IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-08-02 DOI: 10.1007/s00059-023-05199-x

Aniela Petrescu, Jens-Uwe Voigt

引用次数: 0

Analysis of risk factors for systemic inflammatory response syndrome in patients after transcatheter aortic valve replacement. 经导管主动脉瓣置换术后患者全身炎症反应综合征的危险因素分析。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-01-31 DOI: 10.1007/s00059-023-05163-9

Jifang Cheng, Mingqi Dong, Chunjie Wen, Bin Yu, Jiaqi Fan

{"title":"Analysis of risk factors for systemic inflammatory response syndrome in patients after transcatheter aortic valve replacement.","authors":"Jifang Cheng, Mingqi Dong, Chunjie Wen, Bin Yu, Jiaqi Fan","doi":"10.1007/s00059-023-05163-9","DOIUrl":"10.1007/s00059-023-05163-9","url":null,"abstract":"Objective: Our aim was to determine the risk factors of postoperative systemic inflammatory response syndrome (SIRS) in patients with transcatheter aortic valve replacement (TAVR), identify those with a high risk of SIRS, and help reduce SIRS occurrence.Methods: A retrospective cohort study was conducted to collect the clinical data of patients who underwent TAVR from January 2014 to December 2019 at a tertiary hospital in Zhejiang Province. The study included 156 men and 94 women. Patients were divided into SIRS and non-SIRS groups. The pre-, intra-, and postoperative indices of the two groups were recorded. The data of the two groups were compared, and univariate analysis was performed. All statistically significant factors were assessed using binary logistic regression analysis to clarify the risk factors of SIRS after TAVR.Results: Overall, 30 patients developed SIRS after TAVR, with an incidence rate of 12%, an odds ratio (OR) of 0.571, and a 95% confidence interval (CI) of 0.469-0.694 (p = 0.000). There was a significant correlation between SIRS and glucose (OR: 0.823, 95% CI: 0.678-1.000, p = 0.049), albumin (OR: 0.938, 95% CI: 0.881-0.998, p = 0.044), brain natriuretic peptide (OR: 1.000, 95% CI: 1.000-1.000, p = 0.010), sex (OR: 0.412, 95% CI: 0.190-0.892, p = 0.025), and history of hypertension (OR: 0.375, 95% CI: 0.169-0.819, p = 0.014). Multivariate regression analysis demonstrated that age (OR: 1.190, 95%CI: 1.073-1.319, p = 0.001) and body mass index (BMI; OR: 0.559, 95% CI: 0.447-0.698, p = 0.000) were independent risk factors for postoperative SIRS in patients with TAVR.Conclusion: The incidence of SIRS after TAVR was 12%. There was a significant correlation between SIRS and albumin, glucose, and hypertension. The independent risk factors for SIRS after TAVR were age and BMI.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"393-398"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10647349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of outcomes between single long stent and overlapping stents: a meta-analysis of the literature. 单个长支架和重叠支架的疗效比较：一项文献荟萃分析。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-01-11 DOI: 10.1007/s00059-022-05152-4

Faysal Şaylık, Tufan Çınar, Murat Selçuk, Vedat Çiçek, Mert Ilker Hayıroğlu, Ahmet Lütfullah Orhan

{"title":"Comparison of outcomes between single long stent and overlapping stents: a meta-analysis of the literature.","authors":"Faysal Şaylık, Tufan Çınar, Murat Selçuk, Vedat Çiçek, Mert Ilker Hayıroğlu, Ahmet Lütfullah Orhan","doi":"10.1007/s00059-022-05152-4","DOIUrl":"10.1007/s00059-022-05152-4","url":null,"abstract":"Objectives: There is no consensus on whether to treat diffuse coronary artery lesions with a single long stent (SLS) or by overlapping two or more stents (OLS). The goal of this review was to compare the outcomes of these two approaches through a meta-analysis of the literature.Methods: We searched for relevant studies in MEDLINE, Scopus, EMBASE, Google Scholar, and the Cochrane Library. Our meta-analysis included 12 studies (n = 6414) that reported outcomes during the follow-up period.Results: Individuals who received OLS had a greater risk of cardiac mortality and target lesion revascularization (TLR) than those who received SLS (RR: 1.51, CI: 1.03-2.21, p = 0.03, I2 = 0% and RR: 1.64, CI: 1.02-2.65, p = 0.04, I2 = 38%, respectively). The fluoroscopy period in the OLS group was longer than in the SLS group (SMD: 0.35, CI: 0.25-0.46, p < 0.01, I2 = 0%). more contrast volume was sued for the OLS group; however, there was substantial variability in the pooled analysis (I2 = 95%). In terms of all outcomes, there were no differences between stent generation types.Conclusion: In the first meta-analysis of mainly observational data comparing OLS vs. SLS for long coronary lesions, OLS had higher rates of cardiac mortality and TLR as well as longer fluoroscopy times compared to SLS.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"376-383"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10513793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Atrial fibrillation increases the risk of new-onset myocardial infarction amongst working-age population: a propensity-matched study. 工作年龄人群中心房颤动增加新发心肌梗死的风险：一项倾向匹配研究。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-06-01 DOI: 10.1007/s00059-023-05181-7

Bocheng Yue, Qiqi Hou, Julian Bredehorst, Quanle Han, Boheng Zhang, Chao Zhang, Jiawei Zhang, Shuohua Chen, Shouling Wu, Kangbo Li

{"title":"Atrial fibrillation increases the risk of new-onset myocardial infarction amongst working-age population: a propensity-matched study.","authors":"Bocheng Yue, Qiqi Hou, Julian Bredehorst, Quanle Han, Boheng Zhang, Chao Zhang, Jiawei Zhang, Shuohua Chen, Shouling Wu, Kangbo Li","doi":"10.1007/s00059-023-05181-7","DOIUrl":"10.1007/s00059-023-05181-7","url":null,"abstract":"Objective: The aim of this study was to investigate the association between atrial fibrillation (AF) and new-onset myocardial infarction (MI) among a working-age population in an industrial city of North China.Methods: In total 77,670 participants aged under 60 years were selected for this cohort study. Participants were divided into an AF group (n = 121) and a non-AF group (n = 74,565) based on their medical histories. Thereafter, 121 participants from the AF group were propensity-matched with 363 participants from the non-AF group. All participants were followed up from June 2006 to December 2020; new-onset MI was regarded as the endpoint of this study. Multivariate Cox proportional hazards regression analysis models were designed to analyze the correlation between AF and new-onset MI.Results: During the 14-year follow-up, eight cases of new-onset MI were documented in the AF group, while five cases were documented in the non-AF group. The cumulative incidence of new-onset MI in the AF group (7.40%) was markedly higher than in the non-AF group (1.41%; p < 0.001). Atrial fibrillation was associated with an increased risk of new-onset MI in both univariate analysis (hazard ratio: 5.202, 95% confidence interval [CI]: 1.700-15.913) and multivariable-adjusted analysis (hazard ratio: 5.335, 95% CI: 1.683-16.910).Conclusion: Atrial fibrillation increased the risk of new-onset MI amongst working-age individuals in an industrial city of North China.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"408-412"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9560277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2^+/- atrial cardiomyocytes. 羟氯喹对矽肺野生型和PITX2+/-心房心肌细胞心房电生理的影响。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-02-02 DOI: 10.1007/s00059-023-05162-w

Euijun Song

{"title":"Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2+/- atrial cardiomyocytes.","authors":"Euijun Song","doi":"10.1007/s00059-023-05162-w","DOIUrl":"10.1007/s00059-023-05162-w","url":null,"abstract":"Background: Hydroxychloroquine (HCQ) is commonly used in the treatment of autoimmune diseases and increases the risk of QT interval prolongation. However, it is unclear how HCQ affects atrial electrophysiology and the risk of atrial fibrillation (AF).Methods: We quantitatively examined the potential atrial arrhythmogenic effects of HCQ on AF using a computational model of human atrial cardiomyocytes. We measured atrial electrophysiological markers after systematically varying HCQ concentrations.Results: The HCQ concentrations were positively correlated with the action potential duration (APD), resting membrane potential, refractory period, APD alternans threshold, and calcium transient alternans threshold (p < 0.05). By contrast, HCQ concentrations were inversely correlated with the maximum upstroke velocity and calcium transient amplitude (p < 0.05). When the therapeutic concentration (Cmax) of HCQ was applied, HCQ increased APD90 by 1.4% in normal sinus rhythm, 1.8% in wild-type AF, and 2.6% in paired-like homeodomain transcription factor 2 (PITX2)+/- AF, but did not affect the alternans thresholds. The overall in silico results suggest no significant atrial arrhythmogenic effects of HCQ at Cmax, instead implying a potential antiarrhythmic role of low-dose HCQ in AF. However, at an HCQ concentration of fourfold Cmax, a rapid pacing rate of 4 Hz induced prominent APD alternans, particularly in the PITX2+/- AF model.Conclusion: Our in silico analysis suggests a potential antiarrhythmic role of low-dose HCQ in AF. Concomitant PITX2 mutations and high-dose HCQ treatments may increase the risk of AF, and this potential genotype/dose-dependent arrhythmogenic effect of HCQ should be investigated further.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"384-392"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10715521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Imaging diagnostics of cardiac sarcoidosis]. [心脏结节病的影像学诊断]。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-09-08 DOI: 10.1007/s00059-023-05208-z

Ron Blankstein, Stephan Achenbach

{"title":"[Imaging diagnostics of cardiac sarcoidosis].","authors":"Ron Blankstein, Stephan Achenbach","doi":"10.1007/s00059-023-05208-z","DOIUrl":"10.1007/s00059-023-05208-z","url":null,"abstract":"Cardiac involvement is clinically apparent in approximately 5% of all patients with systemic sarcoidosis, whereas evidence of cardiac involvement by imaging studies can be found in approximately 20% of cases. Occasionally, isolated cardiac sarcoidosis is encountered and is the only sign of the disease. The most frequent cardiac manifestations of the multifocal granulomatous inflammation include atrioventricular (AV) blocks and other conduction disorders, ventricular arrhythmias, sudden cardiac death and left and right ventricular wall disorders. Accordingly, symptoms that should raise suspicion include palpitations, lightheadedness and syncope. The diagnostic approach to cardiac sarcoidosis is not straightforward. Typical echocardiographic findings include regional thinning and contraction abnormalities particularly in basal, septal and lateral locations. Infrequently, myocardial hypertrophy may be present; however, the sensitivity of echocardiography is low and cardiac sarcoidosis can be present even when an echocardiogram is unrevealing. Cardiac magnetic resonance imaging (MRI) frequently shows late gadolinium enhancement (LGE) in a multifocal pattern often involving the basal septum and lateral walls. The sensitivity and specificity of MRI for detecting cardiac sarcoidosis are high. Fluorodeoxyglucose positron emission tomography (FDG-PET) plays an important role in the diagnostic algorithm due to its ability to visualize focal inflammatory activity both in the myocardium and in extracardiac locations. This may help target the optimal location for biopsy in order to obtain histologic proof of sarcoidosis and can also be used to follow the response to anti-inflammatory treatment. Notably, the sensitivity of endomyocardial biopsy is poor due to the patchy nature of myocardial involvement. In clinical practice, either histologic evidence of noncaseating granulomas from the myocardium or evidence from extracardiac tissue in combination with typical cardiac imaging findings are required to establish the diagnosis.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"366-371"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10553898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cardiovascular treatment in chronic kidney disease]. [慢性肾脏疾病的心血管治疗]。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-09-11 DOI: 10.1007/s00059-023-05205-2

Vincent Brandenburg, Turgay Saritas, Stephan H Schirmer, Kyrill Rogacev, Gunnar Henrik Heine

引用次数: 0

[Coronary CT angiography and coronary atherosclerosis : Where do we stand today?] [冠状动脉CT血管造影术与冠状动脉粥样硬化：我们今天的处境如何？]

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI: 10.1007/s00059-023-05207-0

Stephan Achenbach

{"title":"[Coronary CT angiography and coronary atherosclerosis : Where do we stand today?]","authors":"Stephan Achenbach","doi":"10.1007/s00059-023-05207-0","DOIUrl":"10.1007/s00059-023-05207-0","url":null,"abstract":"Cardiac computed tomography (CT) has made substantial progress in recent years. The main field of application is CT coronary angiography for visualization of the coronary arteries and for the detection and exclusion of coronary artery stenosis. This has been included in international guidelines for the management of stable coronary artery disease or chronic coronary syndrome as well as for the diagnostic work-up of patients with acute chest pain; however, it must be taken into account that the diagnostic validity is only sufficiently high when the image quality is good and therefore alternative diagnostic procedures should be included in patients where an unrestricted good image quality is not to be expected. The fact that CT angiography enables the detection not only of coronary stenosis but also of nonobstructive atherosclerotic plaque is interesting for the estimation of the risk of atherosclerotic events. It is practically certain that in the absence of detectable atherosclerotic plaque in CT angiography, statin treatment does not lower the risk of atherosclerotic events. To what extent CT is suitable to provide indications for statin treatment and the threshold for which the presence of nonobstructive plaque should prompt initiation of statin treatment are currently the subject of intensive research.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"352-358"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10444498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of pharmacotherapy targeting COVID-19 disease based on ACE-2: current challenges and future directions. 基于ACE-2的新冠肺炎疾病药物治疗概述：当前挑战和未来方向。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2022-11-04 DOI: 10.1007/s00059-022-05142-6

Antonio Vitiello, Andrea Zovi, Ugo Trama, Francesco Ferrara

引用次数: 1

Computed tomography to guide transcatheter aortic valve implantation. 计算机断层扫描指导经导管主动脉瓣植入术。

IF 1.7 4区医学

Herz Pub Date : 2023-10-01 Epub Date: 2023-08-18 DOI: 10.1007/s00059-023-05203-4

Marwa Daghem, Florian Weidinger, Stephan Achenbach

引用次数: 0

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