神经类固醇对肢端肥大症患者的抑郁和认知功能有影响吗?

IF 1.6 4区 医学 Q4 CELL BIOLOGY
Esra Hatipoglu , Yalcin Hacioglu , Yeliz Polat , Hilmi Furkan Arslan , Sena Oner , Ozlem Balci Ekmekci , Mutlu Niyazoglu
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引用次数: 2

摘要

目的神经甾体激素(NSs)是一类独特的激素,因其对情绪状态和认知功能的影响而闻名。它们是否也参与肢端肥大症的情绪障碍和认知尚不清楚。本研究旨在探讨肢端肥大症患者的情绪状态和认知功能与神经神经系统水平的关系。33例肢端肥大症患者组成肢端肥大症组(AG), 30例年龄和性别匹配的非肢端肥大症患者组成对照组(CG)。测定各组大鼠异孕酮(AP)、孕烯醇酮(PRG)、24s -羟基胆固醇(24OHC)、脱氢表雄酮(DHEA)、硫酸脱氢表雄酮(DHEAS)、雄酮(ADT)、生长激素(GH)、IGF-1水平。贝克抑郁量表(BDI)用于评估抑郁症状,而由经验丰富的心理学家对每个受试者进行广泛的神经心理学评估和几项神经认知测试。结果肢端肥大症患者的24OHC和DHEA水平低于对照组(p = 0.002和p = 0.007)。在认知功能方面,肢端症患者完成1 s系列的时间显著高于对照组,在转换语言流畅性测试、波士顿命名测试(BNT)-语义和BNT-语音、Oktem言语记忆过程测试(VMPT)的最高学习点得分显著低于对照组(p = 0.004, p = 0.01, p <0.001, p = 0.02, p = 0.05)。CG组kas - persistence误差较高(p = 0.03)。AG组AP水平与月后测验(MBT)、动物命名测验(Animal Naming Test)、结构测验(construct)、bnt -自发测验(BNT-spontaneous)得分呈负相关,与bnt -错误答案呈正相关;PRG与VMPT-retention得分呈显著正相关,ADT与MBT和3s Series得分呈显著负相关,DHEAS与vmpt - highest learning point得分呈显著正相关,与MBT得分呈显著负相关。此外,BDI得分与AG中DHEA水平呈正相关。结论肢端肥大症患者可能出现认知功能的改变,神经甾体激素可能导致某些认知功能的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly?

Objective

Neurosteroids (NSs) are a distinct hormone group and, they are known for their contribution into the status of mood and cognitive functions. Whether they are also involved in the mood disturbances and cognition in acromegaly is not known. Herein we aimed to evaluate the relation of mood status and cognitive functions with the NS levels in cases with acromegaly.

Design

A total of 33 cases with acromegaly composed the acromegaly group (AG) and, 30 age and gender-matched cases without acromegaly composed the control group (CG). The levels of Allopregnanolone (AP), pregnenolone (PRG), 24S-hydroxycholesterol (24OHC), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androsterone (ADT), GH and IGF-1 were measured in each group. Beck Depression Inventory (BDI) was used to assess depressive symptoms, whereas an extensive neuropsychological assessment with several neurocognitive tests were carried out for each subject by an experienced psychologist.

Results

Cases with acromegaly had lower 24OHC and DHEA levels (p = 0.002 and p = 0.007, respectively) in comparison to CG. Of the cognitive functions time to complete 1 s Series was significantly higher and, the scores on Switching Verbal Fluency Test, Boston Naming Test (BNT)-semantic and BNT-phonological, the highest learning point of Oktem Verbal Memory Processes Test (VMPT) were significantly lower in cases with acromegaly in comparison to those in controls (p = 0.004, p = 0.01, p < 0.001, p = 0.02 and p = 0.05, respectively). KAS-perseveration errors were higher in CG (p = 0.03). In AG the levels of AP were negatively correlated with the scores on Months backward Test (MBT), Animal Naming Test, Construction, BNT-spontaneous and positively correlated with BNT-incorrect answers; PRG was positively correlated with VMPT-retention scores, ADT was negatively correlated with MBT and 3 s Series scores, DHEAS was positively correlated with VMPT-the highest learning point whereas it was negatively correlated with MBT scores. Additionally, the scores on BDI were positively correlated with DHEA levels in AG.

Conclusion

Cognitive changes may be encountered in acromegaly and, neurosteroids may contribute to the changes in certain cognitive functions.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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