在t细胞急性淋巴细胞白血病中，PHF6与LMO2复合物相互作用。

IF 7.9 1区医学 Q1 HEMATOLOGY

Haematologica Pub Date : 2025-07-10 DOI:10.3324/haematol.2024.287124

Vesna S Stanulović,Sarah Binhassan,Budoor A Jaber,Shimaa Alazmi,Fatma M B Saleman,Sandeep Potluri,Guy Pratt,Christian Ludwig,Douglas G Ward,Maarten Hoogenkamp

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引用次数: 0

摘要

转录介质LIM domain only 2 （LMO2）与TAL1/LYL1、HEB/E2A、LDB1和GATA形成一个大的多蛋白复合物。这个复合体从造血发育开始和分化过程中调控转录。涉及LMO2和TAL1的染色体重排是t细胞淋巴母细胞白血病（TALL）的病因。我们已经鉴定出Plant Homeodomain (PHD)- likefinger 6 （PHF6）是一个新的LMO2相互作用因子。已经发现PHF6的体细胞突变发生在几种类型的白血病中。我们发现PHF6作为T-ALL中TAL1， GATA2， LDB1复合体的一部分与LMO2相互作用并结合到DNA上。这些发现表明，PHF6与TAL1/LMO2/LDB1/GATA2复合体相关，并调节在血液发育中起主要作用的基因，如SPI1 （PU.1）。

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PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia.

The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex regulates transcription from the onset of hematopoietic development and during differentiation. Chromosomal rearrangements involving LMO2 and TAL1 are causative for T-cell lymphoblastic leukemia (TALL). We have identified Plant Homeodomain (PHD)-like Finger 6 (PHF6) as a new LMO2 interacting factor. Somatic mutations in PHF6 have been found to occur in several types of leukemia. We show that PHF6 interacts with LMO2 as a part of the TAL1, GATA2, LDB1 complex in T-ALL and binds to the DNA. These findings show that PHF6 associates with the TAL1/LMO2/LDB1/GATA2 complex and regulates genes that have a major role in blood development, such as SPI1 (PU.1).

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来源期刊

Haematologica 医学-血液学

CiteScore

14.10

自引率

2.00%

发文量

349

审稿时长

3-6 weeks

期刊介绍： Haematologica is a journal that publishes articles within the broad field of hematology. It reports on novel findings in basic, clinical, and translational research. Scope: The scope of the journal includes reporting novel research results that: Have a significant impact on understanding normal hematology or the development of hematological diseases. Are likely to bring important changes to the diagnosis or treatment of hematological diseases.