Hiroshima journal of medical sciences最新文献

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Thermographic study on the preservability of heat effects of footbath with salt. 盐足浴热效应保鲜性的热像学研究。
Toshihide Harada, Yuuki Iwakawa, Hiromi Ikeda, Fumiko Ishizaki, Satomi Aoi, Yumiko Nitta, Akira Yoshida, Noriko Tamura, Tadayuki Iida, Mitsuhisa Shiokawa, Kohsaku Nitta
{"title":"Thermographic study on the preservability of heat effects of footbath with salt.","authors":"Toshihide Harada,&nbsp;Yuuki Iwakawa,&nbsp;Hiromi Ikeda,&nbsp;Fumiko Ishizaki,&nbsp;Satomi Aoi,&nbsp;Yumiko Nitta,&nbsp;Akira Yoshida,&nbsp;Noriko Tamura,&nbsp;Tadayuki Iida,&nbsp;Mitsuhisa Shiokawa,&nbsp;Kohsaku Nitta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infrared thermography provides a non-invasive and dynamic measure of heat. The thermal preservability effects of a salt footbath were evaluated by the infrared thermography technique. The subjects were 23 healthy college students. Feet were soaked for 10 min in a 40-42 degrees C normal footbath. Room temperature was set at 26.5-28 degrees C. At the same time on another day within 3 days of the normal footbath experiment, the same feet were soaked for 10 min in a 40-42 degrees C salt footbath. We measured blood pressure, heart rate and temperatures of the feet, second toes, hands and middle fingers, just before and after immersion and at 10-min intervals thereafter. Mean blood pressure changes showed no difference between the normal and the salt footbath. Mean heart rate changes were higher during the normal footbath than at 0, 15 and 20 min during the salt footbath, respectively (p < 0.05). Mean thermal preservability of the feet tended to be lower after the normal footbath than at 20 and 30 min, respectively, after the salt footbath, but these differences did not reach a statistical significance. Mean thermal preservability of the hands and middle fingers was significantly lower after the normal footbath than at 20 and 30 min, respectively, after the salt footbath (p < 0.05). The results suggest that stimulation by a salt footbath affects surface skin temperature, and that stimulation aimed at increasing skin thermal preservability shows a significant difference between normal and salt footbaths.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 1-3","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33100425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An appropriate compression pace is important for securing the quality of hands-only CPR--a manikin study. 一项人体研究表明,适当的按压速度对于确保徒手心肺复苏的质量非常重要。
Yoshitaka Shimizu, Koichi Tanigawa, Masami Ishikawa, Kazuhisa Ouhara, Kana Oue, Taiga Yoshinaka, Hidemi Kurihara, Masahiro Irifune
{"title":"An appropriate compression pace is important for securing the quality of hands-only CPR--a manikin study.","authors":"Yoshitaka Shimizu,&nbsp;Koichi Tanigawa,&nbsp;Masami Ishikawa,&nbsp;Kazuhisa Ouhara,&nbsp;Kana Oue,&nbsp;Taiga Yoshinaka,&nbsp;Hidemi Kurihara,&nbsp;Masahiro Irifune","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is important to implement good quality chest compressions for cardiopulmonary resuscitation (CPR). This manikin study examined the effects of different compression rates on chest compression depth variables using a metronome sound guide. Fifty sixth-year dentistry students participated in the study. Each participant performed CPR at 3 different compression rates, 110, 100, and 90 compressions per min (pace-110-g, pace-100-g, and pace-90-g) for 2 consecutive one-minute sets with a ten-second break between the sets. The percentage of compressions deeper than 5 cm at pace-110-g decreased significantly from 22.1 ± 4.7% in the first set to 16.7 ± 4.4%* in the second set (*p < 0.05 vs. the first set). However, no significant differences were observed between the first and second sets at pace-100-g and pace-90-g. The results obtained for pace-110-g were compared in detail by gender. In the male group, the percentage of compressions deeper than 5 cm was 43.5 ± 7.5% in the first set, and this decreased significantly to 34.6 ± 7.6%* in the second set (*p < 0.001 vs. the first set). However, the percentage of compressions deeper than 5 cm in the female group was 2.3 ± 1.6%* in the first set and 0.2 ± 0.2%* in the second set (*p < 0.05 vs. male). Our study demonstrated that the compression pace of 110 compressions per min was inadequate to provide chest compressions of an appropriate depth, which decreased rapidly. Therefore, limiting the rate of compressions to within a certain number per min may contribute to minimizing deteriorations in compression depth in hands-only CPR.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 1-3","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33424002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term administration of fluvoxamine attenuates neuropathic pain and involvement of spinal serotonin receptors in diabetic model rats. 长期给予氟伏沙明减轻糖尿病模型大鼠神经性疼痛和脊髓血清素受体的参与。
Takahiro Kato, Seiji Kajiyama, Hiroshi Hamada, Masashi Kawamoto
{"title":"Long-term administration of fluvoxamine attenuates neuropathic pain and involvement of spinal serotonin receptors in diabetic model rats.","authors":"Takahiro Kato,&nbsp;Seiji Kajiyama,&nbsp;Hiroshi Hamada,&nbsp;Masashi Kawamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diabetic neuropathic pain management is difficult even with non-steroidal anti-inflammatory drugs and narcotic analgesics such as morphine. Fluvoxamine, a class of selective serotonin reuptake inhibitors (SSRIs), is widely used to treat depression. Its analgesic effects are also documented for diabetic neuropathic pain, but they are limited because it is administered as a single-dose. In this study, we examined the time course of the antiallodynic effect of fluvoxamine in a rat model of diabetic neuropathic pain, which was induced by a single intraperitoneal administration of streptozotocin (75 mg/kg). In addition, the involvement of spinal serotonin (5-HT) receptors in long-term fluvoxamine treatment was studied by intrathecal administration of 5-HT receptor antagonists. In this study the development of mechanical hyperalgesia was assessed by measuring the hind paw withdrawal threshold using von Frey filaments. The results demonstrated that daily oral administration of fluvoxamine (10, 30, and 100 mg/kg) to diabetic rats from 3 to 8 weeks after streptozotocin administration resulted in a dose-dependent antiallodynic effect. The antiallodynic effect was sustained from 2 to 5 weeks after fluvoxamine administration. The antiallodynic effect of fluvoxamine in the diabetic rats was attenuated by WAY-100635 (a 5-HT(1A) receptor antagonist) intrathecally administered 1 week after the onset of daily administration of fluvoxamine, whereas no significant attenuation was seen when the antagonist was administered 3 and 5 weeks after fluvoxamine administration. The antiallodynic effect of fluvoxamine was also attenuated by ketanserin (a 5-HT(2A/2C) receptor antagonist) and ondansetron (a 5-HT3 receptor antagonist) intrathecally administered 1 and 3 weeks after the onset of daily fluvoxamine administration. However, no significant attenuation was observed when the antagonist was administered 5 weeks after fluvoxamine administration. This study demonstrated that daily oral administration of fluvoxamine can afford a sustained antiallodynic effect against streptozotocin-induced neuropathic pain. Furthermore, there appears to be a time-dependent relevance of different types of 5-HT receptors (5-HT(1A), 5-HT(2A/2C), and 5-HT3) to streptozotocin-induced diabetic neuropathic pain when treated with daily fluvoxamine.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 4","pages":"83-9"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40282148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a job stressor scale for nurses caring for patients with intractable neurological diseases. 难治性神经系统疾病护士工作压力源量表的编制。
Yukako Ando, Tsuyoshi Kataoka, Hitoshi Okamura, Katsutoshi Tanaka, Toshio Kobayashi
{"title":"Development of a job stressor scale for nurses caring for patients with intractable neurological diseases.","authors":"Yukako Ando,&nbsp;Tsuyoshi Kataoka,&nbsp;Hitoshi Okamura,&nbsp;Katsutoshi Tanaka,&nbsp;Toshio Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this research is to verify the reliability and validity of a job stressor scale for nurses caring for patients with intractable neurological diseases. A mail survey was conducted using a self-report questionnaire. The subjects were 263 nurses and assistant nurses working in wards specializing in intractable neurological diseases. The response rate was 71.9% (valid response rate, 66.2%). With regard to reliability, internal consistency and stability were assessed. Internal consistency was examined via Cronbach's alpha. For stability, the test-retest method was performed and stability was examined via intraclass correlation coefficients. With regard to validity, factor validity, criterion-related validity, and content validity were assessed. Exploratory factor analysis was used for factor validity. For criterion-related validity, an existing scale was used as an external criterion; concurrent validity was examined via Spearman's rank correlation coefficients. As a result of analysis, there were 26 items in the scale created with an eight factor structure. Cronbach's a for the 26 items was 0.90; with the exception of two factors, alpha for all of the individual sub-factors was high at 0.7 or higher. The intraclass correlation coefficient for the 26 items was 0.89 (p < 0.001). With regard to criterion-related validity, concurrent validity was confirmed and the correlation coefficient with an external criterion was 0.73 (p < 0.001). For content validity, subjects who responded that \"The questionnaire represents a stressor well or to a degree\" accounted for 81% of the total responses. Reliability and validity were confirmed, so the scale created in the current research is a usable scale.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 4","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40284336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficult anesthesia management in a case of living donor liver transplantation with hypertrophic obstructive cardiomyopathy. 活体肝移植合并肥厚性梗阻性心肌病1例麻醉处理困难。
Takashi Kondo, Shinji Kusunoki, Masahiko Kuroda, Masashi Kawamoto
{"title":"Difficult anesthesia management in a case of living donor liver transplantation with hypertrophic obstructive cardiomyopathy.","authors":"Takashi Kondo,&nbsp;Shinji Kusunoki,&nbsp;Masahiko Kuroda,&nbsp;Masashi Kawamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Liver transplantation with hypertrophic obstructive cardiomyopathy is associated with acute hemodynamic changes, which can exacerbate left ventricular outflow tract obstruction during surgery. Therefore, selection of general anesthetic agents is important, as most can result in hemodynamic instability by reducing systemic vascular resistance and blood pressure. We report successful anesthetic management in a case of living donor liver transplantation with hypertrophic obstructive cardiomyopathy using ketamine, propofol, and fentanyl to avoid vasodilation by anesthetic agents. In addition, landiolol, phenylephrine, and low-dose dopamine were administered to prevent left ventricular outflow tract obstruction, and were found to be effective for improving acute hemodynamic changes during surgery. In the case of this patient, the combination of transesophageal echocardiography and a pulmonary artery catheter was beneficial for intraoperative hemodynamic monitoring.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 4","pages":"91-4"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40282151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of recurrence factors and Gorei-san administration for chronic subdural hematoma after percutaneous subdural tapping. 经皮硬膜下穿刺后慢性硬膜下血肿复发因素及高瑞山给药的评估。
Akitake Okamura, Yukihiko Kawamoto, Eiichirou Sakoda, Taro Murakami, Takeshi Hara
{"title":"Evaluation of recurrence factors and Gorei-san administration for chronic subdural hematoma after percutaneous subdural tapping.","authors":"Akitake Okamura,&nbsp;Yukihiko Kawamoto,&nbsp;Eiichirou Sakoda,&nbsp;Taro Murakami,&nbsp;Takeshi Hara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent reports have shown that administration of Gorei-san (Tsumura, Tokyo, Japan) can prevent recurrence of chronic subdural hematoma (CSDH). However, no report has shown its potential, including its correlation with other recurrent clinical factors. We retrospectively evaluated the recurrent factors and the effects of Gorei-san on CSDH using percutaneous subdural tapping. Between April 2009 and February 2012, we performed percutaneous subdural tapping on 160 patients with intact CSDH. Of this population, 125 patients with unilateral hematoma and measurable initial hematoma pressure were included in this study. From April 2010, Gorei-san was routinely administered to patients. Patient characteristics such as age, sex, neurological grading, alcohol, diabetes mellitus, antiplatelet agent, anticoagulant agent, trauma, midline shift on CT images, hematoma volume on CT images, initial hematoma pressure, volume of the removed hematoma, and administration of Gorei-san were analyzed. Recurrence was recognized in 35/125 (28.0%) patients. Multivariate analysis revealed that a greater midline shift on CT images (p = 0.033) and initial hematoma pressure (p = 0.031) predicted recurrence. Gorei-san was administered to 94/125 (75.2%) patients, but they showed no changes in recurrence (27.7% vs. 29.0%; p = 1.0). Among 13 patients for whom Gorei-san administration was started before surgery, CSDH recurrence was reported in only 1 (7.7%). However, the group showed a significantly lower number of recurrent factors. Patients with a greater midline shift in their CT images or higher initial hematoma pressure need close postsurgical observation. The potential of Gorei-san for preventing recurrence of CSDH needs further examination.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 4","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40282147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of recurrence factors and Gorei-san administration for chronic subdural hematoma after percutaneous subdural tapping. 经皮硬膜下穿刺后慢性硬膜下血肿复发因素及高瑞山给药的评估。
Hiroshima journal of medical sciences Pub Date : 2013-12-01 DOI: 10.4172/2376-0281.1000313
Akitake Okamura, Yukihiko Kawamoto, E. Sakoda, Taro Murakami, T. Hara
{"title":"Evaluation of recurrence factors and Gorei-san administration for chronic subdural hematoma after percutaneous subdural tapping.","authors":"Akitake Okamura, Yukihiko Kawamoto, E. Sakoda, Taro Murakami, T. Hara","doi":"10.4172/2376-0281.1000313","DOIUrl":"https://doi.org/10.4172/2376-0281.1000313","url":null,"abstract":"Recent reports have shown that administration of Gorei-san (Tsumura, Tokyo, Japan) can prevent recurrence of chronic subdural hematoma (CSDH). However, no report has shown its potential, including its correlation with other recurrent clinical factors. We retrospectively evaluated the recurrent factors and the effects of Gorei-san on CSDH using percutaneous subdural tapping. Between April 2009 and February 2012, we performed percutaneous subdural tapping on 160 patients with intact CSDH. Of this population, 125 patients with unilateral hematoma and measurable initial hematoma pressure were included in this study. From April 2010, Gorei-san was routinely administered to patients. Patient characteristics such as age, sex, neurological grading, alcohol, diabetes mellitus, antiplatelet agent, anticoagulant agent, trauma, midline shift on CT images, hematoma volume on CT images, initial hematoma pressure, volume of the removed hematoma, and administration of Gorei-san were analyzed. Recurrence was recognized in 35/125 (28.0%) patients. Multivariate analysis revealed that a greater midline shift on CT images (p = 0.033) and initial hematoma pressure (p = 0.031) predicted recurrence. Gorei-san was administered to 94/125 (75.2%) patients, but they showed no changes in recurrence (27.7% vs. 29.0%; p = 1.0). Among 13 patients for whom Gorei-san administration was started before surgery, CSDH recurrence was reported in only 1 (7.7%). However, the group showed a significantly lower number of recurrent factors. Patients with a greater midline shift in their CT images or higher initial hematoma pressure need close postsurgical observation. The potential of Gorei-san for preventing recurrence of CSDH needs further examination.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 4 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Changes in bone mineral density and metabolism in women: evaluation of bodily characteristics, bone metabolic markers and bone mineral density. 女性骨密度和代谢的变化:身体特征、骨代谢标志物和骨密度的评价。
Tadayuki Iida, Toshihide Harada, Fumiko Ishizaki, Yumiko Nitta, Satomi Aoi, Hiromi Ikeda, Chiho Chikamura, Mitsuhisa Shiokawa, Kohsaku Nitta
{"title":"Changes in bone mineral density and metabolism in women: evaluation of bodily characteristics, bone metabolic markers and bone mineral density.","authors":"Tadayuki Iida,&nbsp;Toshihide Harada,&nbsp;Fumiko Ishizaki,&nbsp;Yumiko Nitta,&nbsp;Satomi Aoi,&nbsp;Hiromi Ikeda,&nbsp;Chiho Chikamura,&nbsp;Mitsuhisa Shiokawa,&nbsp;Kohsaku Nitta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship of bone mineral density (BMD) and bone metabolic markers in women is an interesting field of research. In this study, we aimed to clarify the relationship of body weight, bone metabolic markers and BMD. The subjects were 72 women. The levels of serum bone-specific alkaline phosphatase (BAP), serum type I collagen-cross-linked peptide (s-NTx) and urinary deoxypyridinoline (u-DPD) were measured. The associations between dependent variables (BMD changes/1 or 4 years in the lumbar spine and femoral neck) and explanatory variables (body weight changes/1 or 4 years, the levels of BAP, s-NTx, u-DPD) were evaluated using multiple regression analysis. Changes in the lumbar spine BMD were significantly correlated with changes in height over a year, and those of the femoral neck were significantly correlated with changes in weight over a year. Changes in the lumbar spine BMD over 4 years were significantly correlated with age, BAP and the changes of weight over 4 years. Changes in the femoral neck BMD over 4 years were significantly correlated with the changes in weight for 4 years. These results suggest that BMD changes of different bones correlate with different explanatory variables and that, to predict BMD changes from bone metabolic markers in women, it is necessary to measure BAP levels.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 3","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31904352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic capability of gadoxetate disodium-enhanced liver MRI for diagnosis of hepatocellular carcinoma: comparison with multi-detector CT. 加多赛特二钠增强肝脏MRI对肝细胞癌的诊断价值:与多层CT的比较。
Naoyuki Toyota, Yuko Nakamura, Masashi Hieda, Naoko Akiyama, Hiroaki Terada, Noriaki Matsuura, Masayo Nishiki, Hirotaka Kono, Hiroshi Kohno, Toshimitsu Irei, Yukinobu Yoshikawa, Kazuya Kuraoka, Kiyomi Taniyama, Kazuo Awai
{"title":"Diagnostic capability of gadoxetate disodium-enhanced liver MRI for diagnosis of hepatocellular carcinoma: comparison with multi-detector CT.","authors":"Naoyuki Toyota,&nbsp;Yuko Nakamura,&nbsp;Masashi Hieda,&nbsp;Naoko Akiyama,&nbsp;Hiroaki Terada,&nbsp;Noriaki Matsuura,&nbsp;Masayo Nishiki,&nbsp;Hirotaka Kono,&nbsp;Hiroshi Kohno,&nbsp;Toshimitsu Irei,&nbsp;Yukinobu Yoshikawa,&nbsp;Kazuya Kuraoka,&nbsp;Kiyomi Taniyama,&nbsp;Kazuo Awai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to evaluate the diagnostic capability of gadoxetate disodium (Gd-EOB)-MRI for the detection of hepatocellular carcinoma (HCC) compared with multidetector CT (MDCT). Fifty patients with 57 surgically proven HCCs who underwent Gd-EOB-MRI and MDCT from March 2008 to June 2011 were evaluated. Two observers evaluated MR and CT on a lesion-by-lesion basis. We analyzed sensitivity by grading on a 5-point scale, the degree of arterial enhancement and the differences in histological grades in the diffusion-weighted images (DWI). The results showed that the sensitivity of Gd-EOB-MRI was higher than that of MDCT especially for HCCs that were 1 cm in diameter or smaller. The hepatobiliary phase was useful for the detecting of small HCC. We had few cases in which it was difficult to judge HCC in the arterial enhancement between MRI and MDCT. In the diffusion-weighted image, well differentiated HCC tended to show a low signal intensity, and poorly differentiated HCC tended to show a high signal intensity. In moderately differentiated HCC's, the mean diameter of the high signal intensity group was larger than that of the low signal intensity group (24.5 mm vs. 15.8 mm). In conclusion, Gd-EOB-MRI tended to show higher sensitivity compared to MDCT in the detection of HCC.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 3","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31904353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms. 腹主动脉瘤发育过程中平滑肌细胞中Timp1的诱导。
Batmunkh Bumdelger, Hiroki Kokubo, Ryo Kamata, Masayuki Fujii, Mari Ishida, Takafumi Ishida, Masao Yoshizumi
{"title":"Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms.","authors":"Batmunkh Bumdelger,&nbsp;Hiroki Kokubo,&nbsp;Ryo Kamata,&nbsp;Masayuki Fujii,&nbsp;Mari Ishida,&nbsp;Takafumi Ishida,&nbsp;Masao Yoshizumi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Abdominal aortic aneurysm (AAA) is known to develop mainly by the increased diameter of aorta through metalloproteinases (MMPs). Although activities of MMPs are tightly regulated by the presence of tissue inhibitor of MMPs (TIMPs) and imbalances between MMPs and TIMPs may serve to fragility of arterial wall, little is known about TIMPs behavior in aneurysmal formation. Here, we utilized a murine experimental AAA model, and found that by immunohistochemical analysis, Timp1 as and Timp1 mRNA levels was also revealed in aortic tissue in AAA by RT-PCR. In cultured vascular smooth muscle cells (SMCs), Tumor Necrosis Factor (TNF)-alpha significantly activated both Mmp9 and Timp1 expression, and they were blocked by Jun kinase inhibitor (SP600125) in a dose-dependent manner. Interestingly, a proteasome inhibitor (MG132), which is known as an agent for inhibition of the nuclear factor-kappa B (NF-kappaB), significantly inhibited the TNF-alpha-induced expression of Timp1, whereas MG132, which also works as an activator of c-Jun/AP-1 pathway, strongly increased Mmp9. Taken together, inflammatory cytokines, including TNF-alpha, may simultaneously induce MMPs and TIMPs for the remodeling of the medial layer, leading to the increased diameter of the aorta, the aneurysm.</p>","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 3","pages":"63-7"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31904354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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