Helvetica Chimica Acta最新文献_第10页

Introduction for the Special Collection of Papers in the Honor of Robert Deschenaux. 为纪念罗伯特·德舍诺的特别文集简介。

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-10-04 DOI: 10.1002/hlca.202300168

Jean-François Nierengarten, Jean-Marie Lehn

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iso-Fatty Acid Metabolism in Caenorhabditis elegans’ Ceramide Biosynthesis 秀丽隐杆线虫神经酰胺生物合成中的异脂肪酸代谢

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-10-02 DOI: 10.1002/hlca.202300131

Rocío Rivera Sánchez, Siva Bandi, Marie-Désirée Scheidt, Hanna Laaroussi, Bennett William Fox, Yojiro Ishida, Gaétan Glauser, Sylvain Sutour, Stephan H. von Reuss

{"title":"iso-Fatty Acid Metabolism in Caenorhabditis elegans’ Ceramide Biosynthesis","authors":"Rocío Rivera Sánchez, Siva Bandi, Marie-Désirée Scheidt, Hanna Laaroussi, Bennett William Fox, Yojiro Ishida, Gaétan Glauser, Sylvain Sutour, Stephan H. von Reuss","doi":"10.1002/hlca.202300131","DOIUrl":"10.1002/hlca.202300131","url":null,"abstract":"Ceramide biosynthesis and its connection to iso-fatty acid metabolism in the model organism Caenorhabditis elegans was investigated using a combination of reverse genetics and comparative ESI-(+)-HR-MSe ceramide profiling along with incorporation experiments with bacterial mutants specifically enriched with isotopically labeled branched-chain amino acids or branched-chain fatty acids. Incorporation of a l-leucine-derived isovalerate unit into the conserved d17 : 1iso sphingosine building block proceeds through elo-5 dependent chain elongation and depends on peroxisomal β-oxidation by the 3-ketoacyl-CoA thiolase daf-22, although ceramide profiles of N2 wildtype and daf-22(ok693) are indistinguishable. Biosynthesis of the homologous N-iso-acyl moieties also depends on l-leucine and isovalerate chain elongation but proceeds independently of elo-5 and daf-22. Biosynthesis of the dominating N-docosanoyl moiety depends on elo-3-catalyzed chain elongation of bacteria-derived palmitic acid, whereas the N-tetracosanoyl moiety is derived from de novo lipogenesis.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202300131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135805190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enantio- and Diastereoselective (Ipc)2BOTf-Mediated Aldol Reactions of Morpholine Carboxamides 对映体和非对映体选择性 (Ipc)2BOTf 介导的吗啉羧酰胺醛醇反应

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-29 DOI: 10.1002/hlca.202300126

Lee Pedzisa, Andrii Monastyrskyi, Camille D. Parker, William R. Roush

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Synthesis of {CB11} Monocarborane Sulfonamides by B2-Selective Rhodium-Catalyzed B−H Activation B2选择性铑催化B-H活化合成{CB11}单碳硼烷磺酰胺

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-28 DOI: 10.1002/hlca.202300144

Zehua Ye, Jizeng Sun, Yujie Jin, Chuhao Lin, Jiyong Liu, Simon Duttwyler

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Construction of Cyclobutane-Centered Tricyclic Caged Skeleton through a [5,5]-Rearrangement Triggered Cascade 通过[5,5]-重排触发级联构建以环丁烷为中心的三环笼状骨架

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-28 DOI: 10.1002/hlca.202300149

Mengjie Hu, Mengjiao Zhu, Liying Ru, Jiangtao Ji, Ming Bao, Bo Peng

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The Honeysuckle and the Bindweed Revisited: Synthesis and Stereochemistry of Extended Helical Structures from Coordination Complexes 金银花和联花:配位配合物扩展螺旋结构的合成和立体化学

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-28 DOI: 10.1002/hlca.202300120

Alan M. Downward, Matteo Granelli, Celine Besnard, Laure Guénée, Alan F. Williams

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Rapid Synthesis of Propargyl-γ-Modified Peptide Nucleic Acid Monomers for Late-Stage Functionalization of Oligomers 用于低聚物后期功能化的丙炔修饰肽核酸单体的快速合成

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-27 DOI: 10.1002/hlca.202300110

Miguel López-Tena, Emma E. Watson, Patrick Romanens, Nicolas Winssinger

{"title":"Rapid Synthesis of Propargyl-γ-Modified Peptide Nucleic Acid Monomers for Late-Stage Functionalization of Oligomers","authors":"Miguel López-Tena, Emma E. Watson, Patrick Romanens, Nicolas Winssinger","doi":"10.1002/hlca.202300110","DOIUrl":"10.1002/hlca.202300110","url":null,"abstract":"The exceptional hybridization properties of peptide nucleic acids (PNAs) coupled with the ease of their synthesis has made this artificial nucleic acid mimetic a desirable platform for diagnostics, therapeutics and supramolecular engineering. PNA backbone modifications have been extensively explored to finetune physicochemical properties and for conjugation of functional molecules. Here, we detail the synthesis of a universal γ-propargyl-PNA backbone from serine, and its acylation with the four DNA canonical nucleobases. The availability of serine as d or l enantiomer provide simple accesses to PNA oligomers for hybridization with natural oligonucleotides or for orthogonal hybridization circuitry. We show that late-stage conjugation enables optimization of the physicochemical properties. This approach is appealing due to its orthogonality to Fmoc-SPPS, its flexibility and ease for introducing diversity by on-resin copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). We exemplified the utility of these novel monomers with PNA based hybridization chain reactions (HCRs).","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202300110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135536400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Silylacrylate as a Multipurpose Reagent in Organic Synthesis β‐丙烯酸硅酯在有机合成中的多用途试剂研究

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-25 DOI: 10.1002/hlca.202300141

Sunil K. Ghosh

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Cover Picture: (Helv. Chim. Acta 9/2023) 封面图片：（Helv.Chim.Acta 9/2023）

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-22 DOI: 10.1002/hlca.202370901

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Identification of Favorable Silica Surface Sites for Single-Molecule Magnets 单分子磁体有利的二氧化硅表面位置的鉴定

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2023-09-21 DOI: 10.1002/hlca.202300130

Moritz Bernhardt, Lukas Lätsch, Boris Le Guennic, Christophe Copéret

{"title":"Identification of Favorable Silica Surface Sites for Single-Molecule Magnets","authors":"Moritz Bernhardt, Lukas Lätsch, Boris Le Guennic, Christophe Copéret","doi":"10.1002/hlca.202300130","DOIUrl":"10.1002/hlca.202300130","url":null,"abstract":"Industrial data storage application based on single-molecule magnets (SMMs) necessitates not only strong magnetic remanence at high temperatures but also requires the implementation of SMMs into a solid material to increase their durability and addressability. While the understanding of the relationship between the local structure of the metal and the resulting magnetic behavior is well understood in molecular systems, it remains challenging to establish a similar understanding for magnetic materials, especially for isolated lanthanide sites on surfaces. For instance, dispersed Dy(III) ions on silica prepared via surface organometallic chemistry exhibit slow magnetic relaxation at low temperatures, but the origin of these properties remains unclear. In this work, we modelled ten neutral complexes with coordination numbers (CN) between three and six ([Dy(OSiF3)3(O(SiF3)2)CN-3]) representing possible surface sites for dispersed Dy(III) ions and investigated their SMM potential via ab initio CASSCF/RASSI-SO calculations. Detailed analysis of the data shows the strong influence of the spatial position of the anionic ligands while the neutral ligands only play a minor role for the magnetic properties. In particular, a T-shape like orientation of the anionic ligands is predicted to exhibit good SMM properties making it a promising targeted coordination environment for molecular and surface-based SMMs.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202300130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135824310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0