Hiroshima journal of medical sciences最新文献_第8页

Rurality and participation in mass preventive health services: a nationwide descriptive study. 农村与参与大规模预防保健服务:一项全国性的描述性研究。

Hiroshima journal of medical sciences Pub Date : 2013-09-01

Yu Hatano, Masatoshi Matsumoto, Kazuo Inoue, Keisuke Takeuchi

{"title":"Rurality and participation in mass preventive health services: a nationwide descriptive study.","authors":"Yu Hatano, Masatoshi Matsumoto, Kazuo Inoue, Keisuke Takeuchi","doi":"","DOIUrl":"","url":null,"abstract":"People's engagement in community activities is reportedly stronger in rural areas than in urban areas. However, it is unknown whether this affects the health-seeking behaviour of residents in rural communities. We examined whether the rurality-related index of a community was associated with the participation rate of residents in community-based preventive health services. Based on the national census data on all the 1816 municipalities in Japan in 2007, the correlation was evaluated between the participation rate in cancer screening (stomach cancer, colorectal cancer) or influenza vaccination programmes among those older than 65, and each of the municipality-level variables. The correlations were examined by simple correlation and multiple regression analyses. The correlations were also evaluated between voting rate (a parameter of people's engagement in community activities) and each municipality-level variable with multiple regression analysis. Simple correlation analysis showed that the population density was negatively correlated with the participation rate of all (stomach cancer, colorectal cancer, and influenza) preventive programmes (r = -0.367, -0.171 and -0.188, respectively; each p < 0.001). The significant correlations were maintained even after adjustment for other socioeconomic factors in multiple regression analysis in stomach cancer screening and influenza vaccination (beta = -0.279 and -0.133, respectively: each p < 0.05). Population density was negatively correlated with voting rate (beta = -0.488: p < 0.001). Residents in rural communities were more likely to participate in community-based mass preventive services and were more actively engaged in political activities than their urban counterparts. These results suggest that rural residents have a stronger sense of community, and this could potentially facilitate residents' engagement in mass preventive services.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 3","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31904351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of RANKL and proliferation abilities of cultured human middle ear cholesteatoma epithelial cells. 人中耳胆脂瘤上皮细胞RANKL表达及增殖能力的研究。

Hiroshima journal of medical sciences Pub Date : 2013-03-01

Marin Miyasato, Sachio Takeno, Katsuhiro Hirakawa

引用次数: 0

The valproate serum level in maintenance therapy for bipolar disorder in Japan. 日本双相情感障碍维持治疗中的丙戊酸血清水平。

Hiroshima journal of medical sciences Pub Date : 2013-03-01

Akihiko Machino, Hiroaki Jitsuiki, Yasumasa Okamoto, Satoru Izumitani, Yasuhiro Kimura, Katsuji Suzuki, Teruaki Tanaka, Takeshi Inoue, Tsukasa Koyama, Ken Wada, Yukari Masaoka, Takanobu Sasaki, Reiji Yoshimura, Jun Nakamura, Satsuki Sumitan, Tetsuro Ohmori, Shigeto Yamawaki

{"title":"The valproate serum level in maintenance therapy for bipolar disorder in Japan.","authors":"Akihiko Machino, Hiroaki Jitsuiki, Yasumasa Okamoto, Satoru Izumitani, Yasuhiro Kimura, Katsuji Suzuki, Teruaki Tanaka, Takeshi Inoue, Tsukasa Koyama, Ken Wada, Yukari Masaoka, Takanobu Sasaki, Reiji Yoshimura, Jun Nakamura, Satsuki Sumitan, Tetsuro Ohmori, Shigeto Yamawaki","doi":"","DOIUrl":"","url":null,"abstract":"The appropriate therapeutic serum valproate level in maintenance therapy for bipolar disorder is not well known. We studied the serum valproate levels in seventeen bipolar I and twenty-four bipolar II disorder outpatients who had been treated with stable doses of valproate successfully for at least 12 months as prophylactic therapy. The trough serum valproate levels were 52.2 +/- 20.4 microg/ml in bipolar I, and 41.0 +/- 18.3 microg/ml in bipolar II disorder patients, respectively. A greater trend towards a higher trough level (p = 0.07) was indicated in the bipolar I disorder group. We speculate that these valproate levels may be an approximation to the appropriate valproate levels in maintenance therapy and that there may be a correlation between the level of valproate required for stabilization and the subtype of the bipolar disorder. However, when interpreting these findings, certain limitations to this study? Need to be taken into account as follows. The sample size was small. We could not look at a group on valproate that had relapsed and a group that had dropped out of maintenance therapy. Further studies are needed.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31369469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoration of IGFBP-rP1 increases radiosensitivity and chemosensitivity in hormone-refractory human prostate cancer. IGFBP-rP1的恢复增加激素难治性人前列腺癌的放射敏感性和化疗敏感性。

Hiroshima journal of medical sciences Pub Date : 2013-03-01

Mitsuhiro Seki, Jun Teishima, Hideki Mochizuki, Kazuaki Mutaguchi, Hiroaki Yasumoto, Kiyotaka Oka, Hirotaka Nagamatsu, Koichi Shoji, Akio Matsubara

{"title":"Restoration of IGFBP-rP1 increases radiosensitivity and chemosensitivity in hormone-refractory human prostate cancer.","authors":"Mitsuhiro Seki, Jun Teishima, Hideki Mochizuki, Kazuaki Mutaguchi, Hiroaki Yasumoto, Kiyotaka Oka, Hirotaka Nagamatsu, Koichi Shoji, Akio Matsubara","doi":"","DOIUrl":"","url":null,"abstract":"We previously reported the tumor-suppressive activity of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) through induction of apoptosis in human prostate cancer cells. The aim of this study was to investigate the effects of IGFBP-rP1 for radiosensitivity and chemosensitivity in hormone-refractory human prostate PC-3 cancer cells. Five assays were performed using PC-3 cells transfected with IGFBP-rP1 (PC-3rP1) and control cells transfected with an empty vector (PC-3N): PC-3rP1 and PC-3N were compared by clonogenic survival assay, cell cycle analysis and apoptotic assay for radiosensitivity. The number of colonies of PC-3rP1 cells significantly decreased after 4 and 8 Gy of irradiation, compared with those of PC-3N in the clonogenic survival assay. After 16 hr irradiation at 8 Gy, the percentage of apoptotic cells significantly increased in PC-3rP1 compared with PC-3N. Growth of PC-3rP1 was significantly lower than that of PC-3N after docetaxel treatment both in vitro and in vivo. These results indicate that restoration of IGFBP-rP1 to PC-3 cells increases both their radiosensitivity and chemosensitivity.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"62 1","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31369470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender differences in D-aspartic acid content in skull bone. 颅骨d -天冬氨酸含量的性别差异。

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Aiko Torikoshi-Hatano, Akira Namera, Hiroaki Shiraishi, Yousuke Arima, Hirokazu Toubou, Jiro Ezaki, Masami Morikawa, Masataka Nagao

{"title":"Gender differences in D-aspartic acid content in skull bone.","authors":"Aiko Torikoshi-Hatano, Akira Namera, Hiroaki Shiraishi, Yousuke Arima, Hirokazu Toubou, Jiro Ezaki, Masami Morikawa, Masataka Nagao","doi":"","DOIUrl":"","url":null,"abstract":"In forensic medicine, the personal identification of cadavers is one of the most important tasks. One method of estimating age at death relies on the high correlation between racemization rates in teeth and actual age, and this method has been applied successfully in forensic odontology for several years. In this study, we attempt to facilitate the analysis of racemized amino acids and examine the determination of age at death on the basis of the extent of aspartic acid (Asp) racemization in skull bones. The specimens were obtained from 61 human skull bones (19 females and 42 males) that underwent judicial autopsy from October 2010 to May 2012. The amount of D-Asp and L-Asp, total protein, osteocalcin, and collagen I in the skull bones was measured. Logistic regression analysis was performed for age, sex, and each measured protein. The amount of D-Asp in the female skull bones was significantly different from that in the male skull bones (p = 0.021), whereas the amount of L-Asp was similar. Thus, our study indicates that the amount of D-Asp in skull bones is different between the sexes.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"61 4","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31180836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ischemic stroke patient with free floating thrombus in carotid artery, successfully treated by open carotid thrombectomy: a first case report in Nepal. 缺血性脑卒中患者颈动脉游离漂浮血栓，经颈动脉切开取栓成功治疗:尼泊尔首例报告。

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Prabin Shrestha, Rupendra Adhikari, Samantha Tamrakar, Basanta Pant, Bhagwan Koirala, Satoshi Yamaguchi, Kaoru Kurisu

{"title":"An ischemic stroke patient with free floating thrombus in carotid artery, successfully treated by open carotid thrombectomy: a first case report in Nepal.","authors":"Prabin Shrestha, Rupendra Adhikari, Samantha Tamrakar, Basanta Pant, Bhagwan Koirala, Satoshi Yamaguchi, Kaoru Kurisu","doi":"","DOIUrl":"","url":null,"abstract":"Free floating thrombus in the carotid artery is a well-known phenomenon, though relatively rare. We present a case in which we performed open surgery and achieved successful retrieval of the thrombus. A 40 year-old male patient presented with ischemic stroke and mild left hemiparesis. Computerized tomography and magnetic resonance imaging showed infarction in the right parieto-occipital area. Carotid Doppler study showed carotid stenosis on the right side. Further investigation with CT angiography of the neck vessels confirmed significant carotid artery occlusion with a free-floating thrombus in the internal carotid artery. Carotid endarterectomy was planned under EEG monitoring. The right carotid artery was exposed with a vertical incision along the medial margin of the sternocleido-mastoid muscle. The carotid artery was opened and, as expected, showed a soft, mobile thrombus. Thus thrombectomy was planned. A 2 Fr fogarty catheter was introduced distal to the thrombus, the balloon was inflated and pulled back gently, which removed the thrombus completely. There was no postoperative complication and the patient is fine at 1 year follow-up.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"61 4","pages":"101-3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31182470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Longitudinal study on physical fitness parameters influencing bone mineral density reduction in middle-aged and elderly women: bone mineral density in the lumbar spine, femoral neck, and femur". “影响中老年妇女骨密度降低的体质参数的纵向研究:腰椎、股骨颈和股骨的骨密度”。

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Gary S Beaupre

引用次数: 0

Arterial spin-labeling imaging at 3-T in dural arteriovenous fistulas of cavernous sinus before and after endovascular treatment. 海绵窦硬脑膜动静脉瘘血管内治疗前后的3-T动脉自旋标记成像。

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Shigeyuki Sakamoto, Yoshihiro Kiura, Takahito Okazaki, Katsuhiro Shinagawa, Hiroyuki Miyoshi, Kaoru Kurisu

引用次数: 0

The neurocognitive effects of aripiprazole compared with risperidone in the treatment of schizophrenia. 阿立哌唑与利培酮治疗精神分裂症的神经认知效果比较。

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Goro Sato, Shinpei Yoshimura, Hidehisa Yamashita, Yasumasa Okamoto, Shigeto Yamawaki

{"title":"The neurocognitive effects of aripiprazole compared with risperidone in the treatment of schizophrenia.","authors":"Goro Sato, Shinpei Yoshimura, Hidehisa Yamashita, Yasumasa Okamoto, Shigeto Yamawaki","doi":"","DOIUrl":"","url":null,"abstract":"Aripiprazole is a D2 and D3 receptor partial agonist that is unlike other second generation antipsychotics. The effectiveness of aripiprazole with regard to neurocognitive function and its adverse effects is unclear. The present study evaluates the comparative efficacy, effects on neurocognitive function, and adverse effects of aripiprazole and risperidone in the treatment of hospitalized patients with schizophrenia. This double-blind, cross-over study included 23 patients with schizophrenia who were randomly assigned to be treated first with either aripiprazole or risperidone. After eight weeks on one medication, the patients were switched to the other medication for eight weeks. The patient assessment included the Positive and Negative Syndrome Scale (PANSS), neurocognitive assessments, and adverse events including extrapyramidal symptoms, vital signs, electrocardiogram, and clinical laboratory tests. The study findings indicated that psychopathology assessed with the PANSS, extrapyramidal symptoms and other adverse effects did not differ between aripiprazole and risperidone for the subjects remaining in treatment. In the neurocognitive assessments, the score for disinhibition with aripiprazole was significantly lower than with risperidone (p < 0.05). In addition, serum prolactin levels were significantly lower with aripiprazole (p < 0.001). The treatment drop-out rate was higher for patients receiving aripiprazole than risperidone. In comparing aripiprazole and risperidone, risperidone is better from the viewpoint of treatment continuation. On the other hand, some adverse effects, such as hyperprolactinemia and disinhibition, are less severe with aripiprazole. Thus, for certain applications, aripiprazole may be a beneficial new treatment option for schizophrenia.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"61 4","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31180832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in cardiovascular risk factors over a 24-year follow-up period: a Japanese pediatric cohort study. 24年随访期间心血管危险因素的变化:一项日本儿科队列研究

Hiroshima journal of medical sciences Pub Date : 2012-12-01

Masahiko Kuwabara, Masaharu Yoshihara, Hiroko Hirata, Hirotoshi Sugino, Katsushi Asaoka, Haruyasu Kondo, Kazuo Fujii, Hideki Matsubara, Takashi Nakagawa, Masanori Horie, Hitoshi Ito, Haruyuki Matsumoto, Takuhiro Okamoto, Toru Hiyama, Takahiro Sumiya

{"title":"Changes in cardiovascular risk factors over a 24-year follow-up period: a Japanese pediatric cohort study.","authors":"Masahiko Kuwabara, Masaharu Yoshihara, Hiroko Hirata, Hirotoshi Sugino, Katsushi Asaoka, Haruyasu Kondo, Kazuo Fujii, Hideki Matsubara, Takashi Nakagawa, Masanori Horie, Hitoshi Ito, Haruyuki Matsumoto, Takuhiro Okamoto, Toru Hiyama, Takahiro Sumiya","doi":"","DOIUrl":"","url":null,"abstract":"This study examined changes in body mass index (BMI), fasting blood sugar (FBS), total cholesterol (TC) and HDL-cholesterol (HDL-C) levels over a 24-year follow-up period in a pediatric cohort. An appropriate starting age for intervention to prevent cardiovascular diseases is still unclear. The subjects were 655 children, aged 10-12. A follow-up survey was conducted when the subjects reached ages 13-15, 16-18, and 35-45, respectively, and height, weight, and blood tests including FBS, TC and HDL-C were examined. Forty (6%) of these subjects participated. BMI at ages 35-45 were significantly higher than those at ages 10-12 (p < 0.0001), 13-15 (p < 0.001), and 16-18 (p < 0.001). TC levels at ages 35-45 were significantly higher than at ages 10-12 (p < 0.0001), 13-15 (p < 0.0001), and 16-18 (p < 0.0001). BMI at the end of the follow-up (ages 35-45) had a significant correlation with BMI at ages 13-15 (R = 0.38, p = 0.041) and 16-18 (R = 0.41, p = 0.049). TC and HDL-C values at the end of the follow-up had a significant correlation with those at ages 10-12 (R = 0.55, p = 0.0004; R = 0.55, p = 0.016), 13-15 (R = 0.35, p = 0.045; R = 0.42, p = 0.015), and 16-18 (R = 0.47, p = 0.019; R = 0.44, p = 0.028). These results may suggest that intervention for children in Japan with cardiovascular risk factors should be initiated in the early years of life.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"61 4","pages":"85-9"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31180834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0