Hypertension Research最新文献_第4页

Combined blood pressure and pulse rate as a new risk marker for mortality in hemodialysis patients. 联合血压和脉搏率作为血液透析患者死亡的新危险指标。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-09-01 DOI: 10.1038/s41440-025-02301-0

Takeshi Kanda, Jun Yoshino

引用次数: 0

Clinical significance of severe proteinuria in preeclampsia: a multicenter study of maternal and neonatal outcomes. 子痫前期严重蛋白尿的临床意义：一项孕产妇和新生儿结局的多中心研究。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-09-01 DOI: 10.1038/s41440-025-02360-3

Mamoru Morikawa, Akihide Ohkuchi, Takayuki Iriyama, Kazuya Mimura, Kazushi Watanabe, Takafumi Ushida, Tomoyoshi Nohira, Keiichi Matsubara, Ikuno Kawabata, Shintaro Maki, Katsuhiko Naruse, Hirotada Suzuki, Yu Ariyoshi, Hiroyuki Seki, Ichihara Atsuhiro, Shigeru Saito

{"title":"Clinical significance of severe proteinuria in preeclampsia: a multicenter study of maternal and neonatal outcomes.","authors":"Mamoru Morikawa, Akihide Ohkuchi, Takayuki Iriyama, Kazuya Mimura, Kazushi Watanabe, Takafumi Ushida, Tomoyoshi Nohira, Keiichi Matsubara, Ikuno Kawabata, Shintaro Maki, Katsuhiko Naruse, Hirotada Suzuki, Yu Ariyoshi, Hiroyuki Seki, Ichihara Atsuhiro, Shigeru Saito","doi":"10.1038/s41440-025-02360-3","DOIUrl":"10.1038/s41440-025-02360-3","url":null,"abstract":"This study aimed to determine the association between proteinuria severity and maternal/neonatal outcomes among preeclamptic women with hypertension with proteinuria. We retrospectively assessed 721 women at 11 institutions. All participants had singleton pregnancies and delivered at ≥22 gestational weeks. They were diagnosed with preeclampsia (excluding superimposed preeclampsia) after 20 gestational weeks and had results from a spot urine protein/creatinine ratio test at delivery. The severe proteinuria significantly increased the frequency of preterm delivery in the both women of severe and nonsevere hypertension (72.3% vs. 49.9%, 57.5% vs. 24.8%, p < 0.001, respectively). In the nonsevere hypertension and severe proteinuria group comparison with the severe hypertension and nonsevere proteinuria group, the frequency of women with pulmonary edema/pleural effusion onset was significantly higher (15.0% vs. 5.8%, p = 0.041) and the median serum albumin was significantly lower (2.6 g/dL vs. 2.8 g/dL, p < 0.001). Furthermore, the serum albumin was the laboratory findings with the highest relationship to u-P/C ratio at delivery. Women with preeclampsia with severe hypoalbuminemia had a significant high risk of developing severe proteinuria and pulmonary edema/pleural effusion at delivery than those without severe hypoalbuminemia, respectively. However, severe hypoalbuminemia was not the risk factor for severe hypertension in women with preeclampsia. Women with preeclampsia with severe proteinuria would have worse maternal outcome (pulmonary edema and/or pleural effusion induced by hypoalbuminemia) than those with severe hypertension. In conclusion, obstetricians should be aware of the risk of maternal pulmonary edema/pleural effusion in cases of preeclampsia with nonsevere hypertension with severe proteinuria.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of long-term exposure to ambient air pollution and residential greenness with hypertension among adults: a cross-sectional study in Northwestern of China. 中国西北地区成年人长期暴露于环境空气污染和住宅绿化与高血压的关系：一项横断面研究

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-09-01 DOI: 10.1038/s41440-025-02368-9

Yinlin Cheng, Mingyue Xue, Weidong Ji, Lin Li, Yining Yang, Shengsheng Tang, Hongze Liu, Kuiying Gu, Yi Zhou

{"title":"Association of long-term exposure to ambient air pollution and residential greenness with hypertension among adults: a cross-sectional study in Northwestern of China.","authors":"Yinlin Cheng, Mingyue Xue, Weidong Ji, Lin Li, Yining Yang, Shengsheng Tang, Hongze Liu, Kuiying Gu, Yi Zhou","doi":"10.1038/s41440-025-02368-9","DOIUrl":"10.1038/s41440-025-02368-9","url":null,"abstract":"Hypertension (HTN), a major contributor to cardiovascular diseases, is linked to ambient air pollution and residential greenness. However, their joint associations remain unclear. This research focuses on assessing the individual and joint associations of ambient air pollution and residential greenness on HTN among Northwestern Chinese adults. In this cross-sectional analysis, 4,214,199 participants in Northwestern China were included. HTN was assessed via standardized assessment protocols. Air pollutant concentrations were estimated via the Space-Time Extra-Trees model, and greenness was assessed through the Normalized Difference Vegetation Index (NDVI). Generalized regression models were employed to assess the individual and joint effects of air pollutants and residential greenness on HTN. The prevalence of HTN was 20.43%. The adjusted odd ratio of HTN for each 10 µg/m3 increase in PM1, PM2.5, PM10 and SO2 were 1.571 (95% CI: 1.556-1.585), 1.070 (95% CI: 1.068-1.072), 1.021 (95% CI: 1.020-1.021) and 1.798 (95% CI: 1.770-1.827), each 0.1-unit increase in NDVI were 0.943 (95% CI: 0.940-0.946) respectively. The negative association of residential greenness with HTN appeared to weaken at higher concentrations of air pollutants. Mediation analysis indicated that body mass index (BMI) partially mediated the effects of both air pollutants and NDVI on HTN risk. Our findings reveal that air pollutants are positively correlated with HTN, while residential greenness shows a negative association. However, this negative association is attenuated at higher concentrations of air pollutants. Additionally, the associations of air pollutants and residential greenness with HTN appear partially mediated by BMI.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the ambulatory blood pressure phenotype and its correlation with hemoglobin concentration in untreated hypertensive individuals permanently living in plateau areas. 高原常住未经治疗的高血压患者动态血压表型及其与血红蛋白浓度的相关性研究

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-09-01 DOI: 10.1038/s41440-025-02350-5

Xin Zhang, Runyu Ye, Xiangyu Yang, Xinran Li, Zhipeng Zhang, Qingtao Meng, Xiaoping Chen

{"title":"Study on the ambulatory blood pressure phenotype and its correlation with hemoglobin concentration in untreated hypertensive individuals permanently living in plateau areas.","authors":"Xin Zhang, Runyu Ye, Xiangyu Yang, Xinran Li, Zhipeng Zhang, Qingtao Meng, Xiaoping Chen","doi":"10.1038/s41440-025-02350-5","DOIUrl":"10.1038/s41440-025-02350-5","url":null,"abstract":"Ambulatory blood pressure monitoring (ABPM) studies for high altitude (HA) hypertensive patients are limited. We aimed to explore the hypertension phenotypes, and investigate their associations with hemoglobin in untreated hypertensives permanently living in HA. A total of 342 untreated hypertensive patients were included. Among the whole population, 91.80% had sustained hypertension (SH). In patients with SH, the proportions of isolated daytime hypertension, isolated nocturnal hypertension, and day-night hypertension were 2.87%, 2.87%, and 94.26%, respectively. Compared to patients with hemoglobin ≥16 g/dL, those with hemoglobin <16 g/dL had higher nocturnal average systolic blood pressure (SBP) (140.33 ± 17.46 vs. 136.26 ± 17.55 mmHg, P = 0.03) and a greater proportion of patients with nocturnal SBP fall<10% (55.00% vs. 43.30%, P = 0.03). Bivariate correlation analysis showed that hemoglobin was negatively correlated with the nocturnal average SBP (r = -0.145, P < 0.01) and was positively related to the nocturnal SBP fall (r = 0.136, P = 0.01). We found that the threshold effect value between hemoglobin and nocturnal blood pressure indices was 16 g/dL. The effect value between hemoglobin and nocturnal average SBP was -3.60 (-5.46, -1.74) for hemoglobin <16 g/dL and 0.88 (-1.07, 2.83) for hemoglobin ≥16 g/dL. Correspondingly, the effect values between hemoglobin and nocturnal SBP fall were 1.53 (0.61, 2.45) and -0.26 (-1.23, 0.70). In addition, hemoglobin was independently correlated with the above-mentioned nocturnal blood pressure indices in those with hemoglobin <16 g/dL. In conclusion, nocturnal hypertension was a prevalent ABPM phenotype in HA hypertensive patients. In those with hemoglobin levels <16 g/dL, hemoglobin concentration shows a significant inverse correlation with nocturnal SBP, suggesting that lower hemoglobin levels may warrant enhanced evaluation of nocturnal BP in this population.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key highlights of the Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025) 日本高血压学会高血压管理指南2025 （JSH2025）的主要亮点。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-29 DOI: 10.1038/s41440-025-02331-8

Yusuke Ohya, Atsushi Sakima, Hisatomi Arima, Ako Fukami, Masato Furuhashi, Mari Ishida, Toshihiko Ishimitsu, Hisashi Kai, Kiyoshi Matsumura, Katsuyuki Miura, Masashi Mukoyama, Masanori Munakata, Takatoshi Ohkubo, Hiromi Rakugi, Takeshi Takami, Takuya Tsuchihashi, Nobuhito Hirawa

{"title":"Key highlights of the Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025)","authors":"Yusuke Ohya, Atsushi Sakima, Hisatomi Arima, Ako Fukami, Masato Furuhashi, Mari Ishida, Toshihiko Ishimitsu, Hisashi Kai, Kiyoshi Matsumura, Katsuyuki Miura, Masashi Mukoyama, Masanori Munakata, Takatoshi Ohkubo, Hiromi Rakugi, Takeshi Takami, Takuya Tsuchihashi, Nobuhito Hirawa","doi":"10.1038/s41440-025-02331-8","DOIUrl":"10.1038/s41440-025-02331-8","url":null,"abstract":"Japan has long maintained a robust national health system with universal health coverage and accessible antihypertensive therapy. Nevertheless, population-level blood pressure (BP) control remains suboptimal. To address this public health challenge, the Japanese Society of Hypertension published the Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025 (JSH2025), integrating evidence-based recommendations and practical approaches to improve hypertension care. JSH2025 introduces a dual-format structure comprising clinical question sections developed through systematic reviews and consensus-based narrative chapters. The key updates include universal BP targets of <130/80 mmHg across populations, promotion of home BP monitoring, stratified cardiovascular risk assessment, expanded guidance on digital health and behavioral interventions, and condition-specific management strategies for older adults, women, and cancer survivors. We outline the major updates and innovations in JSH2025 and show their clinical and public health implications.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2500-2511"},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02331-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The new blood pressure target, a new era: individualized management and precision rooted in clinical decision in JSH2025. 《JSH2025》：新血压目标，新时代：个体化管理，精准化临床决策

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-29 DOI: 10.1038/s41440-025-02357-y

Hisashi Kai

引用次数: 0

Obesity and hypertension by sex. 肥胖和高血压的性别。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-29 DOI: 10.1038/s41440-025-02363-0

Teruhide Koyama

引用次数: 0

Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling. 通过单细胞转录组分析解读外周血单核细胞与血压的遗传关联。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-29 DOI: 10.1038/s41440-025-02344-3

Huan Zhang, Kedi Fan, Shuanglong Jia, Qianyi Gao, Zhentao Zhang, Jianing Long, Dianyuan Li, Xingbo Mo

{"title":"Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling.","authors":"Huan Zhang, Kedi Fan, Shuanglong Jia, Qianyi Gao, Zhentao Zhang, Jianing Long, Dianyuan Li, Xingbo Mo","doi":"10.1038/s41440-025-02344-3","DOIUrl":"https://doi.org/10.1038/s41440-025-02344-3","url":null,"abstract":"Functional genes within genomic loci associated with blood pressure (BP) identified by genome-wide association studies (GWASs) are cell type-specific. This study aims to identify such genes in immune cells by employing single-cell transcriptomic analysis in peripheral blood mononuclear cells (PBMCs). By integration of single-cell transcriptomic sequencing data with GWAS (1 million individuals) findings using the summary data-based Mendelian randomization (SMR) method, we identified candidate BP-associated genes across diverse immune cell subsets. We performed single-cell RNA sequencing on PBMCs (111,694 cells) from 10 individuals (three hypertensive, three pre-hypertensive and four normotensive), identifying gene expression in distinct cell types associated with hypertension. Finally, publicly available data from eight individuals were utilized for validation (28,919 cells). Single-cell expression quantitative trait locus analysis revealed that the BP-associated SNPs were associated with expression levels of 353 genes across 14 distinct immune cell types. The single-cell SMR analysis identified 566 significant associations between expression levels of 159 genes and BP. The analysis of data from hypertensive and normotensive individuals unveils 99 differential expression genes across various immune cell types, with ERAP2 exhibiting significant dysregulation in CD8+ T cells and natural killer cells. These findings were corroborated through validation analyses. Our study contributes to a comprehensive understanding of the intricate relationships between genetic variation, immune cell-specific gene expression, and BP. We demonstrate a compelling association between ERAP2 expression levels in CD8+ T cells and natural killer cells and BP.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JSH encourages food companies to develop and promote low-salt foods. JSH鼓励食品公司开发和推广低盐食品。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-29 DOI: 10.1038/s41440-025-02337-2

Takuya Tsuchihashi, Katsuyuki Ando, Hitomi Hayabuchi, Katsuyuki Miura

引用次数: 0

Achievement rate of blood pressure control <130/80 mmHg as the core metric of implementation hypertension, based on the new JSH2025 and AHA/ACC2025 guidelines. 基于新的JSH2025和AHA/ACC2025指南，将血压控制<130/80 mmHg的完成率作为实施高血压的核心指标。

IF 4.6 2区医学

Hypertension Research Pub Date : 2025-08-28 DOI: 10.1038/s41440-025-02355-0

Kazuomi Kario

{"title":"Achievement rate of blood pressure control <130/80 mmHg as the core metric of implementation hypertension, based on the new JSH2025 and AHA/ACC2025 guidelines.","authors":"Kazuomi Kario","doi":"10.1038/s41440-025-02355-0","DOIUrl":"https://doi.org/10.1038/s41440-025-02355-0","url":null,"abstract":"Recent updates to international hypertension guidelines have converged toward a therapeutic target of <130/80 mmHg, as reflected in the JSH2025, AHA/ACC2025, and ESC2024 recommendations. Strong evidence from major outcome trials such as SPRINT, STEP, BPROAD, and ESPRIT has consistently demonstrated the benefit of intensive blood pressure (BP) control, particularly systolic BP < 130 mmHg, across a wide spectrum of hypertensive populations, including the elderly and those with diabetes, CKD, or cardiovascular comorbidities. The JSH2025 guidelines further emphasize home BP management, setting a lower target of <125/75 mmHg, supported by prospective nationwide studies such as J-HOP and HONEST. However, despite these advances in evidence and recommendations, real-world BP control rates remain unsatisfactory, underscoring the critical need for effective implementation strategies. To address this gap, we propose the \"achievement rate of BP control <130/80 mmHg\" as a unified, core implementation metric for hypertension management. This target is consistent with both JSH2025 and AHA/ACC2025 guidelines, as well as with Japan's Asakatsu campaign. We further recommend a dual-layered evaluation framework: a macro-approach (spatial, population-level) using office BP or health-check BP to assess outcomes in the general hypertensive population, and a micro-approach (temporal, individual-level) using home BP to monitor the quality of daily management and treatment adherence. Adopting this integrated framework will enable the simultaneous assessment of both public health impact and individualized care quality, providing a practical and evidence-based index for bridging guidelines with daily clinical practice. Ultimately, widespread application of this unified implementation metric has the potential to accelerate progress toward improved global cardiovascular outcomes. Core metric 130/80 mmHg of implementation hypertension. BP, blood pressure.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0