血清脂蛋白(a)升高，这是生长激素治疗的不良反应

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2022-12-01 DOI:10.1016/j.ghir.2022.101503

Zvi Laron

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引用次数: 1

摘要

许多报告显示，高内源性或治疗性给药的人生长激素(hGH)引起血清脂蛋白A, Lp(A)的增加。血栓性Lp(a)是动脉粥样硬化性心血管疾病(ASCVD)的独立危险因素。因此，假设最近报道的儿童生长激素治疗与心血管发病率之间的关联可能是由于生长激素对Lp(a)合成的影响。因此，建议在儿童和成人hGH治疗前和治疗期间检测血清Lp(a)水平。

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Increase of serum lipoprotein (a), an adverse effect of growth hormone treatment

A number of reports show that high endogenous, or therapeutic administration of human growth hormone (hGH) cause an increase of serum lipoprotein a, Lp(a). Being thrombogenic Lp(a) is an independent risk factor of atherosclerotic cardiovascular disease (ASCVD). Hence, it is hypothesized that the recently reported association between childhood hGH treatment and cardiovascular morbidity is probably due to the GH effect on Lp(a) synthesis. It is therefore suggested to determine serum Lp(a) levels before and during hGH treatment in children and adults.

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.