镍（II）催化的炔烃与甲酰胺的氢氨基化反应，生成不饱和酰胺

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2024-06-03 DOI:10.1002/hlca.202400020

Tiangui Li, Shiyang Wang, Zongxiang Xia, Jinbo Zhao, Dongyue Zhang, Yuanqi Wu, Yu Liu

引用次数: 0

摘要

镍催化活化 C(sp2)-H键仍然是一个难以攻克的难题。在此，我们实现了镍催化选择性活化甲酰胺的 C(sp2)-H键，使其与内部炔烃发生加成反应，从而高产率地得到α,β-不饱和酰胺化合物。该方案的特点是催化剂系统廉价且无毒。初步的机理研究揭示了反应途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nickel(II)-Catalyzed Hydrocarbamoylation of Alkynes with Formamides towards Unsaturated Amides

Ni-catalyzed activation of C(sp²)−H bond remains an elusive challenge. Herein, we realized a Ni-catalyzed selective activation of C(sp²)−H bond of formamides, which underwent addition reaction with internal alkynes to provide α,β-unsaturated amide compounds in high yields. The protocol was featured by the cheap and nontoxic catalyst system. Preliminary mechanistic studies shed light on the reaction pathways.

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.