Hiroshima journal of medical sciences最新文献

Establishment of an antiemetic protocol for chemotherapy-induced nausea and vomiting evaluated using the Multinational Association of Supportive Care in Cancer Antiemesis Tool in colorectal cancer 使用多国癌症支持护理协会止吐工具评估结直肠癌化疗引起的恶心和呕吐的止吐方案的建立

Hiroshima journal of medical sciences Pub Date : 2021-06-30 DOI: 10.24811/HJMS.70.1_1

M. Shimomura, Y. Shimada, K. Toyota, H. Egi, H. Ohdan, Tadateru Takahashi

引用次数: 0

Incidentally found abdominal para-aortic and inferior mesenteric root lymph node metastases of prostatic adenocarcinoma in a surgical case with sigmoid colon cancer 偶然发现腹部腹主动脉旁及肠系膜下根淋巴结转移的乙状结肠结肠癌手术病例

Hiroshima journal of medical sciences Pub Date : 2021-06-30 DOI: 10.24811/HJMS.70.1_23

Mano Mino, D. Sumitani, Kunihiro Hashimoto, S. Yoshida, Naoya Ooka, M. Shishida, T. Oshiro, M. Yano, Yuzo Okamoto, S. Date, H. Nakayama

引用次数: 0

Low lung diffusing capacity is associated with high cardio-ankle vascular index in patients with chronic obstructive pulmonary disease 慢性阻塞性肺病患者肺弥散能力低与心踝血管指数高相关

Hiroshima journal of medical sciences Pub Date : 2021-06-30 DOI: 10.24811/HJMS.70.1_7

Yoshihiro Kitahara, Mineyo Mito, Arisa Hamada, Misato Senoo, Tetsu Hirakawa, K. Nakano

引用次数: 0

Primary retroperitoneal cyst in pregnancy: A case report based on immunohistochemical analysis and literature review 妊娠期原发性腹膜后囊肿1例免疫组织化学分析及文献复习

Hiroshima journal of medical sciences Pub Date : 2021-06-30 DOI: 10.24811/HJMS.70.1_17

Maiko Sagawa, H. Fujiwara, Rie Urabe, T. Nishida, Y. Katsube

引用次数: 1

Novel Oral Derivative UD-017, a Highly Selective CDK7 Inhibitor, Exhibits Anticancer Activity by Inducing Cell-Cycle Arrest and Apoptosis in Human Colorectal Cancer 新型口服衍生物UD-017是一种高选择性CDK7抑制剂，通过诱导人类结直肠癌细胞周期阻滞和凋亡显示出抗癌活性

Hiroshima journal of medical sciences Pub Date : 2020-07-30 DOI: 10.24811/HJMS.69.1_23

Y. Aga, Takashi Matsushita, Sayaka Ogi, K. Onuma, H. Sunamoto, A. Ogawa, S. Kono, N. Iwase, Y. Tokunaga, S. Ushiyama, F. Nara, Yasushi Konno, M. Yoshizumi, H. Kokubo, K. Yoneda

{"title":"Novel Oral Derivative UD-017, a Highly Selective CDK7 Inhibitor, Exhibits Anticancer Activity by Inducing Cell-Cycle Arrest and Apoptosis in Human Colorectal Cancer","authors":"Y. Aga, Takashi Matsushita, Sayaka Ogi, K. Onuma, H. Sunamoto, A. Ogawa, S. Kono, N. Iwase, Y. Tokunaga, S. Ushiyama, F. Nara, Yasushi Konno, M. Yoshizumi, H. Kokubo, K. Yoneda","doi":"10.24811/HJMS.69.1_23","DOIUrl":"https://doi.org/10.24811/HJMS.69.1_23","url":null,"abstract":"Objective: This study aimed to investigate the anticancer profile of a new cyclin-dependent kinase 7 (CDK7) inhibitor, UD-017, by examining its mechanism of action using HCT-116 colorectal cancer cells. Methods: The anticancer properties of UD-017 were assessed using several assays, including in vitro kinase, proliferation, and apoptosis assays, western blot analysis, and an in vivo xenograft mouse model. Results: UD-017 significantly inhibited CDK7 activity (IC 50 = 16 nM) with high selectivity in an in vitro kinase assay testing a panel of over 300 proteins and lipid kinases. UD-017 also inhibited the growth of HCT-116 cells (GI 50 = 19 nM) and inhibited the phosphorylation of various downstream mediators of CDK7 signaling. In cell cycle and apoptosis assays using HCT-116 cells, UD-017 increased the number of cells in both G1 and G2/M phases and induced apoptosis. In vivo , UD-017 inhibited tumor growth in an HCT-116 xenograft mouse model by 33%, 64%, and 88% at doses of 25, 50, and 100 mg/kg, respectively, with clear dose-dependency. Co-administration of 5-FU and 50 mg/kg UD-017 had a strong synergistic effect, as reflected in the complete inhibition of tumor growth. Conclusion: CDK7 may play a major role in colorectal cancer growth by regulating the cell cycle and apoptosis. UD-017 is a promising candidate therapeutic agent for the treatment of cancer involving CDK7 signaling.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"69 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.24811/HJMS.69.1_23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43723839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Streptococcus gallolyticus ssp. pasteurianus bacteremia during chemotherapy-induced neutropenia in a patient with malignant lymphoma 溶没食子链球菌。恶性淋巴瘤患者化疗期间巴氏杆菌血症引起的中性粒细胞减少

Hiroshima journal of medical sciences Pub Date : 2020-06-30 DOI: 10.24811/HJMS.69.2_47

T. Edahiro, T. Morioka, Kayo Toishigawa, H. Nagoshi, T. Kawase, N. Fukushima, T. Ichinohe

{"title":"Streptococcus gallolyticus ssp. pasteurianus bacteremia during chemotherapy-induced neutropenia in a patient with malignant lymphoma","authors":"T. Edahiro, T. Morioka, Kayo Toishigawa, H. Nagoshi, T. Kawase, N. Fukushima, T. Ichinohe","doi":"10.24811/HJMS.69.2_47","DOIUrl":"https://doi.org/10.24811/HJMS.69.2_47","url":null,"abstract":"Background: Streptococcus gallolyticus ssp. pasteurianus is a commensal bacterium of the alimentary tract in humans and animals. This microorganism not only causes sepsis, endocarditis, and meningitis but is also associated with colorectal tumors. We report herein a rare case of S. gallolyticus ssp. pasteurianus bacteremia in a patient with concomitant colon cancer and aggressive malignant lymphoma during the neutropenic period after chemotherapy against lymphoma. Case presentation: A 79-year-old man was found to have an adenoma in the ascending colon, and endoscopic mucosal resection (EMR) was planned to remove the lesion. However, he was diagnosed with diffuse large B-cell lymphoma during the pre-operation examination. The EMR was postponed, and he received rituximab, cyclophosphamide, etoposide, vincristine, and prednisolone (R-CEOP). He had a neutropenic fever with positive blood cultures for S. gallolyticus ssp. pasteurianus during the first course of R-CEOP. He improved as soon as cefepime was administered. Bacteremia did not recur thereafter, and he underwent EMR after completing six cycles of R-CEOP. The histological diagnosis of the colon tumor was welldifferentiated adenocarcinoma in adenoma. Streptococcus gallolyticus ssp. pasteurianus was not detected in the culture of the resected tissue. Conclusion: Although there have been few reports of bloodstream infection due to S. gallolyticus ssp. pasteurianus in patients with hematological malignancies undergoing cytotoxic chemotherapy, physicians should investigate the presence of coexisting colorectal tumors when this bacterium is isolated from blood cultures.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"69 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46066960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differential Expression Levels of Plasma microRNAs in Neuroblastoma Patients Identified by Next-Generation Sequencing 通过下一代测序鉴定神经母细胞瘤患者血浆微小RNA的差异表达水平

Hiroshima journal of medical sciences Pub Date : 2020-06-30 DOI: 10.24811/HJMS.69.2_39

A. Arfan, S. Kurihara, M. Kojima, Shingo Kimura, Masami Kanawa, Y. Sotomaru, E. Hiyama

引用次数: 0

Association between Helicobacter suis infection and the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma 猪螺杆菌感染与胃黏膜相关淋巴组织淋巴瘤发病机制的关系

Hiroshima journal of medical sciences Pub Date : 2020-06-30 DOI: 10.24811/HJMS.69.2_33

S. Masaki, Hidehiko Takigawa, Shoma Kunisho, Akiko Kimoto, R. Yuge, Shinji Tanaka, Y. Kitadai

引用次数: 3

Atomic Bomb Survivor Studies and their Current Significance: Comparison between the Practices of the ABCC-RERF and the RIRBM 原子弹幸存者研究及其当前意义——ABCC-RERF和RIRBM实践的比较

Hiroshima journal of medical sciences Pub Date : 2020-03-31 DOI: 10.24811/HJMS.69.1_1

A. Kubota, Kaori Iida, S. Tashiro

{"title":"Atomic Bomb Survivor Studies and their Current Significance: Comparison between the Practices of the ABCC-RERF and the RIRBM","authors":"A. Kubota, Kaori Iida, S. Tashiro","doi":"10.24811/HJMS.69.1_1","DOIUrl":"https://doi.org/10.24811/HJMS.69.1_1","url":null,"abstract":"Medical research spurred by radiation exposure is a critically important theme for modern society. Accordingly, studies of this contemporary problem should be based on a perspective that is focused on that origin, medical investigations into the effects of radiation exposure on survivors of the atomic bombs. Therefore, we organized and evaluated survey programs and research of atomic bomb survivors that have been conducted by ABCC (Atomic Bomb Casualty Commission) –RERF (Radiation Effects Research Foundation) and RIRBM (Research Institute for Radiation Biology and Medicine) between 1949 and 1975. ABCC established a set of carefully defined cohorts and launched an integrated research program based on three phases of pure research. That work has formed the foundation for the research that the RERF is engaged in today. And among surveys and studies worldwide that have generated fundamental data on radiation protection standards, the findings of ABCC-RERF surveys and studies have provided important information. It has thus provided various international research organizations (WHO (World Health Organization), ICRP (International Commission on Radiological Protection), UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation), etc.) with important information and indicators. RIRBM has pursued studies and surveys that are distinct from the undertakings led by ABCC-RERF. RIRBM was able to do something that ABCC-RERF would have found difficult to implement: namely, flexibly launching projects on themes that directly met the needs of the local society at the time. Atomic bomb survivors’ medical data continue to grow, from the bombing to the present, and to the future. Data sharing, joint research, and collaboration by research institutions in this field will be effective ways to foster rationally coordinated surveys and studies.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"69 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42079633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Muscle Oxygenation and Vascular Occlusion Determined by Near-infrared Spectroscopy in the Tibialis Anterior Muscle 胫骨前肌近红外光谱测定肌肉氧合与血管闭塞的关系

Hiroshima journal of medical sciences Pub Date : 2020-03-01 DOI: 10.24811/HJMS.69.1_15

Yuuji Tanada, H. Sumii

{"title":"Association between Muscle Oxygenation and Vascular Occlusion Determined by Near-infrared Spectroscopy in the Tibialis Anterior Muscle","authors":"Yuuji Tanada, H. Sumii","doi":"10.24811/HJMS.69.1_15","DOIUrl":"https://doi.org/10.24811/HJMS.69.1_15","url":null,"abstract":"Many previous studies on near-infrared spectroscopy (NIRS) based evaluation of muscle oxygenation, have assessed the association of muscle oxygenation with muscle fatigue and exercise tolerance. To examine the changes in oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) levels, some studies performed occlusion of arterial blood flow in the upper arm and measured the biarticular forearm muscle oxygenation; however, these muscles are subject to contractions based on the position of the arm, which could have led to discrepancies in the findings. Therefore, this study aimed to assess the association between muscle oxygenation and vascular occlusion in the tibialis anterior muscle during isometric exercise using NIRS. Twenty-nine women of mean age of 20.00 ± 1.56 years were included. Maximum isometric contraction performed for successive 30 sec and 60 sec was assessed under occlusive and non-occlusive conditions of the unilateral femoral artery, with and without the use of a tourniquet, at the same time. The O2Hb level was reduced in both conditions, with a significant decrease observed earlier during an initial quarter of the exercise (p < 0.05). This significant decrease in the O2Hb level may be due to decreased oxygenation in the muscle associated with muscle contraction, primarily during aerobic exercise. Under the occlusive condition, the total rate of increase in the HHb levels was smaller than the total rate of decrease in the O2Hb levels. Therefore, adequate oxygen supply to meet the increased demand for the O2Hb cannot be achieved and the increase in the HHb level is suppressed during muscle contractions.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"69 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.24811/HJMS.69.1_15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46546551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0