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30 + 30 Stripes of Appreciation 30 + 30条欣赏条纹
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-06-16 DOI: 10.1002/hlca.202500067
Michel Rickhaus, Michal Juríček
{"title":"30 + 30 Stripes of Appreciation","authors":"Michel Rickhaus,&nbsp;Michal Juríček","doi":"10.1002/hlca.202500067","DOIUrl":"https://doi.org/10.1002/hlca.202500067","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: (Helv. Chim. Acta 6/2025) 封面图片：（Helv.）詹。Acta 6/2025)
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-06-16 DOI: 10.1002/hlca.202570601
{"title":"Cover Picture: (Helv. Chim. Acta 6/2025)","authors":"","doi":"10.1002/hlca.202570601","DOIUrl":"https://doi.org/10.1002/hlca.202570601","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202570601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: (Helv. Chim. Acta 5/2025) 封面图片：（Helv.）詹。Acta 5/2025)
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-05-15 DOI: 10.1002/hlca.202570501
{"title":"Cover Picture: (Helv. Chim. Acta 5/2025)","authors":"","doi":"10.1002/hlca.202570501","DOIUrl":"https://doi.org/10.1002/hlca.202570501","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202570501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Analytes Capture by Engineering Electrostatics at the Entry of Aerolysin Nanopore 气溶纳米孔入口工程静电增强分析物捕获
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-05-09 DOI: 10.1002/hlca.202400180
Marwan El Chazli, Juan Francisco Bada Juarez, Louis W. Perrin, Jiajie Gao, Chan Cao
{"title":"Enhanced Analytes Capture by Engineering Electrostatics at the Entry of Aerolysin Nanopore","authors":"Marwan El Chazli,&nbsp;Juan Francisco Bada Juarez,&nbsp;Louis W. Perrin,&nbsp;Jiajie Gao,&nbsp;Chan Cao","doi":"10.1002/hlca.202400180","DOIUrl":"https://doi.org/10.1002/hlca.202400180","url":null,"abstract":"<p>Nanopore technology is a powerful single-molecule platform for detecting and sequencing a wide range of biomolecules. Among nanopores, aerolysin has emerged as a particularly promising candidate for peptide sensing. However, its ability to capture long biopolymers is limited due to its lack of a vestibule structure. In this study, we engineered electrostatics at the entry of the aerolysin pore and observed an increase in event frequency – up to 2 times higher for DNA and for the peptide compared to wild-type aerolysin. Importantly, this modification did not affect the pore's current-voltage characteristics. When tested with DNA and α-synuclein peptides, the engineered pore (D209R) exhibited comparable dwell times and current blockages to the wild-type pore, while ion selectivity and electroosmotic flux show an increase. These findings highlight that fine-tuning the electrostatic properties at the pore entry can significantly enhance event frequency without compromising key transport properties such as current blockage or dwell time. This improvement expands the utility of aerolysin nanopores for sensing and sequencing applications and paves the way for more effective diagnostic tools and analytical methods in the field of proteomics and biomarker discovery.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction for the Special Collection of Papers in the Honor of the President of the 57th Bürgenstock Conference, Erick M. Carreira 为纪念第57届<s:1>根斯托克会议主席埃里克·m·卡雷拉的特别文集介绍
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-05-03 DOI: 10.1002/hlca.202500069
{"title":"Introduction for the Special Collection of Papers in the Honor of the President of the 57th Bürgenstock Conference, Erick M. Carreira","authors":"","doi":"10.1002/hlca.202500069","DOIUrl":"https://doi.org/10.1002/hlca.202500069","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract Conformer Space 抽象共形空间
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-05-02 DOI: 10.1002/hlca.202500032
Gunnar Jeschke
{"title":"Abstract Conformer Space","authors":"Gunnar Jeschke","doi":"10.1002/hlca.202500032","DOIUrl":"https://doi.org/10.1002/hlca.202500032","url":null,"abstract":"<p>Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other. The radius of gyration of protein ensembles in this abstract conformer space (ACS) converges at ensemble sizes between 50 and 500, depending on the extent of disorder. Upon further increase of ensemble size, the root mean square distance of conformers to their nearest neighbors decreases only slowly. Clustering in ACS can reveal distinct subensembles. For proteins that exist in two states, clustering in a common ACS reveals differences between the ensembles in the two states. The dimension of ACS can be reduced to 2D or 3D by multi-dimensional scaling or principal component analysis. Visualization in these lower-dimensional spaces also reveals differences between protein states or the existence of subensembles. The ratio between the gyration radius in ACS and its counterpart in real space is a global disorder parameter.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simplified Approach for Electrochemical Allylic Oxidation of Olefins 烯烃烯丙基电化学氧化的一种简化方法
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-05-01 DOI: 10.1002/hlca.202500068
Kamil Hofman, Johannes Schneider, Roman Goy, Jan Schütz, Werner Bonrath, Siegfried R. Waldvogel
{"title":"A Simplified Approach for Electrochemical Allylic Oxidation of Olefins","authors":"Kamil Hofman,&nbsp;Johannes Schneider,&nbsp;Roman Goy,&nbsp;Jan Schütz,&nbsp;Werner Bonrath,&nbsp;Siegfried R. Waldvogel","doi":"10.1002/hlca.202500068","DOIUrl":"https://doi.org/10.1002/hlca.202500068","url":null,"abstract":"<p>A simple method for the electrochemical allylic oxidation of olefins to enones based on peroxide-mediated C–H activation is presented. <i>t</i>-Butyl hydroperoxide serves a dual role as mediator and oxygen source, avoiding the utilization of expensive transition metal catalysts, potentially explosive supporting electrolytes such as perchlorates, or additional environmentally harmful mediators. This elegant methodology allows for an operationally simple and sustainable late-stage transformation of delicate natural compounds such as terpenes or steroids into highly value-added building blocks. Such an approach provides a greener alternative to conventional oxidation methods used for industrial applications. In total, 25 examples are demonstrated with isolated yields up to 80%. The robust scalability of the method was also demonstrated, and chromatography could be avoided in scale-up simply by using recrystallization, which decreases the cost of downstream processing.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green-Tuning of (Chir)Optical Properties for Axially-Chiral Boramidines 轴手性硼脒（Chir）光学性质的绿色调谐
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-04-28 DOI: 10.1002/hlca.202500059
Nidal Saleh, Lorenzo Arrico, Francesco Zinna, Jérôme Lacour
{"title":"Green-Tuning of (Chir)Optical Properties for Axially-Chiral Boramidines","authors":"Nidal Saleh,&nbsp;Lorenzo Arrico,&nbsp;Francesco Zinna,&nbsp;Jérôme Lacour","doi":"10.1002/hlca.202500059","DOIUrl":"https://doi.org/10.1002/hlca.202500059","url":null,"abstract":"<p>The integration of boron into π-conjugated systems is a reliable approach to enhance photophysical properties. In this context, boramidines have emerged as a promising class of fluorophores. In this work, the design, synthesis, and chiroptical properties of novel axially chiral isoquinoline-derived boramidines are reported. Thanks to metal-catalyzed cross-coupling allied with atroposelective C─H arylation strategies or chiral stationary phase HPLC resolution, enantioenriched boramidines <b>1</b> and <b>2</b> are afforded (<i>ee</i> 90%–99%). Comparing with more classical boramidines, investigations reveal (i) bathochromic absorption shifts in the UV–vis region (&gt;50 nm) and (ii) emission maxima now in the green and cyan domains, along with fluorescence quantum yields reaching 70% in N<sub>2</sub>-saturated environments. Chiroptical measurements demonstrate well-defined electronic circular dichroism (ECD) spectra and circularly polarized luminescence (CPL) signals with |<i>g</i><sub>lum</sub>| values up to 2 × 10⁻<sup>3</sup>.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Polymer Functionalization by Means of Extreme Ultraviolet 极紫外技术在高分子功能化中的应用
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-04-26 DOI: 10.1002/hlca.202400100
Di Qu, Minglei Wang, Léonard Bezinge, Celine Hensky, Filippo Longo, Claudia Masucci, Mirushe Suloska, Jing Wang, Davide Bleiner
{"title":"Efficient Polymer Functionalization by Means of Extreme Ultraviolet","authors":"Di Qu,&nbsp;Minglei Wang,&nbsp;Léonard Bezinge,&nbsp;Celine Hensky,&nbsp;Filippo Longo,&nbsp;Claudia Masucci,&nbsp;Mirushe Suloska,&nbsp;Jing Wang,&nbsp;Davide Bleiner","doi":"10.1002/hlca.202400100","DOIUrl":"https://doi.org/10.1002/hlca.202400100","url":null,"abstract":"<p>Extreme ultraviolet (XUV) radiation is highly efficient for functionalization of solid materials by means of pronounced radical formation. To prevent collective effects, and study single photon effects, a low-fluence XUV source with 200 μJ/cm<sup>2</sup> was used to irradiate polymers such as poly-methyl methacrylate (PMMA) and poly-tetrafluoroethylene (PTFE). The unexposed and XUV-exposed sample domains were analyzed with time-of-flight secondary ion mass spectrometry (TOF-SIMS), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). The findings show that XUV photons drive photochemical modification of the surface, fragmentation, and ionization of the desorbed products. Besides a theoretical analysis, the XUV-induced surface modification of PTFE is discussed a new application for surface functionalization.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards Nickel-Catalysed Olefin Metathesis: A Computational Study of Nickelacyclobutane Fragmentation Reactions 镍催化烯烃复分解：镍环丁烷裂解反应的计算研究
IF 1.5 4区 化学
Helvetica Chimica Acta Pub Date : 2025-04-25 DOI: 10.1002/hlca.202500044
Olaf L. Kooijman, Marc-Etienne Moret
{"title":"Towards Nickel-Catalysed Olefin Metathesis: A Computational Study of Nickelacyclobutane Fragmentation Reactions","authors":"Olaf L. Kooijman,&nbsp;Marc-Etienne Moret","doi":"10.1002/hlca.202500044","DOIUrl":"https://doi.org/10.1002/hlca.202500044","url":null,"abstract":"<p>A detailed picture of the reactivity of metallacyclobutanes is key to the understanding and development of new reactions relying on these reactive intermediates, including olefin metathesis and cyclopropanation. More than 40 years ago, Miyashita and Grubbs reported experimental studies on the thermal decomposition pathways of a phosphine-supported nickelacyclobutane (NiCB) suggesting that nickel may be amenable to both cyclopropanation and olefin metathesis. Here we report a computational investigation of this system that shows that cyclopropane reductive elimination is the primary decomposition pathway for monometallic NiCBs, independently of the number of coordinated phosphine ligands. Further calculations suggest that bimetallic species may be responsible for the olefinic products of apparent [2+2] cycloreversion.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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