Hepatology International最新文献_第3页

Pathological transcriptional retention of Cyp26b1 in perirenal adipose-derived stem cells contributes to MASLD progression. 肾周脂肪来源干细胞中Cyp26b1的病理性转录保留有助于MASLD的进展。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.1007/s12072-026-11118-z

Yannan Zhang, Zheng Li, Jinyu Sun, Changhao Xu, Min Gao, Hui Shen, Dongxu Hua, Qiyang Xie, Yi Xiao, Yuanjie Huang, Peng Li, Wei Sun, Xiangqing Kong

{"title":"Pathological transcriptional retention of Cyp26b1 in perirenal adipose-derived stem cells contributes to MASLD progression.","authors":"Yannan Zhang, Zheng Li, Jinyu Sun, Changhao Xu, Min Gao, Hui Shen, Dongxu Hua, Qiyang Xie, Yi Xiao, Yuanjie Huang, Peng Li, Wei Sun, Xiangqing Kong","doi":"10.1007/s12072-026-11118-z","DOIUrl":"10.1007/s12072-026-11118-z","url":null,"abstract":"Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder linked to metabolic syndrome, but its extrahepatic drivers and persistence mechanisms remain unclear.Methods: Transcriptomics was performed on adipose-derived stem cells (ADSCs) from distinct adipose depots in dynamic MASLD mouse models. A dietary reversal model was used to assess transcriptional retention. Candidate genes were identified via integrated DNA methylome and transcriptome analysis. Cyp26b1 function was tested by perirenal ADSCs-specific knockdown, and involved downstream mechanisms were investigated.Results: Perirenal ADSCs exhibited an early dysregulated transcriptional signature in MASLD and retained high transcriptional retention after reversal. Multi-omics identified Cyp26b1 as a persistent, epigenetically regulated driver. Knockdown of Cyp26b1 in perirenal ADSCs attenuated MASLD progression, potentially by modulating the CCL3-CCR5 axis to alleviate hepatic steatosis and inflammation.Conclusion: This study reveals an ADSC-mediated perirenal adipose-liver axis and establishes pathological \"memory\" in ADSCs as a perpetuating factor in MASLD. Transcriptional retention in perirenal ADSCs and its key regulator Cyp26b1 represent potential theoretical targets for exploring the mechanism and intervention of cellular \"memory\" in MASLD.","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1353-1371"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining the definition of acute autoimmune hepatitis: implications for classification and prognosis. 改进急性自身免疫性肝炎的定义：对分类和预后的影响。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-02-02 DOI: 10.1007/s12072-026-11040-4

Xuping Zhang, Qian Li, Peipei Zhang

引用次数: 0

Response to letter to editor-Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon. 对编辑的回复：使用聚乙二醇化干扰素治疗的无活性携带者在第24周快速HBsAg血清清除的机器学习预测。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-03-14 DOI: 10.1007/s12072-026-11048-w

Jianxia Dong, Sujun Zheng, Xinyue Chen

引用次数: 0

Strengthening the stratification of autoimmune hepatitis: toward enhanced clinical applicability. 加强自身免疫性肝炎的分层：提高临床适用性。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-02-04 DOI: 10.1007/s12072-026-11039-x

Yingting Zhu, Zirui Weng, Lin Miao

引用次数: 0

Response to Letter to Editor: Revisiting MASLD-based pregnancy risk stratification. 致编辑的回复：重新审视基于masld的妊娠风险分层。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-02-04 DOI: 10.1007/s12072-026-11046-y

Young Mi Jung, Geum Joon Cho, Won Kim

引用次数: 0

Suppression of macrophage membrane cholesterol efflux by SLAMF7-induced IL-7 signaling improves immunotherapy efficacy in hepatocellular carcinoma. 通过slamf7诱导的IL-7信号抑制巨噬细胞膜胆固醇外排可提高肝癌的免疫治疗效果。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2026-06-09 DOI: 10.1007/s12072-026-11111-6

Jialei Weng, Fu Wang, Wenxin Xu, Liqian Zhao, Yushun Chang, Haowen Lu, Kai Xu, Heming Zheng, Yifan Wang, Xiujun Cai

{"title":"Suppression of macrophage membrane cholesterol efflux by SLAMF7-induced IL-7 signaling improves immunotherapy efficacy in hepatocellular carcinoma.","authors":"Jialei Weng, Fu Wang, Wenxin Xu, Liqian Zhao, Yushun Chang, Haowen Lu, Kai Xu, Heming Zheng, Yifan Wang, Xiujun Cai","doi":"10.1007/s12072-026-11111-6","DOIUrl":"10.1007/s12072-026-11111-6","url":null,"abstract":"Background: The limited efficacy of immunotherapy in hepatocellular carcinoma (HCC) is largely attributed to the formation of an immunosuppressive tumor microenvironment, in which abnormal cholesterol metabolism plays an important role. Here, we investigated the effects of signaling lymphocytic activation molecule family member 7 (SLAMF7) on the cholesterol metabolism of HCC.Methods: Metabolomics was performed in spontaneous HCC tissues with hepatocyte-specific Slamf7 knockout. An in vitro coculture system was constructed, and cytokine matrix, protein profiling, and transcriptome sequencing were applied to explore the function of SLAMF7 in HCC.Results: Profiling of the metabolomics of spontaneous HCC with Slamf7 knockout and the proteomics of SLAMF7-overexpressing HCC cells clarified the inhibition of cholesterol synthesis by SLAMF7 in HCC cells. Furthermore, HCC cell-intrinsic SLAMF7 inhibited membrane cholesterol efflux and function reprogramming in macrophages. Mechanistically, SLAMF7 interacted with DHCR24 and enhanced the binding and ubiquitination degradation of DHCR24 by MARCH6 via its intracellular domain to inhibit cholesterol synthesis in HCC cells. Reduction of cholesterol content in lipid rafts impaired the AKT activation and promoted entry of dephosphorylated FOXO1 into nucleus for IL-7 transcription. Subsequently, IL-7 reduced membrane cholesterol efflux by inhibiting the NF-κB pathway and ABCA1 transcription in macrophages. Pharmacological enhancement of IL-7 signaling improved the efficacy of anti-PD-1 antibody in HCC mouse models with low SLAMF7 level.Conclusions: Our study molecularly identifies a key role of SLAMF7 in cholesterol metabolism and trafficking between HCC cells and macrophages and gives a rationale for targeting IL-7 signaling as an effective strategy to sensitize HCC to immunotherapy.","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1479-1496"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: A commentary on "Safety of tenofovir alafenamide in the context of hyperlipidemia and cardiovascular diseases: a nationwide analysis". 回复：关于“替诺福韦阿拉那胺在高脂血症和心血管疾病中的安全性：一项全国性分析”的评论。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2025-10-25 DOI: 10.1007/s12072-025-10941-0

Jae-Young Kim, Hyuk Kim, Jeong-Ju Yoo, Sang Gyune Kim, Young-Seok Kim

引用次数: 0

Comments on recurrence patterns in HCC with microvascular invasion. 肝细胞癌伴微血管侵犯复发模式的探讨。

IF 7.8 2区医学

Hepatology International Pub Date : 2026-10-01 Epub Date: 2025-12-22 DOI: 10.1007/s12072-025-10993-2

Xingxing Yao, Enhui Lv, Kequn Chai

引用次数: 0

Untapped potential of efruxifermin in lean MASH. fruxifermin在瘦肉型MASH中尚未开发的潜力。