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Cancer-related thrombosis: impact of biological sex on the risk of rethrombosis and bleeding. 癌症相关血栓：生理性别对再血栓和出血风险的影响。
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2024-12-12 DOI: 10.3324/haematol.2024.286152
Silvia García Adrián, Claudia Iglesias Pérez, Alberto Carmona-Bayonas, Laura Ortega Morán, Jaime Rubio Pérez, Purificación Martínez Del Prado, Eva Martínez De Castro, Fernando Neria, Isaura Fernández Pérez, Marta García De Herreros, Marta Carmona Campos, Ignacio García Escobar, Rut Porta Balanyà, David Marrupe González, Paula Jiménez Fonseca, María Esperanza Guirao García, Manuel Sánchez Cánovas, José Muñoz Langa, Pedro Pérez Segura, Ma José Méndez Vidal, Andrés J Muñoz Martín, Spanish Society Of Medical Oncology
{"title":"Cancer-related thrombosis: impact of biological sex on the risk of rethrombosis and bleeding.","authors":"Silvia García Adrián, Claudia Iglesias Pérez, Alberto Carmona-Bayonas, Laura Ortega Morán, Jaime Rubio Pérez, Purificación Martínez Del Prado, Eva Martínez De Castro, Fernando Neria, Isaura Fernández Pérez, Marta García De Herreros, Marta Carmona Campos, Ignacio García Escobar, Rut Porta Balanyà, David Marrupe González, Paula Jiménez Fonseca, María Esperanza Guirao García, Manuel Sánchez Cánovas, José Muñoz Langa, Pedro Pérez Segura, Ma José Méndez Vidal, Andrés J Muñoz Martín, Spanish Society Of Medical Oncology","doi":"10.3324/haematol.2024.286152","DOIUrl":"10.3324/haematol.2024.286152","url":null,"abstract":"<p><p>Patients with cancer have a higher risk of re-thrombosis and bleeding secondary to anticoagulant treatment than have individuals without cancer. Given the lack of specific clinical trials, the decision regarding the optimal duration of treatment must consider multiple factors, including sex. The current study used data from the international, prospective TESEO Registry that includes consecutive patients diagnosed with cancer-associated thrombosis. Between July 2018 and December 2022, 2,823 patients were included in the TESEO Registry, 1,351 (48%) of whom were female. The most common venous thromboembolic event (VTE) in both sexes was pulmonary embolism, with an incidence of 58.0% among men and 54.3% in women (P=0.045). After a median follow-up of 6.9 months (interquartile range, 1.9-14.4), the re-thrombosis rate at the end of follow-up was 10.0% in males and 15.0% in females (P=0.14). The location of the primary tumor in the gastrointestinal tract was associated with a greater risk of re-thrombosis, whereas sex had no significant impact. Men had twice as many major bleeds. Additional risk factors for major bleeding included situations of risk due to tumor site or thrombocytopenia, as well as the presence of active tumor bleeding at the time of VTE diagnosis. Overall survival was longer among women. Given the higher incidence of major bleeding among men, sex should be deemed a relevant factor when deciding the duration of anticoagulant treatment in cancer patients.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1513-1522"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The improved prognosis of FLT3-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world study using large-scale electronic health record data. 靶向治疗时代急性髓性白血病flt3 -内部串联重复而非酪氨酸激酶结构域突变的预后改善：一项使用大规模电子健康记录数据的现实世界研究
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-02-06 DOI: 10.3324/haematol.2024.286695
Matthew Schwede, Gladys Rodriguez, Vanessa E Kennedy, Solomon Henry, Douglas Wood, Gabriel N Mannis, Ravindra Majeti, Jonathan H Chen, Eran Bendavid, Tian Yi Zhang
{"title":"The improved prognosis of <i>FLT3</i>-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world study using large-scale electronic health record data.","authors":"Matthew Schwede, Gladys Rodriguez, Vanessa E Kennedy, Solomon Henry, Douglas Wood, Gabriel N Mannis, Ravindra Majeti, Jonathan H Chen, Eran Bendavid, Tian Yi Zhang","doi":"10.3324/haematol.2024.286695","DOIUrl":"10.3324/haematol.2024.286695","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1634-1638"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venetoclax in combination with hypomethylating agents in newly diagnosed and relapsed CBFβ::MYH11+ acute myeloid leukemia. Venetoclax联合低甲基化药物治疗新诊断和复发的CBFβ::MYH11+急性髓性白血病
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-02-20 DOI: 10.3324/haematol.2024.286836
Ziyu Feng, Xiaohui Hu, Weiyang Li, Ting Xu, Yang Xu, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Yanming Zhang, Depei Wu, Ying Wang
{"title":"Venetoclax in combination with hypomethylating agents in newly diagnosed and relapsed <i>CBFβ::MYH11<sup>+</sup></i> acute myeloid leukemia.","authors":"Ziyu Feng, Xiaohui Hu, Weiyang Li, Ting Xu, Yang Xu, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Yanming Zhang, Depei Wu, Ying Wang","doi":"10.3324/haematol.2024.286836","DOIUrl":"10.3324/haematol.2024.286836","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1639-1643"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia. 血浆置换治疗急性淋巴细胞白血病成人患者经peg -天冬酰胺酶治疗后高氨血症诱导的意识降低。
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-03-13 DOI: 10.3324/haematol.2024.286972
Felix Klingler, Anika Forstreuter, Luisa Stegat, Sofie Kämereit, Felix Ullrich, Florian Udonta, Christian Krebs, Dominik Wichmann, Carsten Bokemeyer, Nicola Goekbuget, Walter Fiedler, Franziska Modemann
{"title":"Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia.","authors":"Felix Klingler, Anika Forstreuter, Luisa Stegat, Sofie Kämereit, Felix Ullrich, Florian Udonta, Christian Krebs, Dominik Wichmann, Carsten Bokemeyer, Nicola Goekbuget, Walter Fiedler, Franziska Modemann","doi":"10.3324/haematol.2024.286972","DOIUrl":"10.3324/haematol.2024.286972","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1660-1664"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the generation and function of megakaryocytes in health and disease. 巨核细胞在健康和疾病中的产生和功能的新见解。
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI: 10.3324/haematol.2024.287236
Changhong Du, Jun Chen, Junping Wang
{"title":"New insights into the generation and function of megakaryocytes in health and disease.","authors":"Changhong Du, Jun Chen, Junping Wang","doi":"10.3324/haematol.2024.287236","DOIUrl":"10.3324/haematol.2024.287236","url":null,"abstract":"<p><p>Megakaryocytes are canonically viewed as specialized hematopoietic cells that merely produce platelets and that are generated through a series of hematopoietic stem and progenitor cells in the bone marrow. Despite their essential physiological functions, the generation and function of megakaryocytes remain incompletely understood. Recent studies, mostly in mice, have begun to redefine the cellular hierarchy of megakaryopoiesis, and shed new light on the alternative routes and mechanisms of megakaryopoiesis. Moreover, the conception of megakaryocytes as a homogeneous cell population with the sole purpose of platelet production is being challenged. Indeed, megakaryocytes are being shown to be a heterogeneous population of cells with distinct routes of differentiation and versatile functions. In particular, megakaryocytes show abilities reminiscent of immune cells, and are increasingly considered as the root dictating the hemostatic and immune functions of platelets in various physiopathological conditions. Furthermore, although megakaryocytes are well known as a component of the bone marrow niche, maintaining hematopoietic stem cells during homeostasis, the newly identified properties of megakaryocytes further indicate that they may be key supporters of stressed or diseased hematopoietic stem cells during myeloablative injury, aging and hematopoietic malignancy. Therefore, the generation and function of megakaryocytes are more diverse than we previously thought. Here, we review the recent literature that expands our views of megakaryocyte differentiation and heterogeneity, as well as the functions of megakaryocytes, with special focuses on their immune functions and supporting roles for stressed or diseased hematopoietic stem cells.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1500-1512"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patients with high-risk acute promyelocytic leukemia need maintenance therapy for 1 year - the CONS. 高危急性早幼粒细胞白血病患者需要一年的维持治疗。
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-04-03 DOI: 10.3324/haematol.2025.287418
Harry J Iland
{"title":"Patients with high-risk acute promyelocytic leukemia need maintenance therapy for 1 year - the CONS.","authors":"Harry J Iland","doi":"10.3324/haematol.2025.287418","DOIUrl":"10.3324/haematol.2025.287418","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1459-1465"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncogenic NTRK3 mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia. 致瘤性NTRK3突变在急性髓性白血病患者中对原肌球蛋白受体激酶抑制剂表现出不同的敏感性。
IF 8.2 1区 医学
Haematologica Pub Date : 2025-07-01 Epub Date: 2025-02-13 DOI: 10.3324/haematol.2024.285572
Sunil K Joshi, Ariane Huang, Janét Pittsenbarger, Ujwal Shinde, Camilo Posso, Paul D Piehowski, Sara J C Gosline, Richard D Press, Marina A Gritsenko, Chelsea Hutchinson, Karl K Weitz, Kevin Watanabe-Smith, Nicola Long, Karin D Rodland, Jeffrey W Tyner, Brian J Druker, Cristina E Tognon
{"title":"Oncogenic <i>NTRK3</i> mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia.","authors":"Sunil K Joshi, Ariane Huang, Janét Pittsenbarger, Ujwal Shinde, Camilo Posso, Paul D Piehowski, Sara J C Gosline, Richard D Press, Marina A Gritsenko, Chelsea Hutchinson, Karl K Weitz, Kevin Watanabe-Smith, Nicola Long, Karin D Rodland, Jeffrey W Tyner, Brian J Druker, Cristina E Tognon","doi":"10.3324/haematol.2024.285572","DOIUrl":"10.3324/haematol.2024.285572","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"1616-1622"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should we move past erythropoietin-stimulating agent monotherapy in lower-risk myelodysplastic syndromes? 在低风险骨髓增生异常综合征中，我们是否应该放弃促红细胞生成素单药治疗？
IF 10.1 1区 医学
Haematologica Pub Date : 2025-06-26 DOI: 10.3324/haematol.2025.288157
Lee Mozessohn,Rena Buckstein
{"title":"Should we move past erythropoietin-stimulating agent monotherapy in lower-risk myelodysplastic syndromes?","authors":"Lee Mozessohn,Rena Buckstein","doi":"10.3324/haematol.2025.288157","DOIUrl":"https://doi.org/10.3324/haematol.2025.288157","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"9 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chimera's curse: myeloid clonal evolution after CD19-directed CAR T-cell therapy. 嵌合体的诅咒：cd19靶向CAR - t细胞治疗后的髓系克隆进化。
IF 10.1 1区 医学
Haematologica Pub Date : 2025-06-26 DOI: 10.3324/haematol.2025.287976
Gregory W Roloff
{"title":"Chimera's curse: myeloid clonal evolution after CD19-directed CAR T-cell therapy.","authors":"Gregory W Roloff","doi":"10.3324/haematol.2025.287976","DOIUrl":"https://doi.org/10.3324/haematol.2025.287976","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"48 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower-intensity chemo-immunotherapy with cladribine, low-dose cytarabine, venetoclax and blinatumomab produces high response rates in patients with BCR::ABL1-negative B-cell / myeloid mixed phenotype acute leukemia. 在BCR:: abl1阴性的b细胞/髓细胞混合表型急性白血病患者中，低强度化学免疫治疗cladribine、低剂量阿糖胞苷、venetoclax和blinatumumab可产生高有效率。
IF 10.1 1区 医学
Haematologica Pub Date : 2025-06-26 DOI: 10.3324/haematol.2025.287932
Roberta S Azevedo,Wei-Ying Jen,Danielle Hammond,Fadi G Haddad,Alexis Geppner,Ghayas C Issa,Koji Sasaki,Jayastu Senapati,Elias Jabbour,Farhad Ravandi,Hagop Kantarjian,Tapan M Kadia
{"title":"Lower-intensity chemo-immunotherapy with cladribine, low-dose cytarabine, venetoclax and blinatumomab produces high response rates in patients with BCR::ABL1-negative B-cell / myeloid mixed phenotype acute leukemia.","authors":"Roberta S Azevedo,Wei-Ying Jen,Danielle Hammond,Fadi G Haddad,Alexis Geppner,Ghayas C Issa,Koji Sasaki,Jayastu Senapati,Elias Jabbour,Farhad Ravandi,Hagop Kantarjian,Tapan M Kadia","doi":"10.3324/haematol.2025.287932","DOIUrl":"https://doi.org/10.3324/haematol.2025.287932","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"242 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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