Gynecologic oncology最新文献

{"title":"Residual disease isn't the whole story: Bowel and bladder functional outcomes are not optimal following cytoreductive surgery in ovarian cancer","authors":"Stuart Ostby, Leah Grcevich, Sarah Jenkins, Kelly Bruce, John Occhino, Bill Cliby, Carrie Langstraat","doi":"10.1016/j.ygyno.2026.01.188","DOIUrl":"10.1016/j.ygyno.2026.01.188","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S3"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising incidence of endometrioid uterine cancer in young women with low immunogenicity — Are there actionable pathways?","authors":"Nikita Khan , Vignesh Ramchandran , Cheng-I Liao , Nathan Tran , Ruolin Lorraine Jiang , Chunqiao Tian , Kathleen Darcy , Daniel Kapp , Ritu Salani , John Chan","doi":"10.1016/j.ygyno.2026.01.221","DOIUrl":"10.1016/j.ygyno.2026.01.221","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S25"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can AI support clinical decision-making in gynecologic oncology? A NCCN-guideline-based evaluation of ChatGPT and Gemini responses","authors":"Daniel Chen, Kelly Lamiman, Manolis Tsatsas, Albert Palileo, Ryan Hanusek, Allison Schachter, Ioannis Alagkiozidis","doi":"10.1016/j.ygyno.2026.01.201","DOIUrl":"10.1016/j.ygyno.2026.01.201","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S13"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom burden reported by gynecologic cancer patients from real world use of remote symptom monitoring during initial chemotherapy","authors":"Sagar Chokshi , Bryanna Diaz , Chelsea McGowen , Sheila McElhany , Carrie McNair , Naden Kreitz , Sandra Olisakwe , Courtney Williams , Gabrielle Rocque , Jennifer Pierce","doi":"10.1016/j.ygyno.2026.01.202","DOIUrl":"10.1016/j.ygyno.2026.01.202","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S14"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends, predictors, and safety of ovarian preservation in premenopausal women with high-grade endometrioid and non-endometrioid endometrial cancers","authors":"Jaida E. Morgan ,&nbsp;Ling Chen ,&nbsp;Xiao Xu ,&nbsp;Shayan Dioun ,&nbsp;Alexander Buckley ,&nbsp;Thomas Randall ,&nbsp;Tarah Pua ,&nbsp;Caryn M. St. Clair ,&nbsp;June Y. Hou ,&nbsp;Koji Matsuo ,&nbsp;Dawn L. Hershman ,&nbsp;Jason D. Wright","doi":"10.1016/j.ygyno.2026.01.004","DOIUrl":"10.1016/j.ygyno.2026.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>While ovarian preservation has been shown to be safe for premenopausal patients with low-grade, early-stage endometrioid endometrial cancer, there is limited data for higher risk tumors. We assessed the trends, predictors, and survival associated with ovarian preservation at the time of hysterectomy among premenopausal women with high-risk, early-stage endometrial cancers.</div></div><div><h3>Methods</h3><div>Women &lt;50 years of age with stage I-II grade 2 endometrioid or high-risk (grade 3 endometrioid, non-endometrioid) endometrial cancers diagnosed from 2012 to 2022 and recorded in the National Cancer Database (NCDB) were examined. A multivariable logistic regression model, was used to examine factors associated with ovarian preservation. Adjusted survival curves and a Cox proportional hazards model (with inverse probability of treatment weighting [IPTW]) were used to compare the hazards of survvial in women who did and did not undergo ovarian preservation.</div></div><div><h3>Results</h3><div>A total of 7230 women including 295 (4.1 %) who underwent ovarian preservation were identified. The rate of ovarian preservation declined over time. Older age was associated with lower odds of ovarian preservation. After IPTW, 5-year survival was 94.2 % (95 % CI: 90.2–96.6 %) with ovarian preservation and 94.4 % (95 % CI: 93.5–95.2 %) with oophorectomy. In the weighted Cox proportional hazards model, ovarian preservation was not associated with overall survival (HR = 1.05, 95 % CI = 0.57–1.94).</div></div><div><h3>Conclusions</h3><div>Use of ovarian preservation in premenopausal women with high-risk endometrial cancers has decreased over time. Ovarian preservation was not associated with an adverse impact on survival.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 46-52"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of preoperative G8 score with survival, preoperative anemia and vitamin D status in gynecologic cancer patients: 5-year analysis of the Frail-B study","authors":"Valerie Catherine Linz ,&nbsp;Emma Liebau ,&nbsp;Laura Herrmann ,&nbsp;Markus Schepers ,&nbsp;Katharina Gillen ,&nbsp;Michael Mohr ,&nbsp;Mona Wanda Schmidt ,&nbsp;Marcus Schmidt ,&nbsp;Annette Hasenburg","doi":"10.1016/j.ygyno.2026.01.005","DOIUrl":"10.1016/j.ygyno.2026.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>Frailty, nutritional deficiencies, and anemia frequently coexist in gynecologic cancer and may adversely influence clinical outcomes. This study aimed to evaluate the prognostic value of the G8 geriatric screening tool (G8) for survival outcomes in patients undergoing gynecologic oncology surgery, with postoperative complications and selected modifiable preoperative conditions assessed as secondary outcomes.</div></div><div><h3>Methods</h3><div>Patients ≥60 years undergoing gynecologic oncology surgery were prospectively screened for frailty between May 2020 – June 2025. Survival was evaluated with Kaplan-Meier curves and Cox regression. Propensity score matching included demographics, comorbidities, and tumor characteristics; matched samples were analyzed using weighted Cox models.</div></div><div><h3>Results</h3><div>Of 257 screened patients, 180 were included (endometrial <em>n</em> = 72, ovarian <em>n</em> = 71, vulvar <em>n</em> = 26, cervical <em>n</em> = 6, vaginal cancer <em>n</em> = 5; mean age 69.6 ± 7.9 years; follow-up 25.1 ± 16.3 months). G8 positive patients (≤14 points) had more comorbidities and were more likely to present with preoperative anemia, hypoalbuminemia, and vitamin D or B12 deficiency. FIGO stages, surgical approach and postoperative complications were comparable. G8 positive patients were less likely to receive standard adjuvant therapy (<em>p</em> = 0.003). In matched analyses, G8 positivity remained significantly associated with reduced progression-free survival (HR: 1.87, 95% CI: 1.01–3.49, <em>p</em> = 0.047) and showed a trend toward worse overall survival (HR: 2.25, 95% CI: 0.98–5.16, <em>p</em> = 0.055). Surgical resection status was the strongest predictor of oncological outcome.</div></div><div><h3>Conclusions</h3><div>A low preoperative G8 score was associated with reduced progression-free and potentially worse overall survival in older women with gynecologic tumors. The G8 may help identify modifiable factors such as anemia or vitamin D deficiency, while complete tumor resection remained the strongest prognostic factor.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 70-78"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum adenosine deaminase 2 predicts chemotherapy response and survival in advanced high-grade serous ovarian carcinoma","authors":"Collin Sitler ,&nbsp;Kathleen Darcy ,&nbsp;Tamara Abulez ,&nbsp;Chunqiao Tian ,&nbsp;Samantha Streich ,&nbsp;Megan Allen ,&nbsp;Ahmed Hussain ,&nbsp;Christopher Tarney ,&nbsp;Ming Zhou ,&nbsp;Brian Hood ,&nbsp;Katlin Wilson ,&nbsp;Kelly Conrads ,&nbsp;Taylor Deskins ,&nbsp;Leslie Randall ,&nbsp;Laura Havrilesky ,&nbsp;Casey Cosgrove ,&nbsp;Linda Duska ,&nbsp;Christina Washington ,&nbsp;Kathleen Moore ,&nbsp;Neil Phippen ,&nbsp;George Maxwell","doi":"10.1016/j.ygyno.2026.01.190","DOIUrl":"10.1016/j.ygyno.2026.01.190","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S4-S5"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study assessing the accuracy and usefulness of a PET/CT algorithm-based service for treatment response quantification in metastatic cancer","authors":"Abigail Barger,&nbsp;Andre Khazak,&nbsp;Israel Zighelboim,&nbsp;Melissa Wilson,&nbsp;Yull Arriaga,&nbsp;Sarah Huepenbecker","doi":"10.1016/j.ygyno.2026.01.199","DOIUrl":"10.1016/j.ygyno.2026.01.199","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S12"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of immune checkpoint inhibitors in advanced and recurrent vulvar and vaginal cancer","authors":"Cassidy Abdeen ,&nbsp;Reed O'Connor ,&nbsp;Julia Chalif ,&nbsp;Danielle Glassman ,&nbsp;Anna Gonzalez ,&nbsp;Molly Morton ,&nbsp;Jessica Velasquez ,&nbsp;Floor Backes ,&nbsp;David Cohn ,&nbsp;David Cohn ,&nbsp;Larry Copeland ,&nbsp;Casey Cosgrove ,&nbsp;Paulina Haight ,&nbsp;Christa Nagel ,&nbsp;Robert Neff ,&nbsp;David O'Malley ,&nbsp;Laura Chambers","doi":"10.1016/j.ygyno.2026.01.196","DOIUrl":"10.1016/j.ygyno.2026.01.196","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S10"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of patient-reported outcome measures for women with low health literacy in gynecologic oncology – A mixed-methods study","authors":"D.D. Seeratan ,&nbsp;A. Jongkind ,&nbsp;L.R.C.W. van Lonkhuijzen ,&nbsp;M.M. van Muilekom ,&nbsp;N.P.M. Ezendam ,&nbsp;O.C. Damman ,&nbsp;J.W.M. Aarts","doi":"10.1016/j.ygyno.2026.01.009","DOIUrl":"10.1016/j.ygyno.2026.01.009","url":null,"abstract":"<div><h3>Purpose</h3><div>Patient-reported outcome measures (PROMs) are used in oncology to assess patients' wellbeing. It is unclear if PROMs suit patients with low health literacy (HL). This study aimed to determine the prevalence of low HL in gynaecological cancer patients, describe associated clinical and sociodemographic factors, and explore PROMs use and comprehensibility for this group.</div></div><div><h3>Methods</h3><div>Patients treated for a gynaecological malignancy completed a waiting room questionnaire to assess self-perceived HL. Clinical and sociodemographic characteristics were collected via additional questions and the electronic patient file. Those with low HL, identified by the self-perceived HL screener and educational level, were interviewed, covering cognitive debriefings of a PROM-subset and semi-structured questions on attitudes toward PROMs. Patient characteristics were analyzed descriptively. Qualitative interview data were analyzed using Tourangeau's response process model and reflexive thematic analysis.</div></div><div><h3>Results</h3><div>In total, 136 patients completed the waiting room questionnaire. 23.5% (<em>n</em> = 32/136) had self-perceived low HL, of which 18 agreed to interviews. Cognitive debriefings revealed comprehensibility issues, particularly related to interpreting recall periods and response options. Some terms were perceived as ambiguous or emotionally charged. During semi-structured questions, participants expressed digital access issues and reluctance toward PROMs, often due to confusion about their purpose and absence of feedback on prior responses during consultations.</div></div><div><h3>Discussion</h3><div>Challenges with PROM comprehensibility and use among patients with low HL may hinder accurate health status reflection, impacting clinical work and research outcomes. Improvements are needed in clearly communicating PROMs' purpose and feedback on responses. To overcome comprehensibility barriers, PROMs should be developed and validated with low HL populations.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 53-62"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}