Haematologica最新文献

{"title":"Pathogenesis and management of high molecular risk myeloproliferative neoplasms.","authors":"Victoria Y Ling, Florian H Heidel, Megan J Bywater","doi":"10.3324/haematol.2023.283987","DOIUrl":"https://doi.org/10.3324/haematol.2023.283987","url":null,"abstract":"<p><p>Classical myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterised by driver mutations that affect the constitutive activation of JAK-signalling. Additional mutations to an MPN-driver occur in a large number of patients and have been shown be associated with disease presentation and progression. In this review, we will outline the current hypotheses regarding how clonal evolution in MPN is thought to occur and the functional mechanisms as to how concomitant somatic mutations (i.e. mutations in genes other than the 'driver' genes) contribute to disease progression. We will discuss the definitions of high molecular risk MPN, provide an overview as to how concomitant mutations influence the clinical management of MPN and suggest how this rapidly developing genetic risk stratification can be utilised to improve clinical outcomes.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal residual disease assessment in transplant-eligible patients with multiple myeloma: real-world applications of multiparametric flow cytometry-DURAClone (CAREMM-2104).","authors":"Ari Ahn, Sung-Soo Park, Yonggoo Kim, Jung Yeon Lee, Jong-Mi Lee, Jin Jung, Myungshin Kim, Chang-Ki Min","doi":"10.3324/haematol.2024.285278","DOIUrl":"10.3324/haematol.2024.285278","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4100-4105"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab.","authors":"Alexander Biedermann, Maria Patra-Kneuer, Dimitrios Mougiakakos, Maike Büttner-Herold, Doris Mangelberger-Eberl, Johannes Berges, Christian Kellner, Sarah Altmeyer, Jörg Thomas Bittenbring, Christian Augsberger, Kristina Ilieva-Babinsky, Stefan Haskamp, Fabian Beier, Christopher Lischer, Julio Vera, Anja Lührmann, Simone Bertz, Simon Völkl, Benedikt Jacobs, Stefan Steidl, Andreas Mackensen, Heiko Bruns","doi":"10.3324/haematol.2023.284795","DOIUrl":"10.3324/haematol.2023.284795","url":null,"abstract":"<p><p>Macrophages are one of the key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD19 antibody tafasitamab, approved in combination with lenalidomide for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL). However, antibody-dependent cellular phagocytosis (ADCP) in the tumor microenvironment can be counteracted by increased expression of the inhibitory receptor SIRPα on macrophages and its ligand, the immune checkpoint molecule CD47, on tumor cells. The aim of this study was to investigate the impact of the CD47-SIRPα axis on tafasitamab- mediated phagocytosis and explore the potential of anti-CD47 blockade to enhance its antitumor activity. Elevated expression of both SIRPα and CD47 was observed in DLBCL patient-derived lymph node biopsies compared to healthy control lymph nodes. CRISPR-mediated CD47 overexpression affected tafasitamab-mediated ADCP in vitro and increased expression of SIRPα on macrophages correlated with decreased ADCP activity of tafasitamab against DLBCL cell lines. A combination of tafasitamab and an anti-CD47 blocking antibody enhanced ADCP activity of in vitro-generated macrophages. Importantly, tafasitamab-mediated phagocytosis was elevated in combination with CD47 blockade using primary DLBCL cells and patient-derived lymphoma-associated macrophages in an autologous setting. Furthermore, lymphoma cells with low CD19 expression were efficiently eliminated by the combination treatment. Finally, combined treatment of tafasitamab and an anti-CD47 antibody resulted in enhanced tumor volume reduction and survival benefit in lymphoma xenograft mouse models. These findings provide evidence that CD47 blockade can enhance the phagocytic potential of tumor-targeting immunotherapies such as tafasitamab and suggest that there is value in exploring the combination in the clinic.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3928-3940"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141456368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phase II study of post-remission therapy with pembrolizumab in older patients with acute myeloid leukemia.","authors":"Kevin Quann, Konstantinos Lontos, Alison Sehgal, Anastasios Raptis, Annie Im, Robert L Redner, Kathleen A Dorritie, Mounzer Agha, Jing-Zhou Hou, Rafic Farah, James Rossetti, Daniel P Normolle, Theresa L Whiteside, Yen-Michael Sheng Hsu, Michael Boyiadzis","doi":"10.3324/haematol.2024.285313","DOIUrl":"10.3324/haematol.2024.285313","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4106-4111"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal prolactin or estrogen signaling in hepatocytes does not regulate iron homeostasis during pregnancy.","authors":"Vida Zhang, Allison L Fisher, Marguerite S Hewitt, Tomas Ganz, Elizabeta Nemeth, Veena Sangkhae","doi":"10.3324/haematol.2024.285456","DOIUrl":"10.3324/haematol.2024.285456","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4116-4119"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mimicry of inherited red cell disorders: the result of somatic mutations in a clonal myeloid disease.","authors":"Marshall A Lichtman, Audrey N Jajosky","doi":"10.3324/haematol.2024.286211","DOIUrl":"10.3324/haematol.2024.286211","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4137-4139"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-shared genomic alterations within tumors from patients with both myeloproliferative neoplasms and lymphoma.","authors":"Johanne M Holst, Martin B Pedersen, Marie B Enemark, Marcus C Hansen, Patrick R Noerhave, Trine L Plesner, Henrik Frederiksen, Michael B Moeller, Stephen J Hamilton-Dutoit, Peter Noergaard, Bo K Mortensen, Hans B Ommen, Jesper Stentoft, Wayne Tam, Maja Ludvigsen, Wing C Chan, Nicolai J Birkbak, Giorgio Inghirami, Francesco D'Amore","doi":"10.3324/haematol.2023.283798","DOIUrl":"10.3324/haematol.2023.283798","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4067-4072"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ponatinib alone or with chemo-immunotherapy in heavily pre treated Philadelphia-like acute lymphoblastic leukemia: a CAMPUS ALL real-life study.","authors":"Francesca Kaiser, Monia Lunghi, Deborah Cardinali, Vittorio Bellomarino, Marco Beldinanzi, Irene Della Starza, Francesco Malfona, Claudia M Basilico, Marzia Defina, Sara Mastaglio, Fabio Giglio, Davide Lazzarotto, Prassede Salutari, Matteo Piccini, Valeria Cardinali, Antonio Pierini, Nicola S Fracchiolla, Federica Di Biase, Mario Annunziata, Mariangela Di Trani, Robin Foa, Sabina Chiaretti","doi":"10.3324/haematol.2024.285258","DOIUrl":"10.3324/haematol.2024.285258","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4095-4099"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A <i>nu</i> mouse model of diffuse large B-cell lymphoma in constitutional <i>Atm</i> loss.","authors":"Laura K Hilton","doi":"10.3324/haematol.2024.285973","DOIUrl":"10.3324/haematol.2024.285973","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3841-3843"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter, phase Ib study of subcutaneous administration of isatuximab in combination with pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma.","authors":"Hang Quach, Gurdeep Parmar, Enrique M Ocio, H Miles Prince, Albert Oriol, Helen Crowther, Nobuhiro Tsukada, Pierre Bories, Sumit Madan, Nitya Nathwani, Kazutaka Sunami, Dorothee Semiond, Disa Yu, Paul Cordero, Sandrine Macé, Florence Suzan, Philippe Moreau","doi":"10.3324/haematol.2023.284730","DOIUrl":"10.3324/haematol.2023.284730","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"4078-4082"},"PeriodicalIF":8.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}