Herz最新文献_第7页

[Lower extremity arterial disease (LEAD)]. [下肢动脉疾病（LEAD）]。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1007/s00059-024-05252-3

Christine Espinola-Klein

引用次数: 0

Neuroimmune crosstalk : How mental stress fuels vascular inflammation. 神经免疫串扰：精神压力如何助长血管炎症？

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI: 10.1007/s00059-024-05254-1

Ulrike Meyer-Lindemann, Hendrik B Sager

{"title":"Neuroimmune crosstalk : How mental stress fuels vascular inflammation.","authors":"Ulrike Meyer-Lindemann, Hendrik B Sager","doi":"10.1007/s00059-024-05254-1","DOIUrl":"10.1007/s00059-024-05254-1","url":null,"abstract":"Cardiovascular diseases are the leading cause of death worldwide. Pathophysiologically, metabolic and inflammatory processes contribute substantially to the development and progression of cardiovascular diseases. Over the past decade, the role of disease-propagating inflammatory processes has been strengthened and reframed, leading to trials testing anti-inflammatory drugs for the treatment of atherosclerosis and its complications. Despite these achievements, further research in both pre-clinical and clinical studies is warranted to explore new targets, to better identify responders, and to refine therapy strategies to combat inflammation in human disease. Environmental disturbances, so-called lifestyle-associated cardiovascular risk factors, greatly alter the immune system in general and leukocytes in particular, thus affecting the progression of atherosclerosis. Epidemiological studies have shown that exposure to mental stress can be closely linked to the occurrence of cardiovascular disease. Here, we describe how acute and chronic mental stress alter the immune system via neuroimmune interactions, thereby modifying vascular inflammation. In addition, we identify gaps that still need to be addressed in the future.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"249-253"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac disease-induced trauma and stress-related disorders. 心脏病诱发的创伤和压力相关疾病。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-11 DOI: 10.1007/s00059-024-05255-0

Mary Princip, Katharina Ledermann, Rahel Altwegg, Roland von Känel

{"title":"Cardiac disease-induced trauma and stress-related disorders.","authors":"Mary Princip, Katharina Ledermann, Rahel Altwegg, Roland von Känel","doi":"10.1007/s00059-024-05255-0","DOIUrl":"10.1007/s00059-024-05255-0","url":null,"abstract":"Objective: This review aims to present an updated overview of cardiac disease-induced trauma and stress-related disorders such as acute stress disorder (ASD), adjustment disorder (AjD), and posttraumatic stress disorder (PTSD). First, the prevalence of these disorders, their diagnostic criteria, and their differences from other trauma-related disorders are described. Special challenges in diagnosis and treatment are identified, with various screening tools being evaluated for symptom assessment. Additionally, the risk factors studied so far for the development of symptoms of cardiac-induced posttraumatic stress disorder and the bidirectional relationship between posttraumatic stress disorder and cardiovascular diseases are summarized. Various therapeutic interventions, including pharmacological approaches, are also discussed. Finally, various areas for future research are outlined.Background: Experiencing a cardiovascular disease, particularly a life-threatening cardiac event, can potentially lead to stress-related disorders such as ASD, AjD, and cardiac disease-induced PTSD (CDI-PTSD). If left untreated, these disorders are associated with a worsening cardiac prognosis and higher mortality rates. Approaching treatment through a trauma-focused lens may be beneficial for managing CDI-PTSD and stress-related disorders.Conclusion: Future research should explore treatment options for both the patients and the caregivers as well as investigate the long-term effects of trauma-focused interventions on physical and mental health outcomes.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"254-260"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Psychocardiology - on the way to the sunny side of the road : Strenuous, but doable]. [心理心脏病学--在通往阳光大道的路上：艰苦但可行]。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-29 DOI: 10.1007/s00059-024-05258-x

Karl-Heinz Ladwig

引用次数: 0

Depression screening in patients with coronary heart disease : A narrative review of the current evidence. 冠心病患者抑郁筛查：现有证据回顾。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1007/s00059-024-05257-y

Sebastian Kohlmann

{"title":"Depression screening in patients with coronary heart disease : A narrative review of the current evidence.","authors":"Sebastian Kohlmann","doi":"10.1007/s00059-024-05257-y","DOIUrl":"10.1007/s00059-024-05257-y","url":null,"abstract":"In view of the large and sometimes conflicting body of research, this narrative review summarizes the current evidence on depression screening in patients with coronary heart disease. Depression is a risk factor for development and progression of coronary heart disease. Consequently, many international cardiac guidelines recommend screening for depression in patients with coronary heart disease. However, the efficacy and implementation of these guidelines are debated due to the lack of empirical evidence supporting the benefits of routine depression screening. Studies conducted in cardiac routine care support this assumption: Patients with positive depression screens do not receive adequate follow-up care, which highlights gaps in the detection-to-treatment pathway. Barriers to effective screening and treatment include system-level factors, such as insufficient integration of mental health resources in cardiology, and patient-related factors like stigma and low acceptance of mental health treatment. Innovative interventions that address these barriers and involve patients as active partners in depression care should be developed through a theory-driven, transparent, multistage process involving key stakeholders such as patients, nurses, and cardiologists. A sound methodological evaluation of such multilevel interventions could answer the question of whether early detection of depression in patients with coronary heart disease would lead to health benefits.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"261-269"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice. 在ApoE(-/-)小鼠中，Urantide通过Wnt/β-catenin信号通路减轻动脉粥样硬化相关的肝肾损伤。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2023-11-20 DOI: 10.1007/s00059-023-05219-w

Yu-Hang Xu, Jia-Yi Xie, Shen Huang, Tu Wang, Hai-Peng Cui, Juan Zhao

{"title":"Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice.","authors":"Yu-Hang Xu, Jia-Yi Xie, Shen Huang, Tu Wang, Hai-Peng Cui, Juan Zhao","doi":"10.1007/s00059-023-05219-w","DOIUrl":"10.1007/s00059-023-05219-w","url":null,"abstract":"Objective: To investigate the role of urantide in the prevention and treatment of atherosclerosis (AS)-related liver and kidney injury by antagonizing the urotensin II/urotensin receptor (UII/UT) system and regulating the Wnt/β-catenin signaling pathway.Methods: Atherosclerotic ApoE-/- mice were treated with 20 mg/kg, 30 mg/kg, and 40 mg/kg urantide for 14 days.Results: When ApoE-/- mice developed AS, significant pathological changes occurred in the liver and kidney, and the UII/UT system in tissue was highly activated; furthermore, the Wnt/β-catenin signalling pathway was activated, and proteins related to this signalling pathway, such as GSK-3β, AXIN2, CK‑1, and APC, were significantly downregulated. After urantide treatment, the pathological damage to the liver and kidney was effectively improved, the activity of the UII/UT system was effectively inhibited, and the expression of the Wnt/β-catenin signalling pathway and related proteins was restored. Wnt/β-catenin signals were mainly localized in the cytoplasm, renal tubules, and interstitium.Conclusion: Urantide could improve AS-related liver and kidney injury by antagonizing the UII/UT system, and the improvements in liver and kidney function in atherosclerotic ApoE-/- mice may be related to inhibition of the Wnt/β-catenin signalling pathway.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"282-295"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease. 冠状动脉计算机断层扫描导出的血流储备分数对冠状动脉疾病患者心血管事件的预测价值。

IF 1.1 4区医学

Herz Pub Date : 2024-08-01 Epub Date: 2023-11-03 DOI: 10.1007/s00059-023-05220-3

Hongwei Han, Meijun Liu, Yang Yu, Yuan Chen, Yizhou Xu

{"title":"Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease.","authors":"Hongwei Han, Meijun Liu, Yang Yu, Yuan Chen, Yizhou Xu","doi":"10.1007/s00059-023-05220-3","DOIUrl":"10.1007/s00059-023-05220-3","url":null,"abstract":"Background: Coronary computed tomography-derived fractional flow reserve (FFR-CT) assesses whether coronary artery lesions will result in myocardial ischemia. This study aimed to evaluate the predictive value of FFR-CT for cardiovascular events in patients with coronary artery disease (CAD).Methods: Data were collected retrospectively from patients with CAD who underwent FFR-CT at our hospital from January 2020 to February 2022 (1-year average follow-up). Patients were divided into ischemic (FFR-CT ≤ 0.80) and non-ischemic (FFR-CT > 0.80) groups. The incidence of endpoint events (cardiac death, acute myocardial infarction, unplanned revascularization, unstable angina, and stable angina) was calculated. The FFR-CT value was correlated with endpoint events using Cox regression models and Kaplan-Meier survival curves.Results: We recruited 134 patients (93 [69.4%] and 41 [30.6%] patients in the ischemic and non-ischemic groups, respectively). The ischemic group had a higher proportion of men, patients with type 2 diabetes and hypertension, and patients taking antiplatelet drugs and β‑blockers than did the non-ischemic group (all p < 0.05), whereas other parameters were comparable. Multivariate Cox regression analysis revealed no significant differences in cardiac death, acute myocardial infarction, unplanned revascularization, and unstable angina between the groups. The incidence of stable angina events (hazard ratio: 3.092, 95% confidence interval: 1.362-7.022, p = 0.007) was significantly higher in the ischemic group. Kaplan-Meier survival analysis revealed a significant difference in event-free survival for stable angina between the groups (p = 0.002).Conclusion: In patients with CAD, FFR-CT showed an independent predictive value for stable angina within 1 year of examination.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"296-301"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute prevention of a heart attack : Early identification of prodromal symptoms as the Rosetta Stone in decoding the heart attack problem. 心脏病发作的急性预防：早期识别前驱症状是破解心脏病发作问题的罗塞塔石碑。

IF 1.7 4区医学

Herz Pub Date : 2024-06-01 Epub Date: 2024-03-06 DOI: 10.1007/s00059-024-05239-0

Raymond D Bahr

{"title":"Acute prevention of a heart attack : Early identification of prodromal symptoms as the Rosetta Stone in decoding the heart attack problem.","authors":"Raymond D Bahr","doi":"10.1007/s00059-024-05239-0","DOIUrl":"10.1007/s00059-024-05239-0","url":null,"abstract":"Chest discomfort before severe chest pain represents a marker of clinical ischemia and indicates live myocardium in jeopardy and often precedes cardiac arrest or acute myocardial infarction (MI). The intermittent or \"stuttering\" symptoms that precede MI are referred to as \"prodromal symptoms.\" These symptoms have been shown to correlate with cyclic ST changes and repeated episodes of spontaneous reperfusion and occlusion, occurring during a period of hours or days before the acute ischemia proceeds to death or heart damage. These symptoms of premonitory angina have been associated with improved outcomes due to ischemic pre-conditioning or opening of collateral vascular channels around the area of ischemia. Acute prevention of an MI through recognition of prodromal symptoms represents an opportunity to significantly reduce heart attack deaths. The Early Heart Attack Care (EHAC) program puts emphasis on prodromal symptom recognition and allows for a shift in time backward to prevent the ischemic process from proceeding to MI. This strategy has been shown to detect the 15% of patients with ischemia in the low-probability group and to reduce inappropriate admissions to hospital as well as to reduce the number of patients with missed MI being sent home from the emergency department.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"167-174"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Digitalization and clinical decision tools]. [数字化和临床决策工具］

IF 1.7 4区医学

Herz Pub Date : 2024-06-01 Epub Date: 2024-03-07 DOI: 10.1007/s00059-024-05242-5

C Reich, N Frey, E Giannitsis

{"title":"[Digitalization and clinical decision tools].","authors":"C Reich, N Frey, E Giannitsis","doi":"10.1007/s00059-024-05242-5","DOIUrl":"10.1007/s00059-024-05242-5","url":null,"abstract":"Digitalization in cardiovascular emergencies is rapidly evolving, analogous to the development in medicine, driven by the increasingly broader availability of digital structures and improved networks, electronic health records and the interconnectivity of systems. The potential use of digital health in patients with acute chest pain starts even in the prehospital phase with the transmission of a digital electrocardiogram (ECG) as well as telemedical support and digital emergency management, which facilitate optimization of the rescue pathways and reduce critical time intervals. The increasing dissemination and acceptance of guideline apps and clinical decision support tools as well as integrated calculators and electronic scores are anticipated to improve guideline adherence, translating into a better quality of treatment and improved outcomes. Implementation of artificial intelligence to support image analysis and also the prediction of coronary artery stenosis requiring interventional treatment or impending cardiovascular events, such as heart attacks or death, have an enormous potential especially as conventional instruments frequently yield suboptimal results; however, there are barriers to the rapid dissemination of corresponding decision aids, such as the regulatory rules related to approval as a medical product, data protection issues and other legal liability aspects, which must be considered.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"190-197"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment with cardiac electronic implantable devices]. [使用心脏电子植入装置进行治疗]。

IF 1.7 4区医学

Herz Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI: 10.1007/s00059-024-05246-1

Jürgen Kuschyk, Katherine Sattler, Fabian Fastenrath, Boris Rudic, Ibrahim Akin

引用次数: 0