HerzPub Date : 2025-12-01Epub Date: 2025-05-23DOI: 10.1007/s00059-025-05318-w
A Pinchuk, V Adam, P Biehler, P Hägele, S Hanger, S Löbig, F Ausbuettel, C Waechter, P Seizer, S Weyand
{"title":"Impact of functional mitral regurgitation on outcomes of high-power short-duration pulmonary vein isolation in patients with atrial fibrillation.","authors":"A Pinchuk, V Adam, P Biehler, P Hägele, S Hanger, S Löbig, F Ausbuettel, C Waechter, P Seizer, S Weyand","doi":"10.1007/s00059-025-05318-w","DOIUrl":"10.1007/s00059-025-05318-w","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is a common arrhythmia with significant health implications. Mitral regurgitation (MR) frequently coexists with AF and may affect treatment outcomes.</p><p><strong>Methods: </strong>This study aimed to analyze the impact of MR severity on the outcomes of high-power short-duration pulmonary vein isolation (PVI) in patients with AF. This observational cohort study involved 255 patients undergoing their first PVI. A total of 83 patients with moderate or severe MR were propensity score-matched with 83 controls based on age, sex, and body mass index (BMI). Procedural parameters, complication rates, AF recurrence within 1 year of PVI, and MR progression were analyzed.</p><p><strong>Results: </strong>Patients with moderate or severe MR demonstrated a higher percentage of atrial low-voltage areas (23.06% vs. 15.42%, p = 0.04) and more frequently required additional ablations (18.07% vs. 6.02%, p = 0.02). The 1‑year AF recurrence rates were identical between the groups (19.28% each, p = 1.00). The MR grade remained stable without significant differences between the groups after 1 year. However, among patients without AF recurrence, a statistically significant reduction in MR grade was observed after 1 year (1.54 ± 0.64 vs. 1.37 ± 0.53, p < 0.01). By contrast, patients with AF recurrence exhibited a trend toward worsening MR, although this change was not statistically significant (1.53 ± 0.57 vs. 1.75 ± 0.51, p = 0.09).</p><p><strong>Conclusion: </strong>High-power short-duration PVI is safe and effective in AF patients, even among those with moderate or severe MR. Patients with moderate or severe functional MR exhibit more LA low-voltage areas and require more extensive ablations, especially cavotricuspid isthmus CTI ablation, reflecting a more complex disease profile. Maintaining a stable sinus rhythm can contribute to a reduction in MR grade.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"469-478"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-12-01Epub Date: 2025-09-16DOI: 10.1007/s00059-025-05337-7
Elia von Felten, Alexander Breitenstein, Daniel Hofer
{"title":"[Leadless atrial pacemaker : New perspectives in cardiac pacemaker treatment].","authors":"Elia von Felten, Alexander Breitenstein, Daniel Hofer","doi":"10.1007/s00059-025-05337-7","DOIUrl":"10.1007/s00059-025-05337-7","url":null,"abstract":"<p><p>Previous leadless pacemaker systems were confined to the right ventricle, thus limiting the clinical applications. With the introduction of the first leadless atrial cardiac pacemaker, new perspectives in antibradycardia treatment were introduced. This device enables leadless atrial stimulation and electrical atrial sensing with the potential to reduce complications of cardiac pacemaker treatment. The atrial leadless atrial pacemaker is implanted transvenously with a delivery catheter via the femoral vein into the base of the right atrial appendage. In combination with a ventricular leadless pacemaker, a complete dual chamber pacemaker system can be created through galvanically coupled intracorporeal communication. This can be created as an upgrade from an already implanted ventricular or atrial leadless cardiac pacemaker or the system can be implanted directly (de novo). The possibility of an upgrade enables a flexible treatment adapted to the individual progression of the underlying disease. Current limitations for wider clinical use include economic considerations, limited battery capacity and insufficient data concerning retrievability after the battery is exhausted.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"407-416"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12660430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-11-10DOI: 10.1007/s00059-025-05351-9
J Boldt, D Kling, E Schuhmann, H H Scheld, G Hempelmann
{"title":"Retraction Note: Der neue Phosphodiesterasehemmer Enoximone: Einsatzmöglichkeiten im Rahmen herzchirurgischer Eingriffe.","authors":"J Boldt, D Kling, E Schuhmann, H H Scheld, G Hempelmann","doi":"10.1007/s00059-025-05351-9","DOIUrl":"10.1007/s00059-025-05351-9","url":null,"abstract":"","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-11-10DOI: 10.1007/s00059-025-05352-8
J Boldt, B von Bormann, D Kling, U Börner, J Mulch, G Hempelmann
{"title":"Retraction Note: Kolloidosmotischer Druck und extravaskuläres Lungenwasser nach extrakorporaler Zirkulation.","authors":"J Boldt, B von Bormann, D Kling, U Börner, J Mulch, G Hempelmann","doi":"10.1007/s00059-025-05352-8","DOIUrl":"10.1007/s00059-025-05352-8","url":null,"abstract":"","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-10-01Epub Date: 2025-09-05DOI: 10.1007/s00059-025-05330-0
Joanna Jozwiak-Nozdrzykowska, Marcus Sandri, Maja Hanuna, Sotirios Nedios, Alexey Dashkevich
{"title":"[The heart team in heart failure].","authors":"Joanna Jozwiak-Nozdrzykowska, Marcus Sandri, Maja Hanuna, Sotirios Nedios, Alexey Dashkevich","doi":"10.1007/s00059-025-05330-0","DOIUrl":"10.1007/s00059-025-05330-0","url":null,"abstract":"<p><p>In recent years the treatment for heart failure (HF) has become much more complex. This development has highlighted the importance of a multidisciplinary HF team to ensure the best possible individually adapted treatment decisions, taking the patient's personal wishes into account and to achieve optimal results. In Germany, specialized HF practices, clinics and tertiary bespoke HF unit centers were established to ensure qualified care for HF patients. These institutions fulfil defined standards and quality features for outpatient and inpatient treatment and cooperate closely in the framework of HF networks. The interdisciplinary HF team should be involved in the treatment from the initial step of correct diagnosis through availability for changes of the clinical status up to HF-related hospitalization due to acute or advanced HF. The core team encompasses cardiologists, skilled HF nursing personnel, cardiac surgeons and coordinators for heart transplantation and ventricular assist devices and is complimented by other specialists depending on the patient's specific etiology and severity of HF as well as relevant comorbidities. The quality of treatment is also enhanced by personal HF additional qualifications. One of the most essential goals of this multidisciplinary collaboration is patient-centered team-based recommendations and decision making, which aim to improve the prognosis of patients, reduce hospitalization rates and improve the quality of life.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"337-343"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-10-01Epub Date: 2025-08-27DOI: 10.1007/s00059-025-05332-y
M Winhard, M Krane, S Hakmi, J Mehilli, A Ghanem
{"title":"[The heart team in coronary artery disease-perspectives from centers without institutional cardiac surgery].","authors":"M Winhard, M Krane, S Hakmi, J Mehilli, A Ghanem","doi":"10.1007/s00059-025-05332-y","DOIUrl":"10.1007/s00059-025-05332-y","url":null,"abstract":"<p><p>The management of coronary artery disease (CAD) has become more demanding due to evolving therapeutic options and more complex patient profiles. In this context, the heart team has become established: a structured, interdisciplinary decision-making process that brings together the specialist knowledge from cardiology, cardiac surgery, anesthesia and other specialist fields to enable individual and evidence-based treatment recommendations. While this model is well-established in university medical centers, its implementation in nonuniversity hospitals lacking in-house cardiac surgery presents unique challenges. This article explores practical strategies for successfully establishing heart teams in such institutions, including the formation of a stable organized core team for case coordination, formal cooperation with external cardiac surgery centers (often via telemedicine), integration of experienced cardiac anesthesiologists and the establishment of clear internal processes for communication and documentation. Particular attention is given to the technical infrastructure required to support hybrid or virtual conferencing formats.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"356-361"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-10-01Epub Date: 2025-08-28DOI: 10.1007/s00059-025-05328-8
Christoph S Mueller, Christian Hagl, Jörg Hausleiter, Thomas J Stocker
{"title":"The multidisciplinary Heart Team in mitral valve transcatheter edge-to-edge repair.","authors":"Christoph S Mueller, Christian Hagl, Jörg Hausleiter, Thomas J Stocker","doi":"10.1007/s00059-025-05328-8","DOIUrl":"10.1007/s00059-025-05328-8","url":null,"abstract":"<p><p>Treatment options for mitral regurgitation (MR) have markedly evolved over the past few decades, with mitral valve transcatheter edge-to-edge repair (M-TEER) expanding the clinical armamentarium of guideline-directed medical therapy and surgical techniques. However, the variety of mitral valve anatomies, the presence of heart failure (HF), and consideration of the individual patient risk require a multidisciplinary Heart Team approach to identify the optimal treatment for MR for each patient. Despite the growing field of transcatheter mitral interventions and the longstanding availability of surgical mitral valve repair and replacement, evidence from randomized clinical trials comparing intervention with surgery remains scarce. In the meantime, the increasing safety and experience of surgical and interventional procedures have shifted the perspective on mitral valve disease in terms of when and how to treat it. Therefore, the multidisciplinary Heart Team discussion has become of paramount importance in the evaluation and treatment decisions for patients with mitral valve disease.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"319-325"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-10-01Epub Date: 2025-08-25DOI: 10.1007/s00059-025-05327-9
Samira Soltani, Johann Bauersachs
{"title":"[Diagnosis and treatment of heart failure with preserved ejection fraction].","authors":"Samira Soltani, Johann Bauersachs","doi":"10.1007/s00059-025-05327-9","DOIUrl":"10.1007/s00059-025-05327-9","url":null,"abstract":"<p><p>The treatment of heart failure with preserved ejection fraction (HFpEF) involves symptomatic management of congestion with diuretics (class I recommendation) and treatment with sodium-glucose linked transporter 2 (SGLT2) inhibitors for improvement of the prognosis, which have a class I recommendation across the entire spectrum of left ventricular ejection fraction (LVEF) in the current guidelines. The data supporting the recommendation of SGLT2 inhibitors in HFpEF come from the EMPEROR-Preserved and DELIVER studies. The FINEARTS-HF study showed positive effects on cardiovascular death/heart failure hospitalization of the treatment of HFpEF patients with finerenone, a nonsteroidal mineralocorticoid receptor antagonist. The STEP-HFpEF (2023) and SUMMIT (2024) studies investigated the treatment with glucagon-like peptide 1 (GLP-1) analogs in patients with HFpEF and obesity and showed positive outcomes regarding quality of life and, in the latter study, positive effects on heart failure events. The treatment of severe mitral and tricuspid valve regurgitation impacts not only the symptom burden but also hospitalization and overall prognosis in HFpEF patients.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"395-404"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HerzPub Date : 2025-10-01Epub Date: 2025-08-28DOI: 10.1007/s00059-025-05329-7
Marc Adrian Rogmann, Edoardo Zancanaro, Hendrik Treede, Philipp Lurz, Karl-Patrik Kresoja
{"title":"[Interdisciplinary management of tricuspid valve regurgitation].","authors":"Marc Adrian Rogmann, Edoardo Zancanaro, Hendrik Treede, Philipp Lurz, Karl-Patrik Kresoja","doi":"10.1007/s00059-025-05329-7","DOIUrl":"10.1007/s00059-025-05329-7","url":null,"abstract":"<p><p>For decades tricuspid valve regurgitation (TR) was considered clinically insignificant and often left untreated. Only with the emergence of catheter-based treatment, particularly tricuspid transcatheter edge-to-edge repair (T-TEER), the condition has gained increasing clinical attention and therapeutic momentum. Concurrently, the surgical treatment has evolved towards minimally invasive endoscopic operations on the beating heart. This article explores the role of the interdisciplinary heart team in the evaluation and execution of T‑TEER or surgical treatment. Based on current guidelines, clinical trial data and echocardiographic selection criteria, it analyses the need for a structured, interdisciplinary decision-making process. Successful TR management requires broad interdisciplinary expertise, including heart failure management, cardiac imaging, interventional cardiology and cardiac surgery. Structured risk assessments using validated tools such as the TRI-score and imaging-based scoring systems enable an objective evaluation of prognosis and anatomical suitability. A key clinical challenge remains the identification of the optimal timing for an intervention, before irreversible deterioration of the right ventricular function or end-organ damage occurs. In conclusion, delivering high-quality, patient-centred care for severe TR is barely achievable without a well-functioning heart team. Early referral, close coordination with outpatient cardiologists, and comprehensive imaging are essential to achieving favourable and sustainable outcomes.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"326-336"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}