Gastroenterologia y hepatologia最新文献

{"title":"TUBERCULOSIS AND INFLAMMATORY BOWEL DISEASE.","authors":"Lucía Madero, Iria Bastón, Eduard Brunet-Mas, Margalida Calafat","doi":"10.1016/j.gastrohep.2025.502587","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502587","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, carries an increased risk of tuberculosis (TB), particularly in patients treated with immunosuppressive therapies such as anti-TNF agents. The risk is further elevated when combined with immunomodulators. Other drugs, including anti-integrins, IL-12/23 inhibitors, and JAK inhibitors (JAK-i), present a variable risk of TB reactivation. Given this risk, screening for latent tuberculosis infection (LTBI) is essential in IBD patients before initiating immunosuppressive therapy. Guidelines recommend performing this screening ideally at the time of IBD diagnosis or, alternatively, before advanced therapy. Diagnostic tests include the tuberculin skin test (TST) and interferon-gamma release assays (IGRA). In immunocompromised patients, false negatives may occur; therefore, dual testing is advised. Chest X-rays are reserved for cases with positive tests or clinical suspicion. In the presence of LTBI, chemoprophylaxis with isoniazid or rifampicin is recommended prior to initiating immunosuppression. If active TB is diagnosed, immunosuppressive therapy must be discontinued and standard antituberculous treatment initiated. The reintroduction of immunosuppressive therapy should be assessed on a case-by-case basis, prioritizing agents with lower reactivation risk. Finally, BCG vaccination is not recommended in IBD patients undergoing immunosuppressive treatment due to its nature as a live vaccine.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502587"},"PeriodicalIF":1.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRIMARY GASTRIC MELANOMA.","authors":"José Richard Tenazoa- Villalobos, Edgar Fermín Yan- Quiroz, Mónica Alexandra Olivera-Aldana","doi":"10.1016/j.gastrohep.2025.502588","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502588","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502588"},"PeriodicalIF":1.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale for endoscopic detection of Helicobacter pylori infection in a high prevalence area.","authors":"Martínez Montalvo Carlos Mauricio, Gómez Zuleta Martín Alonso, Ruiz Oscar Fernando, Muñoz-Solano Lina Marcela, Forero Vargas Daniel Andrés","doi":"10.1016/j.gastrohep.2025.502578","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502578","url":null,"abstract":"<p><strong>Introduction: </strong>Colombia is a country with a high prevalence of Hp infection and gastric cancer (GC). The objective of this study was to evaluate the diagnostic yield of endoscopic findings for the diagnosis of Hp infection and, based on these findings, develop a new prediction score applicable to the local population.</p><p><strong>Methods: </strong>Endoscopic findings were evaluated, and photographs were taken according to K. Yao's 22 stations in all individuals who underwent gastroscopy between January 1 and August 2023. All patients underwent biopsy with the Sydney protocol and hematoxylin, eosin, and Giemsa staining. Univariate and bivariate analysis was performed, with logistic regression evaluating a new score applicable to the cohort.</p><p><strong>Results: </strong>A total of 200 patients were included. The prevalence of Hp was 47.5%. The presence of nodular gastropathy and abnormalities in the regular arrangement of collecting venules (RAC) were the endoscopic findings with the highest PPV and NPV, respectively, while atrophy assessed with the Kimura-Takemoto score had a very poor correlation with Hp. The Kyoto score had an AUC of 0.71 and the modified Kyoto score had an AUC of 0.76, which is lower than the performance in the Asian population. With the findings with better correlation, a new endoscopic score called ROVIRA was created with a cut-off point ≥3 and an AUC of 0.91 for this cohort, which suggests that it could become a more accurate clinical tool to identify active infection.</p><p><strong>Conclusion: </strong>Endoscopic findings are useful for predicting Hp infection, highlighting that the preserved RAC is sensitive to rule out Hp infection with a high NPV and on the other hand the nodularity or follicular pattern due to its good specificity. The new ROVIRA scale showed better performance than the Kyoto and modified Kyoto scores in this cohort, suggesting its potential as a clinical tool in Colombia or countries where, in addition to a high prevalence of gastric cancer, there is also a high prevalence of Hp. However, these data will require further validation.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502578"},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophagitis dissecans due to glyphosate ingestion.","authors":"Raúl Fernández García, Marta Lecuona Muñoz, Jesús Canales Fernández, Eduardo Redondo Cerezo, María Del Carmen Fernández Cano","doi":"10.1016/j.gastrohep.2025.502586","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502586","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502586"},"PeriodicalIF":1.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Acute Hepatitis E with Unilateral Amyotrophic Neuralgia: A Diagnostic Challenge.","authors":"A Pascual-Dapena, A Pocurull, X Forns","doi":"10.1016/j.gastrohep.2025.502585","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502585","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502585"},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value and clinical implications of 75SeHCAT scan in bile acid diarrhea.","authors":"D Riado Mínguez, F M Fernández-Gordón, M Casado Portolés, C Gómez Labrador, C Cuadrado Tiemblo, C G Suárez Cabredo, L W Wong Becerra, C Castaño Milla","doi":"10.1016/j.gastrohep.2025.502584","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502584","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502584"},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the need for patient-centered approaches to Helicobacter pylori management in geriatric populations.","authors":"Camila S Badell, Eloy F Ruiz","doi":"10.1016/j.gastrohep.2025.502583","DOIUrl":"10.1016/j.gastrohep.2025.502583","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502583"},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic panniculitis as the only manifestation.","authors":"Sara Rodríguez Vega, Yaiza Rey Fanjul, Jorge Rodríguez Prida","doi":"10.1016/j.gastrohep.2025.502582","DOIUrl":"10.1016/j.gastrohep.2025.502582","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502582"},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic journey to the center of the pancreas: 'Ring Drainage' (gastro-pancreato-duodenal).","authors":"Joan B Gornals, Julia Escuer-Turu, Maria Puigcerver-Mas","doi":"10.1016/j.gastrohep.2025.502577","DOIUrl":"10.1016/j.gastrohep.2025.502577","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502577"},"PeriodicalIF":1.9,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and psychometric evaluation of the Spanish version of the Inflammatory Bowel Disease Knowledge (IBD-KNOW) questionnaire.","authors":"Pilar Corsino Roche, Josep-Oriol Casanovas-Marsal, Santiago García López, Raquel Vicente Lidón, Eva Sierra Moros, Sonia Gallego Montañés, Diego Casas Deza, Laura Vicente Manso, Laura Lafarga-Molina","doi":"10.1016/j.gastrohep.2025.502576","DOIUrl":"10.1016/j.gastrohep.2025.502576","url":null,"abstract":"<p><strong>Objective: </strong>To translate, culturally adapt, and validate the Inflammatory Bowel Disease Knowledge questionnaire in adult Spanish-speaking patients with IBD.</p><p><strong>Patients and methods: </strong>A cross-sectional translation and linguistic validation study was conducted with 30 participants aged>18 years with Inflammatory Bowel Disease at the Miguel Servet University Hospital (Zaragoza, Spain). The IBD-KNOW questionnaire was translated and culturally adapted following ISPOR guidelines. Content validity was assessed by a panel of experts using Aiken's V coefficient. Internal consistency was evaluated using Cronbach's alpha, and test-retest reliability was assessed with the intraclass correlation coefficient (ICC). Descriptive analyses and bivariate tests were used to evaluate sociodemographic and clinical variables, as well as associations with IBD knowledge.</p><p><strong>Results: </strong>The study assessed 30 adults (50% female) with an average age of 44.21±15.05 years; mean age at diagnosis 29.24±11.42 years and mean disease duration 14.97±8.70 years. The Spanish version of the IBD-KNOW demonstrated good internal consistency (Cronbach's α=0.74) and strong test-retest reliability (ICC=0.80; 95% CI: 0.62-0.89). No statistically significant differences were found between the test and retest scores (p=0.39) or completion times (p=0.736). The mean questionnaire score was 5.87±1.53 out of 10.</p><p><strong>Conclusions: </strong>The Spanish version of the IBD-KNOW questionnaire is a valid, reliable, and culturally appropriate instrument for assessing disease-related knowledge in Spanish-speaking IBD patients. Its use in clinical settings can support the identification of educational needs and the design of targeted interventions aimed at improving patient engagement and health outcomes.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502576"},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}