Haematologica最新文献

{"title":"Lenalidomide-rituximab or lenalidomide-rituximab-bendamustine for relapsed/refractory follicular lymphoma: primary and final analysis of the randomized phase II HOVON110/ReBeL study.","authors":"Marie José Kersten,Martin Dreyling,Kim M Linton,Dana Chitu,Gerben J C Zwezerijnen,Sanne H Tonino,Marcel Kap,Roberto Liu,Christel Van Hooije,Martine E D Chamuleau,Hein P J Visser,Eva De Jongh,Erik A F Marijt,Maria B L Leys,Yavuz M Bilgin,Jan Dürig,Pamela McKay,Tjeerd Snijders,Andrew Pettitt,Monique C Minnema,Gabriele Prange-Krex,Marloes L H Cuijpers,Lara H Bohmer,Lidwine W Tick,Axel Florschutz,Matthijs Silbermann,Rob Fijnheer,Aart Beeker,Nelleke Tolboom,Cristina Mitea,Anne I J Arens,Sanne E Wiegers,Martijn W Heymans,Wolfram Klapper,Sarah E Coupland,Daphne De Jong,Jeanette K Doorduijn,Josée M Zijlstra","doi":"10.3324/haematol.2025.300152","DOIUrl":"https://doi.org/10.3324/haematol.2025.300152","url":null,"abstract":"The R2 (lenalidomide-rituximab) and R2 with bendamustine (R2B) regimens are both feasible in relapsed/refractory follicular lymphoma (R/R FL), but prospective phase II data on R2B are lacking. In this multinational, prospective, randomised, non-comparative trial, patients with R/R FL were randomised 1:1 to R2 (arm A) or R2B (arm B). Patients achieving CT-based partial or complete remission (PR/CR) received rituximab maintenance every 3 months for 2 years. Co-primary endpoints were investigator-assessed CR rates at end-of-induction (EOI) and severe toxicity rates. Between December 2014 and July 2019, 92 patients were randomized. The trial was stopped prematurely due to slow accrual. CR rates at EOI were 11.4% (95% CI [3.8, 24.6%]) for R2 and 15.2% (CI [6.3, 28.9%]) for R2B. With a median follow-up of 74 months, predefined severe toxicities occurred in 3 (6.8%; CI [1.4, 18.7%]) and 6 pts (13.0%, CI [4.9, 26.3%]) in Arm A and Arm B respectively, with 2 pneumonia-related deaths in arm A and no treatment-related deaths in arm B; 43% and 66% experienced any grade 3-4 AE (2%/7% grade 4). At 60 months, in arms A and B event free survival (EFS) was 39.5% (CI [25.1, 53.6%]) and 56.4% (CI [40.1, 69.3%]). Overall survival (OS) was excellent at 72.1% and 86.3%, respectively. R2 and R2B are both effective treatment regimens for R/R FL. While CT-based CR rates were low, treatment with R2B resulted in numerically longer median EFS and OS, but this was associated with higher toxicity.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"22 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of SUV39H1 as a potent therapeutic target in multiple myeloma.","authors":"Laura Alibert,Sara Ovejero,Julie Devin,Morgane Thomas,Alboukadel Kassambara,Matthieu Angles,Guilhem Requirand,Nicolas Robert,Laure Vincent,Guillaume Cartron,Anne Marie Martinez,Charles Herbaux,Giacomo Cavalli,Jérôme Moreaux,Caroline Bret","doi":"10.3324/haematol.2025.300333","DOIUrl":"https://doi.org/10.3324/haematol.2025.300333","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"405 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome during treatment with the bivalent CD20xCD3 bispecific antibody glofitamab.","authors":"Alberto Fresa,Annarosa Cuccaro,Matteo Bonanni,Domenico Galati,Gerardo Ferrara,Francesco Volzone,Stefania Crisci,Maria Rivieccio,Maria Oro,Eliana Morgillo,Sara Mele,Rosaria De Filippi,Antonio Pinto","doi":"10.3324/haematol.2025.300326","DOIUrl":"https://doi.org/10.3324/haematol.2025.300326","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"44 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origins of iAMP21 in children who later developed paediatric acute lymphoblastic leukemia: an investigation of neonatal blood spots.","authors":"Gustaf Leijonhufvud,Viktor Ljungström,Rose-Marie Amini,Ilone Saft,Anthony M Ford,Britt Gustafsson","doi":"10.3324/haematol.2026.300813","DOIUrl":"https://doi.org/10.3324/haematol.2026.300813","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"2 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosuppressive therapy for severe aplastic anemia in children under the age of 3 years yields a high response rate: a North American collaborative study.","authors":"Talya Wittmann Dayagi,Laura Willis,Staci D Arnold,Jessica Boklan,Michaela Cada,Thomas D Coates,Catherine Corriveau-Bourque,Christopher J Gamper,Amy E Geddis,Bertil Glader,Gary M Kupfer,Taizo A Nakano,Timothy S Olson,Zora R Rogers,Akiko Shimamura,Clifford Takemoto,Alexis A Thompson,David A Williams,Yigal Dror","doi":"10.3324/haematol.2025.300232","DOIUrl":"https://doi.org/10.3324/haematol.2025.300232","url":null,"abstract":"Distinguishing acquired (idiopathic/immune) severe aplastic anemia (SAA) from inherited bone marrow failure syndromes (IBMFS) is critical since only acquired cases respond to immunosuppressive therapy (IST), the standard treatment in cases without a matched sibling donor. Differentiating SAA from IBMFS is particularly challenging in children younger than 3 years, in whom inherited disorders are more prevalent. No age threshold exists to guide IST use in this population. Thus, we evaluated IST outcomes in children aged.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"2 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid neoplasms after follicular helper T-cell lymphomas: a real, but limited risk.","authors":"Ondine Messéant,François Lemonnier","doi":"10.3324/haematol.2025.300464","DOIUrl":"https://doi.org/10.3324/haematol.2025.300464","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"473 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the kinase inhibitor CHZ868 against JAK2 rearrangements in pediatric acute lymphoblastic leukemia.","authors":"Manuel Quadri,Claudia Saitta,Sonia Palamini,Stefano Rebellato,Titus Watrin,Jia-Wey Tu,Sanil Bhatia,Arndt Borkhardt,Chiara Palmi,Andrea Biondi,Giovanni Cazzaniga,Grazia Fazio","doi":"10.3324/haematol.2025.287840","DOIUrl":"https://doi.org/10.3324/haematol.2025.287840","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"24 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RBM15 and ZMYND8 shape acute myeloid leukemia response to BCL2 inhibitors.","authors":"Nataly Cruz-Rodriguez","doi":"10.3324/haematol.2025.288972","DOIUrl":"https://doi.org/10.3324/haematol.2025.288972","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"12 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durable deep molecular response via CD19 chimeric antigen receptor T-cell therapy combined with a third-generation tyrosine kinase inhibitor in acute leukemia of ambiguous lineage with the Philadelphia chromosome: a potential strategy for transplant-ineligible patients.","authors":"Ao Zhang,Benfa Gong,Yuntao Liu,Guangji Zhang,Chunlin Zhou,Shouyun Li,Chengcai Guo,Huihui Yang,Yanhui Li,Lili Wang,Boming Zhang,Hui Wei,Jianxiang Wang,Shaowei Qiu","doi":"10.3324/haematol.2026.300521","DOIUrl":"https://doi.org/10.3324/haematol.2026.300521","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"29 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on: \"Reporting blast percentage for response assessment in acute leukemias: recommendations from an EHA/ELN expert panel\".","authors":"Sa A Wang, Leonor Arenillas, Francesco Buccisano, Monika Bruggemann, Wolfgang Kern, Manuel Menes, Adriana Plesa, Louisa Stone, Dominique Wellnitz, David A Westerman, Brent L Wood, Sylvie D Freeman","doi":"10.3324/haematol.2026.300980","DOIUrl":"https://doi.org/10.3324/haematol.2026.300980","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}