Green Synthesis and Catalysis最新文献_第10页

Photomediated core modification of diaryl dihydrophenzines through three-component alkylarylation of alkenes toward organocatalyzed ATRP 通过烯烃的三组分烷基芳基化实现二芳基二氢苯胺的光催化核心改性，从而实现有机催化 ATRP

Green Synthesis and Catalysis Pub Date : 2024-02-01 DOI: 10.1016/j.gresc.2022.12.001

Yajun Zhang , Hao Wang , Dandan Jiang , Naixian Sun , Wei He , Lili Zhao , Ning Qin , Ning Zhu , Zheng Fang , Kai Guo

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引用次数: 0

Photoinduced radical cascade brominative addition/spirocyclization of N-arylpropiolamides and CBr4 with O2 as oxidant 以 O2 为氧化剂，光诱导 N-芳基丙炔酰胺和 CBr4 的自由基级联溴化加成/螺环化反应

Green Synthesis and Catalysis Pub Date : 2024-01-15 DOI: 10.1016/j.gresc.2024.01.004

Zheng-Wei Wu, Han-Han Kong, Yong Wei, Wen-Chao Zhou, Long Wang, Liang-Qiu Lu, Qing-Qing Yang

引用次数: 0

Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles 电化学 N-olefination 技术用于乙烯基唑的区域和立体选择性合成

Green Synthesis and Catalysis Pub Date : 2024-01-12 DOI: 10.1016/j.gresc.2024.01.005

Kejun Lin, Jianyong Lan, Lin Hao, Tingshun Zhu

引用次数: 0

Directed evolution of stereoselective enzymes meets click reactions: asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase 立体选择性酶的定向进化与点击反应：使用 Cu(I)兼容卤代卤化酶不对称合成手性三唑

Green Synthesis and Catalysis Pub Date : 2024-01-12 DOI: 10.1016/j.gresc.2024.01.001

Shaixiao Tian, Xinying Ge, Qipeng Yan, Min Li, Qun Huang, Xinhua Zhang, Ming Ma, Bo Chen, Jian-bo Wang

{"title":"Directed evolution of stereoselective enzymes meets click reactions: asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase","authors":"Shaixiao Tian, Xinying Ge, Qipeng Yan, Min Li, Qun Huang, Xinhua Zhang, Ming Ma, Bo Chen, Jian-bo Wang","doi":"10.1016/j.gresc.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.gresc.2024.01.001","url":null,"abstract":"We report for the first time the combination of directed evolution focused on enhancing and reversing the stereoselectivity of an enzyme with Cu(I)-mediated click chemistry (CuAAC), providing an asymmetric click approach for versatile chiral triazoles products. In this study, the halohydrin dehalogenase HheG was used as the enzyme which was evolved to induce a stereoselective ring-opening reaction of cyclic epoxides in the presence of NaN3 with the formation of chiral azido products. Two mutants of opposite stereopreference were generated, which convert cyclohexene oxide as well as cycloheptene oxide to (1S, 2S)-2-azidocyclohexanol, (1R, 2R)-2-azidocyclohexanol, (1S, 2S)-2-azidocycloheptanol and (1R, 2R)-2-azidocycloheptanol with essentially high stereoselectivity. The chiral products were then subjected to CuAAC in reactions with structurally different alkynes. Since HheG was found to be compatible with Cu(I), the process was also performed successfully in a unique 2-step one-pot process leading to various chiral triazoles. In order to understand the enhancement and reversal of the evolved enantioselectivity, QM and MD computations were performed. This approach harnesses the modifiability and high stereoselectivity of the evolved biocatalysts in combination with click chemistry. It holds great potential for diverse fields, particularly in the area of pharmaceuticals.","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled generation of ortho-quinone methides and (4+3) cyclization with 2-indolylalcohols by dual photoredox/Brønsted acid relay catalysis 通过光氧化/勃氏酸双重中继催化控制生成邻醌甲酰胺并与 2-吲哚基乙醇发生 (4+3) 环化反应

Green Synthesis and Catalysis Pub Date : 2024-01-09 DOI: 10.1016/j.gresc.2024.01.002

Dong Liang, Panpan Gao, Zhihan Zhang, Wenjing Xiao, Jiarong Chen

引用次数: 0

Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones 可见光诱导的可重复使用的十钨酸盐光催化自由基级联烷基化/异氰酸酯与简单烷烃、醚和酮的环化反应

Green Synthesis and Catalysis Pub Date : 2024-01-06 DOI: 10.1016/j.gresc.2024.01.003

Ke-Li Wang, Hong-Tao Ji, Qiong-Hui Peng, Jun Jiang, Li-Juan Ou, Wei-Min He

引用次数: 0

Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines 水控制的骨架编辑或外围修饰邻位丙酮取代的有机膦

Green Synthesis and Catalysis Pub Date : 2024-01-05 DOI: 10.1016/j.gresc.2023.12.003

Xin-Yue Niu, Chao-Yang Li, Cong-Cong Zhang, Zhan-Wei Bu, Yan Xie, Wen-Jing Zhang, Qi-Lin Wang

引用次数: 0

Facile synthesis of asymmetric tetrablock copolymer by dual thermal and photochemical initiator 利用双重热引发剂和光化学引发剂轻松合成不对称四嵌段共聚物

Green Synthesis and Catalysis Pub Date : 2023-12-18 DOI: 10.1016/j.gresc.2023.11.009

Chenhuai Deng, Yuanhao Lin, Yunye Huang, Linxi Hou, Longqiang Xiao

引用次数: 0

Synthesis of dydrogesterone by aromatization-dearomatization strategy 通过芳香化-脱芳香化策略合成地屈孕酮

Green Synthesis and Catalysis Pub Date : 2023-12-15 DOI: 10.1016/j.gresc.2023.12.001

Heng Bai, Wei Gu, Di Zhao, Guangqing Xu, Wenjun Tang

引用次数: 0

Brønsted acid promoted synthesis of polysubstituted pyrroles from enamines/imines and diazopyruvates: a metal-free cascade approach 在布氏酸的促进下，从烯胺/亚胺和重氮丙酮酸盐合成多代吡咯：一种无金属级联方法

Green Synthesis and Catalysis Pub Date : 2023-12-13 DOI: 10.1016/j.gresc.2023.12.002

Farrukh Sajjad, Ming-Hua Xu

引用次数: 0