Gut Pathogens最新文献

{"title":"The gut-lung axis and microbiome dysbiosis in non-tuberculous mycobacterial infections: immune mechanisms, clinical implications, and therapeutic frontiers.","authors":"Fangfang Zhu, Hao Ying, Seyed Davar Siadat, Abolfazl Fateh","doi":"10.1186/s13099-025-00718-z","DOIUrl":"10.1186/s13099-025-00718-z","url":null,"abstract":"<p><p>Non-tuberculous mycobacteria (NTM) are emerging pathogens of global concern, particularly in regions with declining tuberculosis rates. This review synthesizes current evidence on the epidemiology, immune pathogenesis, and microbiome interactions underlying NTM infections. The rising incidence of NTM is driven by environmental factors, immunocompromised populations, and advanced diagnostics. Clinically, NTM manifests as pulmonary, lymphatic, skin/soft tissue, or disseminated disease, with Mycobacterium avium complex (MAC) and M. abscessus being predominant pathogens. Host immunity, particularly Th1 responses mediated by IL-12/IFN-γ and TLR2 signaling, is critical for controlling NTM, while dysregulated immunity (e.g., elevated Th2 cytokines, PD-1/IL-10 pathways) exacerbates susceptibility. Emerging research highlights the gut-lung axis as a pivotal mediator of disease, where microbiome dysbiosis-marked by reduced Prevotella and Bifidobacterium-impairs systemic immunity and promotes NTM progression. Short-chain fatty acids (SCFAs) and microbial metabolites like inosine modulate macrophage and T-cell responses, offering therapeutic potential. Studies reveal distinct airway microbiome signatures in NTM patients, characterized by enriched Streptococcus and Prevotella, and reduced diversity linked to worse outcomes. Despite advances, treatment remains challenging due to biofilm formation, antibiotic resistance, and relapse rates. This review underscores the need for microbiome-targeted therapies, personalized medicine, and longitudinal studies to unravel causal relationships between microbial ecology and NTM pathogenesis.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"40"},"PeriodicalIF":4.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and risk factors for Helicobacter pylori infection in children under 64 months in Thimphu, Bhutan, and introducing the new in-house immunochromatography test kit: a cross-sectional study.","authors":"Passang Lhamo Sherpa, Takashi Matsumoto, Kinley Tshering, Birendra Pradhan, Junko Akada, Yoshio Yamaoka","doi":"10.1186/s13099-025-00715-2","DOIUrl":"10.1186/s13099-025-00715-2","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (H. pylori) is a lifelong infection, often acquired in childhood and persisting throughout life, that can lead to serious gastric diseases, including gastric cancer in adults. While asymptomatic in most children, it may cause extraintestinal manifestations affecting growth, necessitating distinct pediatric management strategies-particularly in countries with a high risk of gastric cancer. Accurate diagnosis is critical in high-risk populations. The stool antigen test is a reliable, non-invasive method for young children. Despite Bhutan's high H. pylori burden, diagnostic tools remain scarce. This study aimed to determine the prevalence and risk factors of H. pylori infection in Bhutanese children and validate a new in-house immunochromatography test (the A-ICT) kits.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 2023 among children under 64 months of age at three immunization clinics in Thimphu. H. pylori antigen in stool was detected using an ICT kit. After obtaining informed consent, parents completed questionnaires. Data were analyzed using STATA version 14.2 and R version 4.4.1.</p><p><strong>Results: </strong>A total of 226 children (mean age 33.28 months) participated in the study. The A-ICT kit showed high concordance with the commercial kit (Kappa 0.84 [95% CI: 0.78-0.89]) and excellent sensitivity (0.96) and specificity (0.95). The prevalence of H. pylori was 19.54% (95% CI:14.95-24.83). Risk factors included increasing age, having two or more siblings, and fathers who were farmers/wagers, and who worked in government/private sector. Children who were fed with or who ate using a spoon had a significantly lower risk of H. pylori infection than those who were fed or ate with fingers (p < 0.05).</p><p><strong>Conclusions: </strong>The A-ICT kit demonstrated remarkable sensitivity and specificity. Improvements in hygiene and sanitation related to child feeding practices are essential. Awareness programs should target large families and individuals employed in the formal sector, including both household and workplace settings. The validation of the A-ICT is a significant step toward a gastric cancer prevention program that facilitates early diagnosis and H. pylori eradication. The test kit is highly recommended for H. pylori screening and the confirmation of eradication post-treatment given its accuracy, rapidity, and simplicity in execution.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"39"},"PeriodicalIF":4.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functional landscape of the appendix microbiome under conditions of health and disease.","authors":"Md Shahjalal Sagor, Tarequl Islam, Noshin Tabassum Tamanna, Md Kamrul Islam Bappy, Danishuddin, Md Azizul Haque, Maximilian Lackner","doi":"10.1186/s13099-025-00696-2","DOIUrl":"10.1186/s13099-025-00696-2","url":null,"abstract":"<p><p>Traditionally regarded as a vestigial organ, the appendix is now being reevaluated for its significant function in health and nutrition of humans. Serving as a \"safe house\" for beneficial, desired gut bacteria, the appendix is protected by resilient biofilms that create a secure environment. This makes the appendix a\"basin\" for gut microbiota (GM), replenishing the microbial population following disruptions from infections, antibiotic use, or inflammatory bowel disease (IBD). Beyond simply hosting bacteria, the appendix has an active role in functions of the immune system. Disruption of the Appendix Microbiome (AM), such as through appendectomy, was found to result in lowered diversity of gut microorganisms and an increased risk of various diseases. The potential therapeutic applications of the AM are a particularly promising area of research. The appendix's unique microbial environment and its impact on immunity open new avenues for treatments. These include modulating GM to improve cancer treatment outcomes, mitigating IBD, regulating metabolic pathways in obesity and diabetes, influencing neurotransmitter production in neurological disorders, and addressing cardiovascular and autoimmune diseases. This review highlights the appendix's transformation from a misunderstood organ to a critical component of gut health and immunity. It explores the function of the human appendix as a resilient reservoir for desired microorganisms, and its role in disease progression. Furthermore, it examines the potential therapeutic applications of AM, presenting exciting opportunities for future research and treatment innovations.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"38"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-urease therapy: a targeted approach to mitigating antibiotic resistance in Helicobacter pylori while preserving the gut microflora.","authors":"Christina Almarmouri, Mohammed I El-Gamal, Mohamed Haider, Mohamad Hamad, Shamsul Qumar, Merylin Sebastian, Rose Ghemrawi, Jibran Sualeh Muhammad, Christophe Burucoa, Ghalia Khoder","doi":"10.1186/s13099-025-00708-1","DOIUrl":"10.1186/s13099-025-00708-1","url":null,"abstract":"<p><p>The global rise in antibiotic resistance has posed significant challenges to the effective management of Helicobacter pylori (H. pylori), a gastric pathogen linked to chronic gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic therapies, while effective, face significant challenges, such as increasing antibiotic resistance, high recurrence rates, and adverse effects such as gut microflora dysbiosis. These limitations have driven the exploration of alternative antibiotic-free therapies, including the use of plant-based compounds, probiotics, nanoparticles, phage therapy, antimicrobial peptides, and H. pylori vaccines. Among these, urease-targeted therapy has shown particular promise. Urease enables the survival and colonization of H. pylori by neutralizing stomach acidity. Targeting this urease without disrupting beneficial gut microflora offers a selective mechanism to impair H. pylori, due to the absence of this enzyme in most of the human gut microbiome. In this review, we highlight advancements and limitations in the field of antibiotic-free therapies, with a particular focus on anti-urease strategies. We explore the structural and functional characteristics of urease, its role in H. pylori pathogenesis, and its potential as a therapeutic target. For the first time, we provide a comprehensive analysis of natural, semisynthetic, and synthetic anti-urease compounds, emphasizing their mechanisms of action, efficacy, and safety profiles. Advances in silico, in vitro, and in vivo studies have identified several promising anti-urease compounds with high specificity and minimal toxicity. By focusing on urease inhibition as a targeted strategy, this review underscores its potential to overcome antibiotic resistance while minimizing gut dysbiosis and improving the outcomes of H. pylori infection treatment.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"37"},"PeriodicalIF":4.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of ESBL-positive Klebsiella pneumoniae isolated from paired children with and without diarrhea.","authors":"Yuan Zhang, Mengyu Wang, Zhenpeng Li, Yao Peng, Yuhan Yang, Xiao Liu, Zhe Li, Biao Kan, Mei Zeng, Xin Lu","doi":"10.1186/s13099-025-00700-9","DOIUrl":"10.1186/s13099-025-00700-9","url":null,"abstract":"<p><strong>Background: </strong>Klebsiella pneumoniae producing extended-spectrum β-lactamase (ESBL) colonizing and transmitting in the intestine, especially in children, have significant public health implications. Investigating antibiotic resistance, antibiotic resistance genes (ARGs), virulence factor genes (VFGs), and genetic relationships may help us to explore the characteristics and differences of ESBL-positive K. pneumoniae in children with and without diarrhea.</p><p><strong>Methods: </strong>After selecting and pairing, 26 pairs of 52 ESBL-positive K. pneumoniae strains were isolated from 323 children with diarrhea and 393 children without diarrhea. Antimicrobial susceptibility test and whole genome sequencing were performed to explore antibiotic resistance, ARGs, and VFGs. The genetic relationship was explored by conducting a maximum likelihood phylogenetic tree and investigating plasmid and sequence type (ST).</p><p><strong>Results: </strong>All strains showed resistance to cephalosporins, with ESBL-producing genes widely carried (98.1%). Carbapenem-resistant K. pneumoniae (CRKP) were found in both groups. Hypervirulent K. pneumoniae (hvKP) were isolated from children with diarrhea carrying iucA on plasmid. The emergence of ST5670 CRKP and ST2108 hvKP highlighted the necessity for close monitoring of community-acquired K. pneumoniae.</p><p><strong>Conclusions: </strong>Severe drug resistance was found among ESBL-positive K. pneumoniae strains isolated from children with and without diarrhea. Attention must be paid to ESBL-positive K. pneumoniae colonized in the intestine of children, and pathogen and ARG monitoring in children should be strengthened, even in healthy people.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"36"},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts.","authors":"Heidelinde Sammallahti, Sama Rezasoltani, Satu Pekkala, Arto Kokkola, Hamid Asadzadeh Agdaei, Mehdi Azizmohammad Looha, Reza Ghanbari, Farhad Zamani, Amir Sadeghi, Virinder Kaur Sarhadi, Marja Tiirola, Pauli Puolakkainen, Sakari Knuutila","doi":"10.1186/s13099-025-00710-7","DOIUrl":"10.1186/s13099-025-00710-7","url":null,"abstract":"","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"34"},"PeriodicalIF":4.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.","authors":"Rania G Elbaiomy, Xiaoling Luo, Rong Guo, Shiyuan Deng, Meifang Du, Ahmed H El-Sappah, Mohammed Bakeer, Mahmoud M Azzam, Ahmed A Elolimy, Mahmoud Madkour, Zaixin Li, Zhi Zhang","doi":"10.1186/s13099-025-00704-5","DOIUrl":"10.1186/s13099-025-00704-5","url":null,"abstract":"<p><p>The identification of Helicobacter pylori (H. pylori) infection as the primary etiology of gastroduodenal diseases represents a significant advancement in the field of gastroenterology. The management of these diseases has undergone a substantial transformation, and antibiotic treatment is now universally applicable. H. pylori has been the subject of numerous investigations to determine the prevalence of antibiotic resistance. However, many of these studies are limited, particularly regarding the number and representativeness of the strains assessed. Genetic and physiological modifications, such as gene mutations, efflux pump alterations, biofilm formation, and coccoid formation, contribute to the observed resistance. Our review focuses on the emergence of antibiotic-resistant strains, particularly emphasizing the various modifications of H. pylori that confer this resistance. In conclusion, we elucidate the challenges, potential solutions, and prospects in this field, providing researchers with the knowledge necessary to overcome the resistance exhibited by H. pylori.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"35"},"PeriodicalIF":4.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the etiology of diarrheal illness in Cambodia in a case-control study from 2020 to 2023.","authors":"Paksathorn Kietsiri, Siriporn Sornsakrin, Samon Nou, Wilawan Oransathid, Dutsadee Peerapongpaisarn, Wirote Oransathid, Panida Nobthai, Patcharawalai Wassanarungroj, Siriphan Gonwong, Pimmada Sakpaisal, Nuanpan Khemnu, Somethy Sok, Sokh Vannara, Chiek Sivhour, Sidonn Krang, Ly Sovann, Em Sovannarith, Woradee Lurchachaiwong, Sidhartha Chaudhury, Nattaya Ruamsap, Paphavee Lertsethtakarn","doi":"10.1186/s13099-025-00709-0","DOIUrl":"10.1186/s13099-025-00709-0","url":null,"abstract":"<p><p>Diarrheal infection remains a major public health problem in low and middle-income countries (LMICs). Prevention and control of diarrheal diseases are considered a global health priority. This case-control study aims to describe the prevalence of diarrhea etiologic agents and antimicrobial resistance in bacterial enteropathogens for acute diarrhea among children, adult civilians, and military personnel in Cambodia, detecting over 20 bacterial species, viruses, and parasites. A total of 918 subjects with acute diarrhea (cases), 791 aged-matched subjects without diarrhea (controls), and 675 follow-up cases were enrolled from five hospitals in Battambang and Oddor Meanchey provinces from 2020 to 2023. Pathogens were identified from collected stool samples via bacteriology, molecular techniques, immunoassays, and microscopy. Bacterial isolates were tested for antibiotic resistance patterns. From enrolled diarrhea cases, 533 stool samples (58%) were positive for enteric pathogens, compared to 389 samples (49%) in controls, underscoring the high carriage rate of enteric pathogens in this population as well as the difficulties in establishing the etiology of diarrhea cases. The most common enteric pathogens in cases were enteric bacteria with Aeromonas (15%), followed by Plesiomonas (12%), and enteroaggregative E. coli (EAEC) (10%). Shigella (p < 0.05), enterotoxigenic E. coli with heat-stable toxins (ETEC-ST) (p < 0.01), and Plesiomonas (p < 0.01) had a statistically significant association with acute diarrhea cases. Rotavirus was the most common virus found (51% of cases with virus), followed by norovirus (19%), and sapovirus (16%). In terms of antimicrobial resistance, 84% of Shigella isolates were highly resistant to trimethoprim/sulfamethoxazole (SXT), almost 80% of Campylobacter jejuni isolates were resistant to ciprofloxacin (82%) and nalidixic acid (85%). Over 50% of ETEC, Shigella, and EAEC isolates were resistant to ceftriaxone, ciprofloxacin, and SXT, respectively. Overall, our study highlights the high endemicity of enteric bacterial pathogens and the significant carriage rates of these pathogens even in individuals without overt symptoms. Although the overall antimicrobial resistance was moderate, prevalent isolates harbor a significant resistance to the first-line of treatment. This highlights the importance of ongoing diarrhea etiology and antimicrobial resistance (AMR) surveillance efforts to guide the development and implementation of an effective AMR management program in diarrheal infections.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"32"},"PeriodicalIF":4.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Detection of SARS-CoV-2 from patient fecal samples by whole genome sequencing.","authors":"Andreas Papoutsis, Thomas Borody, Siba Dolai, Jordan Daniels, Skylar Steinberg, Brad Barrows, Sabine Hazan","doi":"10.1186/s13099-025-00711-6","DOIUrl":"10.1186/s13099-025-00711-6","url":null,"abstract":"","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"33"},"PeriodicalIF":4.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chicken as a carrier of emerging virulent Helicobacter species: a potential zoonotic risk.","authors":"Ahmed Samir, Hala M Zaher","doi":"10.1186/s13099-025-00707-2","DOIUrl":"10.1186/s13099-025-00707-2","url":null,"abstract":"<p><strong>Background: </strong>The research scope regarding Helicobacter species in chickens, other than H. pullorum, is largely overlooked. This study aimed to investigate the prevalence of emerging Helicobacter species in chickens and the occurrence of the virulence gene cytolethal distending toxin B (cdtB) among the identified Helicobacter species, referring to their public health significance.</p><p><strong>Methods: </strong>A total of 390 cloacal swabs were collected from 205 broilers and 185 layers. The swabs were pooled into 78 pools. DNA was extracted from these pools, followed by Helicobacter 16S rRNA gene PCR. Twenty pools positive for Helicobacter 16S rRNA were analyzed for H. pylori and H. pullorum, then Helicobacter 16S rRNA sequencing was performed on ten negative pools for H. pullorum and H. pylori to identify Helicobacter species. Subsequently, cdtB was investigated in the 20 pools positive for Helicobacter. Following that, partial DNA sequencing of one H. pullorum and one H. brantae cdtB gene from broiler and layer chickens, respectively, was carried out.</p><p><strong>Results: </strong>Overall, 25.6% of the examined pools were positive for Helicobacter spp., with 3 (7.3%) and 17 (45.9%) broiler and layer pools being positive, respectively. All three broiler pools were identified as H. pullorum; seven-layer pools were positive for H. pullorum, while H. pylori could not be detected. Helicobacter 16S rRNA sequencing of ten negative layer pools for H. pullorum and H. pylori revealed 6 H. brantae, 2 H. kayseriensis, 1 H. winghamensis, and 1 Helicobacter sp. Tul. The cdtB gene was found in 10 H. pullorum, 5 H. brantae, 1 H. winghamensis, and 1 Helicobacter sp. Tul. Phylogenetic analysis of Helicobacter 16S rRNA sequences and BLAST analysis of H. pullorum and H. brantae cdtB partial sequences underscore the public health importance of the obtained sequences.</p><p><strong>Conclusion: </strong>This study highlights that the occurrence of emerging virulent Helicobacter species in chicken feces poses a potential zoonotic relevance and public health risk.</p>","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"17 1","pages":"31"},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}