Gastroenterologia y hepatologia最新文献

{"title":"Follicular pancreatitis mimicking pancreatic cancer: A diagnostic challenge.","authors":"Yu Lu, Qiu Wu, Tao Yin","doi":"10.1016/j.gastrohep.2025.502463","DOIUrl":"10.1016/j.gastrohep.2025.502463","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502463"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red yeast rice: From liver toxicity to liver transplantation.","authors":"Miriam Celada-Sendino, Margarita Fernández-de la Varga, Marta Álvarez-Posadilla, Adrián Huergo-Fernández","doi":"10.1016/j.gastrohep.2025.502459","DOIUrl":"10.1016/j.gastrohep.2025.502459","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502459"},"PeriodicalIF":2.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal bleeding secondary to pseudoaneurysm after anticoagulation for splanchnic thrombosis in acute necrohaemorrhagic pancreatitis.","authors":"María Ortiz de Solórzano Reig, Julia López de la Cruz, María Concepción Aso Gonzalvo, Antonio Aguilar Muñiz, Marta Latre Santos, Enrique Ceamanos Ibarra, María Escuín Sanmartín, Guillén Bernal Bandrés, Sergio García Mateo, Judith Millastre Bocos","doi":"10.1016/j.gastrohep.2025.502458","DOIUrl":"10.1016/j.gastrohep.2025.502458","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502458"},"PeriodicalIF":2.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Externalized nurse-led model for hepatitis C virus microelimination and impact of drug use profile","authors":"Anna Miralpeix ,&nbsp;Paula Ibáñez ,&nbsp;Víctor Navarro ,&nbsp;Patricia Colomera ,&nbsp;Montserrat Gálvez ,&nbsp;Zoe Mariño ,&nbsp;Xavier Major ,&nbsp;Joan Colom ,&nbsp;Xavier Forns ,&nbsp;Sabela Lens","doi":"10.1016/j.gastrohep.2024.502288","DOIUrl":"10.1016/j.gastrohep.2024.502288","url":null,"abstract":"<div><h3>Background and objective</h3><div>Direct-acting antivirals have greatly simplified the treatment of hepatitis C virus (HCV), yet circuits that bring diagnosis and treatment closer to people who inject drugs (PWID) are needed to achieve the elimination targets of the WHO. With this purpose we have established an externalized nurse-driven circuit among former and active PWID in an addiction centre (AC) and a harm reduction centre (HRC).</div></div><div><h3>Methods and settings</h3><div>The nursing staff offered HCV screening, diagnosis and treatment to the AC and HRC users, administered medication after the hepatologist's remote prescription to those with an active infection who accepted being treated, and implemented educational and harm reduction interventions.</div></div><div><h3>Participants and results</h3><div>Between October 2018 and March 2021, 566 users accepted screening. 134 (24%) had an active infection, with a higher prevalence among HRC users (42% vs 17%; <em>p</em> <!-->&lt;<!--> <!-->0.001), who were more frequently foreigners, homeless and reported active drug use and syringe sharing. Treatment initiation was similar between groups. Overall sustained viral response (SVR) for intention-to-treat (ITT) and per protocol (PP) was 70% and 88% respectively. Overall adherence was good in both groups; however, SVR was higher in AC users compared to HRC users (ITT-SVR 81% vs 55%). All reinfections (6% by ITT) occurred in the HRC group. Overall loss to follow-up rate was 21%.</div></div><div><h3>Conclusions</h3><div>This patient-centred nurse-driven circuit demonstrates that HCV treatment can be successfully delivered to PWID even with active drug use and socio-economic complexity. User-specific characteristics need to be considered when setting up these interventions to maximize success.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502288"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cystic fibrosis related liver disease in a pediatric cohort","authors":"Saioa Vicente-Santamaría ,&nbsp;María Emilia Torres-Guerrero ,&nbsp;Miguel García-González ,&nbsp;Ana Tabares-González ,&nbsp;Celia Gascón-Galindo ,&nbsp;Concepción Marina López-Cárdenes ,&nbsp;Enrique Blitz-Castro ,&nbsp;Ana Morales-Tirado ,&nbsp;María Inmaculada Mota-Goitia ,&nbsp;José Ramón Gutiérrez-Martínez ,&nbsp;Carlos Tutau-Gómez ,&nbsp;Ruth García-Romero ,&nbsp;Enrique Salcedo-Lobato ,&nbsp;Luis Peña-Quintana ,&nbsp;Ana Reyes-Domínguez ,&nbsp;Encarnación Torcuato-Rubio ,&nbsp;Pilar Ortiz-Pérez ,&nbsp;Ana Estefanía Fernández-Lorenzo ,&nbsp;Ana Moreno-Álvarez ,&nbsp;Alfredo Solar-Boga ,&nbsp;David González-Jiménez","doi":"10.1016/j.gastrohep.2024.502321","DOIUrl":"10.1016/j.gastrohep.2024.502321","url":null,"abstract":"<div><h3>Background</h3><div>Cystic fibrosis (CF) is an autosomal recessive, chronic, potentially lethal genetic disease. CF manifestations are due to mutations in the CF transmembrane receptor transporter (CFTR) gene which codes for a protein (CFTR) that acts as an anion transporter, mainly chlorine, at epithelial cells where it is expressed. Cystic fibrosis related liver disease (CFRLD) includes a spectrum of hepatobiliary manifestations whose diagnosis and follow-up remains a challenge.</div></div><div><h3>Methods</h3><div>Cross-sectional, descriptive study from 10 Spanish cystic fibrosis units. Clinical and biochemical data obtained. Patients categorized into 3 groups according to liver involvement based on ESPGHAN 2017 criteria. Liver stiffness assessed by transient elastography (TE) and findings from abdominal ultrasound recorded. Statistics performed using SPSS v25.0.</div></div><div><h3>Results</h3><div>We obtained hepatic TE data from 155 pediatric CF patients. Forty-four classified as CFRLD, 38 (86%) had CFRLD without cirrhosis and 6 (14%) had cirrhosis. Fourteen patients without CFRLD (12%) had ultrasound abnormalities. Mean liver elastography value (kPa) was 4.7 (3.5–5.3) in non-CFRLD and 6.09 (4.4–6.7) in CFRLD (<em>p</em> <!-->=<!--> <!-->0.01; <em>T</em> Student [<em>T</em>]).</div></div><div><h3>Conclusions</h3><div>CFRLD is common in children with CF. Transient elastography is a useful method for diagnosis and follow-up, as higher values of TE are found in patients with CFRLD.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502321"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ictericia sostenida tras colangiopancreatografía retrógrada endoscópica","authors":"Idoia Agulleiro Beraza,&nbsp;Eduardo Leo Carnerero,&nbsp;José Manuel Sousa Martín,&nbsp;Rose Marie Vallejo Vigo","doi":"10.1016/j.gastrohep.2024.502264","DOIUrl":"10.1016/j.gastrohep.2024.502264","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502264"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From food to alcohol: Why some patients develop new addictions after bariatric surgery","authors":"Edilmar Alvarado-Tapias ,&nbsp;Ramon Bataller ,&nbsp;David Martí-Aguado","doi":"10.1016/j.gastrohep.2025.502430","DOIUrl":"10.1016/j.gastrohep.2025.502430","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502430"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing outcomes with maintenance IV UST in highly bio-exposed patients with IBD. Efficacy and adjusted regimen in real world","authors":"Alejandro Mínguez ,&nbsp;Elena Coello ,&nbsp;Alejandro Garrido ,&nbsp;Paula Ripoll ,&nbsp;María Gomez ,&nbsp;Mariam Aguas ,&nbsp;Marisa Iborra ,&nbsp;Elena Cerrillo ,&nbsp;Lluis Tortosa ,&nbsp;Virginia Bayarri ,&nbsp;Noemí Bueno ,&nbsp;Maria José Fernández ,&nbsp;Remedios Marqués ,&nbsp;Pilar Nos ,&nbsp;Guillermo Bastida","doi":"10.1016/j.gastrohep.2024.502253","DOIUrl":"10.1016/j.gastrohep.2024.502253","url":null,"abstract":"<div><h3>Background and aims</h3><div>Ustekinumab is an effective treatment for inflammatory bowel diseases. However, some patients do not respond to conventional doses. The aim of the study was to evaluate the effectiveness of intravenous maintenance ustekinumab in patients with secondary failure.</div></div><div><h3>Methods</h3><div>Single-center, retrospective study in adult patients with intravenous maintenance ustekinumab. The reduction of biochemical activity markers, ustekinumab trough levels and clinical indices of activity were evaluated. Biological remission was defined as the percentage decrease fecal calprotectin ≥80% and/or final fecal calprotectin ≤250 and C reactive protein &lt;5<!--> <!-->mg/L.</div></div><div><h3>Results</h3><div>Thirty-one patients were included: Crohn's disease 77.4%. All included patients were bio-exposed and 61.3% had carried ≥2 biologics.</div><div>Pre-intravenous maintenance mean Harvey–Bradshaw Index was 6.5<!--> <!-->±<!--> <!-->4.38 vs 5<!--> <!-->±<!--> <!-->3.1 at week 8 (<em>p</em> <!-->=<!--> <!-->0.024) vs 4.1<!--> <!-->±<!--> <!-->3.1 at week 24 (<em>p</em> <!-->=<!--> <!-->0.019). The median ustekinumab trough level pre-intravenous maintenance was 1.40<!--> <!-->μg/ml [IQR 2.3] vs 5.35<!--> <!-->μg/ml [IQR 4.1] at week 8 (<em>p</em> <!-->&lt;<!--> <!-->0.001) vs 4.8<!--> <!-->μg/ml [IQR 3.9] at week 24 (<em>p</em> <!-->&lt;<!--> <!-->0.001). The pre-intravenous maintenance median fecal calprotectin was 809<!--> <!-->μg/g [IQR: 2256] vs 423<!--> <!-->μg/g [IQR: 999] at week 8 (<em>p</em> <!-->=<!--> <!-->0.025) vs 333<!--> <!-->μg/g [508] (<em>p</em> <!-->=<!--> <!-->0.001) at week 24.</div><div>At the end of follow-up 48% went into biological remission. The presence of perianal disease was associated with lower biological remission (70.6% vs 27.3%, <em>p</em> <!-->=<!--> <!-->0.025). Median intravenous ustekinumab maintenance time was 8.55 [IQR 23.9] months. In 83.9% of patients no serious infections or malignancy were documented.</div></div><div><h3>Conclusions</h3><div>The use of maintenance intravenous ustekinumab appears to be an effective and safe strategy that can be evaluated as a salvage treatment especially in highly bio-exposed patients.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502253"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of colonic spirochetosis","authors":"Marc Lleixà Rioboo ,&nbsp;Karmele Sáez de Gordoa ,&nbsp;Oswaldo Ortiz","doi":"10.1016/j.gastrohep.2024.502316","DOIUrl":"10.1016/j.gastrohep.2024.502316","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502316"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory bowel disease in the gypsy community in England and Scotland","authors":"Affifa Farrukh,&nbsp;John F. Mayberry","doi":"10.1016/j.gastrohep.2024.502295","DOIUrl":"10.1016/j.gastrohep.2024.502295","url":null,"abstract":"<div><h3>Introduction</h3><div>The travelling community in England and Scotland may consist of between 150,000 and 500,000 members. In Scotland ethnicity codings for hospital admissions includes: Gypsies, Roma, Irish travellers and show people. Few Trusts in England break down codings for “Other British” in such detail.</div></div><div><h3>Method</h3><div>One hundred and thirty-two NHS Trusts were approached in England and 14 NHS Boards in Scotland through a Freedom of Information request to provide details of admission to hospital between 2016 and 2022 with ulcerative colitis and had undergone a panproctocolectomy and those with Crohn's disease and had undergone a hemicolectomy.</div></div><div><h3>Results</h3><div>Of the 132 NHS Trusts approached in England only 7 were able to provide data on hospital admissions for inflammatory bowel disease from this community; whereas in Scotland 13 of 14 did so. There were 1012 admissions with ulcerative colitis and based on the number of admissions per patient in Somerset NHS Foundation Trust this would represent 138 patients. In contrast, there were 901 admissions with Crohn's disease and at least 9 patients underwent a hemicolectomy.</div></div><div><h3>Conclusion</h3><div>The inadequacy of data collection related to this community is discussed.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 5","pages":"Article 502295"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}