弥漫性大b细胞淋巴瘤新的双特异性抗体。

IF 8.2 1区 医学 Q1 HEMATOLOGY
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-02-06 DOI:10.3324/haematol.2024.285343
Adrian G Minson, Michael J Dickinson
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引用次数: 0

摘要

CD20xCD3 t细胞结合双特异性抗体是复发或难治性弥漫性大b细胞淋巴瘤(DLBCL)患者的一种高度活跃的新治疗选择。Epcoritamab和glofitamab均已在30多个国家被批准作为DLBCL的单药治疗,此前已有两条治疗线;odronexamab最近获得欧洲批准,mosunetuzumab是有效的,正在开发作为联合合作伙伴。这些药物可以安全地与其他免疫疗法和化疗联合使用,单臂和随机试验的结果表明,这类药物在早期治疗中发挥着更大的作用。本文综述了CD20xCD3双特异性抗体在DLBCL中的临床发展,I期和II期试验如何告知它们的当前使用,以及药物之间的关键区别。我们关注的是那些处于研发前沿的双特异性抗体的有效性和安全性。我们还考虑了对耐药机制的新认识。最后,我们回顾了关键的正在进行的试验和组合,并考虑了双特异性抗体在DLBCL可用治疗序列中的潜在未来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New bispecific antibodies in diffuse large B-cell lymphoma.

CD20xCD3 T-cell-engaging bispecific antibodies are a highly active new treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Epcoritamab and glofitamab have both been approved in over 30 countries as monotherapy for DLBCL after two prior treatment lines; odronextamab has recent European approval, and mosunetuzumab is active and is being developed as a combination partner. These agents can be safely combined with other immunotherapies and chemotherapy, and single-arm and randomized trial outcomes promise an expanding role for this class of drugs in earlier treatment lines. This review examines the clinical development of the CD20xCD3 bispecific antibodies in DLBCL, how the phase I and II trials inform their current use, and the key distinctions between the agents. We focus on the efficacy and safety of those bispecific antibodies most advanced in development. We also consider emerging understandings of resistance mechanisms. Finally, we review key ongoing trials and combinations and consider the potential future of bispecific antibodies within the sequence of available treatments for DLBCL.

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来源期刊
Haematologica
Haematologica 医学-血液学
CiteScore
14.10
自引率
2.00%
发文量
349
审稿时长
3-6 weeks
期刊介绍: Haematologica is a journal that publishes articles within the broad field of hematology. It reports on novel findings in basic, clinical, and translational research. Scope: The scope of the journal includes reporting novel research results that: Have a significant impact on understanding normal hematology or the development of hematological diseases. Are likely to bring important changes to the diagnosis or treatment of hematological diseases.
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