Haematologica最新文献

{"title":"Update on long-term outcomes of a cohort of patients with TCF3::HLF positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation.","authors":"Aida Zeckanovic, Brice Mouttet, Luciana Vinti, Philip Ancliff, Benoît Brethon, Gunnar Cario, Sarah Elitzur, Volkan Hazar, Joachim Kunz, Anja Möricke, Jerry Stein, Yöntem Yaman, Jochen Buechner, Magnus Aasved Hjort, David O'Connor, Angus Hodder, Jack Bartram, Julia Alten, Draga Barbaric, Gabriele Escherich, Nicolas Boissel, Loïc Vasseur, Emmanuelle Clappier, Laure Farnault, Sarah Bonnet, Katharine Patrick, Martin Schrappe, Sema Anak, André Baruchel, Franco Locatelli, Martin Stanulla, Arend Von Stackelberg, Nicole Bodmer, Jean-Pierre Bourquin","doi":"10.3324/haematol.2024.286111","DOIUrl":"https://doi.org/10.3324/haematol.2024.286111","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation.","authors":"Eva N Hamulyák, Tzu-Fei Wang, Lisa Baumann Kreuziger, Varun Iyengar, Brian J Carney, Ann Hoeben, Berna C Özdemir, Rosana D Cordova Serrano, Kristen M Sanfilippo, Shira Rozenblatt, Ludo F M Beenen, Shlomit Yust-Katz, Erez Halperin, Ariela Arad, Aharon Lubetsky, Marc Carrier, Benjamin Massat, Harry R Büller, Galia Spectre, Jeffrey I Zwicker, Avi Leader","doi":"10.3324/haematol.2024.286973","DOIUrl":"https://doi.org/10.3324/haematol.2024.286973","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nontuberculous mycobacterial infections following teclistamab in multiple myeloma.","authors":"Matthew Ho, Luca Paruzzo, Janna Minehart, Teja Voruganti, Pooja Devi, Dan T Vogl, Adam D Cohen, Alfred L Garfall, Adam J Waxman, Shivani Kapur, Edward A Stadtmauer, Sandra Susanibar Adaniya, Sarah Longworth","doi":"10.3324/haematol.2024.286675","DOIUrl":"10.3324/haematol.2024.286675","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexamethasone added to induction and post-remission therapy in older patients with newly diagnosed acute myeloid leukemia: a multicenter, phase II trial (DEXAML-02).","authors":"Sarah Bertoli, Emilie Bérard, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Yosr Hicheri, Omar Benbrahim, Martin Carre, Corentin Orvain, Anne Banos, Marc Bernard, Emmanuel Gyan, Alain Saad, Safia Chebrek, Gabrielle Roth Guepin, Veronique Dorvaux, Laurence Sanhes, Maria Pilar Gallego-Hernanz, Carole Exbrayat, Laure Vincent, Chantal Himberlin, Célestine Simand, Norbert Vey, Cindy Fenoll, Ariane Mineur, Anne Huynh, Francois Vergez, Isabelle Luquet, Laetitia Largeaud, Eric Delabesse, Arnaud Pigneux, Christian Récher","doi":"10.3324/haematol.2024.286807","DOIUrl":"https://doi.org/10.3324/haematol.2024.286807","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The improved prognosis of <i>FLT3</i>-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world study using large-scale electronic health record data.","authors":"Matthew Schwede, Gladys Rodriguez, Vanessa E Kennedy, Solomon Henry, Douglas Wood, Gabriel N Mannis, Ravindra Majeti, Jonathan H Chen, Eran Bendavid, Tian Yi Zhang","doi":"10.3324/haematol.2024.286695","DOIUrl":"https://doi.org/10.3324/haematol.2024.286695","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context and timing matters in acute myeloid leukemia: females are the superior hosts.","authors":"Kerstin B Kaufmann, Stephanie Z Xie","doi":"10.3324/haematol.2024.287056","DOIUrl":"https://doi.org/10.3324/haematol.2024.287056","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of adult acute myeloid leukemia patients with extramedullary disease and treatment with venetoclax/ hypomethylating agents.","authors":"Sabine Kayser, Khaled Sanber, Giovanni Marconi, Agnese Mattei, Marlise R Luskin, Amar Kelkar, Marco Cerrano, Daniel Tuyet Kristensen, Anne Stidsholt Roug, Chiara Sartor, Fabio Giglio, Marta Riva, Lorenzo Rizzo, Francesco Saraceni, Selene Guerzoni, Federica Lessi, Erika Borlenghi, Mark J Levis, Richard F Schlenk, Tania Jain, Cristina Papayannidis","doi":"10.3324/haematol.2024.285985","DOIUrl":"10.3324/haematol.2024.285985","url":null,"abstract":"<p><p>We evaluated response to venetoclax/hypomethylating agents (HMA) in 46 patients with acute myeloid leukemia (AML) characterized by extramedullary disease. The median age of these patients was 65 years (range, 19-81). The patients had a median of two sites of extramedullary disease (range, 1-5) and 35 (76%) had concurrent bone marrow involvement. Twenty (43%) patients had high-risk genetic features according to the European LeukemiaNet 2022 classification. Twenty-nine (63%) had relapsed or were refractory after intensive chemotherapy, including 13 (28%) who had undergone prior allogeneic hematopoietic cell transplantation. Patients received a median of two cycles of venetoclax/HMA (range, 1-31). Twenty (43%) patients achieved complete remission (CR) or CR with incomplete hematologic recovery (CRi) after venetoclax/HMA and five (11%) achieved a partial remission (PR). Six patients were subsequently consolidated with allogeneic hematopoietic cell transplantation (CR/CRi, N=4; PR, N=2). The median follow-up was 49.1 months (95% confidence interval [95% CI]: 26.1 months - not reached) and the median overall survival was 6.4 months (95% CI: 5.1-11 months). One-year and 2-year overall survival rates were 29.3% (95% CI: 18.6-46.2%) and 12.3% (95% CI: 5.5-27.6%), respectively. Age, with a cutoff of 60 years, did not have an impact on overall survival (P=0.90). Relapse occurred in 12 of 20 (60%) patients who achieved CR/CRi after venetoclax/ HMA treatment. Of those, all except one succumbed to their disease. Six (30%) patients were in CR/CRi at last follow-up and two (10%) died in CR. In our cohort of patients with AML with extramedullary disease with high-risk features, treatment with venetoclax/HMA resulted in an encouraging overall response rate of 54% with a CR/CRi rate of 43.5%. However, venetoclax/ HMA alone may not be effective in maintaining disease control.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"378-384"},"PeriodicalIF":8.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alessandro Pileri: an enthusiastic pioneer of modern hematology.","authors":"Mario Boccadoro, Paolo Corradini, Massimo Massaia, Corrado Tarella","doi":"10.3324/haematol.2024.287046","DOIUrl":"10.3324/haematol.2024.287046","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"110 2","pages":"267"},"PeriodicalIF":8.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic age acceleration in hematopoietic stem cell transplantation.","authors":"Margherita Ursi, Katarzyna Malgorzata Kwiatkowska, Chiara Pirazzini, Gianluca Storci, Daria Messelodi, Salvatore Nicola Bertuccio, Serena De Matteis, Francesco Iannotta, Enrica Tomassini, Marcello Roberto, Maria Naddeo, Noemi Laprovitera, Irene Salamon, Barbara Sinigaglia, Elisa Dan, Francesco De Felice, Francesco Barbato, Enrico Maffini, Sadia Falcioni, Mario Arpinati, Manuela Ferracin, Massimiliano Bonafè, Paolo Garagnani, Francesca Bonifazi","doi":"10.3324/haematol.2024.285291","DOIUrl":"10.3324/haematol.2024.285291","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"481-484"},"PeriodicalIF":8.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tagraxofusp in combination with pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma shows encouraging preliminary efficacy with a manageable safety profile.","authors":"Paul Richardson, Myo Htut, Emma Scott, Claudia Paba Prada, Ira Gupta","doi":"10.3324/haematol.2024.285380","DOIUrl":"10.3324/haematol.2024.285380","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"488-492"},"PeriodicalIF":8.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}