Haematologica最新文献

{"title":"ALK-positive histiocytosis and a clonally related chronic myelomonocytic leukemia.","authors":"Gerben E Breimer,Elisa A Rozeman,Weibel W Braunius,Laura G M Daenen,Lennart A Kester,Roos J Leguit,Rutger Mahieu,Nienke Solleveld-Westerink,Louise Straatman,Frans Schutgens","doi":"10.3324/haematol.2025.288275","DOIUrl":"https://doi.org/10.3324/haematol.2025.288275","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"70 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of demographic factors on clinical outcomes of patients with acute myeloid leukemia.","authors":"Cassandra Duarte,Diana Abbot,Grace Bosma,Andrew Kent,Marc Schwartz,Cailin Collins,Mathew G Angelos,Christine McMahon,Jonathon Gutman,Daniel A Pollyea,Maria Amaya","doi":"10.3324/haematol.2025.288131","DOIUrl":"https://doi.org/10.3324/haematol.2025.288131","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"129 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCRL2 and who? An important driver in TP53-mutant myeloid leukemias.","authors":"Olivia Arnold,Caner Saygin","doi":"10.3324/haematol.2025.288631","DOIUrl":"https://doi.org/10.3324/haematol.2025.288631","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"33 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on: a case series of patients with β- thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies.","authors":"Fabiana Busti,Domenico Girelli","doi":"10.3324/haematol.2025.289073","DOIUrl":"https://doi.org/10.3324/haematol.2025.289073","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"24 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The glutaminase activity of ASNS fuels glutamine metabolism in leukemia.","authors":"Wai-Kin Chan,Lin Tan,Sara A Martinez,Di Du,Thomas D Horvath,Michael Pontikos,Leona A Rusling,Yulun Chiu,Bao Q Tran,Susan B Rempe,Sergei Sukharev,John N Weinstein,Philip L Lorenzi","doi":"10.3324/haematol.2024.287099","DOIUrl":"https://doi.org/10.3324/haematol.2024.287099","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"24 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on: Hepatitis B virus reactivation following T-cell engager therapy in multiple myeloma despite negative hepatitis B core antibody serology: implications for screening in patients with haematological malignancies.","authors":"Matthew J Rees, Hang Quach, Darren Jardine, Alexander Thompson","doi":"10.3324/haematol.2025.289053","DOIUrl":"https://doi.org/10.3324/haematol.2025.289053","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response.","authors":"Paul D Barone,Siarhei Dzedzik,Ashley S Kleinman,Christopher R Chin,Cem Meydan,Itzel Valencia,Mayumi Sugita,Monica L Guzman,Joshua A Fein,Justin D Kaner,Pinkal Desai,Gail J Roboz,Ari M Melnick,Christopher E Mason,Sanjay S Patel","doi":"10.3324/haematol.2025.288054","DOIUrl":"https://doi.org/10.3324/haematol.2025.288054","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"33 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic risk classification in acute myeloid leukemia patients treated with hematopoietic cell transplantation and post-transplant cyclophosphamide.","authors":"Marta Villalba,Juan Montoro,Aitana Balaguer-Roselló,Pedro Chorão,Pedro Asensi Cantó,Pablo Granados,Inés Gómez-Seguí,Pilar Solves,Esperanza Such,José Cervera,Eva Barrragán,Marta Santiago,José V Gil-Ortí,Brais Lamas,Ana Bataller,Alberto Louro,Javier De la Rubia,Miguel Á Sanz,Jaime Sanz","doi":"10.3324/haematol.2025.287860","DOIUrl":"https://doi.org/10.3324/haematol.2025.287860","url":null,"abstract":"We analyzed outcomes of 217 AML patients in complete remission who underwent allogeneic HCT with myeloablative conditioning and post-transplant cyclophosphamide-based GVHD prophylaxis, aiming to assess the prognostic significance of genetic risk categories. In the overall cohort, the 2-year overall survival (OS) and event-free survival (EFS) were 77% (95% CI, 71-83) and 72% (95% CI, 66- 78), respectively. ELN2022 risk stratification lacked prognostic value in HCT. Instead, we identified four risk categories with distinct impact on OS: standard risk (ELN2022 favorable/intermediate and adverse-risk without high-risk genetic under the defined subcategories), intermediate risk (≥2 myelodysplasia-related gene mutations) (HR 2.23, 95% CI 1.14-4.92), adverse risk (complex karyotype, monosomal karyotype, inv(3)/t(3;3), KMT2A rearrangement) (hazard ratio (HR) 4.24, 95% CI 2.00 - 9.02), and very adverse risk (TP53 mutations) (HR 6.81, 95% CI 3.00 - 15.5). These categories demonstrated similar predictive power for EFS and cumulative incidence of relapse. Moreover, integrating pre-transplant MRD refined risk stratification, identified MRDnegative patients with ≥2 myelodysplasia-related gene mutations whose OS and EFS were comparable to standard-risk patients. This refined classification improves the prognostic value of ELN2022 for AML patients undergoing allogeneic HCT with modern platform by integrating genetic features and MRD status to better guide post-transplant management.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"27 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity.","authors":"Monika Dzieciatkowska, Ariel Hay, Aaron Issaian, Gregory R Keele, Shaun Bevers, Travis Nemkov, Julie A Reisz, Mark Maslanka, Daniel Stephenson, Amy L Moore, Xutao Deng, Mars Stone, Kirk C Hansen, Steve Kleinman, Philip J Norris, Michael P Busch, Grier P Page, Nareg Roubinian, Yang Xia, James C Zimring, Angelo D'Alessandro","doi":"10.3324/haematol.2025.288332","DOIUrl":"10.3324/haematol.2025.288332","url":null,"abstract":"<p><p>Caffeine is the most widely consumed psychoactive substance globally, yet its peripheral physiological effects remain incompletely understood. Leveraging comprehensive data from 13,091 blood donors in the REDS RBC-Omics study, we identify caffeine as a significant modulator of red blood cell (RBC) storage quality and transfusion outcomes. Elevated caffeine levels were reproducible across multiple donations from 643 recalled donors, selected based on their extremes in hemolytic propensity. Both in the screening and recalled cohorts, higher caffeine levels were associated with disrupted RBC metabolism, characterized by reduced glycolysis, depletion of adenylate pools or 2,3-bisphosphoglycerate, and increased markers of oxidative stress and osmotic fragility, including kynurenine accumulation. These observations were recapitulated in plasma and RBCs of eight volunteers upon consumption of a cup of coffee independently of brewing method (Chemex vs espresso). Clinically, elevated caffeine correlated with increased hemolysis and lower post-transfusion hemoglobin increments, especially pronounced in recipients transfused with RBCs from donors carrying common polymorphisms in the ADORA2b gene, a key regulator of RBC metabolism in hypoxia. These human findings were mechanistically validated using a murine model deficient in ADORA2b, which demonstrated impaired glycolytic flux, compromised antioxidant defenses - including caffeine-dependent direct inhibition of recombinantly-expressed glucose 6-phosphate dehydrogenase, and decreased transfusion efficacy (lower hemoglobin increments, higher bilirubin posttransfusion), effects further exacerbated by caffeine exposure during storage. Our study positions caffeine consumption as a modifiable factor in blood transfusion practice, advocating for precision strategies that integrate genetic and exposome factors, and identifies metabolic interventions to enhance blood quality and clinical outcomes.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The invisible divide: the impact of racial and geographic disparities on multiple myeloma outcomes - insights from a single-site study.","authors":"Michael A Bauer,Phillip Farmer,Joseph L Su,Mario Schootman,Chenghui Li,Frits Van Rhee,Samer Al Hadidi,Carolina Schinke,John D Shaughnessy,Fenghuang Zhan,Cody Ashby","doi":"10.3324/haematol.2025.287760","DOIUrl":"https://doi.org/10.3324/haematol.2025.287760","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"61 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}