[Bariatric surgery versus GLP-1 and dual GIP/GLP-1 receptor agonists : Effects on weight, risk factors and prognosis].

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Herz Pub Date : 2025-06-13 DOI:10.1007/s00059-025-05319-9
Jürgen Ordemann, Ulf Elbelt
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引用次数: 0

Abstract

To overcome the increasing prevalence of obesity and associated secondary diseases, effective treatment strategies are required. While bariatric surgery (BS) is an established method for significant and sustainable weight reduction, drug treatment with glucagon-like peptide 1 (GLP-1), GLP‑1 receptor agonists (GLP‑1 RA) and dual glucose-dependent insulinotropic peptide (GIP)/GLP‑1 RA has gained increasing importance in recent years. This article highlights the effects of these both treatment approaches on body weight, cardiometabolic risk factors and long-term prognosis, particularly with respect to cardiovascular events and remission of type 2 diabetes. While BS shows more robust weight loss and greater improvement in metabolic parameters, GLP‑1 RA and dual GIP/GLP‑1 RA offer a conservative treatment alternative with a good safety profile. The choice of treatment should be individualized based on the patient risk profile and preferences.

[减肥手术与GLP-1和双重GIP/GLP-1受体激动剂:对体重、危险因素和预后的影响]。
为了克服肥胖和相关继发性疾病的日益流行,需要有效的治疗策略。虽然减肥手术(BS)是一种公认的显著和可持续的减肥方法,但胰高血糖素样肽1 (GLP-1)、GLP-1受体激动剂(GLP-1 RA)和双葡萄糖依赖性胰岛素肽(GIP)/GLP -1 RA的药物治疗近年来越来越重要。这篇文章强调了这两种治疗方法对体重、心脏代谢危险因素和长期预后的影响,特别是关于心血管事件和2型糖尿病的缓解。虽然BS显示出更强劲的体重减轻和更大的代谢参数改善,但GLP‑1 RA和双GIP/GLP‑1 RA提供了一种保守的治疗选择,具有良好的安全性。治疗的选择应根据患者的风险概况和偏好进行个体化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Herz
Herz 医学-心血管系统
CiteScore
3.00
自引率
5.90%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Herz is the high-level journal for further education for all physicians interested in cardiology. The individual issues of the journal each deal with specific topics and comprise review articles in English and German written by competent and esteemed authors. They provide up-to-date and comprehensive information concerning the speciality dealt with in the issue. Due to the fact that all relevant aspects of the pertinent topic of an issue are considered, an overview of the current status and progress in cardiology is presented. Reviews and original articles round off the spectrum of information provided.
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