Hepatology International最新文献

{"title":"Converging pathways: the interaction between estimated glucose disposal rate and atherogenic index of plasma in MASLD risk stratification.","authors":"Mingxing Chang, Peipu Shen, Guifang Shen","doi":"10.1007/s12072-026-11098-0","DOIUrl":"10.1007/s12072-026-11098-0","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health burden linked to insulin resistance and atherogenic dyslipidemia, estimated by the glucose disposal rate (eGDR) and atherogenic index of plasma (AIP), respectively. However, the nature of their combined association-whether additive or interactive-with MASLD risk, and its utility for risk stratification, remains unexplored.</p><p><strong>Methods: </strong>In this large-scale cross-sectional analysis of 30,143 adults, we calculated eGDR and AIP from routine clinical measures. Their independent and joint associations with ultrasonography-defined MASLD were assessed using multivariable logistic regression, restricted cubic splines (RCS), and interaction analysis. Based on RCS-derived thresholds, participants were categorized into four metabolic phenotypes for combined risk assessment.</p><p><strong>Results: </strong>Both lower eGDR and higher AIP were independently and nonlinearly associated with greater MASLD risk (p for trend < 0.001). A significant interaction was observed (p < 0.001), revealing a convergent pattern: the protective association of high eGDR appeared attenuated as AIP increased, and the risk disparity attributable to AIP narrowed markedly at low eGDR levels. Participants with the combined low-eGDR/high-AIP phenotype had the highest MASLD odds (OR = 3.42, 95% CI 3.07-3.81). These findings were robust to alternative adjustment strategies and phenotype definitions in sensitivity analyses.</p><p><strong>Conclusions: </strong>eGDR and AIP exhibit a significant interactive association with MASLD risk, characterized by a convergent pattern: the incremental risk associated with atherogenic dyslipidemia (high AIP) appeared less pronounced under conditions of severe insulin resistance (low eGDR). Integrating these two metrics identifies a distinct high-risk phenotype and may inform future risk stratification strategies. Longitudinal studies are needed to establish causality and clinical utility.</p>","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1340-1352"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and dementia: is hepatic steatosis an innocent bystander or an active contributor to cognitive decline?","authors":"Cameron Gofton, Elie Matar, Jacob George","doi":"10.1007/s12072-026-11149-6","DOIUrl":"10.1007/s12072-026-11149-6","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1295-1298"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Refining Surgical Indications for Hepatocellular Carcinoma in Patients with Clinically Significant Portal Hypertension\".","authors":"Yukihiro Watanabe, Masayasu Aikawa, Yoshiki Murase, Kenichiro Takase, Yuichiro Watanabe, Hiroaki Ono, Katsuya Okada, Kojun Okamoto, Isamu Koyama","doi":"10.1007/s12072-025-10960-x","DOIUrl":"10.1007/s12072-025-10960-x","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1506-1507"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145632650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon\".","authors":"Famei Xu","doi":"10.1007/s12072-026-11042-2","DOIUrl":"10.1007/s12072-026-11042-2","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1535-1536"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden structure, visible effects: uneven genotype missingness and its implications for interpreting Peg-IFN efficacy in CHB trials.","authors":"Binqi Wang, Danna Zheng, Jinshi Zhang","doi":"10.1007/s12072-026-11068-6","DOIUrl":"10.1007/s12072-026-11068-6","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1551-1552"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The Asian Pacific Association of the Study of the Liver expert survey on artificial intelligence-assisted reporting of liver histopathology in metabolic dysfunction associated fatty liver disease.","authors":"H Elangovan, K Akbary, A Rastogi, A Wee, G Soon, L Adams, E Carr-Boyd, A Clouston, C L Cooper, W K Chan, Y Y Dan, R Dela-Cruz, G Goh, S S Hamid, D Q Huang, T Kawaguchi, H Kim, W Kim, S U Kim, J D Jia, C J Liu, F Liu, W Q Leow, M D Muthiah, I Ng, D Payawal, A F Pan, S Pervez, G Shiha, T Tanwandee, Y Tanaka, L Thiyaphat, M Vij, Y Yilmaz, F Yilmaz, M L Yu, K Zalata, M H Zheng, J G Fan, S K Sarin, V Wong, J George","doi":"10.1007/s12072-026-11131-2","DOIUrl":"10.1007/s12072-026-11131-2","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1681-1683"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon\".","authors":"Qiongying Xu, Jiehua Han, Jiali Zhu","doi":"10.1007/s12072-025-11010-2","DOIUrl":"10.1007/s12072-025-11010-2","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1516-1517"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Autoimmune liver diseases in the Asia Pacific region: proceedings of the autoimmune liver disease course at APASL 2025\".","authors":"Bin Wu","doi":"10.1007/s12072-026-11054-y","DOIUrl":"10.1007/s12072-026-11054-y","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1547-1548"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APASL STC 2025 Tokyo.","authors":"","doi":"10.1007/s12072-026-11125-0","DOIUrl":"10.1007/s12072-026-11125-0","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1561-1680"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric autoimmune hepatitis in the Asia-Pacific region: practical considerations for guideline implementation.","authors":"Yimamujiang Aximu, Xuping Zhang, Peipei Zhang","doi":"10.1007/s12072-025-11005-z","DOIUrl":"10.1007/s12072-025-11005-z","url":null,"abstract":"","PeriodicalId":12901,"journal":{"name":"Hepatology International","volume":" ","pages":"1518-1519"},"PeriodicalIF":7.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}