Gynecologic oncology最新文献

{"title":"Impact of the 21st century CURES act on physician practice in gynecologic oncology","authors":"Rose Emlein, Jennifer Jorgensen","doi":"10.1016/j.ygyno.2026.01.208","DOIUrl":"10.1016/j.ygyno.2026.01.208","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S17-S18"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S0090-8258(26)00786-9","DOIUrl":"10.1016/S0090-8258(26)00786-9","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page i"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: Comparative outcomes of simple versus radical hysterectomy in patients with and without very low-risk early-stage cervical cancer: An exploratory analysis from the Gynecologic Cancer Intergroup Canadian Cancer Trials Group Cx.5/SHAPE trial","authors":"R. Wendel Naumann","doi":"10.1016/j.ygyno.2026.02.005","DOIUrl":"10.1016/j.ygyno.2026.02.005","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages A1-A2"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on oncological outcomes during follow-up in gynaecological cancer: A nationwide retrospective cohort study","authors":"E.M. Vermaas ,&nbsp;H.H.B. Wenzel ,&nbsp;M.A. van der Aa ,&nbsp;M. Snijders ,&nbsp;B.F.M. Slangen ,&nbsp;L.R.C.W. van Lonkhuijzen ,&nbsp;J.W.M. Aarts","doi":"10.1016/j.ygyno.2026.01.002","DOIUrl":"10.1016/j.ygyno.2026.01.002","url":null,"abstract":"<div><h3>Introduction</h3><div>During the coronavirus disease 2019 (COVID-19) pandemic, hospital-based follow-up care after gynaecological cancer was suddenly upended in order to reduce virus transmission, impacting the frequency and delivery of outpatient follow-up consultations in gynaecologic follow-up care. The objective of this study is to investigate the impact of the changes in follow-up care delivery on oncological outcomes in gynaecologic cancer survivors.</div></div><div><h3>Methods</h3><div>This nationwide population-based retrospective cohort study used data from the Netherlands Cancer Registry (NCR) and the Nationwide Network of Histopathology and Cytopathology (PALGA). Patients treated for epithelial ovarian, cervical, high stage endometrial or vulvar cancer, who either received the first two years of follow-up care pre-pandemic (2017–2019) or during the COVID-19 pandemic (2020−2021), were included. Two-year recurrence-free survival (RFS) and two-year overall survival (OS) were calculated, and analyses were adjusted for confounding.</div></div><div><h3>Results</h3><div>A total of 9062 patients were included, of whom 48.6 % (<em>n</em> = 4408) received follow-up pre-pandemic and 51.4 % (<em>n</em> = 4654) during COVID-19. RFS was comparable between pre-pandemic and COVID-19 cohorts in ovarian (hazard ratio [HR] 1.10, 95 % confidence interval [CI] 0.94–1.28), cervical (HR 1.07, 95 % CI 0.81–1.40), endometrial (HR 1.19, 95 % CI 0.93–1.53) and vulvar cancer (HR 1.01, 95 % CI 0.77–1.31). Moreover, there were no significant differences in OS, also after multivariable adjustments.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that two-year RFS and two-year OS during follow-up after treatment for a gynaecologic malignancy were not impacted by the follow-up care, as provided during the COVID-19 pandemic. These findings indicate that adaptations in follow-up care during the COVID-19 pandemic were not associated with worse oncological outcomes, warranting further investigation into more flexible follow-up strategies.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 79-88"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a mobile health platform for patient education and remote symptom monitoring in patients with advanced ovarian cancer undergoing primary chemotherapy1","authors":"Haller J. Smith ,&nbsp;Kaitlyn Dinkins ,&nbsp;Margaret I. Liang ,&nbsp;Daniel I. Chu ,&nbsp;Warner K. Huh","doi":"10.1016/j.ygyno.2025.12.006","DOIUrl":"10.1016/j.ygyno.2025.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To design and implement a mobile health (mHealth) patient engagement platform for use in patients with advanced ovarian cancer undergoing primary chemotherapy.</div></div><div><h3>Methods</h3><div>This prospective pilot study included patients with newly diagnosed epithelial ovarian cancer undergoing primary chemotherapy at a single institution from 8/2021–11/2023. Patients were offered enrollment in a mHealth platform which provided access to an education library and sent weekly health checks for the duration of their chemotherapy. Mild symptoms triggered recommendations for care at home, while more severe symptoms prompted a call or alert to the care team. The primary outcome was feasibility of the intervention. Secondary outcomes included frequency and severity of symptoms reported, recommended interventions, and patient reported outcomes (PROs).</div></div><div><h3>Results</h3><div>44 patients were enrolled during the study period. Activation rate was 79.5 %. Of the patients who activated, adherence was high with 77.1 % of patients still active at 3 months. Mean number of health checks completed was 16.1 (range 1–50). Commonly reported symptoms were fatigue (26.4 %), joint pain (24.2 %), neuropathy (22.2 %), and abdominal pain (18.7 %). Of 578 total health checks, 60.2 % triggered additional education, 20.9 % prompted a call to the care team, and 9.9 % resulted in an automated alert. 94 % of patients completed at least one PRO survey.</div></div><div><h3>Conclusions</h3><div>This mHealth intervention was feasible in patients with advanced ovarian cancer undergoing primary chemotherapy and was associated with high adherence. mHealth interventions may help better identify adverse effects in patients undergoing chemotherapy and provide earlier opportunities for intervention compared to standard in-person visits.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 27-31"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of simple versus radical hysterectomy in patients with and without very low-risk early-stage cervical cancer: An exploratory analysis from the Gynecologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial","authors":"Se Ik Kim ,&nbsp;Jae-Weon Kim ,&nbsp;Janice S. Kwon ,&nbsp;Sarah E. Ferguson ,&nbsp;Alexandra Sebastianelli ,&nbsp;Paul Bessette ,&nbsp;Sven Mahner ,&nbsp;Tristan Gauthier ,&nbsp;Cor de Kroon ,&nbsp;Willemien van Driel ,&nbsp;Karin Williamson ,&nbsp;Frederic Goffin ,&nbsp;Stephan Polterauer ,&nbsp;Brynhildur Eyjólfsdóttir ,&nbsp;Jung-Yun Lee ,&nbsp;Patrick J. Maguire ,&nbsp;Ingolf Juhasz-Böss ,&nbsp;Hyunji Lim ,&nbsp;Aeran Seol ,&nbsp;Lois Shepherd ,&nbsp;Marie Plante","doi":"10.1016/j.ygyno.2026.01.001","DOIUrl":"10.1016/j.ygyno.2026.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>To compare oncologic outcomes and perioperative morbidity between simple hysterectomy (SH) and radical hysterectomy (RH) in patients with and without very low-risk early-stage cervical cancer from the phase III Simple Hysterectomy And PElvic node assessment (SHAPE) trial.</div></div><div><h3>Methods</h3><div>Patients who underwent SH or RH in the SHAPE trial were classified into the Conservative SHAPE group (very low-risk), meeting criteria similar to the ConCerv trial, and the Liberal SHAPE group (without very low-risk), including everyone else. Between the SH and RH arms in each group, survival outcomes, including recurrence-free survival (RFS) and overall survival (OS), and intraoperative and postoperative morbidities were compared. Factors associated with recurrence and mortality rates were also investigated.</div></div><div><h3>Results</h3><div>In the Conservative SHAPE group (<em>n</em> = 107), no recurrence was observed in either SH or RH arms, and only one non-cancer-related death in the RH arm during a median follow-up of 4.5 years. In the Liberal SHAPE group (<em>n</em> = 575), the SH arm showed similar 3-year pelvic RFS (96.9 % vs. 97.4 %; HR, 1.15; 95 % CI, 0.49–2.70), extrapelvic RFS (97.7 % vs. 99.6 %; HR, 3.64; 95 % CI, 0.76–17.5), overall RFS (95.4 % vs. 97.4 %; HR, 1.56; 95 % CI, 0.70–3.48), and OS (98.9 % vs. 99.3 %; HR, 1.21; 95 % CI, 0.41–3.59), compared with the RH arm. In multivariate analyses, SH was not associated with recurrence and mortality rates, while absence of residual disease in the hysterectomy specimen was associated with lower recurrence. In both groups, SH was associated with a lower risk of urinary retention and incontinence.</div></div><div><h3>Conclusion</h3><div>There were similar recurrence and survival outcomes but less morbidity from simple hysterectomy compared to radical hysterectomy in patients with and without very low-risk early-stage cervical cancer from the SHAPE trial.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 37-45"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined impact of body composition and frailty on treatment tolerance and outcomes in patients with endometrial cancer","authors":"Alexandra Diggs ,&nbsp;Miller Singleton ,&nbsp;Luz Cuaboy ,&nbsp;Gabriel Aleixo ,&nbsp;Hyman Muss ,&nbsp;Kirsten Nyrop ,&nbsp;Xianming Tan ,&nbsp;Victoria Bae-Jump ,&nbsp;Lindsey Buckingham","doi":"10.1016/j.ygyno.2026.01.205","DOIUrl":"10.1016/j.ygyno.2026.01.205","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S15-S16"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in epithelial ovarian cancer outcomes among U.S. Hispanic subgroups","authors":"Nikita Khan,&nbsp;Karen Asher,&nbsp;Daniel Moncada,&nbsp;Shawn Doss,&nbsp;Heidi David,&nbsp;Danny Yakoub,&nbsp;Bunja Rungruang","doi":"10.1016/j.ygyno.2026.01.217","DOIUrl":"10.1016/j.ygyno.2026.01.217","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S22-S23"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond surgical complexity: Impact of perioperative risk on survival after extensive cytoreduction and hyperthermic intraperitoneal chemotherapy for ovarian cancer","authors":"Luis Felipe Falla Zuniga ,&nbsp;Teresa Diaz-Montes ,&nbsp;Mary Caitlin King ,&nbsp;Vladislav Kovalik ,&nbsp;Kseniia Uzhegova ,&nbsp;Carol Nieroda ,&nbsp;Vadim Gushchin ,&nbsp;Armando Sardi","doi":"10.1016/j.ygyno.2026.01.192","DOIUrl":"10.1016/j.ygyno.2026.01.192","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S7"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of primary debulking surgery vs neoadjuvant chemotherapy in advanced ovarian cancer: Insights from a single institution","authors":"Andrew Polio ,&nbsp;Ruth Bondurant ,&nbsp;Vaughan Schwob ,&nbsp;Bradley Loeffler ,&nbsp;Michael Goodheart","doi":"10.1016/j.ygyno.2026.01.220","DOIUrl":"10.1016/j.ygyno.2026.01.220","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S24-S25"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}