Growth Hormone & Igf Research最新文献

{"title":"Effect of metformin on thyroid cancer risk in patients with acromegaly: A preliminary observational study","authors":"Cem Sulu ,&nbsp;Ayyuce Begum Bektas ,&nbsp;Suleyman Sami Guzel ,&nbsp;Kubilay Tay ,&nbsp;Serdar Sahin ,&nbsp;Emre Durcan ,&nbsp;Hande Mefkure Ozkaya ,&nbsp;Pinar Kadioglu","doi":"10.1016/j.ghir.2022.101484","DOIUrl":"10.1016/j.ghir.2022.101484","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the role of metformin<span><span> on thyroid cancer risk </span>in patients<span> with acromegaly.</span></span></p></div><div><h3>Methods</h3><p>Medical charts of 534 patients with acromegaly that were followed-up between 1983 and 2019 were reviewed. Patients with follow-up duration at least 6 months were included. Cohort entry was defined as first visit date. The date of each case's thyroid cancer diagnosis was defined as index date. Patients were followed until the index date, death, or last visit date, whichever came first. Nested case-control study design was selected to evaluate the association between metformin and the thyroid cancer risk in patients with acromegaly.</p></div><div><h3>Results</h3><p>291 patients with acromegaly were included into final analysis. The mean age at acromegaly diagnosis was 42.3 ± 1.3 years. The median follow-up duration was 76 [34–132] months. Among 291 patients, 13 patients (4.5%) had thyroid cancer. Thirty-one percent (<em>n</em> = 92) of the patients used metformin for 6 months or longer. One standard deviation (SD) increase in average growth hormone increased the odds of having thyroid cancer by 1.164 folds (<em>p</em> = 0.017). One SD increase of the average insulin-like growth factor 1 to upper limit of normal ratio increased the odds of having thyroid cancer by 1.201 folds (<em>p</em> = 0.004). If a patient used metformin for at least 6 months, the odds to have thyroid cancer was decreased, multiplied by 0.62 with a 95% confidence interval of [0.47, 0.83] (<em>p</em> = 0.0013). The risk of thyroid cancer decreased with increasing duration of metformin use.</p></div><div><h3>Conclusion</h3><p>Metformin may decrease the thyroid cancer risk in patients with acromegaly.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"66 ","pages":"Article 101484"},"PeriodicalIF":1.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40531049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acromegaly-related cutis verticis gyrata","authors":"João Roque,&nbsp;Pedro Marques","doi":"10.1016/j.ghir.2022.101497","DOIUrl":"10.1016/j.ghir.2022.101497","url":null,"abstract":"<div><h3>Objective</h3><p><span>Acromegaly is a disorder caused by hypersecretion of growth hormone (GH), resulting in excessive levels of insulin-like growth factor 1 (IGF-1), and almost always due to a </span>pituitary tumor<span><span><span><span>. It is classically associated with acral enlargement, prominent facial features and soft tissue overgrowth. </span>Skin manifestations include </span>hirsutism<span><span>, acne, skin tags, </span>oily skin<span> and acanthosis nigricans. However, other uncommon dermatological features, such as </span></span></span>cutis verticis gyrata<span> (CVG), may also occur. Here, we review acromegaly-related CVG aiming to raise awareness for its possible occurrence in this setting, and we discuss its pathophysiology, presentation, management and differential diagnosis.</span></span></p></div><div><h3>Design</h3><p>A comprehensive literature search regarding CVG, particularly CVG related to acromegaly, has been carried out. Case reports, original studies and review papers, were considered.</p></div><div><h3>Results</h3><p><span>CVG is a rare benign skin lesion characterized by thickened and folded </span>scalp<span>, resembling the brain gyri and sulci. The diagnosis of CVG mainly relies on clinical examination, although tissue biopsy may be necessary in case of uncertain etiology. In acromegaly, CVG appears to be driven by the trophic effects of GH and IGF-1 on skin and soft tissues. While CVG is uncommon in acromegaly, it seems to occur more frequently in male patients. The management of acromegaly-related CVG essentially relies on controlling the serum levels of GH and IGF-1. Surgical skin procedures should be reserved for patients with severe aesthetic distress, after achieving the best possible control of acromegaly.</span></p></div><div><h3>Conclusions</h3><p>CVG is a rare manifestation of acromegaly that may allow an earlier diagnosis and a swifter treatment of these patients, which in turn may improve or entirely reverse such remarkable skin lesions.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"66 ","pages":"Article 101497"},"PeriodicalIF":1.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency","authors":"Luiz A. Oliveira-Neto ,&nbsp;Jéssica K.F. Nascimento ,&nbsp;Roberto Salvatori ,&nbsp;Alécia A. Oliveira-Santos ,&nbsp;Rafaela S. Girão ,&nbsp;Evânio V. Silva ,&nbsp;André L.M. Santos ,&nbsp;Matheus M. Cunha ,&nbsp;Marcos A.V. Bittencourt ,&nbsp;Gustavo T. Rodrigues ,&nbsp;Bruna M.R. Andrade ,&nbsp;Alaíde H.A. Oliveira ,&nbsp;Eugênia H.O. Valença ,&nbsp;Manuel H. Aguiar-Oliveira","doi":"10.1016/j.ghir.2022.101469","DOIUrl":"10.1016/j.ghir.2022.101469","url":null,"abstract":"<div><h3>Objective</h3><p>To understand the growth of teeth and mandibular and maxillary bones in subjects with isolated growth hormone deficiency (IGHD).</p></div><div><h3>Material and methods</h3><p>Mesiodistal tooth width of 28 maxillary and mandibular dental models of 14 adult IGHD subjects (9 men) were digitalized and compared to 40 models of 20 normal-statured controls (11 men). The mean SDS of the maxillary and mandibular teeth were compared with height, cephalic perimeter, total anterior facial height, total maxillary and mandibular length, and maxillary and mandibular arches.</p></div><div><h3>Results</h3><p><span>All average mesiodistal dimensions in absolute values of the 14 dental pairs were reduced in the IGHD group. Eight of 28 (28.6%) mesiodistal dimensions in IGHD subjects of both sexes had an average SDS below −2, thirteen of them (46.4%) had mean SDS between −1 and − 2, and seven of them (25.0%) had SDS above −1. The highest SDS values were the upper lateral incisor (−0.32 in women), and the </span>upper canine<span> (−0.91 in men). The lowest SDS values were the 2nd upper molar (−3.51 in men), and the 2nd upper premolar (−2.64 in women). The ascending order of the mean SDS was height, total maxillary length, total mandibular length, total anterior height of the face, cephalic perimeter, the maxillary arches width, the mesiodistal width of the mandibular teeth, the mesiodistal width of the maxillary teeth and the mandibular arches width.</span></p></div><div><h3>Conclusions</h3><p>Reduction in mesiodistal width is present in untreated IGHD adults with magnitude of tooth size reduction being lower than height, cephalic perimeter, total anterior facial height, and most jaw measurements. IGHD abolishes the sexual dimorphism in mesiodistal dental measures.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101469"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87476144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In missed abortion the decrease of IGF-1 down-regulates PI3K/AKT signaling pathway reducing the secretion of progesterone and β-hCG","authors":"Weitao Liang ,&nbsp;Tianyuan Zhu ,&nbsp;Na Tan ,&nbsp;Guangzhuang Jing ,&nbsp;Li'ao Xie ,&nbsp;Yuhui Dang ,&nbsp;Zhilan Li","doi":"10.1016/j.ghir.2022.101479","DOIUrl":"10.1016/j.ghir.2022.101479","url":null,"abstract":"<div><h3>Objective</h3><p>To explore whether the reduction of IGF-1 in missed abortion down-regulates PI3K/AKT signaling pathway<span><span>, thereby causing trophoblast cell apoptosis and reducing the secretion of β-hCG and </span>progesterone.</span></p></div><div><h3>Design</h3><p>12 pairs of serum and villous tissues were selected from missed abortion patients and normal early pregnant women who had terminated pregnancy by artificial abortion. The subjects in two groups had same age and gestational week. Wes Simple Western system and qRT-PCR were used to detect the expression of IGF-1, IGF-1R, PI3K/AKT signaling pathway and apoptosis-related factors in villous tissues. Radioimmunoassay and Enzyme-linked immunosorbent assay were used to detect β-hCG, progesterone and IGF-1 in serum.</p></div><div><h3>Results</h3><p>The serum levels of β-hCG, progesterone and IGF-1 were decreased in missed abortion group than those in normal early pregnant women. In addition, compared with normal early pregnant women, the genes and proteins levels of IGF-1 and PI3K/AKT signaling pathway and anti-apoptosis related factors were significantly decreased.</p></div><div><h3>Conclusions</h3><p>Our results suggested that the reduction of IGF-1 in missed abortion patients could down-regulate the expression of PI3K/AKT signaling pathway, thereby increasing the apoptosis of trophoblast cells, leading to decreased secretion of β-hCG and progesterone, which may be one of the important mechanisms of missed abortion.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101479"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40399389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced exercise-induced growth hormone secretion among children with attention-deficit hyperactivity disorder","authors":"Dan Nemet ,&nbsp;Sigal Ben-Zaken ,&nbsp;Roi A. Eliakim ,&nbsp;Alon Eliakim","doi":"10.1016/j.ghir.2022.101485","DOIUrl":"10.1016/j.ghir.2022.101485","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Attention-deficit/hyperactivity disorder (ADHD) is typically a chronic, often lifelong condition. Data suggest that ADHD itself and its treatment may be associated with dysregulated growth, including height and </span>BMI. The reason for this association is yet unknown. The objective of this study was to examine differences in growth hormone (GH) response to exercise between children who had received a diagnosis of ADHD and age- and gender-matched controls. We reasoned that the normal increase in circulating GH seen in response to exercise would be blunted in children with ADHD.</p></div><div><h3>Methods</h3><p>We recruited 13 treatment-naïve children with newly diagnosed ADHD and 14 age-matched controls (all male) and measured GH response to an exercise test in which the work was scaled to each subject's physical capability.</p></div><div><h3>Results</h3><p>There was no difference in the peak heart rate achieved during exercise between controls and ADHD participants (196.6 ± 1.5 vs. 196.5 ± 2.1 bpm, respectively) and lactate response to exercise (53.8 ± 5.0 vs. 47.9 ± 3.8 mg/dl, respectively). After exercise, GH increased significantly in the control subjects (<em>p</em> &lt; 0.005), while GH responses were substantially blunted in the ADHD group (p = NS) even though the work performed did not differ from controls.</p></div><div><h3>Conclusions</h3><p>Our data suggest that GH excretion after exercise challenge in children with ADHD is impaired. This can be detected using a minimally invasive, nonpharmacologic challenge and may link ADHD with growth impairment in some children.</p><p><em>Trial registration number:</em> <span>NCT00945971</span><svg><path></path></svg></p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101485"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40594507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes","authors":"Takaoki Saneyasu,&nbsp;Tomonori Nakamura,&nbsp;Kazuhisa Honda,&nbsp;Hiroshi Kamisoyama","doi":"10.1016/j.ghir.2022.101478","DOIUrl":"10.1016/j.ghir.2022.101478","url":null,"abstract":"<div><h3>Objective</h3><p>We examined whether auto/paracrine insulin-like growth factor-1 (IGF-1) contributes to the phosphorylation of Akt and ERK in chicken myotubes.</p></div><div><h3>Methods</h3><p>Chicken myotubes were treated with IGF-1 siRNA, and then total RNA and protein were harvested for real-time PCR and western blot analysis.</p></div><div><h3>Results</h3><p>Treatment with IGF-1 siRNA inhibited the phosphorylation of Akt and ERK, but not of ribosomal protein S6, in chicken myotubes. Interestingly, IGF-1 siRNA downregulated the expression of IGF-2.</p></div><div><h3>Conclusions</h3><p>The results of this study suggest that auto/paracrine IGF-1 contributes to Akt and ERK phosphorylation in chicken myotubes.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101478"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39991022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin response to growth hormone stimulation tests","authors":"Avivah Silbergeld ,&nbsp;Chen Barazani ,&nbsp;Zvi Laron","doi":"10.1016/j.ghir.2022.101483","DOIUrl":"10.1016/j.ghir.2022.101483","url":null,"abstract":"<div><h3>Background</h3><p>Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received little attention.</p></div><div><h3>Objective</h3><p>To determine the PRL response to GH stimulation tests.</p></div><div><h3>Subjects</h3><p>Prepubertal and early pubertal boys (<em>n</em> = 581) and girls (<em>n</em> = 502) with idiopathic, non-syndromatic short stature.</p></div><div><h3>Design</h3><p><span>Data was retrieved from the computerized records of the Endocrine Laboratory, Schneider Children's Medical Center. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), </span>Clonidine<span> (Clon) and Clonidine with arginine (Clon+Arg), were compared. Both PRL and GH were determined by radioimmunoassay.</span></p></div><div><h3>Results</h3><p><span>Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed the PRL secretion (</span><em>p</em> &lt; 0.0001). It is also evident that in both boys and girls Clon alone and Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg than with Clon alone are attributed to the pubertal stage.</p></div><div><h3>Conclusion</h3><p>This study provides further information on the Prolactin-Growth hormone relationship in children.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101483"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40565193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","authors":"Stephanie A. Osganian ,&nbsp;Sonu Subudhi ,&nbsp;Ricard Masia ,&nbsp;Hannah K. Drescher ,&nbsp;Lea M. Bartsch ,&nbsp;Mark L. Chicote ,&nbsp;Raymond T. Chung ,&nbsp;Denise W. Gee ,&nbsp;Elan R. Witkowski ,&nbsp;Miriam A. Bredella ,&nbsp;Georg M. Lauer ,&nbsp;Kathleen E. Corey ,&nbsp;Laura E. Dichtel","doi":"10.1016/j.ghir.2022.101482","DOIUrl":"10.1016/j.ghir.2022.101482","url":null,"abstract":"<div><h3>Objective</h3><p><span><span><span>The GH and IGF-1 axis is a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) given its lipolytic, anti-inflammatory and anti-fibrotic properties. IGF-1 receptor (IGF-1R) and </span>GH receptor (GHR) expression in adult, human hepatic tissue is not well understood across the spectrum of NAFLD severity. Therefore, we sought to investigate hepatic IGF-1R and </span>GHR expression in subjects with NAFLD utilizing </span>gene expression analysis<span> (GEA) and immunohistochemistry (IHC).</span></p></div><div><h3>Design</h3><p>GEA (<em>n</em> = 318) and IHC (<em>n</em><span><span> = 30) cohorts were identified from the Massachusetts General Hospital NAFLD Tissue Repository. GEA subjects were categorized based on histopathology<span> as normal liver histology<span> (NLH), steatosis only (Steatosis), nonalcoholic steatohepatitis (NASH) without fibrosis (NASH F0), and NASH with fibrosis (NASH F1–4) with GEA by the Nanostring nCounter assay. IHC subjects were matched for age, </span></span></span>body mass index (BMI), sex, and diabetic status across three groups (</span><em>n</em> = 10 each): NLH, Steatosis, and NASH with fibrosis (NASH F1–3). IHC for IGF-1R, IGF-1 and GHR was performed on formalin-fixed, paraffin-embedded hepatic tissue samples.</p></div><div><h3>Results</h3><p>IGF-1R gene expression did not differ across NAFLD severity while IGF-1 gene expression decreased with increasing NAFLD severity, including when controlled for BMI and age. GHR expression did not differ by severity of NAFLD based on GEA or IHC.</p></div><div><h3>Conclusions</h3><p>IGF-1R and GHR expression levels were not significantly different across NAFLD disease severity. However, expression of IGF-1 was lower with increasing severity of NAFLD. Additional research is needed regarding the contribution of the GH/IGF-1 axis to the pathophysiology of NAFLD and NASH.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"65 ","pages":"Article 101482"},"PeriodicalIF":1.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth hormone modulates Trypanosoma cruzi infection in vitro","authors":"Patricia Mora-Criollo ,&nbsp;Reetobrata Basu ,&nbsp;Yanrong Qian ,&nbsp;Jaime A. Costales ,&nbsp;Jaime Guevara-Aguirre ,&nbsp;Mario J. Grijalva ,&nbsp;John J. Kopchick","doi":"10.1016/j.ghir.2022.101460","DOIUrl":"10.1016/j.ghir.2022.101460","url":null,"abstract":"<div><h3>Objective</h3><p><span>Chagas disease<span> (CD) is caused by the protozoan parasite, </span></span><span><span>Trypanosoma cruzi</span></span>. It affects 7 to 8 million people worldwide and leads to approximately 50,000 deaths per year. <em>In vitro</em> and <em>in vivo</em><span> studies had demonstrated that Trypanosoma cruziinfection causes an imbalance in the hypothalamic-pituitary-adrenal (HPA) axis that is accompanied by a progressive decrease in growth hormone (GH) and prolactin (PRL) production. In humans, inactivating mutations in the GH receptor<span> gene cause Laron Syndrome<span> (LS), an autosomal recessive disorder. Affected subjects are short, have increased adiposity, decreased insulin-like growth factor-I (IGF</span></span></span><img><span>I), increased serum GH levels, are highly resistant to diabetes and cancer, and display slow cognitive decline. In addition, CD incidence in these individuals is diminished despite living in highly endemic areas. Consequently, we decided to investigate the </span><em>in vitro</em> effect of GH/IGF-I on <em>T. cruzi</em> infection<em>.</em></p></div><div><h3>Design</h3><p><span>We first treated the parasite and/or host cells with different peptide hormones including GH, IGF</span><img>I, and PRL. Then, we treated cells using different combinations of GH/IGF-I attempting to mimic the GH/IGF-I serum levels observed in LS subjects.</p></div><div><h3>Results</h3><p>We found that exogenous GH confers protection against <em>T. cruzi</em> infection. Moreover, this effect is mediated by GH and not IGF<img>I. The combination of relatively high GH (50 ng/ml) and low IGF-I (20 ng/ml), mimicking the hormonal pattern seen in LS individuals, consistently decreased <em>T. cruzi</em> infection <em>in vitro</em>.</p></div><div><h3>Conclusions</h3><p>The combination of relatively high GH and low IGF-I serum levels in LS individuals may be an underlying condition providing partial protection against <em>T. cruzi</em> infection.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"64 ","pages":"Article 101460"},"PeriodicalIF":1.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83042263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of IGF-I axis genetic polymorphisms among decathlon athletes","authors":"Sigal Ben-Zaken ,&nbsp;Yoav Meckel ,&nbsp;Liina Remmel ,&nbsp;Dan Nemet ,&nbsp;Jaak Jürimäe ,&nbsp;Alon Eliakim","doi":"10.1016/j.ghir.2022.101468","DOIUrl":"10.1016/j.ghir.2022.101468","url":null,"abstract":"<div><h3>Objective</h3><p>Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was to assess the prevalence of IGF genetic polymorphisms<span> among decathletes, to present an optimal genetic profile for enhancing performance.</span></p></div><div><h3>Methods</h3><p>The participants included 151 male athletes and 75 male non-athletic controls from Israel and Estonia. Athletes were divided into four groups, according to the field of expertise: (a) 40 sprinters and long jumpers; (b) 40 middle distance runners; (c) 44 Weightlifters; and (d) 27 decathletes. Genomic DNA was extracted from the participants' buccal epithelial cells using standard protocol and then analyzed for IGF1 axis related genetic polymorphism using the allelic discrimination assay.</p></div><div><h3>Results</h3><p>A significantly higher prevalence of the <em>IGF1</em> rs35767 TT genotype was found among decathletes compared to the other athletes, as well as a lower prevalence of the <em>IGF1</em> rs7136446 GG genotype, a higher prevalence of the <em>IGF1R</em> rs1464430 AA genotype, and a higher prevalence of the <em>IGF2</em> rs680 GG genotype. Moreover, among the decathletes, carriers of the <em>IGF1</em> rs7136446 GG genotype achieved higher decathlon scores compared to A-allele carriers.</p></div><div><h3>Conclusions</h3><p>The findings of this study suggest a potential beneficial role for some IGF-axis polymorphisms (mainly the <em>IGF1</em> 1245 TT and the <em>IGF2</em> GG) among decathletes, both of which are associated with improved speed performance.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"64 ","pages":"Article 101468"},"PeriodicalIF":1.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86607194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}