP measurement.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding clinical inertia in hypertension management: clues from real-world data.","authors":"Michihiro Satoh","doi":"10.1038/s41440-025-02359-w","DOIUrl":"10.1038/s41440-025-02359-w","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging the public on World Hypertension Day 2025: \"Asakatsu\"-Inspired BP screening and educational forum in Hiroshima, Japan.","authors":"Mari Ishida, Miho Kusaka, Hideo Matsuura, Yukihito Higashi, Ryoji Ozono, Masato Kajikawa, Tatsuya Maruhashi, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Wakako Kawarazaki, Keisuke Shinohara, Kento Kitada, Satoko Nakamura, Ken Kaseda, Mitsuru Ohishi, Shigeru Shibata, Akira Nishiyama, Kazuomi Kario","doi":"10.1038/s41440-025-02333-6","DOIUrl":"https://doi.org/10.1038/s41440-025-02333-6","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typical distribution of hypertensive cerebral microbleed: a matched case-control study using primary aldosteronism.","authors":"Shuhei Ikeda, Yusuke Yakushiji, Kotaro Iida, Tatsuya Doyama, Toshihiro Ide, Kohei Suzuyama, Haruki Koike","doi":"10.1038/s41440-025-02352-3","DOIUrl":"10.1038/s41440-025-02352-3","url":null,"abstract":"<p><p>The topographical distribution of non-strictly lobar cerebral microbleed (CMB) is considered as a neuroimaging marker of hypertensive arteriopathy, but pathological evidence remains insufficient. This case-control study assessed patients with primary aldosteronism (PA), a leading cause of secondary hypertension, to characterize the CMB distribution features of typical hypertensive arteriopathy. A PA group (n = 11) and an age-matched non-hypertensive control group (n = 22) were classified into subgroups based on the presence of any CMB or no CMB using paramagnetic-sensitive MRI. Patients with any CMB were further divided into strictly lobar CMB and non-strictly lobar CMB, defined as either strictly deep and/or infratentorial (D/I) CMB or \"mixed\" (i.e., CMB in both lobar and D/I regions). CMB prevalence was higher in the PA group (81.8% vs. 13.6%, p < 0.001), showing non-strictly lobar patterns in all cases. Total CMB count was also higher (median 3 vs. 0; p < 0.001). Adjusted odds ratios for any CMB and non-strictly lobar CMB were 80.24 and 89.89, respectively. These findings suggest that PA-related small vessel injury affects both deep and cortical/leptomeningeal arterioles, demonstrating a strong association between pure hypertensive small vessel disease and non-strictly lobar CMB distribution.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The skin renin-angiotensin system and hypertension: A TRAP for blood flow capture and water release.","authors":"Masashi Mukoyama","doi":"10.1038/s41440-025-02329-2","DOIUrl":"https://doi.org/10.1038/s41440-025-02329-2","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evening home pulse pressure predicted cardiovascular events and mortality in older adults with hypertension: findings based on the STEP trial.","authors":"Yufei Ji, Xinyi Peng, Sifei Chen, Qirui Song, Jingjing Bai, Jun Cai","doi":"10.1038/s41440-025-02349-y","DOIUrl":"https://doi.org/10.1038/s41440-025-02349-y","url":null,"abstract":"<p><p>Hypertension is a key predictor of cardiovascular disease (CVD) and mortality. Home blood pressure monitoring (HBPM) is a cost-effective way to assess CVD risk, though existing research mainly focuses on morning systolic (SBP) and diastolic (DBP) blood pressure measurements. This study aimed to evaluate whether evening pulse pressure (PP) measured at home could better predict CVD risk and mortality in Chinese older adults with hypertension. Data from the STEP trial, a multicenter, randomized controlled trial, were analyzed. Morning and evening home BP was measured twice a day at least once a week from enrollment to 12 months of follow-up, based on which PP was calculated and categorized into tertiles. The primary outcome was a composite of cardiovascular events and all-cause mortality. Among 7703 participants included in this analysis, 284 composite events occurred during a median follow-up of 3.43 years. Compared to the first tertile evening PP group, the third tertile evening PP group exhibited a 60% (HR = 1.60; 95% CI: 1.12-2.29) higher risk of primary outcome in the final adjusted model. A 26% increased risk was observed with each tertile increment (HR = 1.26; 95% CI: 1.05-1.50, P _trend = 0.0112). For each 10 mmHg increase in evening PP, the risk of outcome events increased by approximately 33%. Higher evening home PP significantly predicts an increased risk of composite events (NRI: 0.16, 95% CI: 0.02-0.29), unlike morning SBP, PP, or evening SBP. Efforts to monitor evening home PP may be an effective strategy to improve BP control and prevent CVD and mortality. Trial Registration: STEP ClinicalTrials.gov number, NCT03015311.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The JSH Morning Hypertension Eradication Program Project.","authors":"Kazuomi Kario, Akira Nishiyama, Shigeru Shibata, Masaki Mogi, Hisatomi Arima, Takuya Kishi, Mari Ishida, Masato Furuhashi, Atsuhiro Ichihara, Tomohiro Katsuya, Katsuyuki Miura, Shin-Ichiro Miura, Mitsuru Ohishi, Hirotaka Shibata, Tatsuo Shimosawa, Akira Sugawara, Kouichi Tamura, Kazunori Toyoda, Koichi Yamamoto, Satoshi Hoshide, Naoki Nakagawa, Hirofumi Tomita, Atsushi Tanaka, Atsushi Hozawa, Tsuguru Hatta, Akihiro Nomura, Mai Kabayama, Hiromi Rakugi, Yusuke Ohya, Koichi Node","doi":"10.1038/s41440-025-02330-9","DOIUrl":"https://doi.org/10.1038/s41440-025-02330-9","url":null,"abstract":"<p><p>Hypertension is the greatest risk factor for cardiovascular diseases and significantly contributes to cardiovascular mortality. In Japan, the hypertensive population is estimated at 43 million, with only 27% achieving well-controlled blood pressure (BP). The onset of major cardiovascular events, including stroke, myocardial infarction, heart failure, and aortic dissection, frequently occurs during the early morning hours. Accordingly, for over 20 years, the Japanese Society of Hypertension (JSH) has prioritized the management of early morning hypertension and has emphasized the importance of antihypertensive treatment guided by home BP in its treatment guidelines. However, even among hypertensive patients with multiple medications, control of morning BP remains suboptimal, with fewer than 30% achieving target levels below 130/80 mmHg. To address this serious situation, JSH announced their Declaration for the Eradication of Morning Hypertension in 2025, in conjunction with the release of the Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025. The primary specific measure of the declaration involves the Asakatsu BP Action Plan - the Morning Blood Pressure 130 Campaign - which encourages individuals to monitor their morning blood pressure (BP) in various settings, such as homes, workplaces, and BP kiosks set up in public spaces. Additionally, JSH is promoting a Systematic Review Project to raise awareness of the importance of early morning hypertension management nationally and internationally, and a Data Science Project to examine how digital technology can contribute to the promotion of personalized and anticipation medicine through \"digital hypertension\" research.</p>","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modifying effect of 11β-HSD in hypertension of diabetic patients.","authors":"Pengcheng Yuan, Wenqian Huo","doi":"10.1038/s41440-025-02356-z","DOIUrl":"10.1038/s41440-025-02356-z","url":null,"abstract":"","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}