Hiroshima journal of medical sciences最新文献_第6页

Laparoscopic Repair and Percutaneous Endoscopic Gastrostomy to Treat Giant Esophageal Hiatal Hernia with Gastric Obstruction: A Case Report. 腹腔镜下修补及经皮内镜胃造口术治疗巨大食管裂孔疝合并胃梗阻1例。

Hiroshima journal of medical sciences Pub Date : 2015-06-01

Yoichi Hamai, Jun Hihara, Kazuaki Tanabe, Takaoki Furukawa, Ichiko Yamakita, Yuta Ibuki, Morihito Okada

引用次数: 0

Ten Cases of Colovesical Fistula due to Sigmoid Diverticulitis. 乙状体憩室炎致结肠瘘10例。

Hiroshima journal of medical sciences Pub Date : 2015-06-01

Hideaki Miyaso, Kazuhide Iwakawa, Yuki Hamada, Nanako Yasui, Gou Nishii, Masaaki Akai, Kengo Kawada, Takashi Nonoshita, Hiroki Kajioka, Kenta Isoda, Kouji Kitada, Manabu Nishie, Ryosuke Hamano, Naoyuki Tokunaga, Yosuke Tsunemitsu, Shinya Otsuka, Masaru Inagaki, Hiromi Iwagaki

{"title":"Ten Cases of Colovesical Fistula due to Sigmoid Diverticulitis.","authors":"Hideaki Miyaso, Kazuhide Iwakawa, Yuki Hamada, Nanako Yasui, Gou Nishii, Masaaki Akai, Kengo Kawada, Takashi Nonoshita, Hiroki Kajioka, Kenta Isoda, Kouji Kitada, Manabu Nishie, Ryosuke Hamano, Naoyuki Tokunaga, Yosuke Tsunemitsu, Shinya Otsuka, Masaru Inagaki, Hiromi Iwagaki","doi":"","DOIUrl":"","url":null,"abstract":"Colovesical fistula (CVF) resulting from colon diverticulosis is a comparatively rare disease, and neither the diagnosis nor treatment has been established. Our experience with CVF due to sigmoid diverticulitis over a 9-year period was reviewed to clarify the clinical presentation and diagnostic confirmation. Ten patients with CVF were identified in this period, and chief complaints, laboratory findings, presenting symptoms, diagnostic investigations, and subsequent treatments were reviewed. Preoperative urinalysis showing bacteriuria (100%) was the most common presentation, followed by fecaluria (40%), abdominal pain (40%), pneumaturia (30%), hematuria (30%), pain on urination (30%), pollakiuria (10%), and dysuria (10%). The abilities of various preoperative investigations to identify CVF were: computed tomography (CT), 88.9%; magnetic resonance imaging, 40%; cystoscopy, 30%, and gastrografin irrigoscopy, 22.2%. Colonoscopy (0%) was not diagnostic. Bowel resection was performed in nine of ten patients. When inflammation was intense, covering ileostomy was performed, and an omental plasty was placed between the bowel anastomosis and bladder. When CVF is suspected, we recommend CT followed by colonoscopy and cystoscopy as a first-line investigation to rule out malignancy as a cause. Other modalities should only be used if the diagnosis is in doubt or additional information is needed to plan operative management. Primary colic anastomosis appears to be safely performed by applying omental plasty and covering ileostomy.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"64 1-2","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33869087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible Contribution of a Diverticulum to the Development and Rupture of Colonic Lymphangioma. 憩室对结肠淋巴管瘤的发展和破裂的可能作用。

Hiroshima journal of medical sciences Pub Date : 2015-06-01

Takahiro Zenda, Tomomi Hagishita, Makio Moriya, Tadashi Kamesui, Junzo Shimizu, Isao Nakanishi

引用次数: 0

A Japanese pedigree of familial cerebral cavernous malformations--a case report. 日本家族性脑海绵状血管瘤家系1例报告。

Hiroshima journal of medical sciences Pub Date : 2014-12-01

Yasutaka Imada, Kiyoshi Yuki, Keisuke Migita, Takashi Sadatomo, Masashi Kuwabara, Toru Yamada, Kaoru Kurisu

引用次数: 0

Neck circumference has possibility as a predictor for metabolic syndrome in postmenopausal women. 颈围有可能作为绝经后妇女代谢综合征的预测因子。

Hiroshima journal of medical sciences Pub Date : 2014-12-01

Satomi Aoi, Takashi Miyake, Toshihide Harada, Fumiko Ishizaki, Hiromi Ikeda, Yumiko Nitta, Tadayuki Iida, Chiho Chikamura, Noriko Tamura, Kohsaku Nitta, Hideki Miyaguchi

{"title":"Neck circumference has possibility as a predictor for metabolic syndrome in postmenopausal women.","authors":"Satomi Aoi, Takashi Miyake, Toshihide Harada, Fumiko Ishizaki, Hiromi Ikeda, Yumiko Nitta, Tadayuki Iida, Chiho Chikamura, Noriko Tamura, Kohsaku Nitta, Hideki Miyaguchi","doi":"","DOIUrl":"","url":null,"abstract":"Subcutaneous fat depots play an important role in regulating metabolic profile in Japanese postmenopausal women. We investigated the possibility of neck circumference (NC) as a surrogate marker for metabolic disease risk estimates in Japanese postmenopausal women. We examined the association of NC with several markers of insulin resistance, lipid metabolism and atherosclerosis in 64 healthy postmenopausal women aged 63.6 ± 7.1 years in community-based samples in Japan. As a result, NC was significantly associated with indices of whole body obesity and visceral fat accumulation, such as body mass index (BMI) and Waist circumference (WC). In the analysis of biomarkers for insulin resistance, NC was positively correlated to HbA1c, homeostasis model assessment ratio (HOMA-R) and leptin. In addition, an increase in triglycerides (TG) and a decrease in HDL-cholesterol (HDL-C) were also associated with NC. Interestingly, NC was also associated with atherosclerosis-related indices. The measurement of NC is an easy, inexpensive and reproducible method for assessment of obesity, and a possible predictor to identify the risk for future metabolic diseases in Japanese postmenopausal women.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 4","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33075994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body mass index as a predictor of postoperative complications in loop ileostomy closure after rectal resection in Japanese patients. 体重指数作为日本患者直肠切除术后回肠袢闭合术后并发症的预测因子。

Hiroshima journal of medical sciences Pub Date : 2014-12-01

Yasufumi Saito, Yuji Takakura, Takao Hinoi, Hiroyuki Egi, Hirotaka Tashiro, Hideki Ohdan

{"title":"Body mass index as a predictor of postoperative complications in loop ileostomy closure after rectal resection in Japanese patients.","authors":"Yasufumi Saito, Yuji Takakura, Takao Hinoi, Hiroyuki Egi, Hirotaka Tashiro, Hideki Ohdan","doi":"","DOIUrl":"","url":null,"abstract":"Loop ileostomy is widely employed after low rectal anastomosis to prevent pelvic sepsis from anastomotic leakage. However, stoma closure carries a risk of morbidity and even mortality in some cases. It is important to assess complications after stoma closure for maximizing the benefit of making loop ileostomy. The aim of this study was to review and examine the possible risk factors associated with complications after closure of loop ileostomies. A retrospective analysis, which focused on risk factors for complications after surgery, was performed for 82 consecutive patients who underwent elective closure of loop ileostomy from 2005-2012 at Hiroshima University Hospital. Postoperative complications developed in 22 patients (26.8%): 12 (14.6%) had an ileus, 8 (9.8%) had a wound infection, 2 (2.4%) had an intraperitoneal abscess and 1 had pseudomembranous enterocolitis. There was no postoperative mortality. In univariate analysis, gender and higher body mass index (BMI) were identified as significant risk factors for postoperative complications. After multivariate analysis, a BMI of 24 kg/m2 was identified as the cut-off value, above which significantly higher incidences of postoperative complications were observed. Furthermore, patients who succeeded in reducing their weight (BMI < 24 kg/m2) between the first and second surgeries had less morbidity than patients who remained obese (BMI > 24 kg/m2). Our study showed that the majority of complications associated with ileostomy closure are ileus. A BMI > 24 kg/m2 is an independent risk factor for postoperative complications. Weight loss programs before stoma closure might reduce postoperative complications.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 4","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33075995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of petrous apex cholesterol granuloma successfully treated with endoscopic endonasal surgery. 经鼻内窥镜手术成功治疗石质尖胆固醇肉芽肿1例。

Hiroshima journal of medical sciences Pub Date : 2014-12-01

Sayuru Miyamura, Satoshi Yamaguchi, Atsushi Tominaga, Yasuyuki Kinoshita, Masaaki Takeda, Satoshi Usui, Mizuki Morishige, Kazuhiko Sugiyama, Kaoru Kurisu

{"title":"A case of petrous apex cholesterol granuloma successfully treated with endoscopic endonasal surgery.","authors":"Sayuru Miyamura, Satoshi Yamaguchi, Atsushi Tominaga, Yasuyuki Kinoshita, Masaaki Takeda, Satoshi Usui, Mizuki Morishige, Kazuhiko Sugiyama, Kaoru Kurisu","doi":"","DOIUrl":"","url":null,"abstract":"A transcranial approach in combination with a transpetrosal setting has been the mainstream of surgical treatment of cholesterol granulomas in the petrous apex. However, endoscopic endonasal surgery has become a choice of treatment for these lesions with recent advancements in surgical techniques and instruments. We report a successful case of cholesterol granuloma managed with endoscopic endonasal surgery. A 45-year-old woman, who had a long-standing history of otitis media, presented with left abducens nerve palsy and discomfort around the left eye. Magnetic resonance (MR) imaging showed a large cystic lesion, suggesting cholesterol granuloma, in the left middle fossa abutting the cavernous sinus and lateral wall of the sphenoid sinus. We chose an endoscopic endonasal approach to drain the contents of the cyst because the lesion protruded into the left sphenoid sinus. The sphenoid sinus was widely opened and the cyst wall was fenestrated with the assistance of an image guidance navigation system. Postoperative MR images confirmed the complete collapse of the cyst. She has been free from symptoms since the operation.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 4","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33075996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of the multidrug resistance gene in human tumors. 多药耐药基因在人类肿瘤中的表达。

Hiroshima journal of medical sciences Pub Date : 2014-10-17 DOI: 10.11501/3052469

Rung-sa Kim

{"title":"Expression of the multidrug resistance gene in human tumors.","authors":"Rung-sa Kim","doi":"10.11501/3052469","DOIUrl":"https://doi.org/10.11501/3052469","url":null,"abstract":"The expression of MDR1 gene was investigated in human solid tumors with respect to adriamycin resistance. Forty fresh human surgical specimens were analyzed by RNA dot blot assay for their expression of the human MDR1 gene and by immunohistological staining using a monoclonal antibody against P-glycoprotein (MDR1 gene product). The MDR1 mRNA level was increased in 11 cases of 40 cancer patients, including three rectal cancers, two breast cancers, two gastric cancers, one colon cancer, one renal cell carcinoma, one gall bladder cancer and one malignant lymphoma of stomach. However, considerable variation of the MDR1 mRNA level was noted among cancers of a specific type. Immunohistochemical studies with the monoclonal antibody were shown to be positive in 18 tumors. In all tumors tested, the MDR1 mRNA level and the immunohistochemical analysis showed a significant correlation. However, two of five tumors which resisted adriamycin treatment were found to be negative in MDR1 transcript, but positive in immunohistological analysis. These results indicate that immunohistochemical analysis would be more sensitive for detecting P-glycoprotein-expression, and that resistance to adriamycin, being multifactorial, can be associated at least, in part with the increased amount of MDR1 gene product.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"39 3 1","pages":"71-7"},"PeriodicalIF":0.0,"publicationDate":"2014-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64430920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

A case of gastric cancer following living donor liver transplantation. 活体肝移植术后胃癌1例。

Hiroshima journal of medical sciences Pub Date : 2014-09-01

Hiroki Takehara, Kazuaki Tanabe, Nobuaki Fujikuni, Hiroyuki Tahara, Kentaro Ide, Yuka Tanaka, Wataru Yasui, Hideki Ohdan

{"title":"A case of gastric cancer following living donor liver transplantation.","authors":"Hiroki Takehara, Kazuaki Tanabe, Nobuaki Fujikuni, Hiroyuki Tahara, Kentaro Ide, Yuka Tanaka, Wataru Yasui, Hideki Ohdan","doi":"","DOIUrl":"","url":null,"abstract":"Only a few cases of de novo malignancy, especially gastric cancer after living donor liver transplantation (LDLT), have been reported. We report a case of gastric cancer following LDLT, after which immunosuppressants were minimized in accordance with the results of the mixed lymphocyte reaction (MLR) assay. A 65-year-old woman had previously undergone LDLT for hepatocellular carcinoma associated with hepatitis B virus infection. The liver graft had been donated by her son. During the course of postoperative surveillance with the MLR assay in order to minimize immunosuppressants, she was incidentally found to have gastric cancer during an endoscopic examination, 8 years after the liver transplantation. She underwent total gastrectomy with lymph node dissection. In this case, gastric cancer was detected 8 years after LDLT, which is longer than previously reported intervals between LDLT and malignancy detection. The number of patients undergoing LDLT is increasing, and the prognosis after liver transplantation has improved. Therefore, endoscopic surveillance programs are important for detecting malignancies in the early stages in liver transplant recipients.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 1-3","pages":"23-6"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33424004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness of the introduction of low-dose CT screening in Japanese smokers aged 55 to 74 years old. 日本55 ~ 74岁吸烟者采用低剂量CT筛查的成本效益

Hiroshima journal of medical sciences Pub Date : 2014-09-01

Hiroki Tabata, Tomoyuki Akita, Akiko Matsuura, Terumi Kaishima, Toshihiko Matsuoka, Masayuki Ohisa, Kazuo Awai, Junko Tanaka

{"title":"Cost-effectiveness of the introduction of low-dose CT screening in Japanese smokers aged 55 to 74 years old.","authors":"Hiroki Tabata, Tomoyuki Akita, Akiko Matsuura, Terumi Kaishima, Toshihiko Matsuoka, Masayuki Ohisa, Kazuo Awai, Junko Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"The validity of low-dose CT screening for lung cancer in heavy smokers was supported by the results of National Lung Screening Trials (NLST) conducted in the U.S.A. The present study investigated the appropriateness of the introduction of low-dose CT screening for lung cancer in Japanese smokers aged between 55 and 74 years old, in terms of cost-effectiveness and age. To examine changes in the shift from conventional chest radiography (CR) to low-dose CT (LDCT) screening for lung cancer, we estimated the incremental cost-effectiveness ratio (ICER) using Iinuma's mathematical model, and also conducted sensitivity analysis to determine the requirements for the introduction of a population-based screening. As the result, the incremental cost for one life-year saved was one million yen or lower when the costs of the screening were 8,000 and 6,000 yen and the recall rate was 10% for male and female smokers aged 55 to 59 years old, respectively. The recall rate was smaller when the interval between cancer screenings was two years, and the subjects were males. The higher the age of the subject, the smaller the incremental cost. In conclusion, at present, the mean cost of the LDCT test is approximately 10,000 yen in Japan. With a reduction in this cost by a few thousand yen, all Japanese smokers aged 55 to 74 years will be able to undergo LDCT screening for lung cancer annually.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"63 1-3","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33424003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0