Helvetica Chimica Acta最新文献

Cover Picture: (Helv. Chim. Acta 3/2025)

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-03-14 DOI: 10.1002/hlca.202570301

引用次数: 0

Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-02-22 DOI: 10.1002/hlca.202400193

Anamarija Nikoletić, Mirela Maleković, Gül Kozalak, Cornelia G. Palivan, Oya Tagit

{"title":"Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery","authors":"Anamarija Nikoletić, Mirela Maleković, Gül Kozalak, Cornelia G. Palivan, Oya Tagit","doi":"10.1002/hlca.202400193","DOIUrl":"https://doi.org/10.1002/hlca.202400193","url":null,"abstract":"Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associated with the treatment of complex diseases. Inorganic nanoparticles with unique optical, electronic, and magnetic properties serve as efficient transducers, converting external stimuli into localized heat to trigger thermoresponsive nanocarriers. This review explores the design and application of thermoresponsive nanocarriers transduced by inorganic nanoparticles as DDS. Following a brief description of temperature-triggered phase transition of polymers and heat generation mechanisms by inorganic nanoparticles, strategies to integrate these components into hybrid systems are described. Examples demonstrating the utility of these hybrid systems as advanced DDS are discussed, highlighting their potential for precise drug release alongside theranostic capabilities by combining therapy with imaging. Despite the challenges in design, synthesis, and biological applications, thermoresponsive polymer-inorganic hybrids hold immense promise for transforming drug delivery and biomedical innovations.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202400193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Picture: (Helv. Chim. Acta 2/2025)

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-02-14 DOI: 10.1002/hlca.202570201

引用次数: 0

Introduction for the Special Collection in the Honor of Scott Denmark

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-30 DOI: 10.1002/hlca.202400183

Jeffrey Bode, Cathleen Crudden

引用次数: 0

Synthesis of α-Fluoroketones from Carboxylic Acids via Decarboxylation of Fluorinated Malonates

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-29 DOI: 10.1002/hlca.202400187

Raffael Davenport, Rolandas Cibiras, Gabriel Schäfer

引用次数: 0

Effect of Particle Size and Alloying with Gallium and Zinc in Copper Nanoparticles from Ab Initio Molecular Dynamics

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-24 DOI: 10.1002/hlca.202400124

Andreas Müller, Aleix Comas-Vives, Christophe Copéret

{"title":"Effect of Particle Size and Alloying with Gallium and Zinc in Copper Nanoparticles from Ab Initio Molecular Dynamics","authors":"Andreas Müller, Aleix Comas-Vives, Christophe Copéret","doi":"10.1002/hlca.202400124","DOIUrl":"https://doi.org/10.1002/hlca.202400124","url":null,"abstract":"Supported nanoparticles (NPs) are an intense field of research in industry and academia due to their unique catalytic properties. Yet, establishing relationships between structure and activity is challenging due to multiple possible compositions, interfaces, and alloy formation. This is especially pronounced for bimetallic NPs used in the CO2-hydrogenation-to-methanol, where the structure responds dynamically to the chemical potential of the reactants and products, resulting in distinct surface structures depending on the exact reaction conditions. These phenomena have been highlighted by combining ab initio Molecular Dynamics (AIMD) and Metadynamics (MTD) with in situ X-ray absorption spectroscopy, chemisorption, and CO-IR. Here, we aim to understand how particle size and simulation temperature influence the structure and dynamics of small Cu NPs using the diffusion coefficients and the radial distribution function/atomic pair density function as descriptors using AIMD simulations. We found that decreasing the particle size or increasing the simulation temperature results in increased atom mobility, highlighted by the increased metal diffusion and resulting in reduced particle crystallinity. We also find that alloying Cu with Ga significantly increases the diffusion of both elements in the particle compared to the monometallic ones. In contrast, such diffusion lies in between the individual elements composing the CuZn particles.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202400124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and Magnetic Properties of a Series of Uranium Bis-Siloxide Complexes

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-23 DOI: 10.1002/hlca.202400189

Luciano Barluzzi, Ivica Zivkovic, Farzaneh Fadaei-Tirani, Rodolphe Clérac, Marinella Mazzanti

{"title":"Structure and Magnetic Properties of a Series of Uranium Bis-Siloxide Complexes","authors":"Luciano Barluzzi, Ivica Zivkovic, Farzaneh Fadaei-Tirani, Rodolphe Clérac, Marinella Mazzanti","doi":"10.1002/hlca.202400189","DOIUrl":"https://doi.org/10.1002/hlca.202400189","url":null,"abstract":"Despite their synthetic interest and potential attractive properties, the preparation of heteroleptic U(III) complexes containing monodentate ligands remains challenging. Here we report the synthesis, structure and magnetic properties of three heteroleptic U(III) complexes containing two siloxide donors in the coordination sphere. The bis-siloxide monoiodide complex [U(OSi(OtBu)3)2I(thf)3], 1 provides a very attractive precursor for accessing heteroleptic complexes and rationally modify the binding angle between the two strongly donating siloxide ligands. Here we reacted 1 with macrocyclic ligands to yield complexes [[U(OSi(OtBu)3)2(crypt)]I, 3 and [[U(OSi(OtBu)3)2(18c6)]I, 4. Magnetic studies of these compounds offer a snapshot on how the SMM properties depend on the local symmetry in the presence of siloxide ligands. The static and dynamic magnetic properties of these compounds reveal a weak dependence of their single-molecule magnet behavior on the local symmetry.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Picture: (Helv. Chim. Acta 1/2025)

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-17 DOI: 10.1002/hlca.202570101

引用次数: 0

Amoxicillin Concentrations in Samples of Musculoskeletal Infections

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-13 DOI: 10.1002/hlca.202400178

Joana Erdmann, Richard Kuehl, Mario Morgenstern, Dirk Bumann, Martin Clauss, Nina Khanna, Katharina M. Rentsch

{"title":"Amoxicillin Concentrations in Samples of Musculoskeletal Infections","authors":"Joana Erdmann, Richard Kuehl, Mario Morgenstern, Dirk Bumann, Martin Clauss, Nina Khanna, Katharina M. Rentsch","doi":"10.1002/hlca.202400178","DOIUrl":"https://doi.org/10.1002/hlca.202400178","url":null,"abstract":"Amoxicillin is a frequently used beta-lactam antibiotic and at the same time a fragile analyte. Aim of this work was to investigate the sensitive properties of amoxicillin in biological samples and validate a quantification method for amoxicillin in soft tissue samples. Simple protein precipitation and 2D-High performance liquid chromatography coupled to tandem mass spectrometry was used for sample preparation and analysis. The formation of a covalent amoxicillin methanol-adduct could be observed in varying extents depending on matrix and sample preparation method. In-Source Products (ISPs) were investigated in plasma, soft tissue, and water and no differences could be observed. We successfully validated a method for amoxicillin determination in tissue samples using the sum of 2 ISPs of amoxicillin for quantification. 37 study samples of different deep-seated infections could be analyzed. Measured amoxicillin concentrations ranged from below 0.5 mg/kg up to 87 mg/kg. Concentrations in abscesses were lower than in other infections.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202400178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Threshold Photoelectron Spectrum of 3,4-Dimethylenecyclobutene

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2025-01-11 DOI: 10.1002/hlca.202400197

Emil Karaev, Dorothee Schaffner, Marius Gerlach, Tobias Preitschopf, Patrick Hemberger, Ingo Fischer

引用次数: 0