HaematologicaPub Date : 2026-04-09DOI: 10.3324/haematol.2025.289196
Axel André, Estelle Bourbon, Guillaume Cartron, Franck Morschhauser, Amandine Fayard, Laure Ricard, Roberta Di Blasi, Adrien Chauchet, Stéphanie Guidez, Cristina Castilla-Llorente, Gabriel Brisou, Pierre Bories, Roch Houot, Anne Cuozzo, Elodie Gat, François Lemonnier, Camille Laurent
{"title":"Anti-CD19 CAR T-cell therapy in relapsed/refractory T-cell/histiocyte-rich large B-cell lymphoma: insights from the French DESCAR-T registry, a LYSA study.","authors":"Axel André, Estelle Bourbon, Guillaume Cartron, Franck Morschhauser, Amandine Fayard, Laure Ricard, Roberta Di Blasi, Adrien Chauchet, Stéphanie Guidez, Cristina Castilla-Llorente, Gabriel Brisou, Pierre Bories, Roch Houot, Anne Cuozzo, Elodie Gat, François Lemonnier, Camille Laurent","doi":"10.3324/haematol.2025.289196","DOIUrl":"https://doi.org/10.3324/haematol.2025.289196","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HaematologicaPub Date : 2026-04-02DOI: 10.3324/haematol.2026.300922
Yu-Sung Chang,Hsin-An Hou
{"title":"Response to Comment on: \"Prognostic implications of myelodysplasia-related gene mutations in NPM1-mutated acute myeloid leukemia: a systematic review and meta-analysis\".","authors":"Yu-Sung Chang,Hsin-An Hou","doi":"10.3324/haematol.2026.300922","DOIUrl":"https://doi.org/10.3324/haematol.2026.300922","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"25 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CAR-T therapy for relapsed/refractory large B-cell lymphoma in people living with HIV: efficacy, toxicity and treatment considerations.","authors":"Angela Hwang,Amy A Kirkwood,Prudence Hardefeldt,Mathew Amrith,Maeve O'Reilly,Andrea Kuhnl,Michael Northend,Paul Maciocia,Sridhar Chaganti,Kate Cwynarski,Robin Sanderson,Claire Roddie","doi":"10.3324/haematol.2025.300151","DOIUrl":"https://doi.org/10.3324/haematol.2025.300151","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"106 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HaematologicaPub Date : 2026-04-02DOI: 10.3324/haematol.2026.300842
Donna Przepiorka,Emily Y Jen
{"title":"Implications of the EHA/ELN guidelines for reporting blast percentage. Comment on: \"Reporting blast percentage for response assessment in acute leukemias: recommendations from an EHA/ELN expert panel\".","authors":"Donna Przepiorka,Emily Y Jen","doi":"10.3324/haematol.2026.300842","DOIUrl":"https://doi.org/10.3324/haematol.2026.300842","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"229 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HaematologicaPub Date : 2026-04-02DOI: 10.3324/haematol.2025.300202
Guillaume Berton,Jan Philipp Bewersdorf,Julia Gilhodes,Alexandre Iat,Amel Soua,Daniel J DeAngelo,Leora Boussi,Rory M Shallis,Andrius Žučenka,Rebecca P Bystrom,Kelly Ling,Luis E Aguirre,Richard M Stone,Marlise R Luskin,Jacqueline S Garcia,Eric S Winer,Evan C Chen,Martha Wadleigh,Lourdes Mendez,Nikolai Podoltsev,Urbain Tauveron-Jalenques,Luca Lanino,Eytan Stein,Amer M Zeidan,Edouard Forcade,Thomas Cluzeau,Pierre-Yves Dumas,Mael Heiblig,Raynier Devillier,Shai Shimony,Aaron D Goldberg,Maximilian Stahl,Sylvain Garciaz
{"title":"Hypomethylating agents plus venetoclax versus intensive chemotherapy prior to transplant in high-risk acute myeloid leukemia.","authors":"Guillaume Berton,Jan Philipp Bewersdorf,Julia Gilhodes,Alexandre Iat,Amel Soua,Daniel J DeAngelo,Leora Boussi,Rory M Shallis,Andrius Žučenka,Rebecca P Bystrom,Kelly Ling,Luis E Aguirre,Richard M Stone,Marlise R Luskin,Jacqueline S Garcia,Eric S Winer,Evan C Chen,Martha Wadleigh,Lourdes Mendez,Nikolai Podoltsev,Urbain Tauveron-Jalenques,Luca Lanino,Eytan Stein,Amer M Zeidan,Edouard Forcade,Thomas Cluzeau,Pierre-Yves Dumas,Mael Heiblig,Raynier Devillier,Shai Shimony,Aaron D Goldberg,Maximilian Stahl,Sylvain Garciaz","doi":"10.3324/haematol.2025.300202","DOIUrl":"https://doi.org/10.3324/haematol.2025.300202","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"5 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HaematologicaPub Date : 2026-04-02DOI: 10.3324/haematol.2025.300383
Connor M D Williams,Jacqueline E Noll,Dylan Harnas,Hayley B Parkinson,Duncan R Hewett,Andrew C W Zannettino,Kate Vandyke,Thomas R Cox,Vasilios Panagopoulos
{"title":"Therapeutic inhibition of myeloperoxidase with AZD5904 attenuates disease progression in mouse models of early-stage and relapsed multiple myeloma.","authors":"Connor M D Williams,Jacqueline E Noll,Dylan Harnas,Hayley B Parkinson,Duncan R Hewett,Andrew C W Zannettino,Kate Vandyke,Thomas R Cox,Vasilios Panagopoulos","doi":"10.3324/haematol.2025.300383","DOIUrl":"https://doi.org/10.3324/haematol.2025.300383","url":null,"abstract":"Despite advances in therapeutic strategies for multiple myeloma (MM), long-term outcomes remain poor, largely due to inevitable relapse and acquired drug resistance. Reciprocal interactions between malignant MM plasma cells (PCs) and the bone marrow microenvironment (BMME) drive disease progression, immune evasion, and therapeutic resistance, positioning the BM niche as a focus for targeted therapeutics. Myeloperoxidase (MPO) has recently emerged as a key regulator of MM progression via modification of the BMME. Here, we evaluate the efficacy of AZD5904, an orally bioavailable, irreversible MPO inhibitor, in preclinical models of MM. Initiation of MPO inhibition with AZD5904 during the early stages of MM tumour development significantly reduced tumour burden in the KaLwRij/5TGM1 and Vk*Myc murine models, however had no effect when initiated in established disease. Furthermore, AZD5904 modulated immune responses by decreasing PD1+ T cells in vivo and restoring CD8+ T cell cytotoxicity in vitro. While combining AZD5904 with the frontline agent bortezomib did not provide additional benefit in limiting disease progression, adjuvant AZD5904 following bortezomib treatment markedly delayed 5TGM1 tumour relapse. These findings suggest that while MPO inhibition may not enhance efficacy of bortezomib induction therapy, it holds promise as a maintenance strategy to improve long-term outcomes in MM. Collectively, our data support further investigation of AZD5904 as a novel maintenance therapy targeting the BM microenvironment, with potential to enhance and sustain the effectiveness of existing, standard of care regimens.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"17 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HaematologicaPub Date : 2026-04-02DOI: 10.3324/haematol.2025.300314
Carmen de Ramon Ortiz,Hana Abouzeid,Chiara De Bernardi,André Durham,Gregory Mathoux,Stavroula Masouridi,Thomas A Mckee,David Sibon,Olivier Hermine,David M Weinstock,Kristof Egervari,Jerome Tamburini
{"title":"Azacitidine-induced remission enables allogeneic transplantation in TET2/BCOR-mutant relapsed extranodal natural killer/T-cell lymphoma: a case report.","authors":"Carmen de Ramon Ortiz,Hana Abouzeid,Chiara De Bernardi,André Durham,Gregory Mathoux,Stavroula Masouridi,Thomas A Mckee,David Sibon,Olivier Hermine,David M Weinstock,Kristof Egervari,Jerome Tamburini","doi":"10.3324/haematol.2025.300314","DOIUrl":"https://doi.org/10.3324/haematol.2025.300314","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"58 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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