成人型颗粒细胞肿瘤样本中的信号转导通路活性

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-03-03 DOI:10.1016/j.ygyno.2025.02.018

G.J. Brink , J.W. Groeneweg , P. van der Ploeg , G.N. Jonges , E.H. Gort , P.O. Witteveen , R.P. Zweemer , J.M.J. Piek

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引用次数: 0

摘要

目的研究成人型颗粒细胞瘤（aGCT）的信号转导通路（STP）活性，以寻找潜在的治疗靶点。这些结果比较了STP在健康卵巢组织和低、高级别浆液性卵巢癌（LGSC和HGSC）中的活性。方法采用基于rna的方法评估stp在以下致癌途径中的活性：刺猬蛋白（HH）、转化生长因子β (TGF-β)、Notch、磷酸肌肽3激酶（PI3K）、丝裂原活化蛋白激酶（MAPK）、雄激素受体（AR）和雌激素受体（ER）。结果纳入31例agct和1例健康颗粒细胞样本，并与24例LGSC和50例HGSC样本进行比较。在aGCT中，与健康颗粒细胞相比，HH、Notch、PI3K和ER通路的活性显著提高。与LGSC和HGSC相比，aGCT表现出更高的PI3K通路活性，而较低的HH、TGF-β、Notch、MAPK、AR和ER通路活性。结论sour结果显示aGCT样品具有较高的PI3K通路活性。途径活性与健康颗粒细胞和浆液性卵巢癌的发现形成对比。因此，PI3K通路可能是治疗的靶点，特别是对于aGCT患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Signal transduction pathway activity in adult-type granulosa cell tumor samples

查看原文本刊更多论文

Signal transduction pathway activity in adult-type granulosa cell tumor samples

Objective

This study aims to evaluate signal transduction pathway (STP) activity in adult-type granulosa cell tumors (aGCT) in order to identify potential therapeutic targets. These results are compared with STP activity in healthy ovarian tissue and low and high grade serous ovarian carcinoma (LGSC and HGSC).

Methods

STP activity was assessed by a RNA-based assay for the following oncogenic pathways: Hedhehog (HH), transforming growth factor beta (TGF-β), Notch, phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), androgen receptor (AR) and estrogen receptor (ER).

Results

Samples of 31 aGCTs and a healthy granulosa cell were included and compared with 24 LGSC and 50 HGSC samples. In aGCT, significantly higher activity of the HH, Notch, PI3K and ER pathways was found, as compared to healthy granulosa cells. When compared with LGSC and HGSC, aGCT exhibited significantly higher PI3K pathway activity and lower HH, TGF-β, Notch, MAPK, AR, and ER pathway activity.

Conclusions

Our results show high PI3K pathway activity in aGCT samples. Pathway activity contrasts with findings in both healthy granulosa cells and serous ovarian carcinoma. Therefore, the PI3K pathway may be a target for treatment, specifically for aGCT patients.

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy