Haematologica最新文献_第6页

Oxygen release from hemoglobin has limited effects on mitochondrial respiration measured from red blood cells. Reply to the Comment on "Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress". 血红蛋白释放氧气对红细胞线粒体呼吸的影响有限。对 "成熟镰状红细胞中功能线粒体的保留增加与镰状倾向、溶血和氧化应激的增加有关 "评论的答复

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.286361

Antoine Stier, Sofia Esperti, Elie Nader, Damien Roussel, Philippe Connes

引用次数: 0

The CLL hunters: finally, BTK got arrested. CLL猎人：最后，BTK被逮捕了。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.286469

Loic Ysebaert

引用次数: 0

Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma. A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry. 多发性骨髓瘤中的呼吸道合胞病毒和其他疫苗可预防的感染。一项基于瑞典骨髓瘤登记处 2008-2021 年诊断的 8672 名骨髓瘤患者的人群研究。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285161

Sigrun Einarsdottir, Ingigerdur Sverrisdottir, Mariana Villegas-Scivetti, Chris Day, Ingemar Turesson, Gunnar Juliusson, Markus Hansson, Gunnar Larfors, Cecilie Hveding Blimark

引用次数: 0

Blinatumomab is associated with better post-transplant outcome than chemotherapy in children with high-risk, first-relapse B-cell acute lymphoblastic leukemia irrespective of the conditioning regimen. 对于高风险首次复发B细胞急性淋巴细胞白血病患儿，无论采用哪种治疗方案，Blinatumomab的移植后疗效均优于化疗。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285837

Christina Peters, Angela Bruno, Carmelo Rizzari, Alessandra Brescianini, Arend Von Stackelberg, Christin Linderkamp, Yi Zeng, Gerhard Zugmaier, Franco Locatelli

引用次数: 0

Hodgkin/Reed-Sternberg cells induce GPNMB expression and release from macrophages to suppress T-cell responses to the Epstein-Barr virus-encoded LMP2A protein. 霍奇金/里德-斯登堡细胞诱导巨噬细胞表达和释放 GPNMB，从而抑制 T 细胞对 Epstein-Barr 病毒编码的 LMP2A 蛋白的反应。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285319

Navta Masand, Tracey A Perry, Matthew Pugh, Eanna Fennell, Aoife Hennessy, Wenbin Wei, Katerina Bouchalova, David Burns, Pamela Kearns, Graham Taylor, Katerina Vrzalikova, Paul G Murray

引用次数: 0

Immunoglobulin prophylaxis prevents hospital admissions for fever in pediatric acute lymphoblastic leukemia: results of a multicenter randomized trial. 免疫球蛋白预防可防止小儿急性淋巴细胞白血病患者因发热入院：一项多中心随机试验的结果。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285428

Kirsten A Thus, Hester A De Groot-Kruseman, Pauline Winkler-Seinstra, Marta Fiocco, Heidi Segers, Cor Van den Bos, Inge M Van der Sluis, Wim J E Tissing, Margreet A Veening, Christian Michel Zwaan, Cornelis M Van Tilburg, Rob Pieters, Marc Bierings

{"title":"Immunoglobulin prophylaxis prevents hospital admissions for fever in pediatric acute lymphoblastic leukemia: results of a multicenter randomized trial.","authors":"Kirsten A Thus, Hester A De Groot-Kruseman, Pauline Winkler-Seinstra, Marta Fiocco, Heidi Segers, Cor Van den Bos, Inge M Van der Sluis, Wim J E Tissing, Margreet A Veening, Christian Michel Zwaan, Cornelis M Van Tilburg, Rob Pieters, Marc Bierings","doi":"10.3324/haematol.2024.285428","DOIUrl":"10.3324/haematol.2024.285428","url":null,"abstract":"Infections lead to substantial morbidity during the treatment of acute lymphoblastic leukemia (ALL) in which the adaptive immune system is severely affected, leading to declining serum immunoglobulin levels. We performed a trial to investigate whether intravenous immunoglobulin (IVIG) prophylaxis in pediatric patients with ALL could prevent admissions for fever. This randomized controlled trial was a subtrial of the national Dutch multicenter ALL study. Patients aged 1-19 years with medium-risk ALL were randomized into two groups receiving either IVIG prophylaxis (0.7 g/kg IVIG given every 3 weeks, starting on day 22 after diagnosis) or well-defined standard of care (control group). Between October 2012 and March 2019, 91 (51%) patients were randomly assigned to IVIG prophylaxis and 86 (49%) to the control arm. In the IVIG prophylaxis group there were 206 admissions for fever versus 271 in the control group (P=0.011). IVIG prophylaxis was not associated with bacteremia. However, there were significantly fewer admissions for fever with negative blood cultures in the IVIG prophylaxis group than in the control group (113 vs. 200, P<0.001). The difference in number of admissions for fever was observed specifically during maintenance treatment (100 vs. 166, P<0.001) resulting in fewer courses of antibiotic treatment (78 vs. 137, P<0.001) and fewer cases of chemotherapy adaptation (72 vs. 134, P<0.001). In conclusion, in pediatric patients with medium-risk ALL, IVIG prophylaxis was associated with significantly fewer admissions for fever with negative blood cultures during maintenance treatment, resulting in fewer courses of antibiotic treatment and fewer chemotherapy adaptations.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"47-54"},"PeriodicalIF":8.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population. 多种族人群范可尼贫血患者的特征和基因型-表型相关性的勘误。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.286363

Orna Steinberg-Shemer, Tracie A Goldberg, Joanne Yacobovich, Carina Levin, Ariel Koren, Shoshana Revel-Vilk, Tal Ben-Ami, Amir A Kuperman, Vered Shkalim Zemer, Amos Toren, Joseph Kapelushnik, Ayelet Ben-Barak, Hagit Miskin, Tanya Krasnov, Sharon Noy-Lotan, Orly Dgany, Hannah Tamary

引用次数: 0

Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers. 布卢姆综合征疑似患者和携带者的不确定潜能克隆造血频率增加。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285239

Isabella Lin, Angela Wei, Tsumugi A Gebo, Paul C Boutros, Maeve Flanagan, Nicole Kucine, Christopher Cunniff, Valerie A Arboleda, Vivian Y Chang

引用次数: 0

A novel prognostic nomogram based on imaging and molecular parameters for newly diagnosed extranodal natural killer/T-cell lymphoma patients. 基于影像学和分子参数的新预后提名图，适用于新诊断的结节外自然杀伤/T细胞淋巴瘤患者。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285362

Dezhi Huang, Fu Li, Shijia Lin, Jing Xia, Bangdong Liu, Xinlei Li, Naya Ma, Yishuo Duan, Yunjing Zeng, Sha Zhou, Shuhan Tang, Wenqiu Huang, Lingyi Rao, Li Gao, Qiong Li, Xi Zhang, Jun Rao

引用次数: 0

Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid leukemia. 单细胞蛋白质转录组图谱分析揭示了早期慢性髓性白血病患者接受细胞修复性羟基脲治疗后干细胞和祖细胞特征的改变。

IF 8.2 1区医学

Haematologica Pub Date : 2025-01-01 DOI: 10.3324/haematol.2024.285071

Hana Komic, Malin S Nilsson, Lovisa Wennström, Tagore Sanketh Bandaru, Pekka Jaako, Kristoffer Hellstrand, Fredrik B Thorén, Anna Martner

{"title":"Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid leukemia.","authors":"Hana Komic, Malin S Nilsson, Lovisa Wennström, Tagore Sanketh Bandaru, Pekka Jaako, Kristoffer Hellstrand, Fredrik B Thorén, Anna Martner","doi":"10.3324/haematol.2024.285071","DOIUrl":"10.3324/haematol.2024.285071","url":null,"abstract":"Hydroxyurea (HU) is frequently used in the early phase of chronic myeloid leukemia (CML) to achieve cytoreduction prior to tyrosine kinase inhibitor therapy. However, its impact on CML stem and progenitor cells (SPC) remains largely unknown. This study utilized targeted proteo-transcriptomic expression data on 596 genes and 51 surface proteins in 60,000 CD14-CD34+ cells from chronic phase CML patients to determine effects of short-term HU treatment (4-19 days) on CML SPC. Peripheral blood and bone marrow samples were obtained from 17 CML patients eligible for short-term HU treatment (3 patients before and after HU, 7 patients before HU and 7 patients after HU) and subjected to single-cell CITE-sequencing and/or flow cytometry analysis. The analysis revealed enhanced frequencies of hemoglobin-expressing (HBA1, HBA2, HBB) erythroid progenitor cells in blood and bone marrow following HU treatment. In addition, there was an accumulation of cell subsets with S/G2/M phase-related gene and protein expression, likely representing cells arrested in, or progressing slowly through, the cell cycle. The increased frequency of cells in S/G2/M phase after HU was observed already among the most immature leukemic stem cells (LSC), and patients with a large fraction of LSC in the S/G2/M phase showed poor responsiveness to tyrosine kinase inhibitor treatment. We conclude that short-term HU treatment entails differentiation of erythroid progenitor cells and alters the characteristics of LSC in CML. The results imply that studies of LSC and progenitor populations in CML should take effects of initial HU therapy into account.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"117-128"},"PeriodicalIF":8.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0