Hiroshima journal of medical sciences最新文献_第10页

Influences of pyrexia and age on theophylline clearance in young children with asthma. 发热和年龄对幼儿哮喘患儿茶碱清除率的影响。

Hiroshima journal of medical sciences Pub Date : 2012-03-01

Keisuke Imai, Yumiko Munehisa, Yoshiko Yoshikuni, Tadayuki Morita, Hiroaki Nomura, Yasuhiro Kimura, Yuichi Mimaki, Kenji Kihira

{"title":"Influences of pyrexia and age on theophylline clearance in young children with asthma.","authors":"Keisuke Imai, Yumiko Munehisa, Yoshiko Yoshikuni, Tadayuki Morita, Hiroaki Nomura, Yasuhiro Kimura, Yuichi Mimaki, Kenji Kihira","doi":"","DOIUrl":"","url":null,"abstract":"Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (> or = 38 degrees C) and a non-pyrexia group (< 38 degrees C). Theophylline clearance was 0.064 +/- 0.017 liters/kg/hr in the non-pyrexia group and 0.049 +/- 0.010 liters/kg/hr in the pyrexia group. Theophylline clearance in the non-pyrexia and pyrexia groups was 0.044 +/- 0.007 liters/kg/hr and 0.030 +/- 0.009 liters/kg/hr (< or = 6 months), 0.071 +/- 0.011 liters/kg/hr and 0.047 +/- 0.008 liters/kg/hr (6 to < or = 12 months), 0.084 +/- 0.012 liters/kg/hr and 0.055 +/- 0.006 liters/ kg/hr (1 to < or = 2 years), and 0.065 +/- 0.007 liters/kg/hr and 0.051 +/- 0.001 liters/kg/hr (2 to < or = 3 years), respectively. In all age groups, theophylline clearance of the pyrexia group was significantly less than that of the non-pyrexia group (p < 0.01), showing that there was a significant pharmacokinetic difference in theophylline clearance between the groups. Multivariate statistical analysis showed that theophylline clearance was affected by pyrexia and age. This study showed that the presence of pyrexia decreases theophylline clearance, and that it affects theophylline clearance in an age-dependent manner. Based on the results of this study, dosages should be designed based on the clearance at the time of pyrexia.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"61 1","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30693138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare diagnostic challenge in acute appendicitis: a case report. 急性阑尾炎罕见的诊断挑战:1例报告。

Hiroshima journal of medical sciences Pub Date : 2012-03-01

Masumi Kawashima, Yasushi Hashimoto, Takeshi Sudo, Kenichiro Uemura, Akira Nakashima, Taijiro Sueda, Yoshiaki Murakami

引用次数: 0

Recanalization after successful occlusion by transcatheter arterial embolization with N-butyl cyanoacrylate for traumatic splenic artery injury. 外伤性脾动脉损伤经导管动脉栓塞成功闭塞后再通。

Hiroshima journal of medical sciences Pub Date : 2011-12-01

Masaki Ishikawa, Hideaki Kakizawa, Wataru Yamasaki, Syuji Date, Masashi Hieda, Kenji Kajiwara, Kazuo Awai

引用次数: 0

Relationships among blood leptin and adiponectin levels, fat mass, and bone mineral density in Japanese pre- and postmenopausal women. 日本绝经前和绝经后妇女血瘦素和脂联素水平、脂肪量和骨密度之间的关系

Hiroshima journal of medical sciences Pub Date : 2011-12-01

Tadayuki Iida, Tokio Domoto, Atsushi Takigawa, Satoru Nakamura, Yoji Kato, Masanori Togo, Chiho Chikamura, Toshihide Harada, Fumiko Ishizaki, Yuichiro Ono

{"title":"Relationships among blood leptin and adiponectin levels, fat mass, and bone mineral density in Japanese pre- and postmenopausal women.","authors":"Tadayuki Iida, Tokio Domoto, Atsushi Takigawa, Satoru Nakamura, Yoji Kato, Masanori Togo, Chiho Chikamura, Toshihide Harada, Fumiko Ishizaki, Yuichiro Ono","doi":"","DOIUrl":"","url":null,"abstract":"We conducted a survey of 111 healthy middle-aged and older women, aged 40 to 80 years, to elucidate the relationships between blood leptin and adiponectin levels and bone mineral density (BMD) in September 2008. We examined the associations between the blood levels of these adipocytokines and the lumbar spine (L2-L4), left femoral, and distal forearm BMD after adjustment for the age and body fat percentage. No correlation was observed between leptin and the BMD. This is presumably due to the fact that the influence of menopause, age, duration of postmenopausal period, and body fat percentage on the BMD is greater than that of leptin levels in healthy women. The adiponectin levels were significantly correlated negatively with the lumbar spine and femoral BMD in premenopausal women, and with forearm BMD in postmenopausal women, regardless of adjustment for age and body fat percentage. It seems likely that adiponectin influences the BMD at different skeletal sites in pre- and postmenopausal women.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"60 4","pages":"71-8"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30504922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of iliac artery rupture during percutaneous transluminal angioplasty: a report of three cases. 经皮腔内血管成形术中髂动脉破裂的治疗:附3例报告。

Hiroshima journal of medical sciences Pub Date : 2011-12-01

Katsutoshi Sato, Kazumasa Orihashi, Yoshiharu Hamanaka, Shinji Hirai, Norimasa Mitsui, Naru Chatani

引用次数: 0

A first case of hepatic angiosarcoma treated with recombinant interleukin-2. 重组白细胞介素-2治疗肝血管肉瘤1例。

Hiroshima journal of medical sciences Pub Date : 2011-12-01

Fukiko Mitsui, Hiroshi Aikata, Yoshimasa Hashimoto, Yuko Nagaoki, Yuki Kimura, Yoshio Katamura, Tomokazu Kawaoka, Shintaro Takaki, Nobuhiko Hiraga, Masataka Tsuge, Koji Waki, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Shoichi Takahashi, Koji Arihiro, Kazuaki Chayama

{"title":"A first case of hepatic angiosarcoma treated with recombinant interleukin-2.","authors":"Fukiko Mitsui, Hiroshi Aikata, Yoshimasa Hashimoto, Yuko Nagaoki, Yuki Kimura, Yoshio Katamura, Tomokazu Kawaoka, Shintaro Takaki, Nobuhiko Hiraga, Masataka Tsuge, Koji Waki, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Shoichi Takahashi, Koji Arihiro, Kazuaki Chayama","doi":"","DOIUrl":"","url":null,"abstract":"A 60 year-old woman was admitted to our hospital because of management of multiple liver tumors. According to image findings and liver biopsy, she was diagnosed as having epithelioid hemangioendothelioma of the liver accompanied by metastases in the spleen, lungs and bones. Based on the spread of the liver tumors and the extensive systemic metastases, she was considered inoperable. Instead, she received hepatic arterial infusion therapy using recombinant interleukin-2. However, she died due to liver failure about two months after admission. Autopsy revealed that the liver tumor was angiosarcoma. It is difficult to differentiate angiosarcoma from epithelioid hemangioendothelioma based on the image findings and pathological findings of percutaneous liver biopsy. Many cases are diagnosed as angiosarcoma at autopsy. There is no established effective treatment for hepatic angiosarcoma, because the tumor stage at the time of diagnosis is often progressive. To date, immunotherapy with recombinant interleukin-2 has been reported to be effective clinically for cutaneous angiosarcoma, such as of the scalp and facial skin. To our knowledge, there have been no reported cases of hepatic angiosarcoma treated with recombinant interleukin-2. Our case is important should recombinant interleukin-2 be considered effective for hepatic angiosarcoma in the future.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"60 4","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30506361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New dopamine agonist pramipexole improves parkinsonism and depression in Parkinson's disease. 新的多巴胺激动剂普拉克索改善帕金森病的帕金森病和抑郁症。

Hiroshima journal of medical sciences Pub Date : 2011-12-01

Toshihide Harada, Fumiko Ishizaki, Nobuko Horie, Yumiko Nitta, Tohru Yamada, Tomohiro Sasaki, Tomoomi Nagakane, Yoshiteru Yasumatsu, Kohsaku Nitta, Hiroyuki Katsuoka

引用次数: 0

Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease. 3- o -甲基多巴与恩他卡酮治疗晚期帕金森病临床疗效的关系

Hiroshima journal of medical sciences Pub Date : 2011-09-01

Aiko Ishihara, Takafumi Miyachi, Takeshi Nakamura, Toshiho Ohtsuki, Yasuhiro Kimura, Kenji Kihira, Takemori Yamawaki, Masayasu Matsumoto

引用次数: 0

Six-year experience of permanent prostate brachytherapy for clinically localized prostate cancer. 临床局限性前列腺癌永久前列腺近距离放射治疗六年经验。

Hiroshima journal of medical sciences Pub Date : 2011-09-01

Jun Teishima, Masahiro Kenjo, Kohei Kobatake, Hideo Iwamoto, Akihiro Goriki, Mami Oki, Koichi Shoji, Katsutoshi Miyamoto, Hiroshi Masumoto, Shogo Inoue, Kanao Kobayashi, Shinya Ohara, Mitsuru Kajiwara, Tomoki Kimura, Yuji Murakami, Yuko Kaneyasu, Ikuno Nishibuchi, Yasushi Nagata, Akio Matsubara

{"title":"Six-year experience of permanent prostate brachytherapy for clinically localized prostate cancer.","authors":"Jun Teishima, Masahiro Kenjo, Kohei Kobatake, Hideo Iwamoto, Akihiro Goriki, Mami Oki, Koichi Shoji, Katsutoshi Miyamoto, Hiroshi Masumoto, Shogo Inoue, Kanao Kobayashi, Shinya Ohara, Mitsuru Kajiwara, Tomoki Kimura, Yuji Murakami, Yuko Kaneyasu, Ikuno Nishibuchi, Yasushi Nagata, Akio Matsubara","doi":"","DOIUrl":"","url":null,"abstract":"This report presents the outcome of prostate permanent brachytherapy (PPB). One hundred and seventy-two patients with clinically localized prostate cancer were treated with permanent brachytherapy using iodine-125 seeds (125-I) at Hiroshima University Hospital from July 2004 to June 2010. This study evaluated the efficacy of PPB in these patients. The median patient age was 69 years (range 53 to 82 years), the median prostate-specific antigen (PSA) value before biopsy was 6.75 ng/ml (range 3.5 to 47.9 ng/ml), and the median prostate volume was 23.1 ml (range 10.1 to 57 ml). The median follow-up was 37 months (range 1 to 72 months). The serum PSA levels decreased continuously after PPB throughout the entire follow-up period in 97% of patients without neoadjuvant hormonal therapy. No relapse occurred during the follow-up period in patients at low risk. Our 6-year experience suggests that PPB is effective for localized prostate cancer. Patients with prostate cancer that does not require combined external beam radiation therapy (EBRT) have the best chance of responding to treatment.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"60 3","pages":"51-6"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40128428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of idiopathic intracranial hypertension related with vesicoureteral reflux. 特发性颅内高压伴膀胱输尿管反流1例。

Hiroshima journal of medical sciences Pub Date : 2011-09-01

Cihangir Akgün, Gökmen A Taşkin, Sinan Akbayram, Avni Kaya, Hayrettin Temel, Sevil Ai Yuca, Hüseyin Caksen

引用次数: 0