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Refining post-blinatumomab risk stratification through ultrasensitive-based measurable residual disease assessment. 通过基于超灵敏的可测量的残留疾病评估来改进布利纳单抗后风险分层。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2026.300941
Yazeed Samara,Ibrahim Aldoss
{"title":"Refining post-blinatumomab risk stratification through ultrasensitive-based measurable residual disease assessment.","authors":"Yazeed Samara,Ibrahim Aldoss","doi":"10.3324/haematol.2026.300941","DOIUrl":"https://doi.org/10.3324/haematol.2026.300941","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"54 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing reverse chimeric antigen receptor T cells for precise targeting of immunemediated thrombotic thrombocytopenic purpura. 建立反向嵌合抗原受体T细胞精确靶向免疫介导的血栓性血小板减少性紫癜。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2026.300520
Rutuja S Gupte,Sara Rovira Puig,Liliana R Loureiro,Margot Dierickx,Alexandra Von Jutrzenka-Trzebiatowski,Michael Bachmann,Jan Voorberg,Karen Vanhoorelbeke,Claudia Arndt,Anja Feldmann
{"title":"Establishing reverse chimeric antigen receptor T cells for precise targeting of immunemediated thrombotic thrombocytopenic purpura.","authors":"Rutuja S Gupte,Sara Rovira Puig,Liliana R Loureiro,Margot Dierickx,Alexandra Von Jutrzenka-Trzebiatowski,Michael Bachmann,Jan Voorberg,Karen Vanhoorelbeke,Claudia Arndt,Anja Feldmann","doi":"10.3324/haematol.2026.300520","DOIUrl":"https://doi.org/10.3324/haematol.2026.300520","url":null,"abstract":"Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) is a life-threatening autoimmune disorder caused by autoantibodies that target the metalloprotease ADAMTS13. This prevents the cleavage of Ultra-Large von Willebrand Factor (UL-VWF), thereby forming microthrombi in the microvasculature. While current treatments are effective, ADAMTS13 relapses occur in up to 15% of the patients after rituximab administration. In this study, we propose a novel approach addressing the unmet need for treatment of patients with ADAMTS13 refractoriness and for patients requiring repeated treatment. Our strategy involves developing two targeted therapies that aim to achieve highly effective and safe B cell depletion. For the first time, we employ adapter Chimeric Antigen Receptor (CAR) T cells called Reverse CAR (RevCAR) T cells to (i) achieve a broader and deeper B cell depletion by targeting CD19 and (ii) selectively deplete the disease-causing anti-ADAMTS13 autoreactive B cells to increase precision and safety in iTTP treatment. Therefore, we have developed novel Target Modules (RevTMs) against CD19+ and anti-ADAMTS13 autoreactive B cells. We show that the RevCAR T cells successfully and specifically kill target hybridomas and Nalm-6 cells in a RevTM-dependent manner and at low effector-to-target cell ratios. Moreover, the RevCAR T cells are able to eliminate the target cells even in the presence of high concentrations of ADAMTS13 autoantibodies. Overall, our findings demonstrate for the first time, a proof-ofconcept that anti-ADAMTS13 autoreactive B cells can be selectively depleted by the RevCAR T cell platform paving the way for an effective and safe therapy for iTTP.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"9 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene expression profile of adult T-cell leukemia/lymphoma with human T-cell lymphotropic virus type 1-infected Hodgkin and Reed-Sternberg-like cells is more similar to classic Hodgkin lymphoma than typical adult T-cell leukemia/lymphoma. 人t细胞嗜淋巴病毒1型感染霍奇金细胞和reed - sternberg样细胞的成人t细胞白血病/淋巴瘤的基因表达谱更类似于经典霍奇金淋巴瘤而不是典型的成人t细胞白血病/淋巴瘤。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2025.289270
Shohei Miyagi,Kyohei Mori,Kohta Miyawaki,Masatoshi Shimo,Tomoko Tamaki,Shugo Sakihama,Mitsuyoshi Takatori,Koichi Akashi,Kennosuke Karube,Koji Kato
{"title":"Gene expression profile of adult T-cell leukemia/lymphoma with human T-cell lymphotropic virus type 1-infected Hodgkin and Reed-Sternberg-like cells is more similar to classic Hodgkin lymphoma than typical adult T-cell leukemia/lymphoma.","authors":"Shohei Miyagi,Kyohei Mori,Kohta Miyawaki,Masatoshi Shimo,Tomoko Tamaki,Shugo Sakihama,Mitsuyoshi Takatori,Koichi Akashi,Kennosuke Karube,Koji Kato","doi":"10.3324/haematol.2025.289270","DOIUrl":"https://doi.org/10.3324/haematol.2025.289270","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"109 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual case of basophilic meningitis revealing a chronicphase chronic myeloid leukemia: a report after almost three years of follow-up. 一个罕见的嗜碱性脑膜炎病例显示慢性粒细胞白血病：经过近三年的随访报告。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2025.300120
Ramy Rahmé,Matteo Dragani,Carole Fleury,Giulia Tueur,Paule Moussounda Bamba,Héloïse Torres-Villaros,Audrey Giocanti-Aurégan,Roland Bangbotche,Gregory Lazarian,Fanny Baran-Marszak,Claude Gardin,Thorsten Braun
{"title":"An unusual case of basophilic meningitis revealing a chronicphase chronic myeloid leukemia: a report after almost three years of follow-up.","authors":"Ramy Rahmé,Matteo Dragani,Carole Fleury,Giulia Tueur,Paule Moussounda Bamba,Héloïse Torres-Villaros,Audrey Giocanti-Aurégan,Roland Bangbotche,Gregory Lazarian,Fanny Baran-Marszak,Claude Gardin,Thorsten Braun","doi":"10.3324/haematol.2025.300120","DOIUrl":"https://doi.org/10.3324/haematol.2025.300120","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"138 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inherited HHV-6A reactivation linked to impaired immune reconstitution following hematopoietic stem cell transplantation. 遗传性HHV-6A再激活与造血干细胞移植后免疫重建受损有关。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2026.300575
Leo Hannolainen,Heljä Lång,Lari Pyöriä,Kaisa Vepsäläinen,Svetlana Vakkilainen,Klaus Hedman,Eliisa Kekäläinen,Zachery Dickson,Samppa Ryhänen,Maria F Perdomo
{"title":"Inherited HHV-6A reactivation linked to impaired immune reconstitution following hematopoietic stem cell transplantation.","authors":"Leo Hannolainen,Heljä Lång,Lari Pyöriä,Kaisa Vepsäläinen,Svetlana Vakkilainen,Klaus Hedman,Eliisa Kekäläinen,Zachery Dickson,Samppa Ryhänen,Maria F Perdomo","doi":"10.3324/haematol.2026.300575","DOIUrl":"https://doi.org/10.3324/haematol.2026.300575","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"441 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TP53 mutation analysis in myelodysplastic syndromes - long or short read sequencing? 骨髓增生异常综合征的TP53突变分析——长读测序还是短读测序？
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2026.300932
Moshe Mittelman,Liran Shlush
{"title":"TP53 mutation analysis in myelodysplastic syndromes - long or short read sequencing?","authors":"Moshe Mittelman,Liran Shlush","doi":"10.3324/haematol.2026.300932","DOIUrl":"https://doi.org/10.3324/haematol.2026.300932","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"19 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of microbial exposure and risk of infectionpromoted acute lymphoblastic leukaemia. 微生物暴露的时间和感染的风险促进急性淋巴细胞白血病。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2025.289280
Valeria Cazzaniga,Elham Shamsaei,Julia Procter,Peter John-Baptiste,Anthony M Ford,Mel Greaves
{"title":"Timing of microbial exposure and risk of infectionpromoted acute lymphoblastic leukaemia.","authors":"Valeria Cazzaniga,Elham Shamsaei,Julia Procter,Peter John-Baptiste,Anthony M Ford,Mel Greaves","doi":"10.3324/haematol.2025.289280","DOIUrl":"https://doi.org/10.3324/haematol.2025.289280","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"22 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal exchange blood is a rich source of hematopoietic stem and progenitor cells for transplantation. 新生儿换血是移植所需造血干细胞和祖细胞的丰富来源。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-16 DOI: 10.3324/haematol.2025.300370
Yang Liu,Pablo Giusti,Hong Qian,Ping Chun Wu,Tengyu Wang,Stan De Haan,Jacek Toporski,Agneta Wikman,Petter Höglund,Emöke Deschmann,Roland Fiskesund
{"title":"Neonatal exchange blood is a rich source of hematopoietic stem and progenitor cells for transplantation.","authors":"Yang Liu,Pablo Giusti,Hong Qian,Ping Chun Wu,Tengyu Wang,Stan De Haan,Jacek Toporski,Agneta Wikman,Petter Höglund,Emöke Deschmann,Roland Fiskesund","doi":"10.3324/haematol.2025.300370","DOIUrl":"https://doi.org/10.3324/haematol.2025.300370","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"84 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genetic landscape of extramedullary plasmacytoma: a comparative analysis with extramedullary disease of multiple myeloma. 髓外浆细胞瘤的遗传景观：与多发性骨髓瘤髓外疾病的比较分析。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-09 DOI: 10.3324/haematol.2025.300201
Antonio Vogelsberg,Julia Salmerón-Villalobos,Anna-Lisa Wilhelmi,Franziska Otto,Aylin Schneider,Barbara Mankel,Eyyub Bag,Ariadna Colmenero,Matthias S Dettmer,Marina Narbaitz,Alexandar Tzankov,Itziar Salaverria,Irina Bonzheim,Falko Fend
{"title":"The genetic landscape of extramedullary plasmacytoma: a comparative analysis with extramedullary disease of multiple myeloma.","authors":"Antonio Vogelsberg,Julia Salmerón-Villalobos,Anna-Lisa Wilhelmi,Franziska Otto,Aylin Schneider,Barbara Mankel,Eyyub Bag,Ariadna Colmenero,Matthias S Dettmer,Marina Narbaitz,Alexandar Tzankov,Itziar Salaverria,Irina Bonzheim,Falko Fend","doi":"10.3324/haematol.2025.300201","DOIUrl":"https://doi.org/10.3324/haematol.2025.300201","url":null,"abstract":"Extramedullary (or extraosseous) plasmacytoma (EMP) is a localized plasma cell neoplasm lacking apparent bone marrow involvement and other features of multiple myeloma (MM). The prognosis is usually favorable and progression to MM is infrequent. The genetic landscape of EMP remains largely unknown. Importantly, EMP must be distinguished from extramedullary disease of MM (EMD), which typically exhibits aggressive behavior. We performed a comprehensive molecular analysis of EMP (n=24) in comparison to EMD (n=24) using fluorescence in situ hybridization (FISH), copy number (CN) profiling, and targeted nextgeneration sequencing. Overall, EMP shared several genetic features with MM, but exhibited markedly lower complexity than EMD. EMP revealed a mean of 4.3 CN changes vs. 19.3 in EMD (p.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"21 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease course of FLT3 mutated extramedullary acute myeloid leukemia and efficacy of gilteritinib. FLT3突变的髓外急性髓性白血病病程及吉替尼的疗效。
IF 10.1 1区 医学
Haematologica Pub Date : 2026-04-09 DOI: 10.3324/haematol.2026.300540
Francesco Angotzi,Erika Borlenghi,Chiara Sartor,Maria Benedetta Giannini,Giovanni Marconi,Edoardo Tamellini,Mauro Turrini,Federica Loscocco,Ernesta Audisio,Vincenzo Federico,Calogero Vetro,Francesco Grimaldi,Andrea Visentin,Felicetto Ferrara,Livio Trentin,Carmela Gurrieri,Federica Lessi
{"title":"Disease course of FLT3 mutated extramedullary acute myeloid leukemia and efficacy of gilteritinib.","authors":"Francesco Angotzi,Erika Borlenghi,Chiara Sartor,Maria Benedetta Giannini,Giovanni Marconi,Edoardo Tamellini,Mauro Turrini,Federica Loscocco,Ernesta Audisio,Vincenzo Federico,Calogero Vetro,Francesco Grimaldi,Andrea Visentin,Felicetto Ferrara,Livio Trentin,Carmela Gurrieri,Federica Lessi","doi":"10.3324/haematol.2026.300540","DOIUrl":"https://doi.org/10.3324/haematol.2026.300540","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"5 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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