IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-03-12 DOI: 10.1007/s00059-026-05370-0

Stephan Willems

引用次数: 0

[Sudden cardiac death in structural heart disease : Update on prevention]. 【结构性心脏病的心源性猝死：预防进展】。

IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1007/s00059-026-05367-9

Nora Wainstejn, Alireza Sepehri Shamloo, Verena Tscholl, Gerhard Hindricks, Wilhelm Haverkamp, Nicolaos Dagres

{"title":"[Sudden cardiac death in structural heart disease : Update on prevention].","authors":"Nora Wainstejn, Alireza Sepehri Shamloo, Verena Tscholl, Gerhard Hindricks, Wilhelm Haverkamp, Nicolaos Dagres","doi":"10.1007/s00059-026-05367-9","DOIUrl":"10.1007/s00059-026-05367-9","url":null,"abstract":"Sudden cardiac death (SCD) remains one of the leading causes of death despite major advances in cardiovascular diagnostics and treatment. Evidence supporting primary prophylactic implantable cardioverter defibrillator (ICD) implantation is still derived from trials conducted more than two decades ago and no longer reflects contemporary clinical practice. Modern heart failure treatment, improved coronary artery disease (CAD) management and refined prevention strategies have substantially reduced the risk of SCD and question the role of the left ventricular ejection fraction (LVEF) as the primary selection criterion. Recent studies further demonstrated that a universal survival benefit due to an ICD is absent in several patient groups previously considered to have a high risk. Current developments emphasize individualized risk stratification incorporating the overall risk, imaging-based markers such as scar architecture on cardiac magnetic resonance imaging (MRI), genetic variants, modifiable therapeutic factors and electrocardiographic parameters. In addition, artificial intelligence (AI)-based approaches offer new opportunities for risk prediction in both high-risk populations and the general population. Ongoing trials, such as PROFID-EHRA and CONTEMP-ICD are expected to fundamentally reshape the risk stratification and guideline recommendations. Until then, decisions regarding ICD implantation remain an interdisciplinary challenge.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"100-107"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetrandrine has protective role in myocardial ischemia/reperfusion injury via the TRPV2/Ca²⁺/calcineurin/NFAT axis. 粉防己碱通过TRPV2/Ca2+/钙调磷酸酶/NFAT轴对心肌缺血/再灌注损伤具有保护作用。

IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2025-09-10 DOI: 10.1007/s00059-025-05334-w

Wenbing Jiang, Lelin Jiang, Yiying Liu, Xiaoli Zhao, Shu'e Huang, Ying Liu, Huanghui Sun, Fanlu Guan

{"title":"Tetrandrine has protective role in myocardial ischemia/reperfusion injury via the TRPV2/Ca2+/calcineurin/NFAT axis.","authors":"Wenbing Jiang, Lelin Jiang, Yiying Liu, Xiaoli Zhao, Shu'e Huang, Ying Liu, Huanghui Sun, Fanlu Guan","doi":"10.1007/s00059-025-05334-w","DOIUrl":"10.1007/s00059-025-05334-w","url":null,"abstract":"Background: The protective function of the tetrandrine (TET)-mediated transient receptor potential vanilloid 2 (TRPV2) channel in myocardial ischemia/reperfusion injury (MI/RI) has been established in numerous investigations. The objective of the current study was to explain how TRPV2 further modulates downstream factors to influence the progression of MI/RI.Methods: To this end, an MI/RI model in rats and a hypoxia-reoxygenation (H/R) cell model in H9c2 cells were constructed. Based on western blotting analyses, the effects of TRPV2 on the levels of apoptosis-related proteins as well as calcineurin and nuclear factor of activated T cells (NFAT) were ascertained. Evans blue/triphenyltetrazolium chloride (TTC) double staining and H&E staining were, respectively, used to examine the pathological changes and infarction size of myocardial tissues in rats. Cardiomyocyte apoptosis was assessed with TUNEL assays and flow cytometry. Ca2+ concentration and reactive oxygen species (ROS) production were determined using a calcium assay kit and dichlorodihydrofluorescein diacetate (DCFH-DA) staining, respectively.Results: Downregulated TRPV2 showed a significant ameliorative effect on cardiomyocyte histopathology and infarction area. Cardiomyocyte apoptosis, Ca2+ concentration, and ROS amounts were also inhibited when TRPV2 was silenced. Furthermore, results indicated that TET could significantly decrease TRPV2, while knocking down TRPV2 markedly suppressed the expression of calcineurin and NFAT.Conclusion: These findings shed light on the possible mechanisms behind the TET-mediated TRPV2 channel in MI/RI, indicating that TET has protective functions through downregulation of TRPV2 expression and suppression of the Ca2+/calcineurin/NFAT pathway.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"133-142"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Potential of imaging in the clinical routine : Focus on cardiovascular MRI]. [影像学在临床常规中的潜力：以心血管MRI为重点]。

IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1007/s00059-025-05359-1

Nadine Abanador-Kamper, Torben Lange, Alexander Schulz, Theresa Reiter, Grigorios Korosoglou, Andreas Schuster, Jan Gröschel, Jeanette Schulz-Menger

{"title":"[Potential of imaging in the clinical routine : Focus on cardiovascular MRI].","authors":"Nadine Abanador-Kamper, Torben Lange, Alexander Schulz, Theresa Reiter, Grigorios Korosoglou, Andreas Schuster, Jan Gröschel, Jeanette Schulz-Menger","doi":"10.1007/s00059-025-05359-1","DOIUrl":"10.1007/s00059-025-05359-1","url":null,"abstract":"Cardiac magnetic resonance imaging (CMR) provides decisive advantages, particularly in coronary heart disease, myocarditis and cardiomyopathy. It accurately detects ischemia, scarring, edema and microvascular disorders, enables reliable risk stratification and supports treatment decisions such as revascularization or medication adjustments. Modern quantitative perfusion methods and artificial intelligence (AI)-based analyses further increase the diagnostic accuracy. In inflammatory myocardial and pericardial diseases, CMR using mapping techniques and late gadolinium enhancement (LGE) forms the basis for differentiated diagnostics and estimation of the prognosis. It also enables a precise etiological classification and provides prognostically relevant parameters in cases of hypertrophic, dilated, arrhythmogenic and restrictive cardiomyopathies. In the diagnostics of valvular diseases and the planning of interventional procedures and cardiac tumors, CMR provides essential additional information and demonstrates a high sensitivity and specificity. New techniques such as quantitative 4‑dimensional (4D) flow measurements, high-resolution 3D imaging and electrocardiograph (ECG)-independent scans will further increase its value. Due to the increasing number of CMR examinations, standardized procedures, qualified personnel and structured training programs are essential to ensure a high quality of care in the long term.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"116-125"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Update ERC guidelines 2025 on cardiopulmonary resuscitation]. [更新ERC心肺复苏指南2025]。

IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1007/s00059-026-05365-x

Guido Michels, Bernd W Böttiger, Hans-Jörg Busch, Camilla Metelmann, Tobias Wengenmayer, Dawid L Staudacher

引用次数: 0

[Cardiac arrhythmias-Cellular mechanisms, consequences and challenges in the diagnostics using human models]. [心律失常-使用人体模型诊断的细胞机制，后果和挑战]。

IF 0.9 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1007/s00059-026-05369-7

Katrin Streckfuß-Bömeke, Christoph Maack, Samuel Sossalla

{"title":"[Cardiac arrhythmias-Cellular mechanisms, consequences and challenges in the diagnostics using human models].","authors":"Katrin Streckfuß-Bömeke, Christoph Maack, Samuel Sossalla","doi":"10.1007/s00059-026-05369-7","DOIUrl":"10.1007/s00059-026-05369-7","url":null,"abstract":"Cardiac arrhythmias significantly contribute to morbidity and mortality in cardiovascular diseases. Hereditary ion channel disorders, including Brugada syndrome, long/short QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT), represent critical entities with elevated risk of malignant ventricular arrhythmias. Although beta-blockers, ion channel modulators and implantable cardioverter defibrillators (ICD) are available and the indications for them are increasingly based on genetic analyses, variants of uncertain significance (VUS) substantially impair the risk stratification. Atrial tachyarrhythmias, particular atrial fibrillation, can cause an often-reversible arrhythmia-induced cardiomyopathy (AIC). Pathophysiologically, the Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays an important role in atrial and ventricular arrhythmias. It can be activated by various pathological triggers, such as high heart rate, neuroendocrine activation and oxidative stress, the latter often resulting from mechano-energetic uncoupling. The development of effective treatment options for arrhythmia-associated cardiovascular diseases requires the use of human model systems in addition to animal experimental approaches, due to the genetic heterogeneity and systemic comorbidities. Patient-specific cardiac stem cell-models enable the classification of VUS and personalised drug testing. The integration of new methodological approaches into existing animal experimental approaches thus paves the way for functionally validated precision medicine and could fundamentally transform the treatment of both disease patterns.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"81-91"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-TEER-interventional repair of tricuspid regurgitation. t - teer介入修复三尖瓣反流。

IF 0.9 4区医学

Herz Pub Date : 2026-02-27 DOI: 10.1007/s00059-026-05373-x

Dominik Berliner, Sven Schallhorn, Johann Bauersachs

引用次数: 0

Erratum to: Atherogenic index as an associative marker for coronary artery disease. 致动脉粥样硬化指数是冠状动脉疾病的相关标志物。

IF 0.9 4区医学

Herz Pub Date : 2026-02-26 DOI: 10.1007/s00059-026-05374-w

Basavaraj Utagi, Dilip Johny, Aditya Ojha, Adesh Kumar

引用次数: 0

M-TEER-interventional repair of mitral valve regurgitation. m - teer介入修复二尖瓣返流。

IF 0.9 4区医学

Herz Pub Date : 2026-02-24 DOI: 10.1007/s00059-026-05372-y

Christos Iliadis, Stephan Baldus

引用次数: 0

[Cardiovascular imaging using cardiac computed tomography and cardiac magnetic resonance imaging]. [使用心脏计算机断层扫描和心脏磁共振成像的心血管成像]。

IF 0.9 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1007/s00059-025-05350-w

Nadine Abanador-Kamper, Andreas A Giannopoulos, Miltiadis Georgiadis, Grigorios Korosoglou

{"title":"[Cardiovascular imaging using cardiac computed tomography and cardiac magnetic resonance imaging].","authors":"Nadine Abanador-Kamper, Andreas A Giannopoulos, Miltiadis Georgiadis, Grigorios Korosoglou","doi":"10.1007/s00059-025-05350-w","DOIUrl":"10.1007/s00059-025-05350-w","url":null,"abstract":"Noninvasive cardiac imaging using cardiac computed tomography (CCT) and cardiac magnetic resonance imaging (CMRI) has become established as an indispensable diagnostic instrument in modern cardiology for the assessment of cardiovascular diseases. Both techniques are complementary in their diagnostic potential and enable an individualized clinical care, including diagnostic confirmation, prognosis estimation and treatment planning. The use of CCT enables a precise visualization of the coronary vessels, including the detection and quantification of luminal stenosis and additional plaque characterization. It is particularly suitable for the noninvasive clarification of coronary artery disease (CAD) in patients with a low to moderate pretest probability and for procedural planning in cardiology. The high negative predictive value of CCT enables its use as a gatekeeper for unnecessary invasive diagnostics of CAD. The use of CMRI provides a combination of functional morphological diagnostics with a precise myocardial tissue characterization, which are helpful for the assessment of CAD, inflammatory heart diseases and cardiomyopathies. Due to the possibility to quantify myocardial damage, CMRI has a high prognostic value. The combination of both non-invasive techniques in the present-day modern cardiac diagnostics is essential for guideline-compliant and patient-centered care by the coverage of the broad spectrum of cardiac diseases and the supplementary methods.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"66-78"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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