发布求助
文献互助 智能选刊 最新文献

Hereditas最新文献

筛选
英文 中文
Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models. 三维宫颈癌模型的细胞可塑性和异质性。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-14 DOI: 10.1186/s41065-026-00668-9
Mercedes Olvera-Valencia, Adriana Grijalva-Pérez, Oliver Millan-Catalan, Martha Estela Albino-Sánchez, Manuel Humberto Cháirez-Ramírez, Rocío Méndez-Martínez, Eduardo López-Urrutia, Carlos Pérez-Plasencia, Alejandro García-Carrancá
{"title":"Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models.","authors":"Mercedes Olvera-Valencia, Adriana Grijalva-Pérez, Oliver Millan-Catalan, Martha Estela Albino-Sánchez, Manuel Humberto Cháirez-Ramírez, Rocío Méndez-Martínez, Eduardo López-Urrutia, Carlos Pérez-Plasencia, Alejandro García-Carrancá","doi":"10.1186/s41065-026-00668-9","DOIUrl":"https://doi.org/10.1186/s41065-026-00668-9","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VEZF1 inhibits ovarian cancer cell ferroptosis and acts as an oncogene via the miR-545-3p/PLAG1 axis. VEZF1抑制卵巢癌细胞铁下垂，并通过miR-545-3p/PLAG1轴作为致癌基因。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-13 DOI: 10.1186/s41065-026-00672-z
Wei Shi, Weiwei Feng, Jing Wan, Xiao-Ping Wan
{"title":"VEZF1 inhibits ovarian cancer cell ferroptosis and acts as an oncogene via the miR-545-3p/PLAG1 axis.","authors":"Wei Shi, Weiwei Feng, Jing Wan, Xiao-Ping Wan","doi":"10.1186/s41065-026-00672-z","DOIUrl":"https://doi.org/10.1186/s41065-026-00672-z","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effect of Saikosaponin D modulating endoplasmic reticulum stress mediated by TLR4/MyD88/NF-κB/NLRP3 pathway on cholestatic liver injury. 柴草皂苷D调节TLR4/MyD88/NF-κB/NLRP3通路介导的内质网应激对胆汁淤积性肝损伤的保护作用。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-11 DOI: 10.1186/s41065-026-00669-8
XianMeng Meng, Wei Chen
{"title":"Protective effect of Saikosaponin D modulating endoplasmic reticulum stress mediated by TLR4/MyD88/NF-κB/NLRP3 pathway on cholestatic liver injury.","authors":"XianMeng Meng, Wei Chen","doi":"10.1186/s41065-026-00669-8","DOIUrl":"https://doi.org/10.1186/s41065-026-00669-8","url":null,"abstract":"<p><strong>Objective: </strong>Cholestatic liver injury (CLI) has lacked a potent treatment due to its incompletely understood pathogenesis. Saikosaponin D (SSD), the main active ingredient of the traditional Chinese medicine Bupleuri Radix, has significant anti-inflammatory and hepatoprotective effects and inhibits hepatic fibrosis. This study specifically investigated the protective effects of SSD in CLI and its related mechanisms.</p><p><strong>Methods: </strong>In bile duct ligation (BDL)-induced CLI in mice, the protective effect of SSD was assessed by serum biochemical index analysis, HE staining of liver tissue, Sirius red staining, immunohistochemistry and ELISA. Bile acid-induced human HepG2 cell line was taken to study the protective effect and potential mechanism of SSD against CLI in vitro. TLR4/MyD88/NF-κB/NLRP3 pathway-related proteins in mouse liver tissues or HepG2 cells were detected by Western blot or immunofluorescence.</p><p><strong>Results: </strong>SSD dose‑dependently improved liver function and reduced hepatocyte necrosis, collagen deposition, and apoptosis. It attenuated oxidative stress injury, inflammatory responses, and endoplasmic reticulum stress (ERS) in BDL mice. SSD also mitigated bile acid‑induced injury and ERS in HepG2 cells. Moreover, SSD suppressed the activation of the TLR4/MyD88/NF‑κB/NLRP3 pathway. The TLR4 inhibitor TAK‑242, similar to SSD, ameliorated bile acid‑induced HepG2 cell injury and ERS, whereas the TLR4 agonist LPS counteracted the protective effects of SSD and its inhibition of ERS in bile acid‑stimulated HepG2 cells.</p><p><strong>Conclusion: </strong>SSD attenuates CLI, an effect that may be associated with the suppression of the TLR4/MyD88/NF‑κB/NLRP3 pathway and the subsequent inhibition of ERS.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin inhibits chondrocyte apoptosis and inflammation in osteoarthritis via the miR-338-3p/EIF4A1 signaling axis. 姜黄素通过miR-338-3p/EIF4A1信号轴抑制骨关节炎软骨细胞凋亡和炎症。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-09 DOI: 10.1186/s41065-026-00674-x
Na Dai, Bin Shi
{"title":"Curcumin inhibits chondrocyte apoptosis and inflammation in osteoarthritis via the miR-338-3p/EIF4A1 signaling axis.","authors":"Na Dai, Bin Shi","doi":"10.1186/s41065-026-00674-x","DOIUrl":"https://doi.org/10.1186/s41065-026-00674-x","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-associated fibroblasts and immune escape-related genes serve as biological markers for the prognosis of colorectal cancer. 肿瘤相关成纤维细胞和免疫逃逸相关基因可作为结直肠癌预后的生物学标志物。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-07 DOI: 10.1186/s41065-026-00676-9
Xia Liu, Aorong Shi, Bai Dai, Yue Chang, Fen Yun, Huan Guan, Rina Sha, Yongfeng Jia
{"title":"Cancer-associated fibroblasts and immune escape-related genes serve as biological markers for the prognosis of colorectal cancer.","authors":"Xia Liu, Aorong Shi, Bai Dai, Yue Chang, Fen Yun, Huan Guan, Rina Sha, Yongfeng Jia","doi":"10.1186/s41065-026-00676-9","DOIUrl":"https://doi.org/10.1186/s41065-026-00676-9","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum LINC01127 serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes. 血清LINC01127可作为败血症的诊断性生物标志物及其对临床结果的预测价值。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-06 DOI: 10.1186/s41065-026-00670-1
Congcong Li, Xiao Gui, Haiyuan Zhu, Jinhui Wang, Yu Xie, Lilin Wang, Yongyang Tian, Shun Li
{"title":"Serum LINC01127 serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes.","authors":"Congcong Li, Xiao Gui, Haiyuan Zhu, Jinhui Wang, Yu Xie, Lilin Wang, Yongyang Tian, Shun Li","doi":"10.1186/s41065-026-00670-1","DOIUrl":"https://doi.org/10.1186/s41065-026-00670-1","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular matrix-growth factor signalling drives the oncogenic mir-125b-2/UCK2 axis in hepatocellular carcinoma. 细胞外基质生长因子信号传导驱动肝癌中致癌mir-125b-2/UCK2轴。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-04-02 DOI: 10.1186/s41065-026-00673-y
YunFeng Zhao, HaoXin Shen, Yibo Sun, JinKun Song, Chen GuangSun, JinXiu Li, HongYu Wang, YinSen Song
{"title":"Extracellular matrix-growth factor signalling drives the oncogenic mir-125b-2/UCK2 axis in hepatocellular carcinoma.","authors":"YunFeng Zhao, HaoXin Shen, Yibo Sun, JinKun Song, Chen GuangSun, JinXiu Li, HongYu Wang, YinSen Song","doi":"10.1186/s41065-026-00673-y","DOIUrl":"https://doi.org/10.1186/s41065-026-00673-y","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition and confirmation of key genes associated with nicotinamide metabolism in acute myocardial infarction. 急性心肌梗死中烟酰胺代谢相关关键基因的识别和确认。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-03-29 DOI: 10.1186/s41065-026-00671-0
Nan Qu, Fawen Bai, Jin Lan
{"title":"Recognition and confirmation of key genes associated with nicotinamide metabolism in acute myocardial infarction.","authors":"Nan Qu, Fawen Bai, Jin Lan","doi":"10.1186/s41065-026-00671-0","DOIUrl":"10.1186/s41065-026-00671-0","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomal lncRNA DLEU2 aggravates inflammatory injury and apoptosis in pediatric viral pneumonia via the miR-330-5p. 外泌体lncRNA DLEU2通过miR-330-5p加重小儿病毒性肺炎的炎症损伤和细胞凋亡。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-03-25 DOI: 10.1186/s41065-026-00665-y
Xinxing Su, Haobin Wang, Jianzhu He, Huagui Bai
{"title":"Exosomal lncRNA DLEU2 aggravates inflammatory injury and apoptosis in pediatric viral pneumonia via the miR-330-5p.","authors":"Xinxing Su, Haobin Wang, Jianzhu He, Huagui Bai","doi":"10.1186/s41065-026-00665-y","DOIUrl":"10.1186/s41065-026-00665-y","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folate-driven changes in snoRNA function: a novel epigenetic-ribosomal axis in hepatocellular carcinoma. 叶酸驱动的snoRNA功能改变：肝细胞癌中一种新的表观遗传-核糖体轴。
IF 2.5 3区 生物学
Hereditas Pub Date : 2026-03-23 DOI: 10.1186/s41065-026-00666-x
Xinxin Song, Deyu Kong, Yongjiao Zi, Xu Wang, Juan Ni
{"title":"Folate-driven changes in snoRNA function: a novel epigenetic-ribosomal axis in hepatocellular carcinoma.","authors":"Xinxin Song, Deyu Kong, Yongjiao Zi, Xu Wang, Juan Ni","doi":"10.1186/s41065-026-00666-x","DOIUrl":"10.1186/s41065-026-00666-x","url":null,"abstract":"","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书