Haematologica最新文献

{"title":"Lessons of nature from trisomy-8 myeloid neoplasia: the riddle of oncogenic clonal drives.","authors":"Hussein Awada, Arda Durmaz, Luca Guarnera, Zachary Brady, Yasuo Kubota, Serhan Unlu, Carmelo Gurnari, Carlos Bravo-Perez, Hassan Awada, Torsten Haferlach, Jaroslaw P Maciejewski, Valeria Visconte","doi":"10.3324/haematol.2026.300822","DOIUrl":"https://doi.org/10.3324/haematol.2026.300822","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing bone health in lymphoma survivors: denosumab superiority to alendronate for R-CHOP-like therapy (the DENOSULY phase III randomized controlled trial).","authors":"Shohei Kikuchi, Eiju Negoro, Ryusuke Horaguchi, Takuma Fujihira, Yoshimi Nabe, Tomoki Minemura, Kento Ono, Yusuke Kamihara, Akinori Wada, Nam H Dang, Yasufumi Masaki, Toshihiro Miyamoto, Takahiro Yamauchi, Tsutomu Sato","doi":"10.3324/haematol.2026.300564","DOIUrl":"https://doi.org/10.3324/haematol.2026.300564","url":null,"abstract":"<p><p>Glucocorticoid-induced osteoporosis (GIOP) poses a critical long-term complication for lymphoma survivors, with cumulative incidence of fractures following R-CHOP-like therapy. Existing GIOP guidelines, typically based on chronic low-dose steroid use, are insufficient for managing this acute, high-risk toxicity of lymphoma therapy-related GIOP (LTR-GIOP). This prospective, multi-center, phase 3 randomized controlled trial (n=100; median age 74-years) compared the efficacy and safety of denosumab versus alendronate in newly diagnosed lymphoma patients receiving R-CHOP-like therapy. Patients were randomized into two groups: one received a total of two subcutaneous injections of denosumab every 6 months, and the other received oral alendronate once a week for 12 months. This study was named DENOSULY and the cases were collected by the Hokuriku Hematology Oncology Study Group. The primary endpoint was the percentage change in lumbar spine (LS) bone mineral density (BMD) at 12 months. Consequently, denosumab demonstrated superiority over alendronate in LS(L1-L4) BMD change (denosumab: +2.8%±4.4% vs. alendronate: -1.3%±5.6%; p=0.0010). Crucially, denosumab also showed superiority at the femoral neck (denosumab: +2.8%±5.8% vs. alendronate: -3.6%±10.3%; p=0.0020), a site where superiority is infrequently demonstrated in non-LTR-GIOP comparisons. Denosumab achieved stronger suppression of the bone resorption marker TRACP-5b (p=0.0003). Since denosumab showed significant superiority over alendronate at both the lumbar spine and femoral neck, denosumab may be the preferred agent in LTR-GIOP. Recognizing R-CHOP recipients as a very high-risk population, our findings underscore the need for immediate, enhanced prophylaxis with denosumab to prevent LTR-GIOP and improve long-term survivorship and quality of life. This trial was registered at www.umin.ac.jp as UMIN000038881.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel tripartite <i>STAT5B::RARA::RP11-750B16.1</i> fusion in variant acute promyelocytic leukemia. Comment on: \"Novel ligand-binding domain truncated <i>CPSF7::RARA::CPSF7</i> tripartite fusion confers primary ATRA resistance in atypical acute promyelocytic leukemia\".","authors":"Zhan Su, Xianqi Feng","doi":"10.3324/haematol.2026.301049","DOIUrl":"https://doi.org/10.3324/haematol.2026.301049","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of leukemic ocular infiltrations with intra-arterial chemotherapy in very early mixed relapse of B-cell acute lymphoblastic leukemia.","authors":"Marta Andrzejewska, Maksymilian Deręgowski, Zuzanna Anioł, Julia Dezor-Garus, Anna Stodolska, Sandra Rutkowska, Anna Przybyłowicz-Chalecka, Olga Zając-Spychała, Anna Gotz-Więckowska, Katarzyna Derwich","doi":"10.3324/haematol.2026.300507","DOIUrl":"https://doi.org/10.3324/haematol.2026.300507","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelodysplastic syndrome with concomitant <i>SF3B1</i> mutation and deletion of chromosome 5 long arm: outcomes and response to treatment.","authors":"Rami Komrokji, Zaker Schwabkey, Zena Komrokji, Najla Al Ali, Luis Aguirre, Maximilian Stahl, Somedeb Ball, Emily Mason, Michael Savona, Valeria Santini, Angela Consagra, Uwe Platzbecker, Anne Sophie Kubasch, Yazan Madanat, Pierre Fenaux, Lin-Pierre Zhao, Mikkael A Sekeres, Namrata Chandhok, Matteo Della Porta, Luca Lanino, Amy DeZern, David Sallman, Eric Padron, Zhuoer Xie, Koji Sasaki, Kensuke Takaoka, Akhil Jain, Monica Del Rey Gonzalez, Maria Diez Campelo, Guillermo Garcia-Manero","doi":"10.3324/haematol.2025.300396","DOIUrl":"https://doi.org/10.3324/haematol.2025.300396","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen promotes acute myelogenous leukemia progression <i>via</i> miR-486/<i>GPR153</i> axis.","authors":"Ming Yang, Xiaofang You, Fan Zhao, Huida Tong, Haris Munir, Kaiwen Wu, Xiaomin Yu, Laixi Bi, Jie Xiang, Misheng Zhao, Shenghui Zhang, Chen Ling, Liqing Zhu","doi":"10.3324/haematol.2025.288109","DOIUrl":"https://doi.org/10.3324/haematol.2025.288109","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is a frequently fatal malignancy of bone marrow stem/progenitor cells. Fibrinogen (Fg), the predominant coagulation factor in plasma, has been reported to have a negative correlation with the prognosis of AML patients. However, the underlying mechanisms through which Fg exerts its effects on AML remain unclear. In this study, we developed a Fg-deficient AML mouse model and utilized AML cell lines and primary human AML cells to explore the role of Fg in AML progression both in vivo and in vitro. Our findings demonstrate that Fg significantly accelerates AML progression in a cancer xenograft model, as well as primary cells from untreated patients with AML. Mechanistically, Fg upregulates the expression of miR-486-5p, which directly targets the orphan receptor GPR153. This interaction activates the downstream mTORC2/AKT signaling pathway, driving AML cell proliferation and migration. Our results highlight a critical molecular mechanism by which Fg contributes to AML progression, offering potential molecular targets for therapeutic intervention.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered immune and treatment response gene expression signatures among povertyexposed children with B-cell acute lymphoblastic leukemia.","authors":"Amy Guillaumet-Adkins, Elnaz Mirzaei Mehrabad, Noori Sotudeh, Sayalee Potdar, Tushara Vijaykumar, Monica Nair, Valeriya Dimitrova, Julia Frede, Yana Pikman, Marian Harris, Andrew E Place, Lewis B Silverman, Jens G Lohr, Kira Bona, Birgit Knoechel","doi":"10.3324/haematol.2025.289187","DOIUrl":"https://doi.org/10.3324/haematol.2025.289187","url":null,"abstract":"<p><p>Children diagnosed with cancer typically receive standardized treatment regimens. Despite highly protocolized care, children living in poverty experience a greater risk of cancer relapse and higher mortality compared to their more affluent peers1,2. Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, and children with ALL exposed to poverty are more likely to experience early relapse3. Using single-cell RNA sequencing to analyze leukemic blasts and their microenvironment at diagnosis we found that poverty-exposed patients with standard-risk B-ALL exhibit transcriptional signatures of steroid resistance at time of diagnosis. Additionally, we observe increased expression of inflammatory signatures in myeloid cells and reduced effector signatures in CD8+ T-cells in children with B-ALL living in poverty. Further investigation of the mechanisms underlying these associations may identify opportunities for risk-adapted therapeutic strategies to improve disease outcomes in pediatric ALL.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to increase the liposomal doxorubicin dosage for frontline therapy in young adults and adults with classic Hodgkin lymphoma? Comment on: \"Is it time to reduce the doxorubicin dosage in Hodgkin lymphoma therapy?\"","authors":"Marco Picardi, Annamaria Vincenzi","doi":"10.3324/haematol.2026.301044","DOIUrl":"https://doi.org/10.3324/haematol.2026.301044","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric blastic plasmacytoid dendritic cell neoplasms are molecularly defined by recurrent <i>MYB</i> rearrangements: clinical and molecular insights.","authors":"Mahsa Khanlari, Marleni Torres Nunez, Jamie L Maciaszek, Mohammad K Eldomery, Wei Wang, Zhongshan Cheng, Jason Myers, Karissa Dieseldorff Jones, Gabriela Gheorghe, Laura Key, Yen-Chun Liu, Rafael Barceiro, Armando Peña, Sharon Castellino, Roy Enrique Rosado, Marcela Barros E Sousa, Jacob R Bledsoe, Naveen Pemmaraju, Jeffery M Klco, Raul C Ribeiro","doi":"10.3324/haematol.2026.300903","DOIUrl":"https://doi.org/10.3324/haematol.2026.300903","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed-duration obinutuzumab-ibrutinib-venetoclax for Richter's transformation: results from the phase II GIVeRS trial.","authors":"Tamar Tadmor, Ohad Benjamini, Neta Goldschmidt, Natlia Kreiniz, Osnat Bairey, Reut Harel, Nadav Sarid, Tsofia Levi, Ofir Wolach, Yair Herishanu","doi":"10.3324/haematol.2026.300749","DOIUrl":"https://doi.org/10.3324/haematol.2026.300749","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}