Hereditas最新文献

{"title":"MiR-518c-5p/miR-4524a-3p can mediate immune escape and chemotherapy resistance in triple-negative breast cancer and predict its outcome.","authors":"Yuan Sun, Liang An, Linna Kong, Xiaoyan Liu, Huihui Zhang, Jiaqi Liu, Pengfei Qian","doi":"10.1186/s41065-025-00572-8","DOIUrl":"https://doi.org/10.1186/s41065-025-00572-8","url":null,"abstract":"<p><strong>Background: </strong>Triple-negative breast cancer (TNBC), is characterized by its highly aggressive nature, with chemotherapy resistance and immune evasion contributing to poor outcomes. The role of major histocompatibility complex class I (MHCI) downregulation in TNBC progression remains incompletely understood.</p><p><strong>Aim: </strong>The present research focused on elucidating the roles of miR-518c-5p/miR-4524a-3p in immune evasion and chemoresistance in TNBC, and evaluating their clinical significance.</p><p><strong>Methods: </strong>Bioinformatics analysis predicted miRNAs targeting HLA-A/B/C, validated by dual-luciferase assays. Functional studies in TNBC cell lines (MDA-MB-231/468 and ADR-resistant sublines) included chromium release, proliferation, invasion, and apoptosis assays. Clinical relevance was assessed in 88 TNBC patients and 88 controls using RT-PCR and survival analysis.</p><p><strong>Results: </strong>MiR-518c-5p/miR-4524a-3p directly targeted HLA-A, HLA-B, and HLA-C, downregulating MHCI expression and promoting immune evasion. Overexpression of miR-518c-5p/miR-4524a-3p enhanced TNBC cell proliferation, invasion, and chemoresistance to doxorubicin, while their inhibition reversed these effects. High expression of miR-518c-5p/miR-4524a-3p correlated with adverse clinical outcomes in TNBC patients, including shorter recurrence-free survival.</p><p><strong>Conclusions: </strong>MiR-518c-5p/miR-4524a-3p contribute to TNBC progression by facilitating immune evasion and chemoresistance. Targeting miR-518c-5p/miR-4524a-3p may represent a promising therapeutic approach for improving TNBC treatment outcomes.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"216"},"PeriodicalIF":2.5,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cystatin C and microalbuminuria as predictive markers for hypertension-related renal complications.","authors":"Jinyu Li, Shiming Guan, Zhuoqun Zou, Lijuan Yang, Bo Qian, Li Shen, Ye Li","doi":"10.1186/s41065-025-00557-7","DOIUrl":"10.1186/s41065-025-00557-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the correlation between blood pressure and the levels of two renal function markers, cystatin C and microalbuminuria, with the goal of evaluating their correlation across varying blood pressure categories.</p><p><strong>Methods: </strong>A cohort of 3,000 participants, comprising 1,500 individuals with a diagnosis of hypertension and 1,500 normotensive controls, was analyzed. Data on blood pressure, serum cystatin C, microalbuminuria, and other relevant clinical parameters were collected at admission. Correlations between these markers and blood pressure levels were analyzed using SPSS 26.0 statistical software.</p><p><strong>Results: </strong>Levels of cystatin C and microalbuminuria were significantly higher in individuals with hypertension compared to the control group (P < 0.05). Furthermore, both biomarkers demonstrated a positive correlation with blood pressure (r = 0.140, P < 0.001). Multiple linear regression analysis revealed that the combined use of cystatin C and microalbuminuria provided a superior predictive value for blood pressure levels (P < 0.001). The combined predictive accuracy (R² = 0.114. R² = 0.112 after rectifying age, body mass index, and blood lipid levels) exceeded that of cystatin C (R² = 0.100) or microalbuminuria (R² = 0.113) when analyzed individually.</p><p><strong>Conclusion: </strong>The biomarkers cystatin C and microalbuminuria are closely correlated with blood pressure levels. Their combined assessment offers an enhanced diagnostic approach for the early detection of renal complications in individuals with hypertension.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"214"},"PeriodicalIF":2.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects.","authors":"Fan Yang, Qiuxia Qin, Juan Liu","doi":"10.1186/s41065-025-00595-1","DOIUrl":"10.1186/s41065-025-00595-1","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"215"},"PeriodicalIF":2.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering CRIP1: a novel core gene in osteoarthritis pathogenesis.","authors":"Qifan Chen, Mengliang Luo, Wenhao Kuang, Xianfang Guo, Hao Wu, Shiqi Wu, Sanmao Liu, Yueliang Wen, Chushong Zhou, Maolin He","doi":"10.1186/s41065-025-00576-4","DOIUrl":"10.1186/s41065-025-00576-4","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"212"},"PeriodicalIF":2.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in non-coding RNA and intestinal epithelial homeostasis: an integrated bibliometric analysis (2007-2024).","authors":"Xinxin Wang, Xuan Li, Yongtian Wen, Bochao Yuan, Xudong Tang, Ting Chen","doi":"10.1186/s41065-025-00560-y","DOIUrl":"10.1186/s41065-025-00560-y","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"213"},"PeriodicalIF":2.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating single-cell RNA sequencing and Mendelian randomization analysis to identify potential drug targets for dilated cardiomyopathy.","authors":"Ruikang Liu, Yiying Liu, Chao Meng, Jun Li, Hui Wang, Xuanchun Huang, Shiyi Tao, Xiao Xia, Lilan Su, Yonghao Li, Weiming Fan, Chiyun Sun","doi":"10.1186/s41065-025-00539-9","DOIUrl":"10.1186/s41065-025-00539-9","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"211"},"PeriodicalIF":2.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Decoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions.","authors":"Jinna Di, Li Tian, Fan Yan, Zhang Zhe, Cai Lin, Liu Jingyu","doi":"10.1186/s41065-025-00582-6","DOIUrl":"10.1186/s41065-025-00582-6","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"210"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12529791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jianpi Qutan Decoction improves hepatic lipid metabolism in atherosclerosis mice via PPARα-CPT1α pathway regulation.","authors":"Xiaoyu Gao, Ying Hai, Dan Ma, Lisi Liu, Ying Pei, Jie Li, Wenping Wang","doi":"10.1186/s41065-025-00580-8","DOIUrl":"10.1186/s41065-025-00580-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate Jianpi Qutan Decoction (JPQT)'s effects on hepatic lipid metabolism via the PPARα-CPT1α pathway.</p><p><strong>Methods: </strong>Eight male C57BL/6J mice served as controls; 32 ApoE^-/- mice were randomized into atherosclerosis (AS), atorvastatin calcium (AC), and low/medium/high-dose JPQT groups. Prior to the intervention, therapeutic targets of JPQT were analyzed using network pharmacology to provide a theoretical basis for subsequent experiments. The AS model was induced by a 12-week high-fat diet. Hepatic triglyceride (TG) and cholesterol (TC) were measured via GPO-PAP. Glucose tolerance (GTT) and insulin tolerance (ITT) were assessed. Pro-inflammatory cytokines were analyzed by ELISA/colorimetry. Fatty acid metabolism enzymes were evaluated using kits. PPARα-CPT1α pathway mRNA and protein expression were quantified via qPCR and Western blot.</p><p><strong>Results: </strong>JPQT and AC reduced aortic plaque lipid deposition. JPQT significantly lowered hepatic TG/TC, blood glucose, insulin, and inflammation. It modulated fatty acid metabolism by promoting ACC phosphorylation, suppressing FAS and FFA while elevating FAβO, with dose-dependent efficacy. Additionally, JPQT upregulated PPARα, CPT1α, and ACOX1 mRNA and protein expression in the liver.</p><p><strong>Conclusion: </strong>JPQT may improves lipid metabolism and reduces AS progression by activating the PPARα-CPT1α pathway, with higher doses yielding stronger effects.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"209"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMAL1 alleviates sepsis-induced acute kidney injury by inhibiting apoptosis, ferroptosis and inflammation.","authors":"Zhipan Chen, Gaoze Chen, Jinhui Shi, Litong Jin","doi":"10.1186/s41065-025-00583-5","DOIUrl":"10.1186/s41065-025-00583-5","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a life-threatening syndrome characterized by organ dysfunction. The kidney is one of the earliest organs to be injured during sepsis. Basic Helix-Loop-Helix ARNT Like 1 (BMAL1) was shown to play a critical role in immune responses. BMAL1 deregulation is related to sepsis-induced injury. Thus, correct understanding of the molecular mechanism of BMAL1 in sepsis-induced acute kidney injury (AKI) may be importance for seeking effective targeted therapy.</p><p><strong>Methods: </strong>Lipopolysaccharide (LPS)-induced renal tubular epithelial cells (HK-2 cells) and a sepsis-AKI model established in C57BL/6 mice using cecal ligation and puncture (CLP) were used for functional analyses. In vitro analyses were conducted using EdU assay, flow cytometry, MTT assay and ELISA, respectively. Levels of mRNA and protein expression were using qRT-PCR and western blotting. Cellular ubiquitination analyzed the ubiquitination effect of USP10 on BMAL1. The binding of HOXA5 to BMAL1 promoter was verified using Chromatin immunoprecipitation and Luciferase reporter assays.</p><p><strong>Results: </strong>BMAL1 overexpression reversed LPS-induced apoptosis, inflammation and ferroptosis in HK-2 cells, as well as attenuated sepsis-induced AKI in mouse models. Mechanistically, USP10 bound to BMAL1 and positively modulated BMAL1 expression by reducing BMAL1 ubiquitination. In addition, HOXA5 induced BMAL1 transcription. Moreover, USP10 or HOXA5 overexpression reversed LPS-induced apoptosis, inflammation and ferroptosis in HK-2 cells, which could be rescued by BMAL1 decrease.</p><p><strong>Conclusion: </strong>BMAL1 overexpression mediated by USP10-induced deubiquitination or HOXA5-induced transcription can attenuate sepsis-induced acute kidney injury, recommending a novel insight for the prevention of sepsis-induced AKI.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"208"},"PeriodicalIF":2.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative study and related factors analysis of sciatic neuropathy in type 2 diabetes mellitus patients by elastic imaging virtual tissue imaging quantification technique.","authors":"Ruixing Liu, Beibei Yu, Gaopan Cao, Lina Ye, Dan Zhang","doi":"10.1186/s41065-025-00565-7","DOIUrl":"10.1186/s41065-025-00565-7","url":null,"abstract":"<p><strong>Background: </strong>The incidence of diabetic peripheral neuropathy (DPN) is increasing every year for type 2 diabetes mellitus (T2DM) patients, and diabetic polyneuropathy is a common type.</p><p><strong>Objective: </strong>To quantify and analyze the factors associated with diabetic polyneuropathy using the virtual tissue imaging quantification (VTIQ) technique.</p><p><strong>Method: </strong>182 patients with T2DM, 137 patients with diabetic polyneuropathy, and 198 healthy volunteers were included in this retrospective cross-sectional diagnostic study. Sciatic neuropathy was evaluated through Doppler ultrasound examination with a VTIQ quantitative analysis system to acquire elastic modulus, cross-sectional area (CSA) and shear wave velocity (SWV). Nerve conduction velocity (NCV) was also evaluated via neurophysiological examination. Logistic regression was used to analyze odds ratios (OR) related diabetic polyneuropathy. The diagnostic accuracy of the VTIQ technique-acquired index on diabetic polyneuropathy was analyzed using the receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>VTIQ technique-acquired indexes all differed significantly among three study groups, among which Elastic modulus and CSA were independently related to diabetic polyneuropathy risk according to the logistic regression analysis. NCV was also an independent risk factor for diabetic polyneuropathy. ROC analysis revealed that Elastic modulus, CSA and NCV can distinguish diabetic polyneuropathy patients from T2DM cases with the AUC of 0.797, 0.654 and 0.775 respectively. But their combination achieved the highest diagnostic value (AUC = 0.883). CSA and SWV of the sciatic nerve are positively correlated with visual analog scale (VAS) scores.</p><p><strong>Conclusion: </strong>VTIQ technology contributes to the diagnosis of diabetic polyneuropathy, it can improve the diagnostic value of neurophysiological examination on sciatic neuropathy for T2DM patients.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"207"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}