Nickel(II)-Catalyzed Hydrocarbamoylation of Alkynes with Formamides towards Unsaturated Amides

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-03 DOI:10.1002/hlca.202400020

Tiangui Li, Shiyang Wang, Zongxiang Xia, Jinbo Zhao, Dongyue Zhang, Yuanqi Wu, Yu Liu

引用次数: 0

Abstract

Ni-catalyzed activation of C(sp²)−H bond remains an elusive challenge. Herein, we realized a Ni-catalyzed selective activation of C(sp²)−H bond of formamides, which underwent addition reaction with internal alkynes to provide α,β-unsaturated amide compounds in high yields. The protocol was featured by the cheap and nontoxic catalyst system. Preliminary mechanistic studies shed light on the reaction pathways.

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镍（II）催化的炔烃与甲酰胺的氢氨基化反应，生成不饱和酰胺

镍催化活化 C(sp2)-H键仍然是一个难以攻克的难题。在此，我们实现了镍催化选择性活化甲酰胺的 C(sp2)-H键，使其与内部炔烃发生加成反应，从而高产率地得到α,β-不饱和酰胺化合物。该方案的特点是催化剂系统廉价且无毒。初步的机理研究揭示了反应途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.