Gastroenterologia y hepatologia最新文献

Assessment of cystic fibrosis related liver disease in a pediatric cohort.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-12-13 DOI: 10.1016/j.gastrohep.2024.502321

S Vicente-Santamaría, M E Torres-Guerrero, M García-González, A Tabares-González, C Gascón-Galindo, C M López-Cárdenes, E Blitz-Castro, A Morales-Tirado, M I Mota Goitia, J R Gutiérrez Martínez, C Tutau Gómez, R García Romero, E Salcedo Lobato, L Peña Quintana, A Reyes Domínguez, E Torcuato Rubio, P Ortiz Pérez, A E Fernández-Lorenzo, A Moreno Álvarez, Alfonso Solar Boga, H Romero Rey, M Álvarez Beltrán, E Masip Simo, D González Jiménez

{"title":"Assessment of cystic fibrosis related liver disease in a pediatric cohort.","authors":"S Vicente-Santamaría, M E Torres-Guerrero, M García-González, A Tabares-González, C Gascón-Galindo, C M López-Cárdenes, E Blitz-Castro, A Morales-Tirado, M I Mota Goitia, J R Gutiérrez Martínez, C Tutau Gómez, R García Romero, E Salcedo Lobato, L Peña Quintana, A Reyes Domínguez, E Torcuato Rubio, P Ortiz Pérez, A E Fernández-Lorenzo, A Moreno Álvarez, Alfonso Solar Boga, H Romero Rey, M Álvarez Beltrán, E Masip Simo, D González Jiménez","doi":"10.1016/j.gastrohep.2024.502321","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2024.502321","url":null,"abstract":"Background: Cystic fibrosis (CF) is an autosomal recessive, chronic, potentially lethal genetic disease. CF manifestations are due to mutations in the CF transmembrane receptor transporter (CFTR) gene which codes for a protein (CFTR) that acts as an anion transporter, mainly chlorine, at epithelial cells where it is expressed. Cystic fibrosis related liver disease (CFRLD) includes a spectrum of hepatobiliary manifestations whose diagnosis and follow-up remains a challenge.Methods: Cross-sectional, descriptive study from 10 Spanish Cystic fibrosis Units. Clinical and biochemical data obtained. Patients categorized into 3 groups according to liver involvement based on ESPGHAN 2017 criteria. Liver stiffness assessed by transient elastography (TE) and findings from abdominal ultrasound recorded. Statistics performed using SPSS v25.0.Results: We obtained hepatic TE data from 155 pediatric CF patients. Forty-four classified as CFRLD, 38 (86%) had CFRLD without cirrhosis and 6 (14%) had cirrhosis. Fourteen patients without CFRLD (12%) had ultrasound abnormalities. Mean liver elastography value (kPa) was 4.7 (3.5-5.3) in non-CFRLD and 6.09 (4.4-6.7) in CFRLD (p=0.01;Tstudent [T]).Conclusions: CFRLD is common in children with CF. Transient elastography is a useful method for diagnosis and follow-up, as higher values of TE are found in patients with CFRLD.","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502321"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of relative adrenal insufficiency in patients with severe alcohol-associated hepatitis-a prospective clinical study.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-12-12 DOI: 10.1016/j.gastrohep.2024.502322

Raúl Alberto Jiménez-Castillo, Carlos Eugenio González-Martínez, Elianee María Tovar-Bojorquez, Carlos Alejandro Cortez-Hernández, Joel Omar Jaquez-Quintana, José Alberto González-González, José Gerardo González-González, Héctor Jesús Maldonado-Garza

{"title":"Prognostic value of relative adrenal insufficiency in patients with severe alcohol-associated hepatitis-a prospective clinical study.","authors":"Raúl Alberto Jiménez-Castillo, Carlos Eugenio González-Martínez, Elianee María Tovar-Bojorquez, Carlos Alejandro Cortez-Hernández, Joel Omar Jaquez-Quintana, José Alberto González-González, José Gerardo González-González, Héctor Jesús Maldonado-Garza","doi":"10.1016/j.gastrohep.2024.502322","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2024.502322","url":null,"abstract":"Background/aims: Relative adrenal insufficiency (RAI) is frequent in patients with liver cirrhosis and affects their prognosis. Scarce data on RAI in patients with alcohol-associated hepatitis (AAH) exists. This study aimed to document the prevalence and prognostic implication of RAI in patients with severe AAH.Patients and methods: Adults with a first episode of AAH were selected. The delta cortisol level was the difference between the serum basal cortisol and 60 minutes after ACTH stimulation. Cox proportional-hazard regression model was used for univariate analysis of prognostic factors with 95% confidence intervals. The Kaplan-Meier and log-rank tests were applied for survival analysis between patients with RAI and without RAI.Results: Twenty-five subjects with a first episode of AAH were included. Eight (32.0%) deaths occurred in our cohort. Univariate analysis showed that presence of RAI (p = 0.049) had a significant impact on 90-day Overall Survival (OS). Serum albumin (p = 0.991), serum creatinine (p = 0.954), sodium (p = 0.986) and international normalized ratio (p = 0.073) did not show a significant impact on 90-day OS. Ninety-day overall survival for patients with RAI was 50.0% vs. 90.9% in those without RAI, (p=0.040).Conclusions: The presence of RAI seems to be a fair predictor of intermediate-term survival in AAH patients.","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502322"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Position statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis on the use of Telemedicine in Inflammatory Bowel Disease.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-12-11 DOI: 10.1016/j.gastrohep.2024.502320

Mariam Aguas Peris, Javier Del Hoyo Francisco, Pilar Nos Mateu, Ana Echarri Piudo, Marta Calvo, Beatriz Gros Alcalde, María Dolores Martín Arranz, Emilio Monte Boquet, Sergio Inglán Agustín, Antonio Valdivia Martínez, Marisa Correcher, Manuel Barreiro-de Acosta, Miriam Mañosa Ciria, Francisco Rodriguez-Moranta, Yamile Zabana, Ana Gutiérrez Casbas

{"title":"Position statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis on the use of Telemedicine in Inflammatory Bowel Disease.","authors":"Mariam Aguas Peris, Javier Del Hoyo Francisco, Pilar Nos Mateu, Ana Echarri Piudo, Marta Calvo, Beatriz Gros Alcalde, María Dolores Martín Arranz, Emilio Monte Boquet, Sergio Inglán Agustín, Antonio Valdivia Martínez, Marisa Correcher, Manuel Barreiro-de Acosta, Miriam Mañosa Ciria, Francisco Rodriguez-Moranta, Yamile Zabana, Ana Gutiérrez Casbas","doi":"10.1016/j.gastrohep.2024.502320","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2024.502320","url":null,"abstract":"Inflammatory Bowel Disease (IBD) is a chronic digestive condition that requires continuous monitoring by healthcare professionals to determine appropriate therapy and manage short- and long-term complications. Telemedicine has become an essential approach for managing chronic conditions such as IBD, improving care accessibility and continuity, decreasing hospitalization rates, and optimizing patient follow-up. It enables rapid treatment adjustments and encourages patient self-management. Additionally, it reduces the burden on the healthcare system by decreasing unnecessary in-person visits and provides real-time support, thereby improving quality of life and clinical outcomes. The objective of this position statement by the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) is to establish recommendations for the use of telemedicine in its different modalities (teleconsulting, telemonitoring, mobile applications and telepharmacy) for patients with IBD and address the legal, ethical, and technical aspects necessary for its proper implementation.","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502320"},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSOCIATION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA WITH HEAD AND NECK CANCER.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-12-09 DOI: 10.1016/j.gastrohep.2024.502318

Cautar El Maimouni, Henry Córdova, Sterling Feliz-Ruiz, Irina Luzko Scheid, Leticia Moreira, Joan Llach, Isis K Araujo, Begoña González-Suárez, Àngels Ginés, Gloria Fernández-Esparrach

{"title":"ASSOCIATION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA WITH HEAD AND NECK CANCER.","authors":"Cautar El Maimouni, Henry Córdova, Sterling Feliz-Ruiz, Irina Luzko Scheid, Leticia Moreira, Joan Llach, Isis K Araujo, Begoña González-Suárez, Àngels Ginés, Gloria Fernández-Esparrach","doi":"10.1016/j.gastrohep.2024.502318","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2024.502318","url":null,"abstract":"Background and objectives: Esophageal squamous cell carcinomas (ESCC) are often accompanied by head and neck squamous cell carcinoma (HNSCC) and vice versa. Our study aimed to describe the prevalence of HNSCC in patients with ESCC, the chronology of appearance and the impact on survival.Methods: A retrospective review was carried out through a computerized database of patients diagnosed with ESCC at Hospital Clinic of Barcelona between January 1999 and June 2019. Demographic data, date of ESCC diagnosis, survival time, primary tumor location, diagnosis of HNSCC and chronological relationship were recorded.Results: A total of 231 patients with ESCC confirmed histologically were included in the study with a median age of 64 years (IQR, 56.0-72.0), and 178 (77%) were male. The majority of the patients had a history of smoking and alcohol consumption (69.7% and 60.6%, respectively). The predominant location of ESCC was the middle esophagus (n=124, 53.7%). Forty-one patients (17.7%) had HNSCC: 21 (51.2 %) were previous, 14 (34.1%) synchronous and 6 (14.6%) metachronous. All the patients were followed and 196 (84.8%) died with a median survival time of 19 months (IQR, 7-66). There were not statistically significant differences among the living patients and the deceased.Conclusions: in our setting, a 17.7% of patients with ESCC have an associated HNSCC with no significant differences in survival between patients with both ESCC and HNSCC compared to those with only ESCC. However, the implementation of a screening program could allow the detection of a second primary tumor at early stages.","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502318"},"PeriodicalIF":2.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperinfestation by Strongyloides stercolaris in an immunodepressed patient due to inflammatory bowel disease.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-29 DOI: 10.1016/j.gastrohep.2024.502317

Marta Fernández Carrasco, Ana Plaza Fernández, Olga Sánchez García

引用次数: 0

A rare case of Colonic Spirochetosis.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-29 DOI: 10.1016/j.gastrohep.2024.502316

Marc Lleixà Rioboo, Karmele Sáez de Gordoa, Oswaldo Ortiz

引用次数: 0

Spanish Working Group in Crohn´s disease and ulcerative colitis (GETECCU) position paper on cardiovascular disease in patients with inflammatory bowel disease.

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-28 DOI: 10.1016/j.gastrohep.2024.502314

Ignacio Marín-Jiménez, Daniel Carpio, Vicent Hernández, Fernando Muñoz, Eduardo Zatarain-Nicolás, Yamile Zabana, Míriam Mañosa, Francisco Rodríguez-Moranta, Manuel Barreiro-de Acosta, Ana Gutiérrez Casbas

{"title":"Spanish Working Group in Crohn´s disease and ulcerative colitis (GETECCU) position paper on cardiovascular disease in patients with inflammatory bowel disease.","authors":"Ignacio Marín-Jiménez, Daniel Carpio, Vicent Hernández, Fernando Muñoz, Eduardo Zatarain-Nicolás, Yamile Zabana, Míriam Mañosa, Francisco Rodríguez-Moranta, Manuel Barreiro-de Acosta, Ana Gutiérrez Casbas","doi":"10.1016/j.gastrohep.2024.502314","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2024.502314","url":null,"abstract":"Cardiovascular diseases (CVD) are the leading cause of death worldwide. Therefore, it is essential to understand their relationship and prevalence in different diseases that may present specific risk factors for them. The objective of this document is to analyze the specific prevalence of CVD in patients with inflammatory bowel disease (IBD), describing the presence of classical and non-classical cardiovascular risk factors in these patients. Additionally, we will detail the pathophysiology of atherosclerosis in this patient group and the different methods used to assess cardiovascular risk, including the use of risk calculators in clinical practice and different ways to assess subclinical atherosclerosis and endothelial dysfunction. Furthermore, we will describe the potential influence of medication used for managing patients with IBD on cardiovascular risk, as well as the potential influence of commonly used drugs for managing CVD on the course of IBD. The document provides comments and evidence-based recommendations based on available evidence and expert opinion. An interdisciplinary group of gastroenterologists specialized in IBD management, along with a consulting cardiologist for this type of patients, participated in the development of these recommendations by the Spanish Group of Work on Crohn's Disease and Ulcerative Colitis (GETECCU).","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502314"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of small bowel capsule endoscopy in patients with Crohn's disease. 小肠胶囊内窥镜对克罗恩病患者的实用性。

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-22 DOI: 10.1016/j.gastrohep.2024.502294

Miquel Marquès-Camí, Nuria Torres-Monclús, Lucía Madero, Eduard Brunet-Mas, Margalida Calafat, Iria Baston-Rey

引用次数: 0

Inflammatory bowel disease in the gypsy community in England and Scotland. 英格兰和苏格兰吉普赛社区的炎症性肠病。

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-22 DOI: 10.1016/j.gastrohep.2024.502295

Affifa Farrukh, John F Mayberry

{"title":"Inflammatory bowel disease in the gypsy community in England and Scotland.","authors":"Affifa Farrukh, John F Mayberry","doi":"10.1016/j.gastrohep.2024.502295","DOIUrl":"10.1016/j.gastrohep.2024.502295","url":null,"abstract":"Introduction: The travelling community in England and Scotland may consist of between 150,000 and 500,000 members. In Scotland ethnicity codings for hospital admissions includes: Gypsies, Roma, Irish travellers and show people. Few Trusts in England break down codings for \"Other British\" in such detail.Method: One hundred and thirty-two NHS Trusts were approached in England and 14 NHS Boards in Scotland through a Freedom of Information request to provide details of admission to hospital between 2016 and 2022 with ulcerative colitis and had undergone a panproctocolectomy and those with Crohn's disease and had undergone a hemicolectomy.Results: Of the 132 NHS Trusts approached in England only 7 were able to provide data on hospital admissions for inflammatory bowel disease from this community; whereas in Scotland 13 of 14 did so. There were 1012 admissions with ulcerative colitis and based on the number of admissions per patient in Somerset NHS Foundation Trust this would represent 138 patients. In contrast, there were 901 admissions with Crohn's disease and at least 9 patients underwent a hemicolectomy.Conclusion: The inadequacy of data collection related to this community is discussed.","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502295"},"PeriodicalIF":2.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Third Space Endoscopy: A reality for the next generation of endoscopists. 第三空间内窥镜：下一代内镜医师的现实。

IF 2.2 4区医学

Gastroenterologia y hepatologia Pub Date : 2024-11-19 DOI: 10.1016/j.gastrohep.2024.502291

Raúl Honrubia López, Aurora Burgos García, Yutaka Mitsunaga, Pedro de María Pallares, Mariana Tavecchia, Cristina Fernández de Castro

引用次数: 0