Hypertension Research最新文献_第5页

Home blood pressure monitoring for improved risk assessment in heart failure: are brachial measurements sufficient? 家用血压监测改善心力衰竭风险评估：肱动脉测量是否足够？

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-25 DOI: 10.1038/s41440-025-02223-x

Alberto Avolio

引用次数: 0

Striving toward effective management of target organ damage. 致力于目标器官损伤的有效管理。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-25 DOI: 10.1038/s41440-025-02219-7

Masato Kajikawa, Yukihito Higashi

引用次数: 0

Extracardiac mechanisms of cardiac output affect unexplained dyspnea on exertion. 心输出量的心外机制影响运动时不明原因的呼吸困难。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-25 DOI: 10.1038/s41440-025-02224-w

Masato Kajikawa, Yukihito Higashi

引用次数: 0

Intensive blood pressure-lowering treatment to prevent cardiovascular events in patients with diabetes: a systematic review and meta-analysis. 强化降压治疗预防糖尿病患者心血管事件：系统回顾和荟萃分析

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-23 DOI: 10.1038/s41440-025-02209-9

Makiko Abe, Hiroyoshi Segawa, Sho Kinguchi, Atsushi Satoh, Ryo Zamami, Toshiyuki Nishikido, Atsushi Tanaka, Hirofumi Ohnishi, Koichi Node, Shigeyuki Saitoh, Hisatomi Arima, Masato Furuhashi

{"title":"Intensive blood pressure-lowering treatment to prevent cardiovascular events in patients with diabetes: a systematic review and meta-analysis.","authors":"Makiko Abe, Hiroyoshi Segawa, Sho Kinguchi, Atsushi Satoh, Ryo Zamami, Toshiyuki Nishikido, Atsushi Tanaka, Hirofumi Ohnishi, Koichi Node, Shigeyuki Saitoh, Hisatomi Arima, Masato Furuhashi","doi":"10.1038/s41440-025-02209-9","DOIUrl":"https://doi.org/10.1038/s41440-025-02209-9","url":null,"abstract":"The effect of intensive blood pressure (BP) reduction on the prevention of cardiovascular events in patients with diabetes remains unclear. This study evaluated the impact of intensive BP-lowering on cardiovascular events in patients with diabetes compared to standard treatment. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted, comparing intensive treatment (target systolic BP < 130 mmHg or diastolic BP < 80 mmHg) with standard treatment in patients with diabetes. Eligible studies were identified through Ovid MEDLINE, Cochrane Library, and Ichushi. Outcomes included cardiovascular events, coronary artery disease, stroke, all-cause and cardiovascular death, and serious adverse events. Data were analyzed using a random-effects model. Sensitivity analyses were performed to assess the effects of systolic and diastolic BP targets separately. The search identified eight eligible trials comprising 16634 patients with diabetes. Intensive BP-lowering treatment significantly reduced cardiovascular events (risk ratio: 0.848; 95% confidence interval: 0.760, 0.947) and stroke (risk ratio: 0.705; 95% confidence interval: 0.541, 0.918), but not coronary artery disease or all-cause death in analyses including J-DOIT3 trial. Sensitivity analyses showed that DBP-targeted treatment was not associated with the risk of cardiovascular events. Incorporating the latest RCT strengthened the association between intensive treatment and reduced coronary artery disease risk, without significantly increasing the risk of serious adverse events. These findings recommend an intensive BP-lowering strategy targeting SBP < 130 mmHg or DBP < 80 mmHg to prevent cardiovascular events, particularly stroke, in patients with diabetes.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Even a cold stone will warm up if you sit on it for 3 years. 即使是一块冰冷的石头，只要你在上面坐上3年，它也会变暖的。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-22 DOI: 10.1038/s41440-025-02213-z

Keisuke Kida, Norio Suzuki

引用次数: 0

Impact of blood pressure variability on the prediction of cancer therapy-related cardiovascular toxicity in patients with multiple myeloma. 血压变异性对多发性骨髓瘤患者癌症治疗相关心血管毒性预测的影响

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-16 DOI: 10.1038/s41440-025-02215-x

Satoshi Morimoto, Atsuhiro Ichihara

引用次数: 0

Fatty acid profiles in aldosterone-producing adenoma: insights into pathogenetic significance. 脂肪酸谱在醛固酮产生腺瘤：洞察病理意义。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-16 DOI: 10.1038/s41440-025-02211-1

Masanori Murakami

引用次数: 0

Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats. 基于大鼠转录组学分析的高血压潜在生物标志物鉴定。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-16 DOI: 10.1038/s41440-025-02200-4

Wei Gu, Jielin Liu, Ya Liu, Zuoguang Wang

{"title":"Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats.","authors":"Wei Gu, Jielin Liu, Ya Liu, Zuoguang Wang","doi":"10.1038/s41440-025-02200-4","DOIUrl":"https://doi.org/10.1038/s41440-025-02200-4","url":null,"abstract":"Hypertension is a complex disorder influenced by genetic predisposition, neural and endocrine dysregulation, cardiovascular and renal dysfunction, and unhealthy lifestyles. It is a major risk factor for many diseases. However, the pathophysiological mechanisms underlying hypertension have not been systematically characterized to date. In this study, we compared physiological and molecular changes between spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY, control strain) models using RNA sequencing. Blood pressure increased significantly in SHR models over 3-15 weeks compared with WKY control rats. Furthermore, indicators of cardiac remodeling and fibrosis were elevated in SHR on echocardiography and immunohistochemical analyses. RNA sequencing findings revealed differentially expressed genes between SHRs and WKYs in each week, which were related to dysregulation of Epstein-Barr virus infection, fluid shear stress and atherosclerosis, RNA degradation, and endocrine resistance. Transcriptome analysis showed that differentially expressed genes related to hypertension were involved in the hypoxia inducible factor-1 (HIF-1) and interleukin-17 (IL-17) signaling pathways. Furthermore, Gene Ontology (GO) functional analysis showed that differentially expressed genes were mainly associated with catalytic activity and protein binding. The Venn diagram analysis identified KCNE1, Lad1, SLC9A3, and Frzb as potential targets of hypertension. In addition, the expression of these four genes exhibited excellent sensitivity and specificity, suggesting their potential diagnostic utility in hypertension. These findings support a theoretical basis for understanding hypertension and related heart remodeling.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nature or nurture? That is the question. 天生的还是后天的？这就是问题所在。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-14 DOI: 10.1038/s41440-025-02210-2

Tatsuo Shimosawa

引用次数: 0

What can be done to reduce undiagnosed or untreated hypertension: effective use of health checkups. 如何减少未确诊或未经治疗的高血压：有效利用健康检查。

IF 4.3 2区医学

Hypertension Research Pub Date : 2025-04-09 DOI: 10.1038/s41440-025-02202-2

Kimika Arakawa

引用次数: 0