Herz最新文献

{"title":"Multidimensional psychosocial screening in routine cardiac care: preliminary findings from a cross-sectional survey.","authors":"Omar Hahad, Jasmin Ghaemi Kerahrodi, Leila I Pasha, Michael Molitor, Matthias Michal, Jonas Tesarz, Philipp Lurz, Julia Lurz","doi":"10.1007/s00059-026-05382-w","DOIUrl":"10.1007/s00059-026-05382-w","url":null,"abstract":"<p><strong>Background: </strong>Psychological distress is common among patients with cardiovascular disease. While European Society of Cardiology (ESC) position papers highlight the relevance of mental health in cardiology care, psychosocial assessment remains inconsistently implemented in routine clinical practice.</p><p><strong>Methods: </strong>In this preliminary cross-sectional survey, patients attending a tertiary cardiology department completed an anonymous multidimensional psychosocial screening during routine care. Standardized instruments assessed depressive symptoms (PHQ-9), generalized anxiety (GAD-7), heart-focused anxiety (HAF-17), sleep disturbances (Jenkins Sleep Scale), resilient coping (BRCS), loneliness (UCLA-3), life satisfaction, perceived stress, social support, medication adherence, and awareness of psychocardiology services.</p><p><strong>Results: </strong>A total of 62 patients were included. Overall levels of depressive and generalized anxiety symptoms were low (PHQ‑9 5.0 ± 4.7; GAD‑7 3.5 ± 4.4), while heart-focused anxiety was more pronounced (HAF-17 21.1 ± 10.6). Perceived stress was reported by 52.1% of participants (43.8% mild, 8.3% severe), and sleep disturbances were frequent (JSS 6.5 ± 5.5). Heart-focused anxiety showed consistent associations with general anxiety, depressive symptoms, stress, and sleep problems (all p < 0.05), but was not related to life satisfaction (p = 0.99). Life satisfaction correlated more strongly with general emotional well-being than with cardiac-specific fears. Despite limited prior awareness of psychocardiology services (7.0% aware), a substantial proportion of patients reported interest in receiving psychosocial support in a cardiology setting (8.8% yes and 47.4% maybe).</p><p><strong>Conclusion: </strong>Psychosocial burden in cardiology patients may extend beyond depression and generalized anxiety. Cardiac-specific fears, stress, and sleep disturbances are prominent but frequently underrecognized domains that may be overlooked by unidimensional screening approaches. A significant proportion of patients were unaware of existing psychocardiology services, suggesting a gap between recommended mental health integration and routine cardiology care. Multidimensional screening may facilitate more targeted identification of patients who could benefit from integrated psychocardiological care.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"380-387"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of carotid intima-media thickness and lipid indices with SYNTAX score in coronary artery disease: a cross-sectional study.","authors":"Dilip Johny, Giridhar Belur Hosmane, Subramanyam Kodangala, Anirban Chakraborty, Aditya Ojha","doi":"10.1007/s00059-026-05394-6","DOIUrl":"https://doi.org/10.1007/s00059-026-05394-6","url":null,"abstract":"<p><strong>Background: </strong>Carotid intima-media thickness (CIMT) is a widely used noninvasive marker of subclinical atherosclerosis, yet its relationship with angiographic coronary disease complexity, quantified with the SYNTAX score, remains incompletely characterized. This study evaluated the correlations between CIMT, low-density lipoprotein cholesterol (LDL-C), the Atherogenic Index of Plasma (AIP), and SYNTAX score in patients with angiographically confirmed coronary artery disease (CAD) in coastal South India.</p><p><strong>Methods: </strong>A total of 115 consecutive patients with proven CAD undergoing elective coronary angiography (≥ 50% stenosis) were enrolled. B‑mode ultrasonography was used to measure CIMT bilaterally. Lipid profiles were obtained from fasting samples, and AIP was computed as log(TG/HDL-C). Pearson correlations, ANOVA, and multivariate logistic regression were used for analysis.</p><p><strong>Results: </strong>Mean CIMT was positively correlated with both SYNTAX score (r = 0.192, p = 0.039) and LDL‑C (r = 0.207, p = 0.026). SYNTAX scores increased progressively across single-, double-, and triple-vessel disease groups (F = 25.50, p < 0.001). There was no significant association between AIP and either CIMT or SYNTAX score. Inter-rater agreement for SYNTAX score categorization was excellent (Cohen's κ = 0.880, 95% confidence interval [CI]: 0.799-0.960, p < 0.001). On multivariate analysis, only age independently predicted high-complexity CAD (OR = 1.661, 95% CI: 1.077-2.561, p = 0.022).</p><p><strong>Conclusion: </strong>The SYNTAX score increased significantly with increasing vessel involvement, and CIMT was modestly correlated with SYNTAX score and LDL‑C. Age was the sole independent predictor of high-complexity CAD. These preliminary findings suggest that CIMT may have potential as a supplementary marker of coronary complexity, but this requires confirmation in larger, prospective studies before any clinical application can be recommended.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research hotspots and emerging trends of exosomes in myocardial infarction: a bibliometric-based visual analysis.","authors":"Runfang Deng, Weiju Liao, Lingling Wu, Dongyi Huang, Tingting Huang, Xingzhen Huang","doi":"10.1007/s00059-026-05379-5","DOIUrl":"10.1007/s00059-026-05379-5","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to summarize the current research status and application of exosomes in the treatment of myocardial infarction (MI) through bibliometric analysis and to provide insights and suggestions for future research.</p><p><strong>Methods: </strong>We searched the Web of Science Core Collection database for publications on exosome-based treatments for MI from 2000 to 2023. Bibliometric and visualization analyses were conducted using VOSviewer and CiteSpace.</p><p><strong>Results: </strong>A total of 6138 authors from 96 institutions in 65 countries and regions published 1062 articles in 358 academic journals. The majority of publications were from China and the United States. Nanjing Medical University and Soochow University are the most active institutions. Cheng was the author with the highest number of publications, while Barile was the most co-cited. The International Journal of Molecular Sciences had the highest publication output while Circulation Research was the most cited journal. Current research focuses on areas likely to be future hot topics, such as \"repair,\" \"mesenchymal stem cells,\" \"progenitor cells,\" \"endothelial cells,\" \"expression,\" \"bone marrow,\" \"apoptosis,\" \"drug delivery,\" \"inflammation,\" and \"cells.\" Future research directions include exploring the mechanisms of exosomes from various cellular sources for MI treatment, investigating different drug delivery modes, developing post-MI therapeutic strategies, regulating apoptotic protein expression, and emphasizing the roles of different stem cells and molecules in exosome studies for MI treatment.</p><p><strong>Conclusion: </strong>In the field of MI, exosomes represent an excellent drug delivery system. This analysis offers valuable insights into research hotspots and cutting-edge directions for scholars in related fields.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"329-349"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic significance of H2FPEF and HFA-PEFF scores with oncostatin M levels in heart failure with preserved ejection fraction.","authors":"Hasan Sari, Oznur Keskin, Yakup Alsancak","doi":"10.1007/s00059-025-05362-6","DOIUrl":"10.1007/s00059-025-05362-6","url":null,"abstract":"<p><strong>Background: </strong>Heart failure with preserved ejection fraction (HFpEF) represents approximately half of all heart failure cases, and its prevalence is rising with an aging population and increasing comorbidities. Diagnosis is challenging due to heterogeneous clinical features and nonspecific symptoms. To improve diagnostic accuracy, scores such as the HFA-PEFF (Heart Failure Association Pre-test Assessment, Echocardiography & Natriuretic Peptide, Functional Testing, Final Etiology) and H2FPEF have been proposed. Oncostatin M (OSM), a cytokine of the interleukin‑6 family, is involved in cardiac inflammation, fibrosis, and remodeling, but its diagnostic role in HFpEF remains unclear.</p><p><strong>Methods: </strong>This single-center, cross-sectional study enrolled 71 patients with suspected HF symptoms (dyspnea, fatigue, edema) and a left ventricular ejection fraction ≥ 50%. Demographic, laboratory, and echocardiographic data were recorded. HFpEF likelihood was assessed using the HFA-PEFF and H2FPEF scores. Serum OSM levels were measured, and patients were classified into low-intermediate- and high-risk groups.</p><p><strong>Results: </strong>Mean patient age was 67.0 years (63.4% female). In the high-risk H2FPEF group, only hypertension showed a significant association (p = 0.032). By contrast, the high-risk HFA-PEFF group showed higher left atrial volume index, left ventricular mass index, and E/e' ratio; NT-proBNP and OSM levels were also significantly increased (51.3 vs. 14.4 pg/mL; p < 0.001). Receiver operating characteristic analysis showed that OSM had strong discriminatory power for the HFA-PEFF but not the H2FPEF score.</p><p><strong>Conclusion: </strong>Serum OSM levels correlated more strongly with the HFA-PEFF score, which incorporates structural and functional cardiac parameters. Thus, OSM may serve as a complementary biomarker to improve HFpEF diagnosis when used with the HFA-PEFF scoring system.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"362-370"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Atrial fibrillation : An overview of the various treatment options].","authors":"Laura Fischbach, Stephan Willems, Arian Sultan","doi":"10.1007/s00059-026-05391-9","DOIUrl":"10.1007/s00059-026-05391-9","url":null,"abstract":"<p><p>Atrial fibrillation is associated with a reduced quality of life, an increased risk of thromboembolic events and higher mortality. A fast and individualized treatment is essential, particularly to positively influence the progression. In addition to risk-adapted oral anticoagulation, early rhythm control is crucial for reducing the burden of symptoms as well as for decreasing hospitalization, ischemic stroke and cardiovascular death. Options for rhythm control include pharmacological strategies, electrical cardioversion, and catheter-based ablation procedures. Electrical cardioversion is particularly suitable for the acute treatment of hemodynamically unstable patients, while pharmacological treatment and catheter ablation represent long-term treatment approaches. Class IC antiarrhythmic drugs such as flecainide and propafenone are contraindicated in patients with structural heart disease.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"389-398"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between paroxysmal atrial fibrillation and the Osaka Prognostic Score.","authors":"Ersin Yıldırım, Önder Demiröz, Emre Eynel, Mustafa Doğuş Gökçek, Direnç Yılmaz, Süleyman Kürşad Özel, Emre Erbil, Doğukan Yalçın, Muhammed Bayram","doi":"10.1007/s00059-026-05396-4","DOIUrl":"https://doi.org/10.1007/s00059-026-05396-4","url":null,"abstract":"<p><strong>Background: </strong>The Osaka Prognostic Score (OPS), which is based on C‑reactive protein (CRP), total lymphocyte count (TLC), and albumin (ALB), has been reported to have prognostic value in several types of cancer. Recent studies have revealed a relationship between the OPS and cardiovascular diseases. The aim of this study was to evaluate the relationship between the OPS and paroxysmal atrial fibrillation (AF), a significant rhythm disorder.</p><p><strong>Methods: </strong>A total of 941 individuals, including 198 patients with a history of AF and 743 patients without AF as the control group, were included in the study. These groups were compared in terms of demographic characteristics and laboratory findings.</p><p><strong>Results: </strong>Univariable and multivariable binary logistic regression analyses revealed an independent relationship between the OPS and AF (odds ratio [OR]: 3.37, p < 0.001). In receiver operating characteristic (ROC) curve analysis, OPS above a cut-off level of 0.5 was associated with the presence of AF, with a sensitivity of 55.6% and a specificity of 77.4% (area under the ROC curve [AUC]: 0.682, p < 0.001).</p><p><strong>Conclusion: </strong>This study found a relationship between the OPS and paroxysmal AF attacks. The OPS may provide additional information for the clinical evaluation of patients with paroxysmal AF in daily practice.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Atherogenic index as an associative marker for coronary artery disease.","authors":"Basavaraj Utagi, Dilip Johny, Aditya Ojha, Adesh Kumar","doi":"10.1007/s00059-026-05374-w","DOIUrl":"10.1007/s00059-026-05374-w","url":null,"abstract":"","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"388"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic index as an associative marker for coronary artery disease.","authors":"Basavaraj Utagi, Dilip Johny, Aditya Ojha, Adesh Kumar","doi":"10.1007/s00059-025-05361-7","DOIUrl":"10.1007/s00059-025-05361-7","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is a significant global health burden, warranting pragmatic, low-cost biomarkers for effective risk stratification. The atherogenic index of plasma (AIP), calculated as log(TG/HDL-C), is a lipid-derived indicator of cardiometabolic risk. We evaluated AIP as an associative marker for CAD and compared its diagnostic performance with commonly used biomarkers.</p><p><strong>Methods: </strong>In a hospital-based, angiography-confirmed case-control cohort (n = 340; 211 cases, 129 controls), we assessed AIP alongside uric acid, creatinine, neutrophil-to-lymphocyte ratio (NLR), TG/HDL‑C, HbA1c, and ejection fraction. Group characteristics were summarized using descriptive statistics, chi-square tests, and ANOVA. Associations with CAD were examined using multivariable logistic regression adjusted for age, sex, body mass index, diabetes, hypertension, smoking status, and statin use. Discriminative performance was evaluated via receiver operating characteristic (ROC) analysis, with pairwise comparisons conducted using DeLong's test.</p><p><strong>Results: </strong>Values of AIP (OR 1.42, 95% CI 1.18-1.69; p = 0.012), uric acid (OR 1.20, 95% CI 1.02-1.42; p = 0.032), and creatinine (OR 1.69, 95% CI 1.03-2.76; p = 0.038) were independently associated with CAD. HbA1c, TG/HDL‑C, NLR, and ejection fraction were not significantly associated in multivariable models. Values of AIP increased with greater angiographic severity. In ROC analysis, AIP showed superior discriminatory ability to uric acid, creatinine, NLR, and HbA1c (all p < 0.05, DeLong test), and performed comparably to TG/HDL‑C, consistent with AIP being its log transformation.</p><p><strong>Conclusion: </strong>Readily available AIP offers incremental prognostic value in symptomatic patients with suspected CAD. These findings are hypothesis-generating; thus, thresholds should be interpreted cautiously pending prospective, multicenter studies.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"352-361"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between HAVOC score and new-onset atrial fibrillation in patients with ST elevation myocardial infarction.","authors":"Emrah Bayam, Macit Kalçık, Ersin Yıldırım, Selahattin Akyol, Anıl Avcı, Zeki Şimşek, Baver Bozan, Doğan Şen, Ramazan Kargın","doi":"10.1007/s00059-026-05381-x","DOIUrl":"10.1007/s00059-026-05381-x","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is a common electrical complication in patients with acute myocardial infarction. The HAVOC score was originally proposed as a clinical tool for predicting AF in patients with cryptogenic stroke or transient ischemic attack. This study evaluated the predictive value of the HAVOC score for new-onset AF (NOAF) in patients with ST-segment elevation myocardial infarction (STEMI).</p><p><strong>Method: </strong>Between August 2019 and December 2024, the data of 1640 patients (mean age: 56.3 ± 11.2 years, male: 1134, 69.1%) with STEMI were retrospectively analyzed. Patients were divided into two groups: those with and those without NOAF. All patients underwent electrocardiographic monitoring and echocardiographic evaluation following primary percutaneous coronary intervention.</p><p><strong>Results: </strong>Overall, NOAF was observed in 115 patients. A comparison of the clinical and demographic characteristics between the groups showed that age, hypertension frequency, chronic obstructive pulmonary disease, and history of stroke were higher in the NOAF group. Left ventricular ejection fraction was significantly lower (38.2 ± 10.8 vs. 47.9 ± 10.1%, p < 0.001) and left atrial diameter (42.2 ± 4.5 vs. 37.5 ± 4.1 mm, p = 0.001) was significantly higher in these patients. Furthermore, the incidence of unsuccessful intervention, contrast-induced nephropathy, and in-hospital mortality as well as the HAVOC score were significantly higher in patients with NOAF. A high HAVOC score (odds ratio [OR] = 1.078; 95% confidence interval [CI]: 1.022-1.258; p = 0.001) was identified as an independent predictor of NOAF in patients with STEMI.</p><p><strong>Conclusion: </strong>The HAVOC score appears to be a useful tool for predicting NOAF in patients with STEMI. Identifying individuals with high HAVOC scores may enable early recognition and prevention of AF-related complications.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"371-379"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine attenuates myocardial inflammation, endothelial dysfunction, and apoptosis in a rat model of alcohol-related cardiac damage.","authors":"Şahhan Kılıç, Süha Asal, Mert Babaoğlu, Cumaali Demirtaş, Eray Metin Güler, Hakan Beyaztaş, Salime Pelin Ergüven, Kübra Şevgin, Samet Yavuz, Tufan Çınar","doi":"10.1007/s00059-026-05392-8","DOIUrl":"https://doi.org/10.1007/s00059-026-05392-8","url":null,"abstract":"<p><strong>Background: </strong>Chronic alcohol consumption is a recognized contributor to non-ischemic dilated cardiomyopathy, particularly in individuals with an underlying genetic predisposition, through myocardial inflammation, oxidative stress, and apoptosis. Colchicine, an NLRP3 inflammasome inhibitor, has cardioprotective potential, but its role in alcohol-induced injury is unknown. This study aimed to evaluate the dose-dependent effects of colchicine (0.1 mg/kg and 0.3 mg/kg) on alcohol-induced cardiac damage in rats.</p><p><strong>Methods: </strong>Overall, 40 Sprague-Dawley rats were randomized into five groups: control, alcohol (20% ethanol, 2.5 g/kg i.p.), colchicine alone, alcohol + standard-dose colchicine, and alcohol + high-dose colchicine. After 28 days, blood, cardiac, and liver tissues were analyzed for oxidative stress, inflammation, vascular injury, and apoptosis markers, along with histopathology.</p><p><strong>Results: </strong>Alcohol exposure significantly increased oxidative stress, inflammatory (interleukin-1β, tumor necrosis factor α, high-sensitivity C‑reactive protein), vascular injury, and apoptotic markers (all p < 0.001). Colchicine attenuated these elevations dose-dependently, with the high dose (0.3 mg/kg) providing significantly greater protection across nearly all parameters (p < 0.001). Histopathology confirmed that colchicine reduced alcohol-induced cardiomyocyte hypertrophy and inflammatory infiltration.</p><p><strong>Conclusion: </strong>Colchicine exerts dose-dependent cardioprotective effects against alcohol-induced injury by mitigating inflammation, oxidative stress, and apoptosis. High-dose colchicine offers superior protection, suggesting its potential therapeutic role in alcohol-related cardiac damage.</p>","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}