Ensuring relevance and equity in patient reported outcomes (PROs) in endometrial cancer: The SGO promote study (Patient Reported Outcomes Measurement Opportunities Through Equity)

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-03-01 DOI:10.1016/j.ygyno.2025.02.020

Lari Wenzel , Chelsea McKinney , Sally Jensen , Devin Peipert , Shaili Ganatra , Jason Bredle , Rachel Sisodia , Kemi M. Doll , Lauren Philp , Rebecca Arend , Jhalak Dholakia , David Cella

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引用次数: 0

Abstract

Objectives

The Society of Gynecologic Oncology (SGO) PROMOTE Study examined the content relevance of the FACT-Endometrial (FACT-En) measure to develop an updated measure that reflects priority symptoms/concerns among diverse endometrial cancer survivors.

Methods

Endometrial cancer patients diagnosed within the past 3 years were recruited through multiple platforms. Concept elicitation was conducted to identify priority symptoms/concerns to generate a symptom index, FACT-Endometrial Symptom Index (FEnSI). Participants listed 10 symptoms/concerns they considered most important during their cancer treatment, then rated the importance of each symptom/concern. Cognitive debriefing interviews assessed whether survey items were understood. Online surveys were administered and psychometric analyses were conducted to assess reliability and validity.

Results

Participants (16 White/Other; 15 Black) reported 49 symptoms/concerns along with a 0–10 importance rating. Responses from 66 participants (65 % White/other; 35 % Black) produced the following scales: Disease Related Symptoms – Physical (DRSP, 8 items) (Crohnbach's alpha 0.78); Disease Related Symptoms – Emotional (DRS-E, 2 items) (0.46); Function/Wellbeing (F/WB, 4 items) (0.73); and Treatment Side Effects (TSE, 9 items, unscored). A Total index score was generated by summing responses to all 23 items. The scales demonstrated construct validity by distinguishing between clinical groups known to differ; the DRSP, F/WB, and Total scores significantly differed across ECOG Performance Status categories (p < 0.05), with large effect sizes (Cohen's d > 0.80). Construct validity was demonstrated with moderate to large (>0.371) correlations with scales from the FACT-En.

Conclusion

The FEnSI is a clinically meaningful patient-reported symptom index reflecting the symptoms/concerns identified as most important by diverse patients with endometrial cancer.

查看原文本刊更多论文

确保子宫内膜癌患者报告结果（PROs）的相关性和公平性：SGO促进研究（通过公平的患者报告结果测量机会）

目的：妇科肿瘤学会（SGO）促进研究检查了fact -子宫内膜（FACT-En）测量的内容相关性，以开发一种反映不同子宫内膜癌幸存者优先症状/关注点的更新测量。方法通过多个平台招募近3年内确诊的子宫内膜癌患者。通过概念启发来确定优先症状/关注点，从而产生症状指数fact -子宫内膜症状指数（FEnSI）。参与者列出了他们认为在癌症治疗过程中最重要的10个症状/担忧，然后对每个症状/担忧的重要性进行评级。认知汇报访谈评估调查项目是否被理解。进行在线调查，并进行心理测量分析以评估信度和效度。参与者(白人/其他；15黑色)报告了49种症状/担忧以及0-10的重要性评级。来自66名参与者的回答(65%白人/其他；35% Black)制作了以下量表：疾病相关症状-身体（DRSP， 8个项目）（Crohnbach's alpha 0.78）；疾病相关症状-情绪（DRS-E， 2项）（0.46）；功能/幸福感（F/WB， 4项）（0.73）；治疗副作用（TSE， 9项，未评分）。总指数得分是通过对所有23个项目的回答求和而生成的。量表通过区分已知不同的临床组来证明结构效度；DRSP、F/WB和总分在ECOG表现状态类别中存在显著差异(p <；0.05)，效应量大(Cohen’s d >；0.80)。结构效度与FACT-En的量表具有中等到较大的相关性（>0.371）。结论FEnSI是一个有临床意义的患者报告的症状指数，反映了不同子宫内膜癌患者认为最重要的症状/关注点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy