Haematologica最新文献_第9页

Characterization of a novel FLI1 mutation in a family with thrombocytopenia and other congenital malformations. 具有血小板减少症和其他先天性畸形的家族中一个新的FLI1突变的特征。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2024.287120

Daniele Ammeti, Serena Barozzi, Alessandro Pecci, Melania Eva Zanchetta, Edward Cesnik, Alessandra Ferlini, Mariabeatrice Sanchini, Laura Verga, Valeria Bozzi, Fabio Corsolini, Michela Faleschini, Anna Savoia, Stefania Bigoni

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Oral administration of a liquid containing nitrous oxide abolishes vaso-occlusive pain in mice with sickle cell disease. 口服含一氧化二氮的液体可消除镰状细胞病小鼠血管闭塞性疼痛。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287789

Ana Oddo, Fuad Abdulla, Annabelle Herold, Kathy Tang, Viacheslav Viatchenko-Karpinski, Iryna A Khasabova, Sergey G Khasabov, Mark Young, John D Belcher, Gregory M Vercellotti, Donald A Simone

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Outcomes for unselected, newly diagnosed multiple myeloma patients. 未选择的新诊断多发性骨髓瘤患者的结局。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287458

Jonathan T Moore, Sarah M Mettias, Jamie Cheung, Regina Swift, Benjamin Eades, Shahrooz Eshaghian, Gary Schwartz, James R Berenson

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Acquired Bernard-Soulier syndrome as the presenting feature of GATA2-related myeloid neoplasm in an adolescent: an insight into the mechanisms underlying the platelet defect. 获得性Bernard-Soulier综合征作为青少年gata2相关髓系肿瘤的表现特征：对血小板缺陷机制的深入研究

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287580

Laureano J Kamiya, María D Morell, Rosana F Marta, Marina Narbaitz, Christophe Marzac, Nora P Goette, Geraldine De Luca, Paola R Lev, María F Metrebian, Daiana Ganiewich, Andrea S Llera, Hana Raslova, Paula G Heller, Ana C Glembotsky

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When 'simplified' may be oversimplified: reassessing frailty scoring in elderly Hodgkin lymphoma. Comment on: A simplified frailty score predicts outcome in curatively treated older patients with classical Hodgkin lymphoma. 何时“简化”可能过于简化：重新评估老年霍奇金淋巴瘤的衰弱评分。评论：一个简化的衰弱评分可以预测经治疗的老年经典霍奇金淋巴瘤患者的预后。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.288186

Kun Huang

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A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera. 阻断白三烯介导的Alox5功能为治疗jak2v617f诱导的真性红细胞增多症提供了一种新的策略。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2024.287186

Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li

{"title":"A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera.","authors":"Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li","doi":"10.3324/haematol.2024.287186","DOIUrl":"https://doi.org/10.3324/haematol.2024.287186","url":null,"abstract":"Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition of the Alox5 pathway attenuates JAK2V617F-induced PV development in mice. However, the molecular mechanism underlying the function of Alox5 in PV remains elusive. It is well established that leukotrienes are important downstream molecules synthesized through the Alox5 pathway in leukocytes and play a key role in mediating Alox5 functions in human asthma. In this study, we found that Montelukast, a leukotriene receptor antagonist, inhibits cell proliferation and induces apoptosis in JAK2V617F-cell lines. Further in vivo studies demonstrated that Montelukast treatment suppresses the development of PV induced by JAK2V617F in mice, comparable to the effect of Alox5 inhibition on PV development. Notably, the inhibitory effect of Montelukast on PV is dependent on selectively eradicating PV stem cells while sparing their normal counterparts. Moreover, we found that Montelukast synergizes with the JAK2 inhibitor (ruxolitinib) to inhibit proliferation of JAK2V617F-expressing hematopoietic cells in vitro and in JAK2V617F mice. Finally, we showed that Montelukast induces caspase-3- and PARP-associated apoptosis of JAK2V617F-expressing cells. These findings indicate that Montelukast is a promising candidate agent and could be combined with an JAK2 inhibitor (such as ruxolitinib) for PV treatment.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Epstein-Barr virus viremia in NK-/T-cell lymphoma: bad boys for life! NK-/ t细胞淋巴瘤中持续性eb病毒血症：终身坏男孩！

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287922

Ana C Xavier, Yanling Liao, Mitchell S Cairo

引用次数: 0

Radiation therapy to manage isolated relapse after chimeric antigen receptor T-cell therapy in multiple myeloma. 放射治疗治疗多发性骨髓瘤嵌合抗原受体t细胞治疗后孤立复发。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287358

Surbhi Srinivas, Lin L Zhu, Noopur Raje, Chirayu G Patel

引用次数: 0

Comprehensive characterization of human bone marrow microenvironment shows age-related changes. 人类骨髓微环境的综合表征显示出与年龄相关的变化。

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287536

Mareike Peters, Patric Teodorescu, Sergiu Pasca, Xuan Zhang, Rulin Wang, Srinivasan Yegnasubramanian, Leighton H Grimes, Nathan Salomonis, Lukasz P Gondek, Gabriel Ghiaur

引用次数: 0

Contribution of genetics to hematopoietic stem cell mobilization: a genome-wide association study of 564 healthy donors mobilized with granulocyte colony-stimulating factor. 遗传学对造血干细胞动员的贡献：564名健康供体粒细胞集落刺激因子动员的全基因组关联研究

IF 8.2 1区医学

Haematologica Pub Date : 2025-06-05 DOI: 10.3324/haematol.2025.287637

Miriam Stenzinger, Susanne Beck, Iordanis Ourailidis, Anna-Lena Volckmar, Nagarajan Paramasivam, Aysel Ahadova, Aitzkoa Lopez de Lapuente Portilla, Phuong La Yen, Bjorn Nilsson, Justo Lorenzo Bermejo, Halvard Bonig, Jan Budczies

{"title":"Contribution of genetics to hematopoietic stem cell mobilization: a genome-wide association study of 564 healthy donors mobilized with granulocyte colony-stimulating factor.","authors":"Miriam Stenzinger, Susanne Beck, Iordanis Ourailidis, Anna-Lena Volckmar, Nagarajan Paramasivam, Aysel Ahadova, Aitzkoa Lopez de Lapuente Portilla, Phuong La Yen, Bjorn Nilsson, Justo Lorenzo Bermejo, Halvard Bonig, Jan Budczies","doi":"10.3324/haematol.2025.287637","DOIUrl":"https://doi.org/10.3324/haematol.2025.287637","url":null,"abstract":"Hematopoietic stem and progenitor cells (HSPC) from mobilized blood are the preferred graft source for allogeneic and autologous stem cell transplantation. The efficiency of CD34+ cell mobilization with granulocyte colony-stimulating factor (G-CSF) varies significantly between individuals, but is reproducible across mobilization cycles within an individual, suggesting a genetic component, a hypothesis that has been previously investigated by testing for candidate single-nucleotide polymorphisms (SNP) associations. As the genetic determinants of HSPC mobilization have not been analyzed on the genomic scale so far, we performed a genome-wide association study (GWAS) in a German population of 564 healthy G-CSF mobilized allogeneic stem cell donors. None of the association between about 5 million variants and the primary outcome investigated (CD34+ cell frequency in peripheral blood) reached genome-wide significance. Focused analysis of 11 variants previously shown to be associated with basal CD34+ cell levels confirmed an association of CXCR4-rs11688530 (A>G) and ARHGAP45-rs36084354 (A>G) with higher CD34+ frequency in G-CSF mobilized healthy donors showing an explained variance of 1.07% (p=0.004) and 0.86% (p=0.01), respectively. Demographic analysis revealed an association of peripheral blood CD34+ cell frequency with sex (Varex = 8.1%) and BMI (Varex = 7.2%) that exceeded the contribution of single variants. The current study is the first GWAS in mobilized stem cell donors and had a statistical power of 80% to detect SNPs with explained variance of ≥6.7% at genome-wide significance. The study results exclude a monogenetic cause of population G-CSF responsiveness and support the view that polygenetic risk scores are required as predictors.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0