Gynecologic oncology最新文献

{"title":"The impact of alternate-day fasting in patients with gynecologic malignancies undergoing chemotherapy (FAST study): Initial results","authors":"Oriana Krivenko, Emily Hinchcliff, Jenna Marcus, Dario Roque, Anne Grace, Olivia Foley, Emma Barber, Isabelle Bednorski","doi":"10.1016/j.ygyno.2026.01.187","DOIUrl":"10.1016/j.ygyno.2026.01.187","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S2-S3"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and ethnic disparities in malignant vaginal cancer 2000–2022","authors":"Ariel Cohen, Wade Barton, Kristy Ward","doi":"10.1016/j.ygyno.2026.01.204","DOIUrl":"10.1016/j.ygyno.2026.01.204","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S15"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors plus progestins on endometrial cancer risk in nonmalignant uterine diseases: A retrospective study","authors":"Ting-Tai Yen , Tina Yi Jin Hsieh , Gin Yi Lee , Chuan Angel Lu , Edward Tanner","doi":"10.1016/j.ygyno.2026.01.195","DOIUrl":"10.1016/j.ygyno.2026.01.195","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S8-S10"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unequal demographic and genomic landscape of uterine serous carcinoma: An analysis of 1400 patients","authors":"Daniel Moncada , Vignesh Ramchandran , Cheng-I Liao , Nathan Tran , Chunqiao Tian , Kathleen Darcy , Daniel Kapp , Ritu Salani , John Chan","doi":"10.1016/j.ygyno.2026.01.222","DOIUrl":"10.1016/j.ygyno.2026.01.222","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S26"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular subtypes of stage III vulvar squamous cell carcinoma predict recurrence and survival outcomes","authors":"Simrit Warring , Mark Hopkins , Michaela McGree , Evdokiya Knyazhanskaya , Kelly Bruce , Angela Fought , Allison Garda , Jamie Bakkum-Gamez","doi":"10.1016/j.ygyno.2026.01.228","DOIUrl":"10.1016/j.ygyno.2026.01.228","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S29-S30"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the administration of SARS-CoV-2 vaccinations and infusion-related hypersensitivity reactions with taxane administration in patients with gynecologic malignancies","authors":"Bethany Werner, Tara Sullivan, Cassidy Blaiss, Sarah Hayward, Daniel Zhao, Laura Holman","doi":"10.1016/j.ygyno.2026.01.230","DOIUrl":"10.1016/j.ygyno.2026.01.230","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S31"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of perioperative circulating tumor DNA in endometrial cancer: systematic review & meta-analysis","authors":"Amna Ahmed ,&nbsp;Gagandeep Saini ,&nbsp;Sarah E. Ferguson ,&nbsp;Rouhi Fazelzad ,&nbsp;Qixuan Li ,&nbsp;Kathy Han ,&nbsp;Trevor Pugh ,&nbsp;Derek Wong ,&nbsp;Raymond H. Kim ,&nbsp;Anjelica Hodgson ,&nbsp;Samuel Leung ,&nbsp;Amy Jamieson ,&nbsp;Jessica N. McAlpine ,&nbsp;Kristina Lindemann ,&nbsp;Franziska Siegenthaler ,&nbsp;Soyoun Rachel Kim","doi":"10.1016/j.ygyno.2025.12.008","DOIUrl":"10.1016/j.ygyno.2025.12.008","url":null,"abstract":"<div><h3>Importance</h3><div>Decisions regarding endometrial cancer (EC) adjuvant therapy can be challenging due to the need to balance the benefits of recurrence reduction with treatment toxicity. Circulating tumor DNA (ctDNA) has the potential to guide adjuvant therapy decisions by stratifying patients based on their risk of recurrence.</div></div><div><h3>Objective</h3><div>To determine the association between perioperative ctDNA positivity and survival outcomes in patients with EC.</div></div><div><h3>Methods</h3><div>An electronic search was performed in MEDLINE, Embase, Cochrane Central, Cochrane Database of Systematic Reviews, and Web of Science and included all articles up to July 23rd, 2025. Studies were included if they assessed patients with EC who had ctDNA assessment before and/or after surgery and reported on survival outcomes. Meta-analysis was done to explore the association between ctDNA levels and survival.</div></div><div><h3>Main outcome and measures</h3><div>The primary outcome was the association between ctDNA positivity pre- or post-operatively and progression-free survival (PFS).</div></div><div><h3>Results</h3><div>Of 2862 articles reviewed, 11 met inclusion criteria, which led to reporting on 1298 patients. Pre-operative as well as post-operative ctDNA positivity was significantly associated with worse PFS (HR 3.69 [95 % confidence interval (CI), 2.58–5.26], HR 12.61 [95 % CI, 8.78–18.13] respectively), with no significant heterogeneity.</div></div><div><h3>Conclusions and relevance</h3><div>This systematic review and meta-analysis demonstrates that perioperative detection of ctDNA positivity is significantly associated with worse PFS and could serve as a valuable tool for EC prognostication and guidance for adjuvant therapy decision-making. Prospective studies that evaluate the role of ctDNA in EC are needed for this to be implemented in clinical practice.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 1-8"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status","authors":"Deepti Jain ,&nbsp;Marya Wahidi ,&nbsp;Judy Effendi ,&nbsp;Lien Hoang ,&nbsp;Cristina Terinte ,&nbsp;Anna Pesci ,&nbsp;Takako Kiyokawa ,&nbsp;Isabel Alvarado-Cabrero ,&nbsp;Esther Oliva ,&nbsp;Natalia Rakislova ,&nbsp;Ana Felix ,&nbsp;Douglas Allison ,&nbsp;Esther Guerra ,&nbsp;Andres Roma ,&nbsp;Oluwole Fadare ,&nbsp;Gulisa Turashvili ,&nbsp;Carlos Parra-Herran ,&nbsp;Gozde Kir ,&nbsp;Ahmet Erbagci ,&nbsp;Anne Mills ,&nbsp;Rouba Ali-Fehmi","doi":"10.1016/j.ygyno.2026.01.012","DOIUrl":"10.1016/j.ygyno.2026.01.012","url":null,"abstract":"<div><h3>Background</h3><div>Our study examines impact of HPV status and patient-specific characteristics on recurrence-free survival (RFS) and overall survival (OS) for SCC and ECA.</div></div><div><h3>Methods</h3><div>This multi-continental retrospective study analyzed clinicopathologic data of 634 patients with microscopically confirmed cervical cancer (CC; only SCC and ECA) across Asia, Europe, and North America. HPV status was determined using PCR or HPV in situ hybridization (ISH) for both HR-HPV (SCC and ECA) and LR-HPV (SCC), using same platform. Descriptive analysis and Cox regression models were produced.</div></div><div><h3>Results</h3><div>Out of total 634 patients, 533 (84.1%) were HPVA and 101 (15.9%) were HPVI. 65% had SCC morphology (88.1%: HPVA; 11.9%: HPVI) and 35% had ECA differentiation (76.6%: HPVA; 23.4%: HPVI). Compared to ECA, patients with SCC were older (median age: 51 vs. 45 years old; <em>p</em> &lt; 0.001), had higher HPVA status (88.1% vs. 76.6%; p &lt; 0.001), and a higher rate of lymph-vascular invasion (LVI; 64.8% vs. 56.8%; <em>p</em> = 0.004). However, patients with ECA had a higher rate of metastases to pelvic organs (13.5% vs. 2.4%; p &lt; 0.001). In univariable analysis, HPV status, tumor type, higher FIGO stage, older age, LVI positive, lymph node metastasis (LNM), and adjuvant treatment were all associated with impaired RFS and OS (all <em>p</em> ≤ 0.007). In multivariable analysis, LVI, HPV status, institution, and tumor type remained significant for RFS, while age at diagnosis, FIGO stage, LVI, and tumor type remained significant for OS.</div></div><div><h3>Conclusion</h3><div>Tumor type and HPV status play significant role in determining survival outcomes in CC.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 89-98"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged remission following severe immunotoxicity in patients receiving PD-1/PDL-1 inhibitor maintenance for gynecologic malignancies","authors":"Taran Carrasco ,&nbsp;Zachary Williams ,&nbsp;Nayana Madhudi ,&nbsp;Trinity Neal ,&nbsp;Mary Cunningham ,&nbsp;Rainer Jones","doi":"10.1016/j.ygyno.2026.01.186","DOIUrl":"10.1016/j.ygyno.2026.01.186","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S1-S2"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IO after IO: Outcomes of pembrolizumab plus lenvatinib (Pem/Len) after prior immunotherapy in recurrent endometrial cancer","authors":"Vaidehi Mujumdar ,&nbsp;Miranda Benfield ,&nbsp;Manvi Punukollu ,&nbsp;Laurel Berry ,&nbsp;R. Wendel Naumann ,&nbsp;Jubilee Brown","doi":"10.1016/j.ygyno.2026.01.193","DOIUrl":"10.1016/j.ygyno.2026.01.193","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S7-S8"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}