Gastroenterologia y hepatologia最新文献

{"title":"Revisión sistemática sobre las estrategias terapéuticas en la dispepsia funcional: abordajes farmacológicos y no farmacológicos según el subtipo clínico.","authors":"Maika Aragunde Marcos, Alberto Ezquerra, Leticia Moreira, Elizabeth Barba","doi":"10.1016/j.gastrohep.2026.502870","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502870","url":null,"abstract":"<p><p>Functional dyspepsia is a disorder of gut-brain interaction that significantly affects quality of life and has a limited therapeutic response. This systematic review, conducted according to PRISMA 2020, analyzed randomized clinical trials published over the past ten years in adults meeting Rome III/IV criteria. Prokinetics showed no consistent benefit, except in some patients with overlapping subtypes. In postprandial distress syndrome, a low-FODMAP diet was not superior to conventional dietary advice, except, in a subgroup analysis, in patients with abdominal distension, while mirtazapine showed signals of benefit in patients with weight loss or early satiety. In epigastric pain syndrome, low-dose amitriptyline was superior to pantoprazole. Herbal therapies, electroacupuncture, transcutaneous auricular vagus nerve stimulation, and multidisciplinary care showed signals of benefit, mostly derived from single trials, whereas cannabidiol was ineffective. Overall, the evidence supports a personalized, stepwise, and biopsychosocial approach to treatment.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502870"},"PeriodicalIF":2.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVOLVE-IBERIA: Real-world evidence on vedolizumab and anti-tumour necrosis factor-α as first- and second-line biologic treatment in Crohn's disease.","authors":"J Fernando Muñoz, Ana Gutiérrez-Casbas, Cristina Rodríguez, Javier P Gisbert, Sabino Riestra, Claudia Herrera de Guise, Isabel Vera-Mendoza, M Pilar Martínez-Montiel, Sónia Bernardo, Isabel Medeiros, Jesús Aparicio, Ignacio Tagarro, Teresa Letosa Abián, Carmen Montoto, Francesc Casellas","doi":"10.1016/j.gastrohep.2026.502871","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502871","url":null,"abstract":"<p><strong>Objective: </strong>Much of the available real-world evidence on the gut-selective α4β7 integrin antibody vedolizumab comes from patients with repeated failure of anti-tumour necrosis factor-α (anti-TNFα) agents and other treatments. The EVOLVE-IBERIA study is aimed to generate additional real-world evidence for vedolizumab and anti-as first- or second-line biologic treatment, in patients with Crohn's disease or ulcerative colitis; here we present the outcomes in patients with Crohn's disease.</p><p><strong>Patients and methods: </strong>Medical charts of patients aged 18 years or older treated with vedolizumab or anti-TNFα as first- or second-line biologic in Spain and Portugal were retrospectively reviewed; both cohorts therefore included biologic-naive and biologic-exposed patients to compare the clinical effectiveness, safety and treatment patterns of vedolizumab and anti, and to characterize healthcare resource utilisation. Analyses were adjusted by means of propensity scores using inverse probability of treatment weighting.</p><p><strong>Results: </strong>A total of 210 patients with Crohn's disease were included; median follow-up was 26.0 months. At Week 52, clinical response rates were 74.8% and 69.8% (p=0.481) and clinical remission rates were 51.3% and 66.5% (p=0.065), in the vedolizumab cohort and in the anti-TNFα cohort, respectively. Treatment-related adverse event rates per 100 patient-years were 1.15 in the vedolizumab cohort and 2.70 in the anti-TNFαcohort (p=0.024).</p><p><strong>Conclusion: </strong>In the real-world setting, the comparable long-term effectiveness and lower incidence of treatment-related adverse events of vedolizumab compared with anti-suggest a favourable benefit: risk ratio of vedolizumab as first- or second-line biologic treatment in patients with Crohn's disease.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502871"},"PeriodicalIF":2.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN UNEXPECTED CAUSE OF GASTRIC OUTLET OBSTRUCTION.","authors":"César Morales-Rodríguez, Víctor Moisés Lizarzaburu-Rodríguez, Ovidio Villena-Mosqueira, Roberto Carlos Tafur-Navarro, Edgar Fermín Yan-Quiroz, José Richard Tenazoa-Villalobos","doi":"10.1016/j.gastrohep.2026.502874","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502874","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502874"},"PeriodicalIF":2.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unexpected Finding in a Small Duodenal Subepithelial Lesion.","authors":"Muchen Ren, Rui Xu, Kuiliang Liu","doi":"10.1016/j.gastrohep.2026.502873","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502873","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502873"},"PeriodicalIF":2.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteína catiónica eosinofílica en saliva como biomarcador de actividad en esofagitis eosinofílica: estudio piloto.","authors":"Maite Odriozola-Garmendia, Jesús Barado, Luis Bujanda","doi":"10.1016/j.gastrohep.2026.502867","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502867","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502867"},"PeriodicalIF":2.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TREATMENT OF PERISTOMAL VARICEAL BLEEDING BY SELECTIVE EMBOLISATION WITHOUT TIPS VIA A TRANSHEPATIC APPROACH.","authors":"Rafael Marrero Díaz, Andrea Pozo Zorita, María Vega Catalina Rodríguez, Andrés Conthe","doi":"10.1016/j.gastrohep.2026.502868","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502868","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502868"},"PeriodicalIF":2.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación clínica y terapéutica de la esofagitis eosinofílica en población pediátrica y adulta en Colombia: estudio multicéntrico transversal","authors":"Fabian Juliao-Baños,&nbsp;Michelle Higuera Carrillo,&nbsp;Adán Lúquez-Mindiola,&nbsp;Wilson Daza,&nbsp;Álvaro Gómez-Venegas,&nbsp;Natali González Rozó,&nbsp;Viviana Parra-Izquierdo,&nbsp;Ailim Margarita Carias Domínguez,&nbsp;Hernando Marulanda-Fernández,&nbsp;José Fernando Vera Chamorro,&nbsp;Jhon Carvajal-Gutiérrez,&nbsp;Juan Pablo Riveros López,&nbsp;Brenda Arturo-Arias,&nbsp;Catalina Ortiz Piedrahita,&nbsp;Pedro Nel Aponte-Ordoñez,&nbsp;Carlos Augusto Cuadros Mendoza,&nbsp;Viviana Parra-Vargas,&nbsp;Stephania Peña Hernández,&nbsp;Jerónimo Toro-Calle,&nbsp;César Augusto Moreno Serrano,&nbsp;William Otero-Regino","doi":"10.1016/j.gastrohep.2026.502659","DOIUrl":"10.1016/j.gastrohep.2026.502659","url":null,"abstract":"<div><h3>Aim</h3><div>Eosinophilic esophagitis (EoE) is a chronic and progressive inflammatory disease with increasing prevalence and incidence worldwide. The objective was to determine the differences in epidemiological, clinical, and treatment characteristics between pediatric and adult patients with EoE in Colombia.</div></div><div><h3>Patients and methods</h3><div>A cross-sectional comparative study was conducted with two independent cohorts of pediatric and adult patients at multiple Colombian centers.</div></div><div><h3>Results</h3><div>286 patients with EoE were analyzed, 143 children and 143 adults, with a predominance of males (61.9%). Regarding symptom onset and time to diagnosis, adults sought medical attention earlier than children (&lt;6 months: 42.0% vs. 22.8%, p<!--> <!-->=<!--> <!-->0.014). Adults presented with more dysphagia (70.0% vs. 32.2%, P &lt;<!--> <!-->0.001) and food impaction (21.0% vs. 2.8%, P &lt;<!--> <!-->0.001), and less weight loss (4.2% vs. 25.7%, P &lt;<!--> <!-->0.001), compared to children. Regarding treatment, adults received more proton pump inhibitors (87.4% vs. 41.1%, p &lt;<!--> <!-->0.001) and more topical steroids (29.4% vs. 16.1%, p<!--> <!-->=<!--> <!-->0.07) than children. The use of systemic corticosteroids was very low in both groups (1.4% vs. 2.8%, p<!--> <!-->=<!--> <!-->0.684). There were no significant differences in dietary treatment (40.0% vs. 32.9%, p<!--> <!-->=<!--> <!-->0.797).</div></div><div><h3>Conclusions</h3><div>Eosinophilic esophagitis in Colombia affects both children and adults and shows clear differences in allergic history, clinical presentation, and treatment strategies. These findings highlight variability in clinical practice between pediatric and adult gastroenterologists within the national context.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 8","pages":"Article 502659"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave ablation as a therapeutic approach in Zollinger–Ellison syndrome","authors":"Diego Romero-Triana,&nbsp;Víctor Domínguez-Prieto,&nbsp;Siyuan Qian-Zhang,&nbsp;Antonio Hermosín-Peña,&nbsp;Pedro Villarejo-Campos","doi":"10.1016/j.gastrohep.2026.502660","DOIUrl":"10.1016/j.gastrohep.2026.502660","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 8","pages":"Article 502660"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile duct's oncological mimetism: Cholangiocarcinoma VS colorectal metastasis","authors":"Ana Díaz Granados,&nbsp;María del Mar García Bretones,&nbsp;Pablo Dabán López,&nbsp;Clotilde Moreno Cortés,&nbsp;María Dolores Hernández García,&nbsp;Enrique Dabán Collado,&nbsp;Benito Mirón Pozo","doi":"10.1016/j.gastrohep.2025.502642","DOIUrl":"10.1016/j.gastrohep.2025.502642","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 8","pages":"Article 502642"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Groove pancreatitis: Radiologic–histologic insights for diagnosis","authors":"Antonio Pérez Serena,&nbsp;Daisy Paola Martínez Betancourt","doi":"10.1016/j.gastrohep.2026.502661","DOIUrl":"10.1016/j.gastrohep.2026.502661","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 8","pages":"Article 502661"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}