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Nodular lymphocyte-predominant Hodgkin lymphoma: advances in disease biology, risk stratification, and treatment. 结节性淋巴细胞为主的霍奇金淋巴瘤：疾病生物学、风险分层和治疗方面的进展。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.285903
Ross T Salvaris, Benjamin M Allanson, Graham Collins, Chan Cheah
{"title":"Nodular lymphocyte-predominant Hodgkin lymphoma: advances in disease biology, risk stratification, and treatment.","authors":"Ross T Salvaris, Benjamin M Allanson, Graham Collins, Chan Cheah","doi":"10.3324/haematol.2024.285903","DOIUrl":"10.3324/haematol.2024.285903","url":null,"abstract":"<p><p>Recent updates have detailed how patients with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) may be better risk stratified using prognostic scoring systems. Most patients with NLPHL present with early-stage disease and have an indolent disease course. To reflect these differences from classic Hodgkin lymphoma, nomenclature has been updated to recognize nodular lymphocyte-predominant B-cell lymphoma as an alternative to NLPHL. The Global NLPHL One Working Group have published their pivotal dataset in 2024 which challenges the prognostic significance of variant immunoarchitectural (IAP) patterns and proposes a new prognostic scoring system. Key identified prognostic factors include age >45 years, stage III-IV disease, hemoglobin <10.5 g/dL and splenic involvement. After multivariate analysis, variant IAP was not shown to be associated with inferior outcome. As most patients with NLPHL have excellent long-term survival, identifying patients where treatment de-escalation is appropriate will help to minimize toxicity. De-escalation strategies include observation after fully resected stage I disease, active surveillance, anti-CD20 antibody monotherapy, radiotherapy in early-stage disease, and avoiding anthracycline- or bleomycin-containing chemotherapy regimens. Evidence supporting the use of novel therapies remains limited with disappointing results from a recently published study of ibrutinib in patients with relapsed NLPHL. Hopefully, future trials will investigate novel agents such as checkpoint inhibitors, T-cell engaging antibodies and chimeric antigen receptor T-cell therapy.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3476-3487"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late-onset NPM1 mutation in a MYC-amplified relapsed/refractory acute myeloid leukemia patient treated with gemtuzumab ozogamicin and glasdegib. 一名接受吉妥珠单抗奥佐米星和格拉斯替吉治疗的 MYC 扩增复发/难治性急性髓性白血病患者的晚期 NPM1 突变。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2023.284922
Sonia Jaramillo, Michael Scherer, Chelsea Szu-Tu, Sergi Beneyto-Calabuig, Carsten Müller-Tidow, Richard F Schlenk, Michael Hundemer, Lars Velten, Caroline Pabst
{"title":"Late-onset <i>NPM1</i> mutation in a MYC-amplified relapsed/refractory acute myeloid leukemia patient treated with gemtuzumab ozogamicin and glasdegib.","authors":"Sonia Jaramillo, Michael Scherer, Chelsea Szu-Tu, Sergi Beneyto-Calabuig, Carsten Müller-Tidow, Richard F Schlenk, Michael Hundemer, Lars Velten, Caroline Pabst","doi":"10.3324/haematol.2023.284922","DOIUrl":"10.3324/haematol.2023.284922","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3811-3815"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Stem cell factor and erythropoietin-independent production of cultured reticulocytes. 勘误：干细胞因子和红细胞生成素对培养网织红细胞的依赖性。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.286256
Emmanuel Olivier, Shouping Zhang, Zi Yan, Eric E Bouhassira
{"title":"<i>Erratum</i> to: Stem cell factor and erythropoietin-independent production of cultured reticulocytes.","authors":"Emmanuel Olivier, Shouping Zhang, Zi Yan, Eric E Bouhassira","doi":"10.3324/haematol.2024.286256","DOIUrl":"10.3324/haematol.2024.286256","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"109 11","pages":"3829-3831"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards personalized prevention of Herpes zoster infection in patients with hematologic diseases or hematopoietic stem cell transplant recipients: a position paper from an ad hoc Italian expert panel. 血液病患者或造血干细胞移植受者带状疱疹感染的个性化预防策略：意大利特设专家组的立场文件。
IF 5.4 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2023.284417
Corrado Girmenia, Fabio Ciceri, Paolo Corradini, Antonio Cuneo, Fortunato D'Ancona, Pellegrino Musto, Antonio Maria Risitano, Maria Teresa Voso, Adriano Venditti, Giovanni Barosi
{"title":"Towards personalized prevention of Herpes zoster infection in patients with hematologic diseases or hematopoietic stem cell transplant recipients: a position paper from an <I>ad hoc</I> Italian expert panel.","authors":"Corrado Girmenia, Fabio Ciceri, Paolo Corradini, Antonio Cuneo, Fortunato D'Ancona, Pellegrino Musto, Antonio Maria Risitano, Maria Teresa Voso, Adriano Venditti, Giovanni Barosi","doi":"10.3324/haematol.2023.284417","DOIUrl":"10.3324/haematol.2023.284417","url":null,"abstract":"<p><p>The identification of patients at high risk of Herpes zoster (HZ) requiring a preventive strategy with antiviral prophylaxis and anti-HZ vaccine is a clinically relevant issue in patients with immunological impairment. The absence of trials comparing vaccination to pharmacological prophylaxis or defining their sequential use makes the optimal preventive strategy uncertain. This article presents the results of group discussion among a panel of experts convened ad hoc to review the literature regarding antiviral prophylaxis and vaccine efficacy and safety in populations with malignant and non-malignant hematologic diseases, and in subjects submitted to hematopoietic stem cell transplantation. The expert panel used consensus methodology and proposed solutions for preventive strategies, producing advice for the management of the most relevant unmet clinical needs. This comprehensive overview aims to support the practice of pharmacological and vaccination-based HZ prevention and inform the design and conduct of new studies in the field.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3496-3504"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of autoimmune diseases in patients with sickle cell disease: a single center retrospective analysis. 镰状细胞病患者自身免疫性疾病的患病率：单中心回顾性分析。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2023.284552
Man Wai Tang, Erfan Nur, Charlotte F J Van Tuijn, Bart J Biemond
{"title":"Prevalence of autoimmune diseases in patients with sickle cell disease: a single center retrospective analysis.","authors":"Man Wai Tang, Erfan Nur, Charlotte F J Van Tuijn, Bart J Biemond","doi":"10.3324/haematol.2023.284552","DOIUrl":"10.3324/haematol.2023.284552","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3735-3738"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HES6: an emerging player in human hematopoiesis. HES6：人类造血过程中的新角色。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.285426
Jian Xu, Wei Du
{"title":"HES6: an emerging player in human hematopoiesis.","authors":"Jian Xu, Wei Du","doi":"10.3324/haematol.2024.285426","DOIUrl":"10.3324/haematol.2024.285426","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3466-3468"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcomes of newly diagnosed POEMS syndrome patients who received first-line lenalidomide-based therapy. 接受来那度胺一线治疗的新确诊 POEMS 综合征患者的长期疗效。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.285282
Xue-Min Gao, An-An Li, Hao Zhao, Kai-Ni Shen, Jian Li
{"title":"Long-term outcomes of newly diagnosed POEMS syndrome patients who received first-line lenalidomide-based therapy.","authors":"Xue-Min Gao, An-An Li, Hao Zhao, Kai-Ni Shen, Jian Li","doi":"10.3324/haematol.2024.285282","DOIUrl":"10.3324/haematol.2024.285282","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3776-3780"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspirin is a life-saving drug for patients with acute myocardial infarction. 阿司匹林是急性心肌梗死患者的救命药。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.286215
Marco Cattaneo
{"title":"Aspirin is a life-saving drug for patients with acute myocardial infarction.","authors":"Marco Cattaneo","doi":"10.3324/haematol.2024.286215","DOIUrl":"10.3324/haematol.2024.286215","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"109 11","pages":"3459-3460"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma. 勘误：泪液中的可溶性 B 细胞成熟抗原是多发性骨髓瘤角膜病的潜在生物标志物和介质。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.285821
Umair Munawar, Johanna Theuersbacher, Maximilian J Steinhardt, Xiang Zhou, Seungbin Han, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Thorsten Keller, Ann-Katrin Regensburger, Eva Teufel, Julia Mersi, Max Bittrich, Franziska Seifert, Malik S Haider, Leo Rasche, Jost Hillenkamp, Hermann Einsele, Daniel Kampik, K Martin Kortüm, Johannes M Waldschmidt
{"title":"<i>Erratum</i> to: Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma.","authors":"Umair Munawar, Johanna Theuersbacher, Maximilian J Steinhardt, Xiang Zhou, Seungbin Han, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Thorsten Keller, Ann-Katrin Regensburger, Eva Teufel, Julia Mersi, Max Bittrich, Franziska Seifert, Malik S Haider, Leo Rasche, Jost Hillenkamp, Hermann Einsele, Daniel Kampik, K Martin Kortüm, Johannes M Waldschmidt","doi":"10.3324/haematol.2024.285821","DOIUrl":"10.3324/haematol.2024.285821","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"109 11","pages":"3828"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study. 儿童费城阳性急性淋巴细胞白血病预防性颅脑放疗无明显疗效：EsPhALL2010 研究的回顾性分析。
IF 8.2 1区 医学
Haematologica Pub Date : 2024-11-01 DOI: 10.3324/haematol.2024.285253
Valentino Conter, Maria Grazia Valsecchi, Paola De Lorenzo, Virginie Gandemer, Mats Heyman, Vaskar Saha, Paulina Diaz, Chi-Kong Li, Andishe Attarbaschi, Gabriele Escherich, Jan Stary, Martin Schrappe, Rob Pieters, Gunnar Cario, Andrea Biondi
{"title":"No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study.","authors":"Valentino Conter, Maria Grazia Valsecchi, Paola De Lorenzo, Virginie Gandemer, Mats Heyman, Vaskar Saha, Paulina Diaz, Chi-Kong Li, Andishe Attarbaschi, Gabriele Escherich, Jan Stary, Martin Schrappe, Rob Pieters, Gunnar Cario, Andrea Biondi","doi":"10.3324/haematol.2024.285253","DOIUrl":"10.3324/haematol.2024.285253","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"3766-3770"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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