IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2023-11-20 DOI: 10.1007/s00059-023-05223-0

Omar Hahad

引用次数: 0

Psychological burden in patients with angina and unobstructed coronary arteries-underestimated, underexplored, undertreated. 冠状动脉未阻塞的心绞痛患者的心理负担--被低估、探索不足、治疗不力。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-06-19 DOI: 10.1007/s00059-024-05253-2

Peter Ong, Astrid Hubert, Zineb Moussaoui, Raffi Bekeredjian, Frank Vitinius, Karl-Heinz Ladwig

引用次数: 0

The predictive value of PRECISE-DAPT score for long-term mortality in patients with acute coronary syndrome complicated by cardiogenic shock. PRECISE-DAPT 评分对急性冠状动脉综合征并发心源性休克患者长期死亡率的预测价值。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-01-03 DOI: 10.1007/s00059-023-05231-0

Sukru Akyuz, Ali Nazmi Calik, Tolga Onuk, Baris Yaylak, Zeynep Kolak, Semih Eren, Feyza Mollaalioglu, Furkan Durak, Mustafa Cetin, Ibrahim Halil Tanboga

{"title":"The predictive value of PRECISE-DAPT score for long-term mortality in patients with acute coronary syndrome complicated by cardiogenic shock.","authors":"Sukru Akyuz, Ali Nazmi Calik, Tolga Onuk, Baris Yaylak, Zeynep Kolak, Semih Eren, Feyza Mollaalioglu, Furkan Durak, Mustafa Cetin, Ibrahim Halil Tanboga","doi":"10.1007/s00059-023-05231-0","DOIUrl":"10.1007/s00059-023-05231-0","url":null,"abstract":"Background: Besides its primary clinical utility in predicting bleeding risk in patients with acute coronary syndrome (ACS), the PRECISE-DAPT (Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Anti-Platelet Therapy) score may also be useful for predicting long-term mortality in ACS patients presenting with cardiogenic shock (CS) since several studies have reported an association between the score and certain cardiovascular conditions or events. The aim of the present study was to evaluate the utility of the PRECISE-DAPT score for predicting the long-term all-cause mortality in patients (n = 293) with ACS presenting with CS.Methods: The PRECISE-DAPT score was calculated for each patient who survived in hospital, and the association with long-term mortality was studied. Median follow-up time was 2.7 years. The performance of the final model was determined with measurements of its discriminative power (Harrell's and Uno's C indices and time-dependent area under the receiver operating characteristic curve [AUC]) and predictive accuracy (coefficient of determination [R2] and likelihood ratio χ2). Hazard ratios (HRs) were used to assess the relationship between the variables of the model and long-term all-cause death.Results: All-cause death occurred in 197 patients (67%). There was a positive association between the PRECISE-DAPT score (change from 17 to 38 was associated with an HR of 2.42 [95% CI: 1.59-3.68], R2 = 0.209, time-dependent AUC = 0.69) and the risk of death such that in the adjusted survival curve, the risk of mortality increased as the PRECISE-DAPT score increased.Conclusion: The PRECISE-DAPT score may be a useful easy-to-use tool for predicting long-term mortality in patients with ACS complicated by CS.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"302-308"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Lower extremity arterial disease (LEAD)]. [下肢动脉疾病（LEAD）]。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1007/s00059-024-05252-3

Christine Espinola-Klein

引用次数: 0

Neuroimmune crosstalk : How mental stress fuels vascular inflammation. 神经免疫串扰：精神压力如何助长血管炎症？

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI: 10.1007/s00059-024-05254-1

Ulrike Meyer-Lindemann, Hendrik B Sager

{"title":"Neuroimmune crosstalk : How mental stress fuels vascular inflammation.","authors":"Ulrike Meyer-Lindemann, Hendrik B Sager","doi":"10.1007/s00059-024-05254-1","DOIUrl":"10.1007/s00059-024-05254-1","url":null,"abstract":"Cardiovascular diseases are the leading cause of death worldwide. Pathophysiologically, metabolic and inflammatory processes contribute substantially to the development and progression of cardiovascular diseases. Over the past decade, the role of disease-propagating inflammatory processes has been strengthened and reframed, leading to trials testing anti-inflammatory drugs for the treatment of atherosclerosis and its complications. Despite these achievements, further research in both pre-clinical and clinical studies is warranted to explore new targets, to better identify responders, and to refine therapy strategies to combat inflammation in human disease. Environmental disturbances, so-called lifestyle-associated cardiovascular risk factors, greatly alter the immune system in general and leukocytes in particular, thus affecting the progression of atherosclerosis. Epidemiological studies have shown that exposure to mental stress can be closely linked to the occurrence of cardiovascular disease. Here, we describe how acute and chronic mental stress alter the immune system via neuroimmune interactions, thereby modifying vascular inflammation. In addition, we identify gaps that still need to be addressed in the future.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"249-253"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac disease-induced trauma and stress-related disorders. 心脏病诱发的创伤和压力相关疾病。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-11 DOI: 10.1007/s00059-024-05255-0

Mary Princip, Katharina Ledermann, Rahel Altwegg, Roland von Känel

{"title":"Cardiac disease-induced trauma and stress-related disorders.","authors":"Mary Princip, Katharina Ledermann, Rahel Altwegg, Roland von Känel","doi":"10.1007/s00059-024-05255-0","DOIUrl":"10.1007/s00059-024-05255-0","url":null,"abstract":"Objective: This review aims to present an updated overview of cardiac disease-induced trauma and stress-related disorders such as acute stress disorder (ASD), adjustment disorder (AjD), and posttraumatic stress disorder (PTSD). First, the prevalence of these disorders, their diagnostic criteria, and their differences from other trauma-related disorders are described. Special challenges in diagnosis and treatment are identified, with various screening tools being evaluated for symptom assessment. Additionally, the risk factors studied so far for the development of symptoms of cardiac-induced posttraumatic stress disorder and the bidirectional relationship between posttraumatic stress disorder and cardiovascular diseases are summarized. Various therapeutic interventions, including pharmacological approaches, are also discussed. Finally, various areas for future research are outlined.Background: Experiencing a cardiovascular disease, particularly a life-threatening cardiac event, can potentially lead to stress-related disorders such as ASD, AjD, and cardiac disease-induced PTSD (CDI-PTSD). If left untreated, these disorders are associated with a worsening cardiac prognosis and higher mortality rates. Approaching treatment through a trauma-focused lens may be beneficial for managing CDI-PTSD and stress-related disorders.Conclusion: Future research should explore treatment options for both the patients and the caregivers as well as investigate the long-term effects of trauma-focused interventions on physical and mental health outcomes.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"254-260"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Psychocardiology - on the way to the sunny side of the road : Strenuous, but doable]. [心理心脏病学--在通往阳光大道的路上：艰苦但可行]。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-29 DOI: 10.1007/s00059-024-05258-x

Karl-Heinz Ladwig

引用次数: 0

Depression screening in patients with coronary heart disease : A narrative review of the current evidence. 冠心病患者抑郁筛查：现有证据回顾。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1007/s00059-024-05257-y

Sebastian Kohlmann

{"title":"Depression screening in patients with coronary heart disease : A narrative review of the current evidence.","authors":"Sebastian Kohlmann","doi":"10.1007/s00059-024-05257-y","DOIUrl":"10.1007/s00059-024-05257-y","url":null,"abstract":"In view of the large and sometimes conflicting body of research, this narrative review summarizes the current evidence on depression screening in patients with coronary heart disease. Depression is a risk factor for development and progression of coronary heart disease. Consequently, many international cardiac guidelines recommend screening for depression in patients with coronary heart disease. However, the efficacy and implementation of these guidelines are debated due to the lack of empirical evidence supporting the benefits of routine depression screening. Studies conducted in cardiac routine care support this assumption: Patients with positive depression screens do not receive adequate follow-up care, which highlights gaps in the detection-to-treatment pathway. Barriers to effective screening and treatment include system-level factors, such as insufficient integration of mental health resources in cardiology, and patient-related factors like stigma and low acceptance of mental health treatment. Innovative interventions that address these barriers and involve patients as active partners in depression care should be developed through a theory-driven, transparent, multistage process involving key stakeholders such as patients, nurses, and cardiologists. A sound methodological evaluation of such multilevel interventions could answer the question of whether early detection of depression in patients with coronary heart disease would lead to health benefits.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"261-269"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice. 在ApoE(-/-)小鼠中，Urantide通过Wnt/β-catenin信号通路减轻动脉粥样硬化相关的肝肾损伤。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2023-11-20 DOI: 10.1007/s00059-023-05219-w

Yu-Hang Xu, Jia-Yi Xie, Shen Huang, Tu Wang, Hai-Peng Cui, Juan Zhao

{"title":"Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice.","authors":"Yu-Hang Xu, Jia-Yi Xie, Shen Huang, Tu Wang, Hai-Peng Cui, Juan Zhao","doi":"10.1007/s00059-023-05219-w","DOIUrl":"10.1007/s00059-023-05219-w","url":null,"abstract":"Objective: To investigate the role of urantide in the prevention and treatment of atherosclerosis (AS)-related liver and kidney injury by antagonizing the urotensin II/urotensin receptor (UII/UT) system and regulating the Wnt/β-catenin signaling pathway.Methods: Atherosclerotic ApoE-/- mice were treated with 20 mg/kg, 30 mg/kg, and 40 mg/kg urantide for 14 days.Results: When ApoE-/- mice developed AS, significant pathological changes occurred in the liver and kidney, and the UII/UT system in tissue was highly activated; furthermore, the Wnt/β-catenin signalling pathway was activated, and proteins related to this signalling pathway, such as GSK-3β, AXIN2, CK‑1, and APC, were significantly downregulated. After urantide treatment, the pathological damage to the liver and kidney was effectively improved, the activity of the UII/UT system was effectively inhibited, and the expression of the Wnt/β-catenin signalling pathway and related proteins was restored. Wnt/β-catenin signals were mainly localized in the cytoplasm, renal tubules, and interstitium.Conclusion: Urantide could improve AS-related liver and kidney injury by antagonizing the UII/UT system, and the improvements in liver and kidney function in atherosclerotic ApoE-/- mice may be related to inhibition of the Wnt/β-catenin signalling pathway.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"282-295"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease. 冠状动脉计算机断层扫描导出的血流储备分数对冠状动脉疾病患者心血管事件的预测价值。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2023-11-03 DOI: 10.1007/s00059-023-05220-3

Hongwei Han, Meijun Liu, Yang Yu, Yuan Chen, Yizhou Xu

{"title":"Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease.","authors":"Hongwei Han, Meijun Liu, Yang Yu, Yuan Chen, Yizhou Xu","doi":"10.1007/s00059-023-05220-3","DOIUrl":"10.1007/s00059-023-05220-3","url":null,"abstract":"Background: Coronary computed tomography-derived fractional flow reserve (FFR-CT) assesses whether coronary artery lesions will result in myocardial ischemia. This study aimed to evaluate the predictive value of FFR-CT for cardiovascular events in patients with coronary artery disease (CAD).Methods: Data were collected retrospectively from patients with CAD who underwent FFR-CT at our hospital from January 2020 to February 2022 (1-year average follow-up). Patients were divided into ischemic (FFR-CT ≤ 0.80) and non-ischemic (FFR-CT > 0.80) groups. The incidence of endpoint events (cardiac death, acute myocardial infarction, unplanned revascularization, unstable angina, and stable angina) was calculated. The FFR-CT value was correlated with endpoint events using Cox regression models and Kaplan-Meier survival curves.Results: We recruited 134 patients (93 [69.4%] and 41 [30.6%] patients in the ischemic and non-ischemic groups, respectively). The ischemic group had a higher proportion of men, patients with type 2 diabetes and hypertension, and patients taking antiplatelet drugs and β‑blockers than did the non-ischemic group (all p < 0.05), whereas other parameters were comparable. Multivariate Cox regression analysis revealed no significant differences in cardiac death, acute myocardial infarction, unplanned revascularization, and unstable angina between the groups. The incidence of stable angina events (hazard ratio: 3.092, 95% confidence interval: 1.362-7.022, p = 0.007) was significantly higher in the ischemic group. Kaplan-Meier survival analysis revealed a significant difference in event-free survival for stable angina between the groups (p = 0.002).Conclusion: In patients with CAD, FFR-CT showed an independent predictive value for stable angina within 1 year of examination.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"296-301"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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